CN203988399U - The instrument bag of rapid build organization engineering skin - Google Patents
The instrument bag of rapid build organization engineering skin Download PDFInfo
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- CN203988399U CN203988399U CN201420295229.8U CN201420295229U CN203988399U CN 203988399 U CN203988399 U CN 203988399U CN 201420295229 U CN201420295229 U CN 201420295229U CN 203988399 U CN203988399 U CN 203988399U
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- instrument bag
- syringe
- solution
- organization engineering
- rapid build
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Abstract
The utility model discloses a kind of instrument bag of rapid build organization engineering skin, inclusion and be arranged on the surgical supplies in inclusion, described surgical supplies comprises digestive enzyme solution lyophilized powder, de-cell Allodermis Matrix substrate, No. 23 knife blades, anodontia tweezers, syringe, syringe needle, the first sodium lactate Ringer ' solution, the second sodium lactate Ringer ' solution, filter screen, sterilized water and microheaters.Instrument bag of the present utility model has fast, without carrying out passage cultivation, the disposable organization engineering skin healing that completes, is built into is fast and can recover the advantages such as skin function.
Description
Technical field
This utility model relates to medical instruments technical field, particularly a kind of instrument bag of rapid build organization engineering skin.
Background technology
To be body lose because inherent or external factor cause skin complete wound surface, and it is repaired is the subject matter in clinical all the time, can be divided into acute wound and chronic wound clinically by the time.Acute wound comprises the skin injury forming after the excisions such as the major diseases such as burn, wound or cicatrix, skin-color disposition disease, innocent and malignant tumour; And chronic wound comprises traumatic ulcer, diabetic ulcer, vascular ulcer, pressure ulcer, radiation ulcer, neoplastic ulcer, cicatricial ulcer etc.In recent years, the sickness rate of chronic wound is ascendant trend year by year, and its course of disease is long, difficult healing, and skin graft survival rate is low, and after skin-grafting, skin function is lost, and causes quality of life to decline.It is reported, the whole world approximately has 1% people to be subjected to the puzzlement of refractory wound surface, and the medical expense of 5% left and right is used to wound repair.According to U.S. wound healing association data, show, the chronic wound over 60% still cannot heal completely after the treatment of half a year, and annual medical care expenses is high.The annual expense that drops into chronic wound treatment in Europe accounts for 2% of hygiene and health expenditure, and meanwhile, the medical expense of repairing because of scar hyperplasia after wound repair is also up to 12,000,000,000 dollars, and these expenses are still increasing every year.
Surgical repair is current primary treatment method.But, no matter traditional grafts, skin flap transplantation, stamp skin grafting dermepenthesis, microparticle skin transplanting, netted skin grafting dermepenthesis, Composite skin etc., or emerging organization engineering skin (refers to dermal fibroblast and extracellular matrix substitute is mixed and made into artificial skin, or the extracellular matrix that uses merely porous substitutes corium implantation wound surface, upper surface transplant epithelial cell covers or treats that self epithelium covers the skin that replaces disease damage), all fail effectively to solve at present the difficult problem of wound repair.Especially a following difficult problem: after major disease fire victim's rehabilitation, scar hyperplasia, sweat gland disappearance, skin lose original function, chronic wound patient protracted course of disease (the lighter greatly consumes medical resource, the serious harm life such as severe one accompanying infection, pyemia).
The apparatus that existing prosthesis is prepared due to needs is many, needs the time of preparation long, carries out passage cultivation under laboratory condition, and the time needing is long, tends to affect postoperative effect.
Utility model content
The purpose of this utility model is to provide a kind of instrument bag of rapid build organization engineering skin, can solve at least one in above-mentioned prior art problem.
According to an aspect of the present utility model, a kind of instrument bag of rapid build organization engineering skin is provided, comprise inclusion and be arranged on the surgical supplies in inclusion, surgical supplies comprises digestive enzyme solution lyophilized powder, de-cell Allodermis Matrix substrate, No. 23 knife blades, anodontia tweezers, syringe, syringe needle, the first sodium lactate Ringer ' solution (also claiming balance liquid), the second sodium lactate Ringer ' solution, filter screen, sterilized water and microheaters.
In some embodiments, digestive enzyme solution lyophilized powder can be trypsin solution lyophilized powder.
