CN203425104U - Sub-retinal space stem cell transplantation device - Google Patents
Sub-retinal space stem cell transplantation device Download PDFInfo
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- CN203425104U CN203425104U CN201320476307.XU CN201320476307U CN203425104U CN 203425104 U CN203425104 U CN 203425104U CN 201320476307 U CN201320476307 U CN 201320476307U CN 203425104 U CN203425104 U CN 203425104U
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- stem cell
- cell transplantation
- transplantation device
- subretinal space
- space stem
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Abstract
The utility model relates to a sub-retinal space stem cell transplantation device, which aims to solve the technical problems of complexity in operation and large potential safety hazards of the traditional sub-retinal space stem cell transplantation device. The sub-retinal space stem cell transplantation device comprises a syringe needle, a sleeve, an injection power propulsion tube, a screw cap, a linear motor, a power supply, a control switch, a quantitative storage tube, a spacing fixation piece and the like, wherein the spacing fixation piece is internally provided with a guide hole, a primary pole of the linear motor is fixedly arranged in the injection power propulsion tube, one end of a secondary pole of the linear motor is fixedly connected with a pushing and pressing piece after penetrating through the guide hole of the spacing fixation piece, one end of the quantitative storage tube is correspondingly communicated with the syringe needle, the other end of the quantitative storage tube is provided with a piston, the piston corresponds to the pushing and pressing piece, and the control switch is arranged on the front section zone of the sleeve adjacent to the syringe needle. The transplantation device disclosed by the utility model has advantages of simplicity in operation, safety and reliability, the retinal perforation risk caused by the discordant operation of two people is overcome, the transplantation difficulty is obviously lowered, and the effect on transplanting sub-retinal space stem cells is improved.
Description
Technical field
This utility model belongs to area of medical devices, particularly relates to the subretinal space stem cell transplantation device of the use of performing the operation in clinical and experimental eye science.
Background technology
Current modal blinding oculopathy comprises cataract, keratopathy, glaucoma and retinal degenerative disease (comprising senile degeneration of macula, retinitis pigmentosa, the retinal degeneration that diabetic renal papillary necrosis and high myopia cause etc.).The cataract that wherein accounts for leading cause of blindness (60%) can be extractd artificial intraocular lenses's implant surgery and recover lost eyesight through day by day perfect modern day cataract; Glaucoma is mainly controlled by early prevention and later stage medicine or operation, and part meets patient's life quality.Retinal degenerative disease is the common cause (surpassing 50%) of developed country's blinding, and China is nearly 200,000 because of the blind patient of this type of disease every year, is the serious blinding oculopathy that there is no in the world effective treatment means at present.Therefore, for the diseases causing blindness that this class sickness rate of retinal degenerative disease is high, harm is heavy, find the great demand for the treatment of means ，Shi China economy, society and people ' s health.Research is found, in retinal degenerative disease generation evolution, is first that the degeneration of retinal pigment epithelium (RPE) and photoreceptor cell，photosensory cell is dead.Therefore, the replacement therapy of photoreceptor cell，photosensory cell and RPE is the critical cellular target of rebuilding retinal function.Research shows, the operability of stem cell replacement therapy and the easy observation of transplanting back vision function make the regenerative therapy of stem cell mediation become the clinical treatment strategy of serious blinding oculopathy.
At present, the conventional microsyringe of domestic and international ophthalmologic clinician and research worker carries out subretinal space stem cell transplantation, because microsyringe is grown (the long 30mm of common metal syringe needle, glass needle pipe range 85mm, the long 128mm of whole syringe), operator inserts injection needle after subretinal space, and hand syringes, needs assistant's pressing handle stem cell to be expelled to subretinal space.The common complication of application of this microsyringe has:
(1) operator is difficult to and assistant's cooperation, micro-have careless syringe needle very easily to wear out retina to enter vitreous chamber, wear out retinal vessel and cause retinal hemorrhage, when serious, cause hematophthalmia, cause subretinal space graft failure, the success rate of carrying out subretinal space stem cell transplantation with microsyringe is greatly about 40～50%.
(2) when microsyringe carries out subretinal space injection, can not control injection volume and the scope of cell, in injection site, form the koppie of transplanted cells, the accumulation of cell can cause unbalanced, the serious survival rate that affects subretinal space transplanted cells that nutrition, secretion, metabolism, the cell polarity of cell distribute.
(3) design due to glass microsyringe is that syringe needle and syringe are integrated, expensive, injection needle is very thin, conventional syringe needle external diameter is 0.184～0.36mm, internal diameter is 0.0826～0.184mm, the sterilization of syringe often adopts medicining liquid dipping method, and autoclave sterilization can cause the acutance of injection needle to decline.
