CN203842092U - Artificial liver support system - Google Patents
Artificial liver support system Download PDFInfo
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- CN203842092U CN203842092U CN201420086837.8U CN201420086837U CN203842092U CN 203842092 U CN203842092 U CN 203842092U CN 201420086837 U CN201420086837 U CN 201420086837U CN 203842092 U CN203842092 U CN 203842092U
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- blood
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- human body
- displacement liquid
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Abstract
The utility model discloses an artificial liver support system which comprises a toxin removing circulation pipeline and a hepatic failure adsorption circulation pipeline. The toxin removing circulation pipeline comprises a human body blood output tube, a first blood pump connected with the human body blood output tube, an arterial pot connected with the output port of the first blood pump, a plasma separator connected with the arterial pot, an intravenous pot connected with the main outlet of the plasma separator and a human body blood input tube connected with the intravenous pot. The hepatic failure adsorption circulation pipeline comprises a second plasma separating pump connected with the secondary outlet of the plasma separator, a high-pass dialyzer connected with the second blood pump, an absorber connected with the first outlet of the high-pass dialyzer, a first peristaltic pump connected with the second output of the high-pass dialyzer and a waste liquid container connected with the first peristaltic pump, wherein the absorber is connected with the human body blood input tube. The artificial liver support system has the advantages that work efficiency is increased, contact of blood cells and the high-pass dialyzer is avoided, and risks of blood clotting and blood platelet lowering are reduced.
Description
Technical field
This utility model relates to medical instruments field, particularly relates to a kind of artificial liver support system.
Background technology
Artificial liver support system is the part function of detoxification that temporarily substitutes liver, the equipment of metabolic function, and it improves the human internal environment that knows clearly, and is also the effective ways that create conditions for liver cell regeneration.The artificial liver technology of existing clinical practice mainly comprises plasmapheresis, MARS system and Prometheus system.Plasmapheresis needs a large amount of exogenous blood plasma to cause the pathophorous risk of haematogenous to increase, and the scarcity of blood products also causes this technology to be difficult to clinically extensively carry out simultaneously.MARS system is treated at every turn needs a large amount of albumin (120g), and needs special device, removes toxin limited as main curative effect taking indirect mode, and prices are rather stiff, and clinical practice is limited.Prometheus system is carried out adsorption removal protein binding toxin by plasma separator separated plasma, after mixing with hemocyte, the blood plasma purifying carries out again during high flux hemodialysis treatment, it is more direct that it removes toxin mode, this treatment is without albumin, but need special device, and hemocyte directly contacts with dialyser, blood coagulation risk and blood platelet reduction risk increase.
Utility model content
The technical problems to be solved in the utility model is to provide a kind of artificial liver support system, has improved work efficiency, avoided contacting of hemocyte and high pass filter, has reduced the risk of blood coagulation, blood platelet reduction.
For solving the problems of the technologies described above, the technical solution of the utility model is: a kind of artificial liver support system is provided, comprise that Dusuqing removes circulation line, liver decline sorption cycle pipeline and displacement liquid circulation line, described Dusuqing removes circulation line and comprises blood of human body outlet tube, the first blood pump being connected with blood of human body outlet tube, the tremulous pulse kettle being connected with the delivery outlet of the first blood pump, the plasma separator being connected with tremulous pulse kettle, the venous chambers being connected with the primary outlet of plasma separator and the blood of human body input pipe being connected with venous chambers, the described liver sorption cycle pipeline that declines comprises and time second blood pump that is connected of outlet of plasma separator, the high penetration parser being connected with the second blood pump, export with first of high penetration parser the adsorber being connected, export the first peristaltic pump being connected and the waste fluid container being connected with the first peristaltic pump with second of high penetration parser, the liquid outlet of described adsorber is connected with blood of human body input pipe, described displacement liquid circulation line is connected with plasma separator, and described displacement liquid circulation line and high penetration parser.This utility model adopts the effect of the first blood pump to make the blood in human body enter plasma separator by tremulous pulse kettle.First the plasma separator adopting is blood plasma and hemocyte by blood separation, then make isolated blood plasma enter adsorption column with certain speed, adsorption column is removed protein binding toxin and fat-soluble toxin, finally by the blood plasma after absorption together with isolated hemocyte in afferent veins kettle.Meanwhile, the first isolated blood plasma of plasma separator enters high penetration parser under the effect of the second blood pump.The both sides of the dialyzer of the high penetration parser adopting are respectively blood plasma and the dialysis solution from plasma separator, both are in the both sides of dialyzer in the other direction flows, by solute gradient, osmotic gradient and the hydraulic pressure gradient of film both sides, be detained too much moisture to reach to remove in toxin and body, simultaneously required material in added body.Enter adsorber through high penetration parser blood plasma after treatment, the absorption principle of described adsorber is consistent with active carbon, by intermolecular Van der Waals force, electrostatic interaction and hydrogen bond, the liver toxin that declines is fixed in hole.Last adsorber blood plasma after treatment and plasma separator blood plasma after treatment and hemocyte mix in blood of human body input pipe, after mixing, input together in human body.When plasma separator and adsorber, use, improved work efficiency; Plasma separator hemocyte isolated after blood plasma just enter high penetration parser, avoided contacting of hemocyte and high pass filter, reduced the risk of blood coagulation, blood platelet reduction.
