CN204181737U - A kind of rat trachea PM2.5 feedway - Google Patents
A kind of rat trachea PM2.5 feedway Download PDFInfo
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- CN204181737U CN204181737U CN201420588865.XU CN201420588865U CN204181737U CN 204181737 U CN204181737 U CN 204181737U CN 201420588865 U CN201420588865 U CN 201420588865U CN 204181737 U CN204181737 U CN 204181737U
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- rat trachea
- way valve
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- feedway
- trachea
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Abstract
A kind of rat trachea PM2.5 feedway of the present utility model, comprise three-way valve, one respirator be communicated with the first blow vent of described three-way valve, the PM2.5 powder feeding structure be communicated with the second blow vent of described three-way valve, and the rat trachea administration intubation tube structure be communicated with the 3rd blow vent of described three-way valve.Rat trachea PM2.5 feedway structure of the present utility model is simple, reliably, can ensure carrying out smoothly of experiment.
Description
Technical field
This utility model relates to area of medical devices, relates in particular to a kind of rat trachea PM2.5 feedway.
Background technology
PM2.5 can affect respiratory system and cardiovascular system, it not only can stimulate respiratory tract, cause cough, dyspnea, asthma, but also a series of health problems such as chronic bronchitis, arrhythmia, non-lethal heart disease, heart and lung diseases patient premature death can be caused.In view of the hazardness that it is huge, recent domestic has carried out large quantifier elimination to the harm of PM2.5.Epidemiological study shows, at present for the research of PM2.5, be confined to it to the epidemiology of animal or human's types of populations with in the toxicity level of isolated cells, tissue water, under but these all can not truly be reflected in human body situation, PM2.5 enters human body by air flue, be stranded in bronchus, alveolar tissue, and may exchange and enter blood circulation to the motion of each histoorgan of whole body, distribution and metabolism behavior.Utilize molecular image technology then can address this problem more easily, but need a kind of simulating nature to breathe, provide the feedway of the trachea PM2.5 containing PM2.5 dry powder air to animal body tracheal strips.
Only have in prior art to rat trachea doser, a kind of rat trachea administration intubation tube disclosed in Chinese patent literature CN201542773U, it contains hollow hoses, is set with support wire in described hollow hoses, the two is slidably matched, and described support wire is longer than described hollow hoses.Rat trachea administration intubation tube structure in this patent documentation is simple, easy to use, successful intubation is high and do not damage rat human body, but inconvenient PM 2.5 air injects in rat body in eupnea ground mode.
Utility model content
For this reason, technical problem to be solved in the utility model is to provide a kind of with the rat trachea PM2.5 feedway brought into by PM2.5 radioactive particle while rats breathing in the trachea of rat and lung.
For solving the problems of the technologies described above, a kind of rat trachea PM2.5 feedway of the present utility model, comprise three-way valve, one respirator be communicated with the first blow vent of described three-way valve, the PM2.5 powder feeding structure be communicated with the second blow vent of described three-way valve, and the rat trachea administration intubation tube structure be communicated with the 3rd blow vent of described three-way valve.
In rat trachea PM2.5 feedway of the present utility model, described PM2.5 powder feeding structure is syringe, and PM2.5 powder is placed in described syringe.
In rat trachea PM2.5 feedway of the present utility model, described syringe is 2.5ml syringe.
In rat trachea PM2.5 feedway of the present utility model, described rat trachea administration intubation tube structure comprises pin cap, the plastic bushing that one end is connected with described pin cap, and is built in the nook closing member in described plastic bushing.
In rat trachea PM2.5 feedway of the present utility model, described rat trachea administration intubation tube structure is the little butterfly venous detaining needle of 18G.
In rat trachea PM2.5 feedway of the present utility model, the built-in nook closing member of described 18G little butterfly venous detaining needle is shorter than the plastic bushing of outside.
In rat trachea PM2.5 feedway of the present utility model, described nook closing member 0.5-1 ㎜ shorter in described plastic bushing.
In rat trachea PM2.5 feedway of the present utility model, the tip of described nook closing member is polished.
In rat trachea PM2.5 feedway of the present utility model, described three-way valve is for being detained pin three-way valve.
Technique scheme of the present utility model has the following advantages compared to existing technology:
1, in this utility model, by three-way valve 1 respectively with respirator, PM2.5 powder feeding structure, and rat trachea administration intubation tube fabric connectivity, in the trachea bringing PM2.5 radioactive particle into rat while realizing respirator air feed and lung, PM2.5 rat doser of the present utility model is simple and reliable for structure, easy to operate, can ensure carrying out smoothly of experiment.