(4) very thin due to syringe needle internal diameter, easy cleaning not after use, solution soaking easily causes that sterilization is not thorough, can cause the pollution of operation.
Summary of the invention
For existing problem in the above-mentioned prior art of better solution, this utility model provides a kind of simple to operate, safe and reliable subretinal space stem cell transplantation device.
In order to realize above-mentioned utility model object, this utility model by the following technical solutions:
Design a kind of subretinal space stem cell transplantation device, comprise syringe needle, sleeve pipe, injection power propulsion tube, spiral cover, described syringe needle, sleeve pipe, injection power propulsion tube, spiral cover is installed connection successively, this grafting device also comprises linear electric motors, drive the power supply of these linear electric motors, control the gauge tap of these linear electric motors start and stop, be installed in this sleeve pipe for pre-installing the quantitative storage pipe of stem cell, be installed on the positioning limiting fixator in described injection power propulsion tube, in described positioning limiting fixator, be provided with pilot hole, the elementary of described linear electric motors is mounted in described injection power propulsion tube, secondary one end of described linear electric motors is fixedly connected with thrust piece through after the pilot hole of described positioning limiting fixator, described quantitative storage pipe one end is communicated in described syringe needle accordingly, its other end is equipped with piston, and this piston is corresponding to described thrust piece, described gauge tap is arranged on the leading portion region of close syringe needle on described sleeve pipe.
Described storage pipe-in-pipe antimere is provided with long and narrow window, and quantitatively stores on the longitudinal axis of managing outer tube wall and be provided with scale at this.
Described gauge tap is apart from quantitatively storing pipe-in-pipe front end 10～20mm.
Described quantitatively storage pipe is made by medical glass;
The model of described syringe needle is any in 28G, 30G, 31G, 32G, 34G.
In described spiral cover, be provided with and butt up against the secondary spring of described linear electric motors.
Described gauge tap is contact witch, is respectively equipped with and advances, stops, retreating button.
Described spiral cover is provided with strip projection.
The power supply that drives described linear electric motors is the built-in power being arranged in described spiral cover, or is external power supply.
The utlity model has actively useful effect:
This utility model subretinal space stem cell transplantation device overcome two people operate inharmonious bring wear out amphiblestroid risk, created simple, easy to operate, to be difficult for pollution grafting device, obviously reduce transplanting difficulty, improved the effect that subretinal space is transplanted stem cell.
The syringe needle of the subretinal space stem cell transplantation device in this utility model and syringe can for split and syringe needle can be disposable, can overcome autoclave sterilization causes the acutance of injection needle to decline, and avoid very thin because of syringe needle internal diameter, easy cleaning not after use, solution soaking easily causes that sterilization is not thorough, thereby causes the problem of the pollution of operation.
3. the subretinal space stem cell transplantation device in this utility model, operator can oneself operate injection process, do not need to coordinate with assistant, having avoided micro-in engagement process has careless syringe needle very easily to wear out the situation generation that retina enters vitreous chamber, wear out retinal vessel and cause retinal hemorrhage, when serious, cause hematophthalmia, cause subretinal space graft failure, the success rate of carrying out subretinal space stem cell transplantation with microsyringe is greatly about 40～50%, subretinal space stem cell transplantation device of the present utility model has improved the success rate of subretinal space stem cell transplantation.
Accompanying drawing explanation
The axonometric chart of the subretinal space stem cell transplantation device in Fig. 1 this utility model;
The cutaway view of the subretinal space stem cell transplantation device in Fig. 2 this utility model.
In the drawings, 1 be syringe needle, 2 for quantitative storage pipe, 3 for sleeve pipe, 4 for piston, 5 for thrust piece, 6 for positioning limiting fixator, 7 for injection power propulsion tube, 8 for linear electric motor primary, 9 for linear electric motors are secondary, 10 for spiral cover, 11 for spring, 12 for gauge tap, 13 be pilot hole.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment, this utility model is described in further detail.
Embodiment 1: a kind of subretinal space stem cell transplantation device, referring to Fig. 1, Fig. 2, comprise syringe needle (30G) 1, built-in piston 4 has also been pre-installed the storage pipe 2 of quantitative stem cell, the sleeve pipe 3 of suit storage pipe, positioning limiting fixator 6, injection power propulsion tube 7, spiral cover 10, line inductance electromotor, the gauge tap 12 of line inductance electromotor, described syringe needle 1 is threaded with storage pipe-in-pipe 3, described quantitative stem cell storage pipe 2 and 3 clampings of storage pipe-in-pipe, described sleeve pipe 3 is connected with injection power propulsion tube 7 threaded one ends, described positioning limiting fixator 6 is fixedly mounted on injection power propulsion tube 7 inwalls, in described positioning limiting fixator 6, be provided with pilot hole 13, elementary 8 of described line inductance electromotor is fixed on injection power propulsion tube 7, secondary 9 one end of described line inductance electromotor are through the pilot hole 13 of positioning limiting fixator 6, and in its termination, thrust piece 5 is housed, described spiral cover 10 is threaded with injection power propulsion tube 7, described gauge tap 12 is arranged on sleeve pipe 3 leading portions.