Further, described displacement liquid circulation line comprises the first displacement liquid container, the second peristaltic pump, the second displacement liquid container being connected with the first displacement liquid container and the 3rd peristaltic pump being connected with the second displacement liquid container, described the second peristaltic pump is connected with tremulous pulse kettle, and described the 3rd peristaltic pump is connected with high penetration parser.The first displacement liquid container provides separating plasma needed displacement liquid for plasma separator, and described the second displacement liquid container provides penetrating fluid for high penetration parser.
Further, on described venous chambers, be provided with escape pipe, trachea folder on described escape pipe, is provided with current limliting folder in the outlet of described venous chambers.Described plasma separator blood plasma after treatment and hemocyte are temporary in venous chambers, make bubble and blood separation, in the time that the gas build in venous chambers is too much, close current limliting folder, open trachea folder, extruding venous chambers is got rid of gas from escape pipe, pressure reduces, and just can reuse.
Further, described artificial liver system also comprises air monitor, and described air monitor comprises that the buoyancy aid, the collection that are arranged in venous chambers are loaded on the permanent magnet in buoyancy aid, the buzzer that is arranged at the magnetic field sensor on venous chambers, the A/D converter being connected with magnetic field sensor, the single-chip microcomputer being connected with A/D converter, the on-off circuit being connected with the outfan of single-chip microcomputer and is connected with on-off circuit.Under the effect of buoyancy aid, permanent magnet changes according to the height of the blood face in venous chambers, the magnetic field size of magnetic field sensor position changes, magnetic field sensor detects the magnetic field size of position and exports analog voltage signal, analog voltage signal is converted to digital voltage signal by A/D converter, single-chip microcomputer receives digital voltage signal, single-chip microcomputer is by digital voltage signal and the contrast of predeterminated voltage value scope, single-chip microcomputer output high level signal in the time that digital voltage signal exceeds predeterminated voltage value scope, on-off circuit starts buzzer after receiving high level signal, in buzzer prompting venous chambers, gas is too much.
Further, described on-off circuit comprises resistance, audion, the first diode and the second diode, the base stage of described audion is connected with the outfan of single-chip microcomputer by resistance, the grounded emitter of described audion, the colelctor electrode of described audion is connected with the negative electrode of the first diode, described the second diode is Zener diode, the anode of described the first diode is connected with the negative electrode of the second diode, the anodic bonding power supply of described the second diode, the anode of described buzzer is connected with the anode of the second diode, shown in the negative electrode of buzzer be connected with the negative electrode of the first diode.
The beneficial effects of the utility model: adopt plasma separator first blood plasma to be separated with hemocyte, only have the blood plasma to enter into high penetration parser, avoided contacting of hemocyte and high pass filter, reduced the risk of blood coagulation, blood platelet reduction.Add, use when plasma separator and adsorber, replaced separately using of plasma separator and adsorber in prior art, improved work efficiency.
Brief description of the drawings
Below in conjunction with accompanying drawing, detailed description of the invention of the present utility model is described in further detail.
Fig. 1 is the structural representation of this utility model artificial liver support system.
Fig. 2 is the enlarged drawing at A place in Fig. 1.
Fig. 3 is the circuit block diagram of air monitor in Fig. 1.
Fig. 4 is the circuit diagram of on-off circuit in Fig. 3.
Detailed description of the invention
Below in conjunction with accompanying drawing, the utility model is described in further detail.
Embodiment: as shown in Figure 1, be the preferred embodiments of this utility model artificial liver support system, this artificial liver support system comprises that Dusuqing removes circulation line 1, liver decline sorption cycle pipeline 2, displacement liquid circulation line 3 and air monitor 4.
Particularly, shown in Fig. 1 and Fig. 2, described Dusuqing except circulation line 1 comprises blood of human body outlet tube 10, the first blood pump 14 being connected with blood of human body outlet tube 10, the tremulous pulse kettle 11 being connected with the delivery outlet of the first blood pump 14, the plasma separator 12 being connected with tremulous pulse kettle 11, the venous chambers 13 being connected with the primary outlet of plasma separator 12 and the blood of human body input pipe 15 that is connected with venous chambers 13.On described venous chambers 13, be provided with escape pipe 130, trachea folder 131 on described escape pipe 130, is provided with current limliting folder 132 in the outlet of described venous chambers 13.
