CN204448036U - A kind of micro-fluidic chip - Google Patents
A kind of micro-fluidic chip Download PDFInfo
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- CN204448036U CN204448036U CN201520009277.0U CN201520009277U CN204448036U CN 204448036 U CN204448036 U CN 204448036U CN 201520009277 U CN201520009277 U CN 201520009277U CN 204448036 U CN204448036 U CN 204448036U
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Abstract
The utility model relates to a kind of micro-fluidic chip, and it comprises a chip substrate and two films, and two films cover upper surface and the lower surface of chip substrate respectively; Chip substrate is provided with a sample holes, some flow channel for liquids and some ventholes; Sample holes is connected with some flow channel for liquids, and the end of each flow channel for liquids is provided with venthole; Sample holes vertically runs through described chip substrate; Each flow channel for liquids is formed by guiding gutter, transfer groove, microfluidic channel and reaction tank; Guiding gutter is arranged on the lower surface of chip substrate, and its one end is communicated with sample holes bottom, and the other end is communicated with transfer groove lower end; Transfer groove vertically runs through chip substrate, and its upper end is communicated with microfluidic channel one end; Microfluidic channel is horizontally set on the upper surface of chip substrate, is communicated with below it with reaction tank, and end is communicated with venthole.The utility model can be widely used in microfluidic art.
Description
Technical field
The utility model relates to a kind of chip, particularly about a kind of micro-fluidic chip.
Background technology
Microflow control technique is based on micro-processing technology, forms network by microchannel, runs through whole system with controlled fluid, in order to replace a kind of technology of the various functions of standard biologic or chemical laboratory.Micro-fluidic chip is the carrier realizing microflow control technique, it possesses the ability on the chip of a biological or chemical laboratory simmer down to several square centimeters even less, drug research and development, medical science are detected, cost that is biological and chemical laboratory significantly reduces, efficiency significantly raises.
Existing micro-fluidic chip generally adopts the hard material of non-film to carry out closing of chip, and not only cost is high, and technological requirement complexity is loaded down with trivial details.The sample holes of chip and guiding gutter are in same level, and the liquid entered only is full of reaction tank by its own face tension force and capillary effect, and therefore the reaction tank degree of depth cannot carry out larger raising.And adopt the chip of membrane sealed, because the sample holes of chip and the upper surface of guiding gutter are all films, when using liquid-transfering device liquid feeding because breaking of film itself causes sample to spill at sample holes place, and the distortion of face may stop lower end microfluidic channel randomly, cause sample cannot entering part passage.
Summary of the invention
For the problems referred to above, it is low that the purpose of this utility model is to provide a kind of cost, can effectively avoid sample to leak outside, and ensures that sample fully can react micro-fluidic chip.
For achieving the above object, the utility model takes following technical scheme: a kind of micro-fluidic chip, is characterized in that: it comprises a chip substrate and two films, and described two films cover upper surface and the lower surface of described chip substrate respectively; Described chip substrate is provided with a sample holes, some flow channel for liquids and some ventholes; Described sample holes is connected with some described flow channel for liquids, and described in each, the end of flow channel for liquids is provided with described venthole; Described sample holes vertically runs through described chip substrate;
Each described flow channel for liquids is formed by a guiding gutter, a transfer groove, a microfluidic channel and a reaction tank; Described guiding gutter is horizontally set on the lower surface of described chip substrate, and one end of described guiding gutter is communicated with the bottom of described sample holes, and the other end of described guiding gutter is communicated with the lower end of described transfer groove; Described transfer groove vertically runs through described chip substrate, and the upper end of described transfer groove is communicated with one end of described microfluidic channel; Described microfluidic channel is horizontally set on the upper surface of described chip substrate, and the other end of described microfluidic channel is communicated with described reaction tank, and the end of described microfluidic channel is communicated with described venthole.
The position at described transfer groove place is set to Buffer Pool, and described Buffer Pool runs through described chip substrate, and the lower end of described Buffer Pool is communicated with described microfluidic channel with described guiding gutter respectively with upper end.
Flow channel for liquids described in each shares same described guiding gutter, and described guiding gutter is communicated with some described transfer grooves.
Flow channel for liquids described in each shares same described guiding gutter, and described guiding gutter is communicated with some described Buffer Pools.
Flow channel for liquids described in each shares same described guiding gutter and same described transfer groove or described Buffer Pool, one end of described transfer groove or described Buffer Pool is communicated with described guiding gutter, and the other end of described transfer groove or described Buffer Pool is communicated with some described microfluidic channel.