2, in this utility model, the built-in nook closing member of 18G little butterfly venous detaining needle is shorter than the plastic bushing of outside, and the tip of nook closing member is polished, after can ensureing that the little butterfly venous detaining needle of 18G inserts rat trachea like this, the needle point of nook closing member and nook closing member all can not hurt the tracheal wall of rat, ensure that effectively carrying out of experiment.
3, in this utility model, three-way valve is selected and is detained pin three-way valve, rat trachea administration intubation tube structure selects little butterfly vein delay pin, PM2.5 powder feeding structure selects 2.5ml syringe, being undertaken improving and assembling, being more convenient for promoting the use of in laboratory by using ready-made structure.
Accompanying drawing explanation
In order to make content of the present utility model be more likely to be clearly understood, below according to specific embodiment of the utility model also by reference to the accompanying drawings, this utility model is described in further detail, wherein
Fig. 1 is the structural representation of the little butterfly venous detaining needle of 18G;
Fig. 2 is that the tip of nook closing member is by the structural representation of the little butterfly venous detaining needle of 18G polished;
The schematic diagram of Fig. 3 rat trachea PM2.5 of the present utility model feedway;
In figure, Reference numeral is expressed as: 1-three-way valve; 2-respirator; 3-rat trachea administration intubation tube structure; 4-syringe; 5-PM2.5 powder, 6-pin cap, 7-plastic bushing, 8-nook closing member.
Detailed description of the invention
Below with reference to accompanying drawing, following embodiment is used to be further elaborated this utility model.
In order to mock inspection PM2.5 behavior in animal body, this experimental group has prepared 131/125I-EC-SiO2 compound PM2.5 radioactive particle, need prepare rat lung dry powder administration model, studies the metabolic process of PM2.5 in lung and body by SPECT-CT.This research is detained pin when rat anesthesia by little butterfly vein, live body tracheal intubation, by the trachea of bringing PM2.5 radioactive particle into rat while respirator air feed and lung.Now by reference to the accompanying drawings, the structure of rat trachea PM2.5 feedway of the present utility model is illustrated.
As shown in Figure 3, a kind of rat trachea PM2.5 feedway of the present embodiment, comprise three-way valve 1, one respirator 2 be communicated with the first blow vent of described three-way valve 1, the PM2.5 powder feeding structure be communicated with the second blow vent of described three-way valve 1, and the rat trachea administration intubation tube structure 3 be communicated with the 3rd blow vent of described three-way valve 1.
Such scheme is core technology scheme of the present utility model, can realize live body tracheal intubation by said structure, by the trachea of bringing PM2.5 radioactive particle into rat while respirator air feed and lung.Rat trachea PM2.5 feedway of the present utility model is simple and reliable for structure, easy to operate, can ensure carrying out smoothly of experiment.
In the present embodiment, described PM2.5 powder feeding structure is that syringe 4, PM2.5 powder 5 is placed in described syringe 4.Described syringe 4 is 2.5ml syringe.
Described rat trachea administration intubation tube structure 3 comprises pin cap 6, the plastic bushing 7 that one end is connected with described pin cap 6, and is built in the nook closing member 8 in described plastic bushing 7.As shown in Figure 1, described rat trachea administration intubation tube structure 3 directly can adopt the little butterfly venous detaining needle of 18G.
As shown in Figure 2, the built-in nook closing member 8 of described 18G little butterfly venous detaining needle is shorter than the plastic bushing 7 of outside.The tip of described nook closing member 8 is polished, and after can ensureing that the little butterfly venous detaining needle of 18G inserts rat trachea like this, the needle point of nook closing member and nook closing member all can not hurt the tracheal wall of rat, ensure that effectively carrying out of experiment.
Usually, when designing, described nook closing member 8 0.5-1 ㎜ shorter in described plastic bushing 7, this numerical value also can be arranged as required certainly.
In this utility model, three-way valve 1 is selected and is detained pin three-way valve, rat trachea administration intubation tube structure 3 selects little butterfly vein delay pin, PM2.5 powder feeding structure selects 2.5ml syringe, being undertaken improving and assembling, being more convenient for promoting the use of in laboratory by using ready-made structure.
The use procedure of PM2.5 dry powder rat trachea doser of the present utility model:
(1) extracted by the built-in nook closing member 8 of little for 18G butterfly venous detaining needle, needle point is polished flat, make it the plastic bushing 7 about 0.5-1mm being shorter than outside, such trocar is at insertion rat trachea, and needle point and steel nook closing member can not hurt rat trachea wall.