In some embodiments, anodontia tweezers can be the anodontia tweezers of ophthalmic.
In some embodiments, syringe can comprise two 5mL syringes and two 10mL syringes.
In some embodiments, syringe needle and syringe match, wherein, mate with 5mL syringe can be for tack syringe needle, what mate with 10mL syringe can be Tip-headed needle head.
In some embodiments, the volume of the first sodium lactate Ringer ' solution and the second sodium lactate Ringer ' solution is 5mL.
In some embodiments, the aperture of filter screen can be 100 μ m.
In some embodiments, sterilized water can be aseptic double-distilled water, altogether 10mL.
In some embodiments, microheater can and keep constant temperature by liquid heat to 37 in vial ℃.
In some embodiments, in inclusion, can be provided with 13 grooves, place successively the syringe of 10mL, syringe, 5mL syringe needle, filter screen and the de-cell Allodermis Matrix substrate of the syringe needle of 10mL, the bottle that is loaded with sterilized water, the bottle that is loaded with enzymatic solution lyophilized powder, microheater, the bottle that is loaded with sodium lactate Ringer ' solution, the bottle that is loaded with sodium lactate Ringer ' solution, anodontia tweezers, No. 23 knife blades, 5mL.12 above-mentioned grooves can also be divided into two lines or three row according to the difference of surgical condition and doctor's use habit, adopt different modes of emplacements.
While preparing this utility model, every utensil all needs to carry out aseptic sterilization, then encapsulates.Instrument bag of the present utility model has following advantage:
1, quick.In operating room, can complete, approximately 30 minutes consuming time altogether, need under laboratory condition, carry out passage cultivation etc. with the past organization engineering skin and compare, there is quick, the disposable advantage completing.
2, instrument bag of the present utility model has seed cell, also has dermal matrix, uses separately instrument bag of the present utility model can build complete organization engineering skin structure, does not need to increase other apparatus again.
3, instrument bag seed cell of the present utility model is basal layer cell, has class pluripotent stem cell active, has multipotency differentiation function, and the organization engineering skin being built into can recover skin function.
4, the not only healing rate quickening of organization engineering skin of using instrument bag of the present utility model to build, and institute's skin grafts can recover skin proper function (perspire and pain are touched the function of sense of heat aspect), has the generation of skin appendages.
While using this utility model, (desirable artificial skin comprises epidermis with corium double-layer structure and is connected between the two closely first to take from body skin graft or artificial skin graft, it has pliability and certain mechanical strength, after being transplanted to wound surface, well attach with wound surface very soon, there is safety, do not take viruliferous advantage, it is ripe that epidermis and corium composition can complete self propagation, differentiation and function as early as possible, formation is closer to physiological permanent Graftskin etc.) standby, skin graft area should be greater than needs wound surface area approximately 10% left and right of repairing.Autologous skin graft or artificial skin graft are covered on the wound surface that needs to repair, prune unnecessary skin graft.
First with the 10mL syringe in instrument bag, insert in aseptic double-distilled water bottle, extract aseptic double-distilled water 10mL, then aseptic double-distilled water is injected to the bottle that enzymatic solution lyophilized powder is housed, fully lyase solution lyophilized powder forms enzymatic solution.Approximately, after 2～3min, the skin graft of having pruned is put in enzymatic solution bottle, with microheater, enzymatic solution bottle is heated to about 15min.Take out skin graft and put into the first sodium lactate Ringer ' solution, in and digestive enzyme.With the anodontia tweezers in instrument bag, tear gently the epidermis of skin graft off, with No. 23 knife blades in instrument bag on skin graft basal layer under basal layer cell shaving.After about 20-30 minute (being no more than at most one hour), take out skin graft, with the second sodium lactate Ringer ' solution, rinse and collect the basal layer cell scraping, obtain cell suspension.With the 5mL syringe in instrument bag, extract after cell suspension, spray drops on filter screen, filters scurf, and cell suspension is standby.
When skin-grafting, first on the wound surface after debridement, transplant de-cell Allodermis Matrix substrate, then the cell suspension after spraying filtering, in de-cell Allodermis Matrix substrate, transplant again above-mentioned got autologous skin graft or artificial skin graft, can rapid build organization engineering skin.
Accompanying drawing explanation
Fig. 1 is the structural representation of instrument bag of the rapid build organization engineering skin of a kind of embodiment of this utility model.
