CN102500005A - Blood transfusion system for autologous blood recovery, filtration and purification - Google Patents

Blood transfusion system for autologous blood recovery, filtration and purification Download PDF

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Publication number
CN102500005A
CN102500005A CN2011102963452A CN201110296345A CN102500005A CN 102500005 A CN102500005 A CN 102500005A CN 2011102963452 A CN2011102963452 A CN 2011102963452A CN 201110296345 A CN201110296345 A CN 201110296345A CN 102500005 A CN102500005 A CN 102500005A
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blood
bag
jar
filtration
storage
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CN2011102963452A
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CN102500005B (en
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蔡宏伟
任飞
焦赫娜
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Central South University
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Central South University
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Abstract

The invention discloses a blood transfusion system for autologous blood recovery, filtration and purification, which comprises a suction head, a blood storage and filtration tank, a blood storage pressurizing bag, a blood ultrafiltration purifier and a blood bag which are sequentially connected through a pipeline. The blood transfusion system has the advantages that by the aid of the complete system which is simple in structure, convenient in use and low in cost, outflow blood is effectively recovered, filtered and purified, impurity particles such as harmful free hemoglobin, inflammatory mediators, cell activation products, small tissue dross, micro-polymers and the like in blood are removed, the blood is concentrated, and adverse transfusion reaction caused by prior filtration-type blood recovery is eliminated. Besides, the system is capable of effectively retaining plasma components and blood platelet components in the blood, and avoiding the influence of cleaning out blood coagulation factors and blood platelets in the blood on a blood coagulation function during cleaning blood recovery. In addition, by the aid of the system, infectious diseases caused by homologous blood transfusion are avoided, shortage of blood sources is relieved, and the economic burden of a patient is reduced.

