CN203736236U - Bronchoalveolar lavage device for mouse respiratory system disease model - Google Patents
Bronchoalveolar lavage device for mouse respiratory system disease model Download PDFInfo
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- CN203736236U CN203736236U CN201420048480.4U CN201420048480U CN203736236U CN 203736236 U CN203736236 U CN 203736236U CN 201420048480 U CN201420048480 U CN 201420048480U CN 203736236 U CN203736236 U CN 203736236U
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- bronchoalveolar lavage
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- disease model
- hose connection
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Abstract
The utility model provides an experiment instrument for relevant mouse bronchoalveolar lavage operations, and particularly relates to a bronchoalveolar lavage device for a mouse respiratory system disease model. The device comprises a trachea cannula, a blunt end, a hose connector, an adapter and a lavage device. The bronchoalveolar lavage device is suitable for bronchoalveolar lavage of mouse respiratory system disease model relevant experiment quantitative liquid and lavage liquid recovery, the recovery rate of lavage liquid is calculated according to the scales of an injector, and the recovery rate is above 90 percent and meets most of experimental requirements. The bronchoalveolar lavage device has the advantages of being reasonable and ingenious in design, convenient to use and operate, simple in structure and low in manufacturing cost, the work of mouse bronchoalveolar lavage is optimized, and the device can be widely applied to mouse bronchoalveolar lavage experiments.
Description
Technical field
This utility model relates to the experiment apparatus that basic medical research small mouse alveolar wass is performed the operation relevant, relates in particular to a kind of recovery that is applied to carry out in mouse breathing systemic disease model mice alveolar wass and irrigating solution.
Background technology
The factor such as the physical and chemical factor, biotic factor suction, avian influenza and the population ages that cause due to atmospheric pollution, smoking, Industrial Economic Development are aging, make respiratory system disease in recent years as the sickness rate such as pulmonary carcinoma, bronchial asthma obviously increase, greatly endanger China's people ' s health.A large amount of Basic medicine experiment achievements in research on the basis of clear and definite respiratory system disease mechanism of causing a disease for clinical treatment provides theory support, the core of Basic medicine experiment is to build experimental animal model, mice alveolar wass is research respiratory system disease necessary links, its success or not has determined to gather quality, the proposition of final decision institute study of disease mechanism of causing a disease and the corresponding Clinical significance of MG of bronchoalveolar lavage fluid cell precipitation and supernatant, lung tissue sample.
Mice alveolar wass is research respiratory system disease experimental animal model important step, mice trachea is thin especially, general tracheal intubation used is all not too applicable to mice trachea, also inconvenient combination with syringe carried out lavation, not only make the mice bronchoalveolar lavage fluid response rate low, also affect the quality of mice bronchoalveolar lavage fluid, can not meet requirement of experiment.
Utility model content
For the problems referred to above, it is a kind of for mouse breathing systemic disease model alveolar wass device that this utility model provides, utilize disposable vein hemostix latex sheath end metal syringe diameter similar to mice trachea, and hose connection is connected to the adapter that 1ml syringe needle is reequiped, while facilitating alveolar wass, be combined with syringe.This device can guarantee that the mice bronchoalveolar lavage fluid response rate reaches more than 90%, and bronchoalveolar lavage fluid quality is high, meets requirement of experiment, can obtain reliable, stable experimental result.
This utility model is realized by following technological means: a kind of for mouse breathing systemic disease model alveolar wass device, comprise tracheal intubation, blunt nosed, hose connection, adapter, fill with haustorium, the lower end of described filling haustorium is connected by the upper end of adapter and hose connection, the lower end of described hose connection connects the upper end of tracheal intubation, the other end of described tracheal intubation is one blunt nosed, described filling haustorium is syringe and the pintle of 1ml syringe, the described about 1.5cm of hose connection length, hose connection is provided with an angle, described adapter selects 1ml syringe to remove the syringe needle of metal needle.
As preferred embodiment, described tracheal intubation be take disposable vein hemostix as raw material.
The metal needle point with angle of described blunt nosed employing one blunt.
Described hose connection angle opening direction is consistent with blunt nosed metal syringe angle direction.
This utility model beneficial effect is:
1) it is similar to mice trachea that this utility model utilizes disposable vein hemostix latex sheath end metal syringe diameter, and hose connection is connected to the adapter that 1ml syringe is removed the syringe needle repacking of metal needle, while facilitating alveolar wass, is combined with syringe.This device can guarantee that the mice bronchoalveolar lavage fluid response rate reaches more than 90%, and bronchoalveolar lavage fluid quality is high, meets requirement of experiment, can obtain reliable, stable experimental result.
2) of the present utility model for mouse breathing systemic disease model alveolar wass device, reasonable in design ingenious, use easy to operately, the work of mice alveolar wass is optimized.
3) of the present utility model for mouse breathing systemic disease model alveolar wass device, advantage simple in structure, cost of manufacture is low, can be widely used in the experiment of mice alveolar wass.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Wherein: 1. tracheal intubation, 2. blunt nosed, 3. hose connection, 4. adapter, 5. fill with haustorium.