The specific embodiment
Below in conjunction with accompanying drawing, this utility model is described in further detail.
Fig. 1 has schematically shown the structure chart of instrument bag of the rapid build organization engineering skin of a kind of embodiment of this utility model.
As shown in Figure 1, a kind of instrument bag of rapid build organization engineering skin of embodiment, comprises inclusion and is arranged on the surgical supplies in inclusion.
In inclusion 1, be provided with 13 grooves, place successively the syringe 231 of 10mL, the tip syringe needle 241 mating with 10mL syringe 231, be loaded with the bottle of sterilized water 200, be loaded with the bottle of 2.5g enzymatic solution lyophilized powder 25, microheater 29, be loaded with the first sodium lactate Ringer ' solution 271 bottle of (also claiming balance liquid), be loaded with the bottle of the second sodium lactate Ringer ' solution 272, anodontia tweezers 22, No. 23 knife blades 21, the syringe 232 of 5mL, the tack syringe needle 242 mating with 5mL syringe 232, filter screen 28 and de-cell Allodermis Matrix substrate 26.In inclusion 1, be also provided with a vacant groove.
Wherein, digestive enzyme solution lyophilized powder 25 is trypsin solution lyophilized powder; Anodontia tweezers 22 are the anodontia tweezers 22 of ophthalmic; The volume of the first sodium lactate Ringer ' solution 271 and the second sodium lactate Ringer ' solution 272 is 5mL; The aperture of filter screen 28 is 100 μ m; Sterilized water 200 is aseptic double-distilled water, and volume is 10mL; Microheater 29 can and keep constant temperature by liquid heat to 37 in vial ℃.
While preparing this utility model, every utensil all needs to carry out aseptic sterilization, then encapsulates.Instrument bag of the present utility model has following advantage:
1, quick.In operating room, can complete, approximately 30 minutes consuming time altogether, need under laboratory condition, carry out passage cultivation etc. with the past organization engineering skin and compare, there is quick, the disposable advantage completing.
2, instrument bag of the present utility model has seed cell, also has dermal matrix, uses separately instrument bag of the present utility model can build complete organization engineering skin structure, does not need to increase other apparatus again.
3, instrument bag seed cell of the present utility model is basal layer cell, has class pluripotent stem cell active, has multipotency differentiation function, and the organization engineering skin being built into can recover skin function.
4, the not only healing rate quickening of organization engineering skin of using instrument bag of the present utility model to build, and institute's skin grafts can recover skin proper function (perspire and pain are touched the function of sense of heat aspect), has the generation of skin appendages.
While using this utility model, (desirable artificial skin comprises epidermis with corium double-layer structure and is connected between the two closely first to take from body skin graft or artificial skin graft, it has pliability and certain mechanical strength, after being transplanted to wound surface, well attach with wound surface very soon, there is safety, do not take viruliferous advantage, it is ripe that epidermis and corium composition can complete self propagation, differentiation and function as early as possible, formation is closer to physiological permanent Graftskin etc.) standby, skin graft area should be greater than needs wound surface area approximately 10% left and right of repairing.Autologous skin graft or artificial skin graft are covered on the wound surface that needs to repair, prune unnecessary skin graft.
First the tip syringe needle in instrument bag 241 and 10mL syringe 231 are screwed, then be inserted in aseptic double-distilled water bottle, extract aseptic double-distilled water 10mL.Aseptic double-distilled water 200 is injected to the bottle that enzymatic solution lyophilized powder 25 is housed, fully lyase solution lyophilized powder 25 forms enzymatic solution.Approximately, after 2～3min, the skin graft of having pruned is put in enzymatic solution bottle, with 29 pairs of enzymatic solution bottles of microheater, heats about 15min.Take out skin graft and put into the first sodium lactate Ringer ' solution 271, in and digestive enzyme.With the anodontia tweezers 22 in instrument bag, tear gently the epidermis of skin graft off, with No. 23 knife blades 21 in instrument bag on skin graft basal layer under basal layer cell shaving.After about 20-30 minute (being no more than at most one hour), take out skin graft, with the second sodium lactate Ringer ' solution 272, rinse and collect the basal layer cell scraping, obtain cell suspension.Tack syringe needle 242 and 5mL syringe 232 are screwed, then drop on filter screen 28 with its extraction cell suspension spray, filter scurf.
