CN203447819U - Single-plate rotating type continuous countercurrent chromatographic device - Google Patents
Single-plate rotating type continuous countercurrent chromatographic device Download PDFInfo
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- CN203447819U CN203447819U CN201320570534.9U CN201320570534U CN203447819U CN 203447819 U CN203447819 U CN 203447819U CN 201320570534 U CN201320570534 U CN 201320570534U CN 203447819 U CN203447819 U CN 203447819U
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Abstract
The utility model discloses a single-plate rotating type continuous countercurrent chromatographic device. The device is controlled by a servo transmission structure, a plurality of jets of washing, elution and recycled liquid can be introduced, air inlets and outlets of chromatographic columns can be sequentially connected in different combination ways to implement a closed-loop chromatographic flow as well as an open-loop chromatographic flow, the number of the chromatographic columns and the position of the liquid can be changed according to needs to reduce the using amounts of an adsorption carrier and a flowing phase and increase the concentration of a separated product, and the stability of separation operation, the quality of the product and the processing capability within a unit time are improved by continuous operation.
Description
Technical field
The utility model relates to the rotary-type continuous flow upstream chromatographic apparatus of a kind of single-deck, is a kind of separation and purification device that is applied to biology, chemistry, field of medicaments.
Background technology
Mainstream technology for biochemistry, field of medicaments subtractive process is adsorption chromatography, ion-exchange chromatography, gel chromatography, affinity chromatography, hydrophobic chromatography and high performance liquid chromatography at present, but a common shortcoming of these technology is exactly andnon-continuous operation manner, although simple to operate, the operation cycle is long, process efficiency is low, has affected the economy of process.The shortcoming of intermittently operated has promoted the apparatus-form of continuous adsorption operation, comprising: moving bed, simulation moving-bed, carrousel adsorption system, continuous flow upstream etc.
Moving bed operation, mobile phase and fixing countercurrent movement between mutually, because the carrier fragmentation of wearing and tearing in motion process is very fast, the chromatography process of inapplicable and bioprotein.
Simulated moving bed technology, great majority adopt three closed systems with four-tape operation, flow to the switching of out position valve by each strand of liquid, and the simulation counter-current operation between realizing mobile phase and fixing is mutually to improve efficiency and the effect of separate targets product.But for bioprotein chromatography technique, need more charging, discharging arrangement, comprise the sequence of operations such as carrier Balance Treatment after the absorption, washing, wash-out, wash-out of target product, inevitably can there is mixing to a certain degree in the mobile phase in wash-out section and regenerator section, can change like this absorption and the separating property of bioprotein, thereby make the operating effect of separation process can depart from original setting requirement.And protein chromatographic import and export are more, the operation of application simulation moving bed, very inconvenient in flow process.
Existing a kind of carrousel continuous adsorption equipment, described in it, carrousel structure is comprised of rotating disc and upper and lower two ends distributor, by the continuous rotation of mechanical device, realizing adsorption column switches continuously, in post, there is mobile phase to pass through always, but on the surfaces of revolution, each switching port is different from the number of fixing card switching port, the liquid stream that occurs sometimes two ducts in handoff procedure flows to a chromatographic column simultaneously, after chromatography, flow into respectively again two different outlets, caused the reduction of intercolumniation mixing and separative efficiency.
The Chinese patent < < that on December 6th, 2006, disclosed publication number was CN1287881C is for the solid tomography devices > > of stepped changed columns continuous flow upstream liquid one of Separation of Proteins, though the phenomenon that it can effectively avoid mixed liquid layer to analyse, but this patent is too loaded down with trivial details in operation, upper and lower two dish R&D costs are very high, pipe joint is a lot, is unfavorable for that personnel operate.
Utility model content
The utility model proposes the rotary-type continuous flow upstream chromatographic apparatus of a kind of single-deck, can reduce consumption and the mobile phase consumption of absorption carrier, improve the product design after separation, improve the stability of lock out operation simultaneously, improve the quality of products and disposal ability in the unit interval.
For realizing this purpose, the method that the utility model adopts is: the rotary-type continuous flow upstream chromatographic apparatus of a kind of single-deck, comprise moving palette and a quiet palette, described moving palette is the disc structure that shape is identical with quiet palette, moving palette and quiet palette overlap, by stent support, support is pivot structure, be vertically connected on moving, quiet palette is central, the bottom vertical of support is connected to round tray central authorities, tray bottom is provided with base, between pallet and base, be provided with drive mechanism, the top symmetry of the bottom of described moving palette and pallet and is respectively provided with 8～64 fixing lug boss that are circularly and evenly distributed, the surface of fixing lug boss is groove structure, between moving palette and pallet, be provided with chromatographic column, the two ends of chromatographic column are connected to moving palette and pallet is thought in corresponding fixing lug boss, quiet palette top is respectively equipped with inlet opening and the fluid hole being circularly and evenly distributed, inlet opening run through moving palette and quiet palette vertical with fluid hole, inlet opening passes into chromatographic column top, fluid hole connects chromatography column bottom by flexible pipe, 8～64 movings, the duct that quiet palette center is circularly and evenly distributed vertically runs through moving, quiet palette, two ends, duct are respectively equipped with symmetrical transmitting probe and receiving transducer.