The described liver sorption cycle pipeline 2 that declines comprises with second blood pump 20, the high penetration parser 21 being connected with the second blood pump 20 that time outlet is connected of plasma separator 12, exports the adsorber 22 that is connected, exports the first peristaltic pump 23 being connected and the waste fluid container 24 being connected with the first peristaltic pump 23 with second of high penetration parser 21 with first of high penetration parser 21, and the liquid outlet of described adsorber 22 is connected with blood of human body input pipe 15.
Described displacement liquid circulation line 3 comprises the first displacement liquid container 30, the second peristaltic pump 31, the second displacement liquid container 32 being connected with the first displacement liquid container 30 and the 3rd peristaltic pump 33 being connected with the second displacement liquid container 32, described the second peristaltic pump 31 is connected with tremulous pulse kettle 11, and described the 3rd peristaltic pump 33 is connected with high penetration parser 21.
Shown in Fig. 2 and Fig. 3, described air monitor 4 comprises that the buoyancy aid 40, the collection that are arranged in venous chambers 13 are loaded on the permanent magnet 41 in buoyancy aid 40, the buzzer 46 that is arranged at the magnetic field sensor 42 on venous chambers 13, the A/D converter 43 being connected with magnetic field sensor 42, the single-chip microcomputer 44 being connected with A/D converter 43, the on-off circuit 45 being connected with the outfan of single-chip microcomputer 44 and is connected with on-off circuit 45.Under the effect of buoyancy aid 40, permanent magnet 41 changes according to the height of the blood face in venous chambers 13, the magnetic field size of magnetic field sensor 42 positions changes, magnetic field sensor 42 detects the magnetic field size of position and exports analog voltage signal, analog voltage signal is converted to digital voltage signal by A/D converter 43, single-chip microcomputer 44 receives digital voltage signal, single-chip microcomputer 44 is by digital voltage signal and the contrast of predeterminated voltage value scope, in the time that digital voltage signal exceeds predeterminated voltage value scope, single-chip microcomputer 44 is exported high level signal, on-off circuit 45 starts buzzer 46 after receiving high level signal, buzzer 46 points out the interior gas of venous chambers 13 too much, to prevent that bubble from entering in human body.
Shown in Fig. 4, described on-off circuit 45 comprises resistance 450, audion 451, the first diode 462 and the second diode 463, the base stage of described audion 451 is connected with the outfan of single-chip microcomputer 44 by resistance 450, the grounded emitter of described audion 451, the colelctor electrode of described audion 451 is connected with the negative electrode of the first diode 462, described the second diode 463 is Zener diode, the anode of described the first diode 462 is connected with the negative electrode of the second diode 463, the anodic bonding power supply of described the second diode 463, the anode of described buzzer 46 is connected with the anode of the second diode 463, shown in the negative electrode of buzzer 46 be connected with the negative electrode of the first diode 462.The base stage of audion 451 receives the high level signal from single-chip microcomputer 44, make audion 451 conductings, now the Nodes of the colelctor electrode of the negative electrode of the first diode 462 and audion 451 is low-voltage, the first diode 462 and the second diode 463 conductings, buzzer 46 also conducting is sounded.The second diode 463 plays the effect of voltage-stabilizing protection the first diode 462.
Operation principle of the present utility model: adopt the effect of the first blood pump 14 to make the blood in human body enter plasma separator 12 by tremulous pulse kettle 11.First the plasma separator 12 adopting is blood plasma and hemocyte by blood separation, then make isolated blood plasma enter adsorption column with certain speed, adsorption column is removed protein binding toxin and fat-soluble toxin, finally by the blood plasma after absorption together with isolated hemocyte in afferent veins kettle.Meanwhile, the first isolated blood plasma of plasma separator 12 enters high penetration parser 21 under the effect of the second blood pump 20.The both sides of the dialyzer of the high penetration parser 21 adopting are respectively blood plasma and the dialysis solution from plasma separator 12, both are in the both sides of dialyzer in the other direction flows, by solute gradient, osmotic gradient and the hydraulic pressure gradient of film both sides, be detained too much moisture to reach to remove in toxin and body, simultaneously required material in added body.Enter adsorber 22 through high penetration parser 21 blood plasma after treatment, the absorption principle of described adsorber 22 is consistent with active carbon, by intermolecular Van der Waals force, electrostatic interaction and hydrogen bond, the liver toxin that declines is fixed in hole.Last adsorber blood plasma after treatment and plasma separator blood plasma after treatment and hemocyte mix in blood of human body input pipe, after mixing, input together in human body.When plasma separator 12 and adsorber 22, use, improved work efficiency; Plasma separator 12 hemocyte isolated after blood plasma just enter high penetration parser 21, avoided contacting of hemocyte and high pass filter, reduced the risk of blood coagulation, blood platelet reduction.The first displacement liquid container 30 provides separating plasma needed displacement liquid for plasma separator 12, and described the second displacement liquid container 32 provides penetrating fluid for high penetration parser 21.