The specific embodiment
As described in Figure 1, it is a kind of for mouse breathing systemic disease model alveolar wass device that this utility model provides, comprise tracheal intubation 1, blunt nosed 2, hose connection 3, adapter 4, fill with haustorium 5, the lower end of described filling haustorium 5 is connected with the upper end of hose connection 3 by adapter 4, the lower end of described hose connection 3 connects the upper end of tracheal intubation 1, the other end of described tracheal intubation 1 is one blunt nosed 2, described filling haustorium 5 is syringe and the pintle of 1ml syringe, the described about 1.5cm of hose connection 3 length, hose connection is provided with an angle, described adapter 4 selects 1ml syringe to remove the syringe needle of metal needle.
Described blunt nosed 2 adopt the metal needle point with angle of a blunt.
Described tracheal intubation 1 is that disposable vein hemostix is removed to the latex sheath inserting on vacuum test tube end syringe needle, and by metal needle point blunt and retain metal syringe angle, during polishing, guarantee that metal tip end is not closed and smooth, while avoiding intubate, puncture mice trachea and cause bronchoalveolar lavage fluid to leak outside or the inflow of breast intracavity liquid, when angle facilitates intubate to avoid lavation simultaneously, tracheal collapse causes blocking tip end.This metal syringe diameter is similar to mice tracheal diameter, can guarantee the fastness of tracheal intubation, is conducive to alveolar wass simultaneously.
The angle opening direction of described hose connection 3 is consistent with blunt nosed 2 metal syringe angle direction, facilitates lavation operation to avoid the rotation of tracheal intubation 1 in connection procedure; Retain the about 1.5cm of hose length, reduce and be detained the response rate that the interior lavation liquid measure of pipe improves bronchoalveolar lavage fluid, also guarantee to fill with the bendability of flexible pipe in haustorium connection procedure simultaneously.
Described adapter 4 is that 1ml syringe metal needle is partly removed, and guarantees that tip end is not closed, retains white portion on syringe needle and guarantees the closely combination flexibly of adapter and hose connection, guarantees air tight, no leakage.
Described filling haustorium 5 access adapters 4, guarantee that syringe graduation faces up, and observe the amount of irrigating solution while facilitating lavation.
This utility model device completes as follows: during experiment, postanesthetic mouse heart blood drawing is put to death, dorsal position is fixing dissects on plate.A: the hose connection that first adapter is closely connected in to tracheal intubation; B: alcohol disinfecting skin of neck, cut off skin, blunt separation muscular tissue, expose trachea separated, the static line that about 5cm is long is through under trachea, something or somebody to fall back on end is cut off T word otch by trachea as far as possible, and the blunt nosed slow insertion trachea of tracheal intubation, to left and right main bronchus bifurcation, is fastened to tracheal intubation with trachea lower fixed line; C: draw the pre-cooling PBS of aequum with 1ml syringe, be connected to adapter and slowly inject in lung; D: slowly extract liquid in lung with 1ml syringe, avoid tracheal collapse; E: repeat c-d process 2-3 time, i.e. recyclable more than 90% bronchoalveolar lavage fluid.
Claims (4)
1. a mouse breathing systemic disease model alveolar wass device, comprise tracheal intubation (1), blunt nosed (2), hose connection (3), adapter (4), fill with haustorium (5), it is characterized in that: the lower end of described filling haustorium (5) is connected with the upper end of hose connection (3) by adapter (4), the lower end of described hose connection (3) connects the upper end of tracheal intubation (1), the other end of described tracheal intubation (1) is one blunt nosed (2), described filling haustorium (5) is syringe and the pintle of 1ml syringe, described hose connection (3) is provided with an angle, described adapter (4) selects 1ml syringe to remove the syringe needle of metal needle.
2. mouse breathing systemic disease model alveolar wass device according to claim 1, is characterized in that: described tracheal intubation (1) preferably disposable vein hemostix is raw material.
3. mouse breathing systemic disease model alveolar wass device according to claim 1, is characterized in that: described hose connection (3) angle opening direction is consistent with blunt nosed (2) metal syringe angle direction.
4. mouse breathing systemic disease model alveolar wass device according to claim 1, is characterized in that: described blunt nosed (2) adopt the metal needle point with angle of a blunt.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420048480.4U CN203736236U (en) | 2014-01-24 | 2014-01-24 | Bronchoalveolar lavage device for mouse respiratory system disease model |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420048480.4U CN203736236U (en) | 2014-01-24 | 2014-01-24 | Bronchoalveolar lavage device for mouse respiratory system disease model |
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| Publication Number | Publication Date |
|---|---|
| CN203736236U true CN203736236U (en) | 2014-07-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201420048480.4U Expired - Fee Related CN203736236U (en) | 2014-01-24 | 2014-01-24 | Bronchoalveolar lavage device for mouse respiratory system disease model |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451163A (en) * | 2020-11-30 | 2021-03-09 | 河南省肿瘤医院 | Novel three-way valve type gravity flow experimental mouse alveolar lavage fluid acquisition device |
-
2014
- 2014-01-24 CN CN201420048480.4U patent/CN203736236U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451163A (en) * | 2020-11-30 | 2021-03-09 | 河南省肿瘤医院 | Novel three-way valve type gravity flow experimental mouse alveolar lavage fluid acquisition device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140730 Termination date: 20150124 |
|
| EXPY | Termination of patent right or utility model |