Offer to described sleeve pipe 3 lateral symmetry long and narrow window, on the outer tube wall longitudinal axis of storage pipe-in-pipe 3, be provided with scale.Described gauge tap 12 is apart from sleeve pipe 3 front end 15mm, long 10mm, wide 4mm.
Described quantitative storage pipe 2 is made by medical glass; Described spiral cover 10 is placed in injection power propulsion tube 7 one end spring 11 is housed.Described spiral cover 10 is provided with for anti-skidding strip projection.
The using method of above-mentioned subretinal space stem cell transplantation device is as follows:
During use, the storage pipe clamp that quantitative stem cell is housed is contained in storage pipe-in-pipe, syringe needle is contained in storage pipe-in-pipe front end, during injection, point Push switch, piston advances forward with the quantitative stem cell storage of the secondary promotion of line inductance electromotor of piston pipe, the stem cell quantitatively storing in pipe is injected to subretinal space, when finishing using, by reset switch, make the secondary reset in linear electric motors.Because storage pipe-in-pipe is provided with scale, injector can be closed down linear electric motors and be controlled injection volume.In addition, quantitatively storage pipe also can be according to the difference of transplanting stem cell volume, and the stem cell that manufactures different volumes is carried memotron, the more quantitative storage pipe that will use according to the size selection of injection volume, can control like this degree of accuracy of injection volume.
Claims (10)
1. a subretinal space stem cell transplantation device, comprise the syringe needle connecting is installed successively, sleeve pipe, injection power propulsion tube, spiral cover, it is characterized in that: this grafting device also comprises linear electric motors, drive the power supply of these linear electric motors, control the gauge tap of these linear electric motors start and stop, be installed on this sleeve pipe for pre-installing the quantitative storage pipe of stem cell, be installed on the positioning limiting fixator in described injection power propulsion tube, described positioning limiting fixator is provided with pilot hole, the elementary of described linear electric motors is mounted in described injection power propulsion tube, secondary one end of described linear electric motors is through fixing thrust piece after the pilot hole of described positioning limiting fixator, described quantitative storage pipe one end is communicated in described syringe needle accordingly, its other end is equipped with piston, and this piston is corresponding to described thrust piece, described gauge tap is arranged on the leading portion region of close syringe needle on described sleeve pipe.
2. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described sleeve pipe lateral symmetry position is provided with long and narrow window, and the longitudinal axis of quantitatively storing pipe outer tube wall along this is provided with scale.
3. according to the subretinal space stem cell transplantation device of claim 1, it is characterized in that: described gauge tap is apart from quantitatively storing pipe-in-pipe front end 10～20mm.
4. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described quantitative storage pipe is made by medical glass.
5. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: the model of described syringe needle is 28G, 30G, 31G, 32G or 34G.
6. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: in described spiral cover, be provided with and butt up against the secondary spring of described linear electric motors.
7. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described spiral cover is provided with strip projection.
8. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described gauge tap is contact witch, be respectively equipped with and advance, stop, retreating button.
9. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: in described spiral cover, be provided with the built-in power that drives described linear electric motors.
10. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described power supply is external power supply.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320476307.XU CN203425104U (en) | 2013-08-06 | 2013-08-06 | Sub-retinal space stem cell transplantation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320476307.XU CN203425104U (en) | 2013-08-06 | 2013-08-06 | Sub-retinal space stem cell transplantation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203425104U true CN203425104U (en) | 2014-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320476307.XU Expired - Fee Related CN203425104U (en) | 2013-08-06 | 2013-08-06 | Sub-retinal space stem cell transplantation device |
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| Country | Link |
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| CN (1) | CN203425104U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405306A (en) * | 2013-08-06 | 2013-11-27 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
-
2013
- 2013-08-06 CN CN201320476307.XU patent/CN203425104U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405306A (en) * | 2013-08-06 | 2013-11-27 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
| WO2015018294A1 (en) * | 2013-08-06 | 2015-02-12 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
| CN103405306B (en) * | 2013-08-06 | 2015-11-18 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140212 Termination date: 20160806 |