The utility model is owing to taking above technical scheme, it has the following advantages: 1, the utility model is due to by arranging transfer groove/Buffer Pool by Sample introduction in the microfluidic channel being arranged at chip substrate upper surface, make sample can be full of reaction tank by self gravitation, thus make the reaction tank degree of depth can obtain larger raising.2, the utility model is closed chip basal body owing to adopting film, reduces production cost and the manufacturing technique requirent of micro-fluidic chip.3, the utility model arranges guiding gutter owing to adopting surface under the die, the distortion caused the film around sample holes when avoiding sample injector application of sample or break and make the problem of micro-fluidic chip leakage or sample introduction difficulty.Therefore, the utility model can be widely used in microfluidic art.
Accompanying drawing explanation
Fig. 1 is overall structure schematic diagram of the present utility model
Fig. 2 is multiple flow channel for liquids structural representation in the utility model
Fig. 3 is overall structure schematic diagram when the utility model flow channel for liquids adopting Buffer Pool
Fig. 4 is multiple flow channel for liquids structural representations when the utility model flow channel for liquids adopting Buffer Pool
Detailed description of the invention
Below in conjunction with drawings and Examples, the utility model is described in detail.
As shown in Fig. 1 ~ 2, the utility model provides a kind of micro-fluidic chip, and it comprises upper surface and lower surface that a chip substrate 1 and two film 2, two films 2 cover chip substrate 1 respectively.Chip substrate 1 is provided with a sample holes 3, some meander-like flow channel for liquids 4 and some ventholes 5, sample holes 3 is connected with some flow channel for liquids 4, and the end of each flow channel for liquids 4 is provided with a venthole 5.Sample holes 3, venthole 5 are all arranged on the upper surface of chip substrate 1, and lay respectively at chip substrate 1 two ends, and sample holes 3 vertically runs through chip substrate 1.
Each flow channel for liquids 4 is formed by guiding gutter 6, transfer groove 7, microfluidic channel 8 and a reaction tank 9.Guiding gutter 6 is horizontally set on the lower surface of chip substrate 1, and its one end is communicated with the bottom of sample holes 3, and the other end is communicated with transfer groove 7 lower end.Transfer groove 7 vertically runs through chip substrate 1, and its upper end is communicated with microfluidic channel 8 one end.Microfluidic channel 8 is horizontally set on the upper surface of chip substrate 1, is communicated with below microfluidic channel 8 with reaction tank 9, and the end of microfluidic channel 8 is communicated with venthole 5.
In above-described embodiment, as shown in Figure 3, the position at transfer groove 7 place can be set to Buffer Pool 10, Buffer Pool 10 runs through chip substrate 1, and Buffer Pool 10 lower end is communicated with microfluidic channel 8 with guiding gutter 6 respectively with upper end.
In the various embodiments described above, each flow channel for liquids 4 can share same guiding gutter 6, and guiding gutter 6 is communicated with some transfer grooves 7 or Buffer Pool 10.
In the various embodiments described above, as shown in Figure 4, each flow channel for liquids 4 can also share same guiding gutter 6 and same transfer groove 7 or Buffer Pool 10, and one end of transfer groove 7 or Buffer Pool 10 is communicated with guiding gutter 6, and the other end is communicated with some microfluidic channel 8.
Adopt above-mentioned micro-fluidic chip, after sample is injected into sample holes 3 through the film 2 of chip substrate 1 upper surface by sample injector, sample enters transfer groove 7/ Buffer Pool 10 vertically running through chip substrate 1 by guiding gutter 6 water conservancy diversion of chip substrate lower surface, then enter reaction tank 9 through microfluidic channel 8.In the process of sample by flow channel for liquids 4, the air in flow channel for liquids 4 is discharged by the venthole being arranged on flow channel for liquids 4 end.
The various embodiments described above are only for illustration of the present invention; wherein the structure of each parts, connected mode and manufacture craft etc. all can change to some extent; every equivalents of carrying out on the basis of technical solution of the present invention and improvement, all should not get rid of outside protection scope of the present invention.