Described drive mechanism comprises interconnective servomotor, delivery pump, time controller and reductor, and delivery pump connects chromatographic column, and gear and the gear on pallet on reductor are intermeshing.
Described top of the trellis is projection cube structure, and projection cube structure is positioned at quiet palette top, between projection cube structure and quiet palette, is provided with some springs.
The moving bottom of palette and the top symmetry of pallet and are respectively provided with 8～32 fixing lug boss that are circularly and evenly distributed.
Described duct number is 8～32.
Its beneficial effect is: by servo-type drive mechanism, controlled, can pass into multiply washing, wash-out and regenerated liquid stream, by the import and export of each chromatographic column are connected in turn with different combinations, both can realize closed loop chromatography flow process, can realize again open loop chromatography flow process, can change as required the position of number and the liquid stream of chromatographic column, to reduce consumption and the mobile phase consumption of absorption carrier, improve the concentration of separated rear product, continuous operation improves the stability of lock out operation, improves the quality of products and the disposal ability in the unit interval
Accompanying drawing explanation
The utility model will illustrate by example and with reference to the mode of accompanying drawing, wherein:
Fig. 1 is that the utility model is faced structure chart;
Fig. 2 is the structural representation of moving palette described in the utility model and quiet palette.
The specific embodiment
Disclosed all features in this description, or the step in disclosed all methods or process, except mutually exclusive feature and/or step, all can combine by any way.
Disclosed arbitrary feature in this description (comprising any accessory claim, summary and accompanying drawing), unless narration especially all can be replaced by other equivalences or the alternative features with similar object.That is,, unless narration especially, each feature is an example in a series of equivalences or similar characteristics.
The rotary-type continuous flow upstream chromatographic apparatus of a kind of single-deck as shown in Figure 1 and Figure 2, comprise moving palette 1 and a quiet palette 2, moving palette 1 is the disc structure that shape is identical with quiet palette 2, moving palette 1 and quiet palette 2 overlap, by support 5, supported, support 5 is pivot structure, be vertically connected on dynamic and static palette central, the top of support 5 is projection cube structure, be positioned at the top of quiet palette 2, between quiet palette 2 and projection cube structure, be provided with many springs, can make like this overlapping tightr of dynamic and static group of keyboard.The bottom vertical of support 5 is connected to round tray 9 central authorities, and pallet 9 bottoms are provided with base 10, between pallet 9 and base 10, is provided with drive mechanism 8.Drive mechanism 8 comprised in order to the servomotor of kinetic energy to be provided, and in order to the delivery pump of pumped liquid stream, in order to control time interlude controller and reductor, the gear on the gear on reductor and pallet 9 is intermeshing, drives the rotation of pallet 9.The moving bottom of palette 1 and the top symmetry of pallet 9 and are respectively provided with 8～32 fixing lug boss that are circularly and evenly distributed 11, fixing lug boss 11 utilizes surperficial groove structure that the two ends of the chromatographic column 3 arranging between moving palette 1 and pallet 9 are fixed, and can increase and decrease as required the number of chromatographic column 3.Quiet palette 2 tops are respectively equipped with inlet opening 21 and the fluid hole 22 being circularly and evenly distributed, inlet opening 21 run through moving palette 1 and quiet palette 2 vertical with fluid hole 22, inlet opening 21 passes into the top of chromatographic column 3, fluid hole 22 connects chromatographic column 3 bottoms by flexible pipe 4, like this, can be by converting interconnecting of flexible pipe and top inlet opening 21, make that chromatographic column 3 is orderly must join end to end, form adsorption section, wash-out section, regenerator section and balancing segment, guarantee that liquid stream is by the flow process designing each chromatographic column of flowing through successively, each strand of liquid stream enters or leaves system in designed position, to realize the continuous chromatography piece-rate system that meets technique needs.8～32 movings, the duct 6 that quiet palette center is circularly and evenly distributed vertically runs through moving, quiet palette, 6 two ends, duct are respectively equipped with symmetrical transmitting probe 71 and receiving transducer 72, two probes are positioned on same vertical line, utilize transmitting and receiving of PLC signal to control, after switching starts, rotation along with moving palette, originally depart from the position, duct of alignment, signal transmission is cut off, servomotor running, drive the rotation of pallet 9 and moving palette 1, quiet palette 2 keeps motionless, when turning to the next position alignment, on control signal connects, there is corresponding control action, make servomotor stall immediately, can complete handoff procedure one time.