These are only embodiment of the present utility model; not thereby limit the scope of the claims of the present invention; every equivalent structure that utilizes this utility model description and accompanying drawing content to do; directly or indirectly be used in other relevant technical fields, all in like manner within scope of patent protection of the present utility model.
Claims (5)
1. an artificial liver support system, it is characterized in that, comprise that Dusuqing removes circulation line, liver decline sorption cycle pipeline and displacement liquid circulation line, described Dusuqing removes circulation line and comprises blood of human body outlet tube, the first blood pump being connected with blood of human body outlet tube, the tremulous pulse kettle being connected with the delivery outlet of the first blood pump, the plasma separator being connected with tremulous pulse kettle, the venous chambers being connected with the primary outlet of plasma separator and the blood of human body input pipe being connected with venous chambers, the described liver sorption cycle pipeline that declines comprises and time second blood pump that is connected of outlet of plasma separator, the high penetration parser being connected with the second blood pump, export with first of high penetration parser the adsorber being connected, export the first peristaltic pump being connected and the waste fluid container being connected with the first peristaltic pump with second of high penetration parser, the liquid outlet of described adsorber is connected with blood of human body input pipe, described displacement liquid circulation line is connected with plasma separator, and described displacement liquid circulation line and high penetration parser.
2. artificial liver support system according to claim 1, it is characterized in that, described displacement liquid circulation line comprises the first displacement liquid container, the second peristaltic pump, the second displacement liquid container being connected with the first displacement liquid container and the 3rd peristaltic pump being connected with the second displacement liquid container, described the second peristaltic pump is connected with tremulous pulse kettle, and described the 3rd peristaltic pump is connected with high penetration parser.
3. artificial liver support system according to claim 1, is characterized in that, on described venous chambers, is provided with escape pipe, and trachea folder on described escape pipe, is provided with current limliting folder in the outlet of described venous chambers.
4. artificial liver support system according to claim 3, it is characterized in that, described artificial liver system also comprises air monitor, and described air monitor comprises that the buoyancy aid, the collection that are arranged in venous chambers are loaded on the permanent magnet in buoyancy aid, the buzzer that is arranged at the magnetic field sensor on venous chambers, the A/D converter being connected with magnetic field sensor, the single-chip microcomputer being connected with A/D converter, the on-off circuit being connected with the outfan of single-chip microcomputer and is connected with on-off circuit.
5. artificial liver support system according to claim 4, it is characterized in that, described on-off circuit comprises resistance, audion, the first diode and the second diode, the base stage of described audion is connected with the outfan of single-chip microcomputer by resistance, the grounded emitter of described audion, the colelctor electrode of described audion is connected with the negative electrode of the first diode, described the second diode is Zener diode, the anode of described the first diode is connected with the negative electrode of the second diode, the anodic bonding power supply of described the second diode, the anode of described buzzer is connected with the anode of the second diode, shown in the negative electrode of buzzer be connected with the negative electrode of the first diode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420086837.8U CN203842092U (en) | 2014-02-27 | 2014-02-27 | Artificial liver support system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420086837.8U CN203842092U (en) | 2014-02-27 | 2014-02-27 | Artificial liver support system |
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| CN203842092U true CN203842092U (en) | 2014-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201420086837.8U Expired - Fee Related CN203842092U (en) | 2014-02-27 | 2014-02-27 | Artificial liver support system |
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| CN (1) | CN203842092U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477713A (en) * | 2015-08-08 | 2016-04-13 | 常州华岳微创医疗器械有限公司 | Cyclic treatment blood purification apparatus |
| CN108136099A (en) * | 2015-09-26 | 2018-06-08 | 费森尤斯医疗保健德国有限公司 | The gas of dissolving in blood is determined in recycling in vitro |
-
2014
- 2014-02-27 CN CN201420086837.8U patent/CN203842092U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477713A (en) * | 2015-08-08 | 2016-04-13 | 常州华岳微创医疗器械有限公司 | Cyclic treatment blood purification apparatus |
| CN108136099A (en) * | 2015-09-26 | 2018-06-08 | 费森尤斯医疗保健德国有限公司 | The gas of dissolving in blood is determined in recycling in vitro |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140924 Termination date: 20150227 |
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| EXPY | Termination of patent right or utility model |