Claims (6)
1. a micro-fluidic chip, is characterized in that: it comprises a chip substrate and two films, and described two films cover upper surface and the lower surface of described chip substrate respectively; Described chip substrate is provided with a sample holes, some flow channel for liquids and some ventholes; Described sample holes is connected with some described flow channel for liquids, and described in each, the end of flow channel for liquids is provided with described venthole; Described sample holes vertically runs through described chip substrate;
Each described flow channel for liquids is formed by a guiding gutter, a transfer groove, a microfluidic channel and a reaction tank; Described guiding gutter is horizontally set on the lower surface of described chip substrate, and one end of described guiding gutter is communicated with the bottom of described sample holes, and the other end of described guiding gutter is communicated with the lower end of described transfer groove; Described transfer groove vertically runs through described chip substrate, and the upper end of described transfer groove is communicated with one end of described microfluidic channel; Described microfluidic channel is horizontally set on the upper surface of described chip substrate, and the other end of described microfluidic channel is communicated with described reaction tank, and the end of described microfluidic channel is communicated with described venthole.
2. a kind of micro-fluidic chip as claimed in claim 1, it is characterized in that: the position at described transfer groove place is set to Buffer Pool, described Buffer Pool runs through described chip substrate, and the lower end of described Buffer Pool is communicated with described microfluidic channel with described guiding gutter respectively with upper end.
3. a kind of micro-fluidic chip as claimed in claim 1, is characterized in that: flow channel for liquids described in each shares same described guiding gutter, and described guiding gutter is communicated with some described transfer grooves.
4. a kind of micro-fluidic chip as claimed in claim 2, is characterized in that: flow channel for liquids described in each shares same described guiding gutter, and described guiding gutter is communicated with some described Buffer Pools.
5. a kind of micro-fluidic chip as described in claim 1 or 3, it is characterized in that: flow channel for liquids described in each shares same described guiding gutter and same described transfer groove, one end of described transfer groove is communicated with described guiding gutter, and the other end of described transfer groove is communicated with some described microfluidic channel.
6. a kind of micro-fluidic chip as described in claim 2 or 4, it is characterized in that: flow channel for liquids described in each shares same described guiding gutter and same described Buffer Pool, one end of described Buffer Pool is communicated with described guiding gutter, and the other end of described Buffer Pool is communicated with some described microfluidic channel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520009277.0U CN204448036U (en) | 2015-01-07 | 2015-01-07 | A kind of micro-fluidic chip |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520009277.0U CN204448036U (en) | 2015-01-07 | 2015-01-07 | A kind of micro-fluidic chip |
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| CN204448036U true CN204448036U (en) | 2015-07-08 |
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| CN201520009277.0U Active CN204448036U (en) | 2015-01-07 | 2015-01-07 | A kind of micro-fluidic chip |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106525724A (en) * | 2016-10-26 | 2017-03-22 | 杭州霆科生物科技有限公司 | Centrifugal fully integrated detection system of methanal and pH value |
| CN107061863A (en) * | 2017-06-13 | 2017-08-18 | 河北工业大学 | A kind of the micro-valve system for generating the parked bubble of control and generation control method |
| CN108624971A (en) * | 2018-05-07 | 2018-10-09 | 京东方科技集团股份有限公司 | Micro fluidic device and preparation method thereof |
| CN111822064A (en) * | 2019-10-09 | 2020-10-27 | 京东方科技集团股份有限公司 | Microfluidic substrate and microfluidic chip |
| CN112033953A (en) * | 2019-06-03 | 2020-12-04 | 利多(香港)有限公司 | Micro-fluidic chip and application |
-
2015
- 2015-01-07 CN CN201520009277.0U patent/CN204448036U/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106525724A (en) * | 2016-10-26 | 2017-03-22 | 杭州霆科生物科技有限公司 | Centrifugal fully integrated detection system of methanal and pH value |
| CN107061863A (en) * | 2017-06-13 | 2017-08-18 | 河北工业大学 | A kind of the micro-valve system for generating the parked bubble of control and generation control method |
| CN107061863B (en) * | 2017-06-13 | 2019-09-06 | 河北工业大学 | It is a kind of to generate the micro-valve system for controlling parked bubble and generate control method |
| CN108624971A (en) * | 2018-05-07 | 2018-10-09 | 京东方科技集团股份有限公司 | Micro fluidic device and preparation method thereof |
| CN108624971B (en) * | 2018-05-07 | 2020-04-24 | 京东方科技集团股份有限公司 | Microfluidic device and preparation method thereof |
| CN112033953A (en) * | 2019-06-03 | 2020-12-04 | 利多(香港)有限公司 | Micro-fluidic chip and application |
| CN112033953B (en) * | 2019-06-03 | 2024-04-19 | 利多(香港)有限公司 | Microfluidic chip and application |
| CN111822064A (en) * | 2019-10-09 | 2020-10-27 | 京东方科技集团股份有限公司 | Microfluidic substrate and microfluidic chip |
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