Description

A kind of autoblood reclaims the filtration, purification blood transfusion system
Technical field
The present invention relates to a kind of autoblood and reclaim the filtration, purification blood transfusion system, harmful cell inflammatory factor in particularly a kind of effectively filtering blood, and the autoblood of erythrocyte, platelet and plasma fraction reclaims the filtration, purification blood transfusion system in the reservation blood.
Background technology
Blood reclaims according to the processing mode of collecting blood being divided into recovery of cleaning type blood and filtering type blood and reclaims.Filtering type blood recovery structure is simple, and is easy to operate.But owing to there is the activation of to a certain degree haemolysis, blood coagulation-fibrinolytic system and inflammatory cell in the removal process; And the free hemoglobin inflammatory mediator and the cell-stimulating product that contain variable concentrations in the recovery blood; Also possibly be mixed with impurity particles such as small tissue debris such as lipochondrion and little aggressiveness simultaneously; Feed back when reclaiming blood; Especially when amount is big, possibly cause complication or untoward reaction such as heating, hypotension and last air flue edema such as renal function injury, hyperpotassemia, disseminated inravascular coagulation, thereby limit its application.And cleaning type blood the reclaimed eccysis plasma fraction 90% or more, platelet, cell debris, dissociate Hb and active substance (activated blood coagulation substance, platelet, complement etc.), thereby range of application is wider.But its operation is complicated, and equipment is expensive, and it has mainly kept red blood cell component, can not effectively keep blood plasma and learn platelet, possibly influence coagulation function during a large amount of infusion, needs to replenish in addition blood plasma and platelet.So still there is not a kind of perfectly blood way of recycling at present.
Summary of the invention
Reclaim side effect than causing application surface extensively not reach filtering type blood cost recovery technical problems of high greatly in order to solve existing cleaning type blood; It is a kind of simple in structure that the present invention provides; Easy to use; With low cost, can remove impurity particles such as the free hemoglobin that reclaims in the blood, inflammatory mediator, cell-stimulating product, small tissue debris, little aggressiveness.Effectively keep plasma fraction in the blood, kept the platelet composition, the autoblood little to the influence of patient's coagulation function reclaims the filtration, purification blood transfusion system.
In order to realize above-mentioned technical purpose, technical scheme of the present invention is that a kind of autoblood reclaims the filtration, purification blood transfusion system; Comprise the attraction head, storage blood hemofiltration jar, storage blood inflating bag, blood ultrafiltration depurator and the blood bag that connect through pipeline successively; Described storage blood hemofiltration jar comprises interior jar and outer jar, jar inside outside described interior jar is arranged at, and the sidewall of interior jar is a filter screen; Attract head to be connected to interior jar through pipeline; Outer jar is connected to through pipeline and stores up the blood inflating bag, and described storage blood inflating bag comprises storage blood inner bag, outer bag of pressurization, simple and easy air pressurization device and Pressure gauge, and what described storage blood inner bag sealed is arranged in the outer bag of pressurization; Described simple and easy air pressurization device is connected to the outer bag of pressurization through pipeline; Described Pressure gauge is connected between simple and easy air pressurization device and the outer bag of pressurization, and the input of storage blood inner bag connects outer jar of storage blood hemofiltration jar, and the outfan of storage blood inner bag connects the blood ultrafiltration depurator.
Described a kind of autoblood reclaims the filtration, purification blood transfusion system; The interior jar of described storage blood hemofiltration jar is provided with the blood circulation inlet; Described blood ultrafiltration depurator is provided with first three-way valve with the pipeline that is connected between the blood bag; Connection pipeline between described storage blood hemofiltration jar and the storage blood inflating bag is provided with second three-way valve; Described first three-way valve comprises the depurator mouth that is used to connect the blood ultrafiltration depurator, the blood bag mouth and first circulation port that is used to be connected the blood circulation inlet or second three-way valve that is used for connecting blood receiving bag, and described second three-way valve comprises the blood jar mouth that is used to connect storage blood hemofiltration jar, the pressurization bag mouth and second circulation port that is used to be connected first three-way valve that is used to connect storage blood inflating bag.
Described a kind of autoblood reclaims the filtration, purification blood transfusion system, also comprises the anticoagulant medicated bag that anticoagulant is housed, and described anticoagulant medicated bag is connected to the attraction head through pipeline.
Described a kind of autoblood reclaims the filtration, purification blood transfusion system, also comprises Micro-Bolt Filter, and described Micro-Bolt Filter is arranged at being connected on the pipeline between first three-way valve and the blood bag.
Described a kind of autoblood reclaims the filtration, purification blood transfusion system, and described storage blood hemofiltration jar is provided with the vacuum suction pipe.
Described a kind of autoblood reclaims the filtration, purification blood transfusion system; Described blood ultrafiltration depurator comprises depurator body and waste fluid bag; The input of described depurator body connects storage blood inflating bag; The outfan of depurator body connects first three-way valve, and the side pipe of depurator body connects waste fluid bag.
Described a kind of autoblood reclaims the filtration, purification blood transfusion system, and the interior pot sidewall of described storage blood hemofiltration jar is the filter screen of 40um.
