CN204162719U - A kind of reaction unit for ankyrin chip or gene chip - Google Patents
A kind of reaction unit for ankyrin chip or gene chip Download PDFInfo
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- CN204162719U CN204162719U CN201420604204.1U CN201420604204U CN204162719U CN 204162719 U CN204162719 U CN 204162719U CN 201420604204 U CN201420604204 U CN 201420604204U CN 204162719 U CN204162719 U CN 204162719U
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Abstract
The utility model relates to a kind of reaction unit for ankyrin chip or gene chip.Described reaction unit comprises: outside framework, and the two bottom sides edge in its frame is provided with symmetrical outstanding support bar; And reaction vessel, its size is set to embed outside framework or take out from outside framework.Described reaction vessel is formed by following assembling parts: stereoplasm frame, is divided into several little lattice in its frame; Soft silicagel pad, its size corresponds to described stereoplasm frame; For the standard glass slide of point sample; And pair of U-shaped frame folder, from both sides by described stereoplasm frame, silicagel pad and described standard glass slide are snapped together, so that described standard glass slide is adjacent to the bottom of closed described stereoplasm frame, make each little lattice on described stereoplasm frame form a little reacting hole.The slide glass of standard can be assembled into the reaction vessel group with standard enzyme target specification by the utility model, and the enzyme plate automated operation instrument of routine carries out automation experiment operation.
Description
Technical field
The utility model relates to a kind of reaction unit for ankyrin chip or gene chip, the slide glass of standard is assembled into the reaction vessel group that has standard enzyme target specification, thus can routine with enzyme plate be specifications design automated operation instrument on carry out automation experiment operation.
Background technology
At present, be that the reaction system of matrix has extensive and important utilization with slide, such as, gene chip, protein chip, SPR etc. be all using the slide glass of standard as antibody, antigen reactive carrier.But, be suitable for being that the full-automatic operation instrument of carrier is little with slide.Most full-automatic operation instrument be all for the enzyme plate of standard for reaction carriers, trigger is washed in such as automatization, automatization enzyme exempts from operation instrument etc.Therefore, be necessary to design a kind of reaction unit, the slide glass of standard be assembled into the reaction vessel group that has standard enzyme target specification, thus can routine with enzyme plate be specifications design automated operation instrument on carry out automation experiment operation.
Summary of the invention
The purpose of this utility model is to provide a kind of reaction unit for ankyrin chip or gene chip, make polylith protein chip can form one and there is standard enzyme target specification, experimental implementation can be carried out according to the mode of enzyme plate, especially can exempt from automated operation instrument carries out automated operation at enzyme.
Reaction unit for ankyrin chip or gene chip described in the utility model, comprising: outside framework, and the two bottom sides edge in its frame is provided with symmetrical outstanding support bar; And reaction vessel, its size is set to embed described outside framework or take out from described outside framework, and when described reaction vessel embeds described outside framework, described reaction vessel is supported by the support bar of described outside framework.Described reaction vessel is formed by following assembling parts: stereoplasm frame, is divided into several little lattice in its frame; Soft silicagel pad, its size corresponds to described stereoplasm frame, and the reagent avoided between the leakage of each reacting hole or Kong Yukong interpenetrates; For the standard glass slide of point sample; And pair of U-shaped frame folder, from both sides by described stereoplasm frame, silicagel pad and described standard glass slide are snapped together, so that described standard glass slide is adjacent to the bottom of closed described stereoplasm frame, make each little lattice on described stereoplasm frame form a little reacting hole.
According to the further feature of reaction unit described in the utility model, the size of described outside framework is consistent with general enzyme plate specification.
According to the further feature of reaction unit described in the utility model, the two bottom sides edge in the frame of described outside framework is provided with four right outstanding support bars, can support the reaction vessel that loading four is independently described at most.
According to the further feature of reaction unit described in the utility model, in the frame of described stereoplasm frame, be divided into 2 × 8 little lattice, 16 reacting holes can be formed.