The utility model is not limited to the aforesaid specific embodiment.The utility model expands to any new feature or any new combination disclosing in this manual, and the arbitrary new method disclosing or step or any new combination of process.
Claims (5)
1. the rotary-type continuous flow upstream chromatographic apparatus of single-deck, comprise moving palette (1) and a quiet palette (2), it is characterized in that, described moving palette (1) is the disc structure that shape is identical with quiet palette (2), moving palette (1) and quiet palette (2) overlap, by support (5), supported, support (5) is pivot structure, be vertically connected on moving, quiet palette is central, the bottom vertical of support (5) is connected to a round tray (9) central authorities, pallet (9) bottom is provided with base (10), between pallet (9) and base (10), be provided with drive mechanism (8), the top symmetry of the bottom of described moving palette (1) and pallet (9) and is respectively provided with 8～64 fixing lug boss that are circularly and evenly distributed (11), the surface of fixing lug boss (11) is groove structure, between moving palette (1) and pallet (9), be provided with chromatographic column (3), the two ends of chromatographic column (3) are connected in moving palette (1) and the corresponding fixing lug boss of pallet (9), quiet palette (2) top is respectively equipped with inlet opening (21) and the fluid hole (22) being circularly and evenly distributed, inlet opening (21) run through moving palette (1) and quiet palette (22) vertical with fluid hole (22), inlet opening (21) passes into chromatographic column (3) top, fluid hole (22) connects chromatographic column (3) bottom by flexible pipe (4), 8～64 movings, the duct (6) that quiet palette center is circularly and evenly distributed vertically runs through moving, quiet palette, two ends, duct (6) are respectively equipped with symmetrical transmitting probe (71) and receiving transducer (72).
2. the rotary-type continuous flow upstream chromatographic apparatus of single-deck according to claim 1, it is characterized in that, described drive mechanism (8) comprises interconnective servomotor, delivery pump, time controller and reductor, delivery pump connects chromatographic column (3), and the gear on the gear on reductor and pallet (9) is intermeshing.
3. the rotary-type continuous flow upstream chromatographic apparatus of single-deck according to claim 1, it is characterized in that, described support (5) top is projection cube structure, and projection cube structure is positioned at quiet palette (2) top, between projection cube structure and quiet palette (2), is provided with some springs (12).
4. the rotary-type continuous flow upstream chromatographic apparatus of single-deck according to claim 1, is characterized in that, the moving bottom of palette (1) and the top symmetry of pallet (9) and be respectively provided with 8～32 fixing lug boss that are circularly and evenly distributed (11).
5. the rotary-type continuous flow upstream chromatographic apparatus of single-deck according to claim 1, is characterized in that, described duct (6) number is 8～32.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320570534.9U CN203447819U (en) | 2013-09-13 | 2013-09-13 | Single-plate rotating type continuous countercurrent chromatographic device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320570534.9U CN203447819U (en) | 2013-09-13 | 2013-09-13 | Single-plate rotating type continuous countercurrent chromatographic device |
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| CN203447819U true CN203447819U (en) | 2014-02-26 |
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| CN201320570534.9U Expired - Fee Related CN203447819U (en) | 2013-09-13 | 2013-09-13 | Single-plate rotating type continuous countercurrent chromatographic device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815460A (en) * | 2015-05-26 | 2015-08-05 | 陕西工信环保科技发展有限公司 | Continuous type adsorption equipment |
| CN113262524A (en) * | 2021-07-19 | 2021-08-17 | 东营威联化学有限公司 | P-xylene adsorption type separation device |
-
2013
- 2013-09-13 CN CN201320570534.9U patent/CN203447819U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815460A (en) * | 2015-05-26 | 2015-08-05 | 陕西工信环保科技发展有限公司 | Continuous type adsorption equipment |
| CN113262524A (en) * | 2021-07-19 | 2021-08-17 | 东营威联化学有限公司 | P-xylene adsorption type separation device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NINGBO TUOPU BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: NINGBO KAER NEW MATERIAL SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20141010 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20141010 Address after: 315000 Zhejiang Province, Ningbo Jiangbei District Hongtang Changxin Road No. 158 building 7 room 316 Patentee after: Ningbo Tuopu Biotechnology Co., Ltd. Address before: 1656, room 1558, 315000 Jiangnan Road, hi tech Zone, Zhejiang, Ningbo Patentee before: Ningbo Ka Er new material Science and Technology Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140226 Termination date: 20160913 |