Technique effect of the present invention is; Through whole system simple in structure, easy to use, with low cost; Realized the hemorrhage and filtration, purification of efficient recovery; Remove impurity particles such as deleterious free hemoglobin, inflammatory mediator, cell-stimulating product, small tissue debris and little aggressiveness in the blood, and concentrate blood, having stopped previously, filtering type blood reclaims caused bad transfusion reaction.This system can effectively keep plasma fraction in the blood simultaneously, kept the platelet composition, has avoided the influence to coagulation function due to thrombin and the platelet in the blood of having reclaimed cleaning and removing of cleaning type blood.This system has avoided allosome blood infusion and the infectious disease that causes, has alleviated the tonicity in blood source, has alleviated patient's financial burden.
Below in conjunction with accompanying drawing the present invention is described further.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Wherein, 1 for attracting head, and 2 are the anticoagulant medicated bag, and 3 are storage blood hemofiltration jar, and 4 is second three-way valve; 5 are storage blood inflating bag, and 6 is simple and easy air pressurization device, and 7 is Pressure gauge, and 8 is the blood ultrafiltration depurator; 9 is waste fluid bag, and 10 is first three-way valve, and 11 is Micro-Bolt Filter, and 12 is the blood bag; 13 are the vacuum suction pipe, and 14 are the blood circulation inlet, and 15 are storage blood inner bag, and 16 are the outer bag of pressurization.
The specific embodiment
Referring to Fig. 1, the present invention includes successively the attraction that connects through pipeline 1, storage blood hemofiltration jar 3, storage blood inflating bag 5, blood ultrafiltration depurator 8 and blood bag 12.In storage blood hemofiltration jar 3 comprises jar with outer jar, interior jar be arranged at outer jar inner, interior jar sidewall is the filter screen of 40um, attracts 1 to be connected to interior jar through pipeline, outer jar is connected to storage blood inflating bag 5 through pipeline, interior jar can be filtered the fast tissue debris of blood clotting etc.Reclaim open its second three-way valve 4 in a certain amount of blood (500-1000ml) back and let preliminary filtering blood get into the storage blood inner bag 15 of storage blood inflating bag 5, storage blood hemofiltration jar 3 is provided with vacuum suction pipe 13 so that make blood circulation smooth and easy.
Storage blood inflating bag 5 comprises storage blood inner bag 15, outer bag 16 of pressurization, simple and easy air pressurization device 6 and Pressure gauge 7; Being arranged in the outer bag 16 of pressurization of storage blood inner bag 15 sealings; Simple and easy air pressurization device 6 is connected to the outer bag 16 of pressurization through pipeline; Pressure gauge 7 is connected between simple and easy air pressurization device 6 and the outer bag 16 of pressurization, and the input of storage blood inner bag 15 connects outer jar of storage blood hemofiltration jar 3, and the outfan of storage blood inner bag 15 connects blood ultrafiltration depurator 8.Close second three-way valve 4 after being full of, and inject air in the bag outside.Simple and easy air pressurization device 6 uses the inflatable ball of simple and easy sphygomanometer commonly used to get final product.On the injecting gas pipeline, be connected to Pressure gauge 7.Simple and easy air pressurization device 6 makes the blood that stores up blood inflating bag 5 inner bags get into the blood ultrafiltration depurator 8 of below after injecting air.The reason that simple and easy air pressurization device 6 is set is because have only pressure differential just can make the 8 performance filtrations of blood ultrafiltration depurator; Its controlled pressure is 200-300mmHg; Can make the blood downlink traffic reach 50-150ml/ minute, 1000ml reclaims the blood filtration time and only needs 10-20 minute.
Blood ultrafiltration depurator 8 comprises depurator body and waste fluid bag 9, and the input of depurator body connects storage blood inflating bag 5, and the outfan of depurator body connects first three-way valve 10, and the side pipe of depurator body connects waste fluid bag 9.The filter membrane of blood ultrafiltration depurator 8 is a PA membrane, and it is nontoxic that it has better biocompatibility.It can simulate the filtering function of normal glomerule, and mainly removes moisture, electrolyte, middle small-molecule substance through the mode of convection current, and the material of macromolecules such as albumen can not pass through.Blood except moisture, electrolyte, middle small-molecule substance and a large amount of inflammatory factors, and has kept albumen, the thrombin in the blood plasma and the type blood cell component has been arranged through blood ultrafiltration depurator 8 after-filtration.
On interior jar of storage blood hemofiltration jar 3, be provided with blood circulation inlet 14; Blood ultrafiltration depurator 8 is provided with first three-way valve 10 with the pipeline that is connected between the blood bag 12; Connection pipeline between storage blood hemofiltration jar 3 and the storage blood inflating bag 5 is provided with second three-way valve 4; First three-way valve 10 comprises the depurator mouth that is used to connect blood ultrafiltration depurator 8, be used for connecting 12 mouthfuls in the blood bag and first circulation port that is used to be connected blood circulation inlet 14 or second three-way valve 4 of blood receiving bag 12, and second three-way valve 4 comprises the blood jar mouth that is used to connect storage blood hemofiltration jar 3, the pressurization bag mouth and second circulation port that is used to be connected first three-way valve 10 that is used to connect storage blood inflating bag 5.Can be connected to storage blood hemofiltration jar 3 or store up blood inflating bag 5 cycle repeats ultrafiltration purification once more from 10 on first three-way valve through the blood after 8 filtrations of blood ultrafiltration depurator, to reach best filter effect.
The anticoagulant medicated bag 2 that anticoagulant is housed is connected to through pipeline and attracts 1; Attracting an infusion anticoagulant in 1 simultaneously when reclaiming blood; The anticoagulant that native system uses is a sodium citrate, and it can effectively prevent the blood coagulation that reclaims to feed back and not needing special antagonism when giving patient simultaneously; Because of its in vivo soon by liver metabolism, and replenish calcium preparation in case of necessity and can resist its anticoagulation.
Blood bag 12 feeds back patient Shi Jia with Micro-Bolt Filter 11, and Micro-Bolt Filter 11 is arranged at being connected on the pipeline between first three-way valve 10 and the blood bag 12.