According to the further feature of reaction unit described in the utility model, described stereoplasm frame offers groove, described U-shaped frame folder has can the outstanding bar of groove described in clamping.Therefore, when being clamped on soft silicagel pad and/or standard glass slide by stereoplasm frame by two U-shaped frame folders, the outstanding bar on U-shaped frame folder is connected in the groove on stereoplasm frame just, thus prevents coming off of U-shaped framework.
The utility model has the following advantages and feature: by outside framework fixation reaction container, thus a composition reaction unit, preferably, described outside framework has standard enzyme target specification, such as the size of 96 hole enzyme plates; Four independently described reaction vessels can be loaded in this outside framework, form a reaction vessel group.And in the frame of the stereoplasm frame of each reaction vessel, be divided into 2 × 8 little lattice, 16 reacting holes can be formed, form the protein chip in 64 holes corresponding with 96 hole enzyme plates or the reaction unit of gene chip thus.Therefore, reaction unit described in the utility model can ankyrin chip or gene chip, then exempts from operating instrument carries out automation experiment operation at the automatization enzyme of routine, thus realizes with slide being the full-automatic operation of carrier.
Accompanying drawing explanation
Fig. 1 is the schematic diagram after the assembling of a specific embodiment of the reaction unit for ankyrin chip or gene chip described in the utility model.
Fig. 2 be the reaction unit shown in Fig. 1 from the upward view viewed from bottom.
Fig. 3 is the schematic diagram of the outside framework of reaction unit described in the utility model, and in this figure, reaction vessel shifts out.
Fig. 4 is the side-view of the reaction vessel of reaction unit described in the utility model, the assembling situation of display each several part.
Fig. 5 is the decomposing schematic representation of the reaction vessel shown in Fig. 4.
In figure, 1: outside framework; 2: support bar; 3: reaction vessel; 4: stereoplasm frame; 5: standard glass slide; 6: silicagel pad; 7:U shape frame presss from both sides.
Embodiment
On the disposable trigger of automatization enzyme, carry out the example that plate is washed in automatization below by way of an antibody chip enzyme linked immunoassay carrier, by reference to the accompanying drawings the utility model is described in detail.
Reaction unit for ankyrin chip or gene chip described in the utility model, as shown in Figure 1, comprising: outside framework 1, and the two bottom sides edge in its frame is provided with symmetrical outstanding support bar 2 (see Fig. 2); And reaction vessel 3, its size is set to embed outside framework 1 or take out from outside framework 1, and when reaction vessel 3 embeds outside framework 1, this reaction vessel 3 is supported by the support bar 2 of this outside framework 1.
In the reaction unit shown in Fig. 1, the two bottom sides edge in the frame of outside framework 1 is provided with four right outstanding support bars 2 (see Fig. 3), can support the reaction vessel 3 that loading four is independently described at most.During concrete making, the size of outside framework 1 is consistent with general enzyme plate specification.
See Fig. 4 and Fig. 5, the reaction vessel 3 of reaction unit described in the utility model is formed by following assembling parts: stereoplasm frame 4, is divided into several little lattice in its frame; For the standard glass slide 5 of point sample; For preventing the soft silicagel pad 6 of leakage, and pair of U-shaped frame folder 7, be snapped together with standard glass slide 5 from both sides by stereoplasm frame 4, silicagel pad 6, so that standard glass slide 5 is adjacent to the bottom of closed stereoplasm frame 4, each little lattice on stereoplasm frame 4 are made to form a little reacting hole (see Fig. 1).During concrete making, stereoplasm frame 4 offers groove, U-shaped frame folder 7 has can the outstanding bar of this groove of clamping.
In embodiment as shown in Figure 1, in the frame of stereoplasm frame, be divided into 2 × 8 little lattice, 16 reacting holes can be formed.With two U-shaped folders, the stereoplasm frame of one piece of standard glass slide, one piece of soft silicagel pad and 16 hole (2 × 8 hole) is assembled into successively the independent reaction container in 16 holes; Can Multiple Antibodies be put in each hole, make antibody chip.
As shown in Figure 1, be fixed on an outside framework by four reaction vessels (antibody chip), every block antibody chip supported by a pair support bar in outside framework.Therefore, four chip blocks fill whole outside framework, and are in an identical level.