(2) after rat anesthesia, under light source irradiation, by the remaining needle that nook closing member 8 processed, insert rat trachea, then emit 6 to extract on built-in draw point pin, allow plastic bushing 7 stay tracheal strips, connect respirator 2, confirm that whether plastic bushing 7 is at tracheal strips, if entering next step operation, if not in intubate again.
(3), after confirming that plastic bushing 7 is trapped in tracheal strips, the second blow vent of three-way valve 1 is connected on pin and emits 6 places, the 3rd blow vent of three-way valve 1 connects respirator 2.
(4) by PM2.5 powder 5, weigh up weight, survey good metering, load in the syringe of 2.5ml syringe 4,2.5ml syringe is connected on the first blow vent of three-way valve 1, ensure that first, second and third blow vent of three-way valve 1 is all open-minded, such PM2.5 powder 5 just along with respirator 2 is to trachea, the lung pipe brought into while gas into rat, ensures the smooth preparation of model.
This utility model, simple, practical, easy to operate, for the foundation of experimental model provides technical support, thus ensure carrying out smoothly of experiment; Research is provided to ensure to mock inspection PM2.5 behavior in animal body.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain that this utility model creates.
Claims (9)
1. a rat trachea PM2.5 feedway, it is characterized in that: comprise three-way valve (1), one respirator (2) be communicated with the first blow vent of described three-way valve (1), PM2.5 powder (5) supply structure be communicated with the second blow vent of described three-way valve (1), and the rat trachea administration intubation tube structure (3) be communicated with the 3rd blow vent of described three-way valve (1).
2. rat trachea PM2.5 feedway according to claim 1, is characterized in that: described PM2.5 powder feeding structure is syringe (4), and PM2.5 powder is placed in described syringe (4).
3. rat trachea PM2.5 feedway according to claim 2, is characterized in that: described syringe (4) is 2.5ml syringe.
4. the rat trachea PM2.5 feedway according to any one of claim 1-3, it is characterized in that: described rat trachea administration intubation tube structure (3) comprises pin cap (6), the plastic bushing (7) that one end is connected with described pin cap (6), and be built in the nook closing member (8) in described plastic bushing (7).
5. rat trachea PM2.5 feedway according to claim 4, is characterized in that: described rat trachea administration intubation tube structure (3) is the little butterfly venous detaining needle of 18G.
6. rat trachea PM2.5 feedway according to claim 5, is characterized in that: the built-in nook closing member (8) of described 18G little butterfly venous detaining needle is shorter than the plastic bushing (7) of outside.
7. rat trachea PM2.5 feedway according to claim 6, is characterized in that: described nook closing member (8) 0.5-1 ㎜ shorter in described plastic bushing (7).
8. rat trachea PM2.5 feedway according to claim 7, is characterized in that: the tip of described nook closing member (8) is polished.
9. rat trachea PM2.5 feedway according to claim 1, is characterized in that: described three-way valve (1) is for being detained pin three-way valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420588865.XU CN204181737U (en) | 2014-10-11 | 2014-10-11 | A kind of rat trachea PM2.5 feedway |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420588865.XU CN204181737U (en) | 2014-10-11 | 2014-10-11 | A kind of rat trachea PM2.5 feedway |
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| CN204181737U true CN204181737U (en) | 2015-03-04 |
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| CN201420588865.XU Expired - Fee Related CN204181737U (en) | 2014-10-11 | 2014-10-11 | A kind of rat trachea PM2.5 feedway |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442958A (en) * | 2016-09-13 | 2017-02-22 | 北京大学 | Atmospheric particulate toxicity study method and system thereof |
| CN107875169A (en) * | 2017-11-13 | 2018-04-06 | 山东省职业卫生与职业病防治研究院 | The method for building up and special Intubaction device of silicosis pulmonary fibrosis animal model |
| CN113777222A (en) * | 2021-02-01 | 2021-12-10 | 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） | Method for detecting influence of environmental pollutants on human body |
-
2014
- 2014-10-11 CN CN201420588865.XU patent/CN204181737U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106442958A (en) * | 2016-09-13 | 2017-02-22 | 北京大学 | Atmospheric particulate toxicity study method and system thereof |
| CN107875169A (en) * | 2017-11-13 | 2018-04-06 | 山东省职业卫生与职业病防治研究院 | The method for building up and special Intubaction device of silicosis pulmonary fibrosis animal model |
| CN113777222A (en) * | 2021-02-01 | 2021-12-10 | 深圳市疾病预防控制中心（深圳市卫生检验中心、深圳市预防医学研究所） | Method for detecting influence of environmental pollutants on human body |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150304 Termination date: 20151011 |
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| EXPY | Termination of patent right or utility model |