Claims (7)

1. an autoblood reclaims the filtration, purification blood transfusion system; It is characterized in that, comprise successively the attraction head, storage blood hemofiltration jar, storage blood inflating bag, blood ultrafiltration depurator and the blood bag that connect through pipeline, in described storage blood hemofiltration jar comprises jar with outer jar; Jar is arranged at outer jar of inside in described; The sidewall of interior jar is a filter screen, attracts head to be connected to interior jar through pipeline, and jar is connected to storage blood inflating bag through pipeline outward; Described storage blood inflating bag comprises storage blood inner bag, the outer bag of pressurization, simple and easy air pressurization device and Pressure gauge; Being arranged in the outer bag of pressurization of described storage blood inner bag sealing, described simple and easy air pressurization device is connected to the outer bag of pressurization through pipeline, and described Pressure gauge is connected between simple and easy air pressurization device and the outer bag of pressurization; The input of storage blood inner bag connects outer jar of storage blood hemofiltration jar, and the outfan of storage blood inner bag connects the blood ultrafiltration depurator.
2. a kind of autoblood according to claim 1 reclaims the filtration, purification blood transfusion system; It is characterized in that; The interior jar of described storage blood hemofiltration jar is provided with the blood circulation inlet; Described blood ultrafiltration depurator is provided with first three-way valve with the pipeline that is connected between the blood bag; Connection pipeline between described storage blood hemofiltration jar and the storage blood inflating bag is provided with second three-way valve; Described first three-way valve comprises the depurator mouth that is used to connect the blood ultrafiltration depurator, the blood bag mouth and first circulation port that is used to be connected the blood circulation inlet or second three-way valve that is used for connecting blood receiving bag, and described second three-way valve comprises the blood jar mouth that is used to connect storage blood hemofiltration jar, the pressurization bag mouth and second circulation port that is used to be connected first three-way valve that is used to connect storage blood inflating bag.
3. a kind of autoblood according to claim 1 reclaims the filtration, purification blood transfusion system, it is characterized in that also comprise the anticoagulant medicated bag that anticoagulant is housed, described anticoagulant medicated bag is connected to the attraction head through pipeline.
4. a kind of autoblood according to claim 1 reclaims the filtration, purification blood transfusion system, it is characterized in that, also comprises Micro-Bolt Filter, and described Micro-Bolt Filter is arranged at being connected on the pipeline between first three-way valve and the blood bag.
5. a kind of autoblood according to claim 1 reclaims the filtration, purification blood transfusion system, it is characterized in that described storage blood hemofiltration jar is provided with the vacuum suction pipe.
6. a kind of autoblood according to claim 1 reclaims the filtration, purification blood transfusion system; It is characterized in that; Described blood ultrafiltration depurator comprises depurator body and waste fluid bag; The input of described depurator body connects storage blood inflating bag, and the outfan of depurator body connects first three-way valve, and the side pipe of depurator body connects waste fluid bag.
7. a kind of autoblood according to claim 1 reclaims the filtration, purification blood transfusion system, it is characterized in that the interior pot sidewall of described storage blood hemofiltration jar is the filter screen of 40um.
CN201110296345.2A 2011-09-30 2011-09-30 Blood transfusion system for autologous blood recovery, filtration and purification Expired - Fee Related CN102500005B (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689403A (en) * 2013-12-08 2015-06-10 杨海龙 Suspended retransfusion set
CN105999445A (en) * 2016-08-02 2016-10-12 宁波市妇女儿童医院 Method for treating recycled blood in cesarean section
CN106110750A (en) * 2016-08-15 2016-11-16 鲁绍荣 A kind of efficiently blood recovery system
CN108853619A (en) * 2018-03-23 2018-11-23 山东大学齐鲁医院 Autogenous vein device with choke preventing function
CN109793957A (en) * 2019-03-27 2019-05-24 南京市儿童医院 A kind of simple Autoblood recovery device
CN110891628A (en) * 2017-06-22 2020-03-17 尼普洛株式会社 Blood purification device
CN111989126A (en) * 2017-12-28 2020-11-24 艾赛普公司 System and method for processing bleeding fluid for autologous infusion

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986956A (en) * 1973-12-04 1976-10-19 Tokyo Shibaura Electric Co., Ltd. Artificial kidney device
US4559034A (en) * 1981-04-16 1985-12-17 Kawasumi Laboratories, Inc. Line for use in body fluid treatment
CN202236538U (en) * 2011-09-30 2012-05-30 中南大学 Recovery, filtration, purification and transfusion system of autoblood

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986956A (en) * 1973-12-04 1976-10-19 Tokyo Shibaura Electric Co., Ltd. Artificial kidney device
US4559034A (en) * 1981-04-16 1985-12-17 Kawasumi Laboratories, Inc. Line for use in body fluid treatment
CN202236538U (en) * 2011-09-30 2012-05-30 中南大学 Recovery, filtration, purification and transfusion system of autoblood

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689403A (en) * 2013-12-08 2015-06-10 杨海龙 Suspended retransfusion set
CN105999445A (en) * 2016-08-02 2016-10-12 宁波市妇女儿童医院 Method for treating recycled blood in cesarean section
CN106110750A (en) * 2016-08-15 2016-11-16 鲁绍荣 A kind of efficiently blood recovery system
CN110891628A (en) * 2017-06-22 2020-03-17 尼普洛株式会社 Blood purification device
US11628241B2 (en) 2017-06-22 2023-04-18 Nipro Corporation Blood purification apparatus
CN111989126A (en) * 2017-12-28 2020-11-24 艾赛普公司 System and method for processing bleeding fluid for autologous infusion
CN108853619A (en) * 2018-03-23 2018-11-23 山东大学齐鲁医院 Autogenous vein device with choke preventing function
CN109793957A (en) * 2019-03-27 2019-05-24 南京市儿童医院 A kind of simple Autoblood recovery device

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