When skin-grafting, first on the wound surface after debridement, transplant de-cell Allodermis Matrix substrate 26, then the cell suspension after spraying filtering, in de-cell Allodermis Matrix substrate, transplant again above-mentioned got autologous skin graft or artificial skin graft, can rapid build organization engineering skin.Above-described is only embodiments more of the present utility model.For the person of ordinary skill of the art, not departing under the prerequisite of this utility model creation design, can also make some distortion and improvement, these all belong to protection domain of the present utility model.
Claims (10)
1. the instrument bag of rapid build organization engineering skin, it is characterized in that, comprise inclusion and be arranged on the surgical supplies in inclusion, described surgical supplies comprises digestive enzyme solution lyophilized powder, de-cell Allodermis Matrix substrate, No. 23 knife blades, anodontia tweezers, syringe, syringe needle, the first sodium lactate Ringer ' solution, the second sodium lactate Ringer ' solution, filter screen, sterilized water and microheaters.
2. the instrument bag of rapid build organization engineering skin according to claim 1, is characterized in that, described digestive enzyme solution lyophilized powder is trypsin solution lyophilized powder.
3. the instrument bag of rapid build organization engineering skin according to claim 2, is characterized in that, described anodontia tweezers are the anodontia tweezers of ophthalmic.
4. the instrument bag of rapid build organization engineering skin according to claim 3, is characterized in that, described syringe comprises two 5mL syringes and two 10mL syringes.
5. the instrument bag of rapid build organization engineering skin according to claim 4, it is characterized in that, described syringe needle and syringe match, and wherein, the syringe needle mating with 5mL syringe is tack syringe needle, what mate syringe needle with 10mL syringe is tip syringe needle.
6. the instrument bag of rapid build organization engineering skin according to claim 5, is characterized in that, the first described sodium lactate Ringer ' solution and the volume of the second sodium lactate Ringer ' solution are 5mL.
7. the instrument bag of rapid build organization engineering skin according to claim 6, is characterized in that, the aperture of described filter screen is 100 μ m.
8. the instrument bag of rapid build organization engineering skin according to claim 7, is characterized in that, described sterilized water is aseptic double-distilled water, altogether 10mL.
9. the instrument bag of rapid build organization engineering skin according to claim 8, is characterized in that, described microheater can and keep constant temperature by liquid heat to 37 in vial ℃.
10. the instrument bag of rapid build organization engineering skin according to claim 9, it is characterized in that, in described inclusion, be provided with 13 grooves, place successively the syringe of 10mL, syringe, 5mL syringe needle, filter screen and the de-cell Allodermis Matrix substrate of the syringe needle of 10mL, the bottle that is loaded with sterilized water, the bottle that is loaded with enzymatic solution lyophilized powder, microheater, the bottle that is loaded with sodium lactate Ringer ' solution, the bottle that is loaded with sodium lactate Ringer ' solution, anodontia tweezers, No. 23 knife blades, 5mL.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420295229.8U CN203988399U (en) | 2014-06-04 | 2014-06-04 | The instrument bag of rapid build organization engineering skin |
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| CN201420295229.8U CN203988399U (en) | 2014-06-04 | 2014-06-04 | The instrument bag of rapid build organization engineering skin |
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| CN203988399U true CN203988399U (en) | 2014-12-10 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989531A (en) * | 2014-06-04 | 2014-08-20 | 朱家源 | Instrument bag for fast building tissue engineering skin |
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2014
- 2014-06-04 CN CN201420295229.8U patent/CN203988399U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989531A (en) * | 2014-06-04 | 2014-08-20 | 朱家源 | Instrument bag for fast building tissue engineering skin |
| CN103989531B (en) * | 2014-06-04 | 2016-05-11 | 朱家源 | The instrument bag of rapid build organization engineering skin |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200901 Address after: Floor 3, No.69, Gongye Road, Shiqiao street, Panyu District, Guangzhou City, Guangdong Province Patentee after: Guangzhou Maishitian Medical Technology Co.,Ltd. Address before: 510080 No. two, No. 58, Zhongshan Road, Guangdong, Guangzhou Patentee before: Zhu Jiayuan |
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| TR01 | Transfer of patent right |