Whole reaction unit (antibody chip group) is placed on traditional disposable trigger of automatization enzyme (such as ThermoScientific Wellwash Versa), 3rd, 6,9,12 row are set to sky washing on trigger, can start to carry out automatization and wash plate experiment.
In like manner, also this reaction unit (antibody chip group) can be placed in automatization enzyme and exempt from the test experience that detector carries out antibody chip.
Except the reaction for antibody chip group, reaction unit of the present utility model also can be used for the reaction of gene chip.
Claims (5)
1., for a reaction unit for ankyrin chip or gene chip, it is characterized in that, comprising:
Outside framework, the two bottom sides edge in its frame is provided with symmetrical outstanding support bar; And
Reaction vessel, its size is set to embed described outside framework or take out from described outside framework, and when described reaction vessel embeds described outside framework, described reaction vessel is supported by the support bar of described outside framework;
Described reaction vessel is formed by following assembling parts:
Stereoplasm frame, is divided into several little lattice in its frame;
For the standard glass slide of point sample;
For preventing the soft silicagel pad of leakage, and
Pair of U-shaped frame presss from both sides, and from both sides by described stereoplasm frame, silicagel pad and described standard glass slide are snapped together, so that described standard glass slide is adjacent to the bottom of closed described stereoplasm frame, makes each little lattice on described stereoplasm frame form a little reacting hole.
2. reaction unit according to claim 1, is characterized in that: the size of described outside framework is consistent with general enzyme plate specification.
3. reaction unit according to claim 1, is characterized in that: the two bottom sides edge in the frame of described outside framework is provided with four right outstanding support bars, can support the reaction vessel that loading four is independently described at most.
4. reaction unit according to claim 1, is characterized in that: be divided into 2 × 8 little lattice in the frame of described stereoplasm frame, can form 16 reacting holes.
5. reaction unit according to claim 1, is characterized in that: described stereoplasm frame offers groove, and described U-shaped frame folder has can the outstanding bar of groove described in clamping.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420604204.1U CN204162719U (en) | 2014-10-17 | 2014-10-17 | A kind of reaction unit for ankyrin chip or gene chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420604204.1U CN204162719U (en) | 2014-10-17 | 2014-10-17 | A kind of reaction unit for ankyrin chip or gene chip |
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| CN204162719U true CN204162719U (en) | 2015-02-18 |
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| CN201420604204.1U Active CN204162719U (en) | 2014-10-17 | 2014-10-17 | A kind of reaction unit for ankyrin chip or gene chip |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593939A (en) * | 2018-07-18 | 2018-09-28 | 广州瑞博奥生物科技有限公司 | A kind of full-automatic protein chip and its application |
| CN110734963A (en) * | 2019-09-28 | 2020-01-31 | 北京安博迪恩生物科技有限公司 | method for detecting 21-trisomy syndrome chromosome karyotype based on efficient chip washing and drying instrument |
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2014
- 2014-10-17 CN CN201420604204.1U patent/CN204162719U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108593939A (en) * | 2018-07-18 | 2018-09-28 | 广州瑞博奥生物科技有限公司 | A kind of full-automatic protein chip and its application |
| CN108593939B (en) * | 2018-07-18 | 2023-11-14 | 瑞博奥(广州)生物科技股份有限公司 | Full-automatic protein chip and application thereof |
| CN110734963A (en) * | 2019-09-28 | 2020-01-31 | 北京安博迪恩生物科技有限公司 | method for detecting 21-trisomy syndrome chromosome karyotype based on efficient chip washing and drying instrument |
| CN110734963B (en) * | 2019-09-28 | 2022-04-29 | 北京安博迪恩生物科技有限公司 | Method for detecting 21-trisomy syndrome chromosome karyotype based on efficient chip washing and drying instrument |
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Address after: No.79, Ruihe Road, Science City, Guangzhou hi tech Industrial Development Zone, Guangdong 510000 Patentee after: Reboo (Guangzhou) Biotechnology Co.,Ltd. Address before: 510663 No. 79 Ruihe Road, Luogang District, Guangzhou City, Guangdong Province Patentee before: RAYBIOTECH, Inc. |