CN103405306A - Subretinal space stem cell transplanter - Google Patents
Subretinal space stem cell transplanter Download PDFInfo
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- CN103405306A CN103405306A CN2013103386358A CN201310338635A CN103405306A CN 103405306 A CN103405306 A CN 103405306A CN 2013103386358 A CN2013103386358 A CN 2013103386358A CN 201310338635 A CN201310338635 A CN 201310338635A CN 103405306 A CN103405306 A CN 103405306A
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- China
- Prior art keywords
- stem cell
- subretinal space
- cell transplantation
- space stem
- transplantation device
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to a subretinal space stem cell transplanter which aims to solve the technical problem that an existing subretinal space stem cell transplanter is complex to operate and large in potential safety hazard. The subretinal space stem cell transplanter comprises a needle head, a sleeve tube, an injection power boosting tube, a rotary cover, a linear motor, a power source, a control switch, a quantitive storage tube, a limiting fixing part and the like. A guide hole is formed in the limiting fixing part. A primary pole of the linear motor is mounted and fixed in the injection power boosting tube, one end of a secondary pole of the linear motor penetrates the guide hole of the limiting fixing part and then is fixedly connected with a pushing and pressing part, one end of the quantitive storage tube is correspondingly communicated with the needle head, the other end of the quantitive storage tube is provided with a piston corresponding to the pushing and pressing part, and the control switch is mounted in the front-end area, close to the needle head, of the sleeve tube. The subretinal space stem cell transplanter is simple in structure, safe and reliable, the risk of retinas perforation due to uncooperative operation of two persons is avoided, transplanting difficulty is obviously lowered, and subretinal space stem cell transplanting effect is improved.
Description
Technical field
The invention belongs to area of medical devices, particularly relate to the subretinal space stem cell transplantation device of operation use in clinical and experimental eye science.
Background technology
Current modal blinding oculopathy comprises cataract, keratopathy, glaucoma and retinal degenerative disease (comprising senile degeneration of macula, retinitis pigmentosa, the retinal degeneration that diabetic renal papillary necrosis and high myopia cause etc.).The cataract that wherein accounts for leading cause of blindness (60%) can be extractd artificial intraocular lenses's implant surgery and recover lost eyesight through day by day perfect modern day cataract; Glaucoma is mainly controlled by early prevention and later stage medicine or operation, and part meets patient's life quality.Retinal degenerative disease is the common cause (surpassing 50%) of developed country's blinding, and the blind patient of the annual therefore class disease of China is nearly 200,000, is the serious blinding oculopathy that there is no in the world effective treatment means at present.Therefore, for the diseases causing blindness that this class sickness rate of retinal degenerative disease is high, harm is heavy finds treatment means, be the great demand of China's economy, society and people ' s health.Research is found, in the retinal degenerative disease carcinogenesis of human, is at first the degeneration death of retinal pigment epithelium (RPE) and photoreceptor cell，photosensory cell.Therefore, the replacement therapy of photoreceptor cell，photosensory cell and RPE is the critical cellular target of rebuilding retinal function.Research shows, the operability of stem cell replacement therapy and the easy observation of transplanting back vision function make the regenerative therapy of stem cell mediation become the clinical treatment strategy of serious blinding oculopathy.
At present, domestic and international ophthalmologic clinician and research worker microsyringe commonly used carries out the subretinal space stem cell transplantation, because microsyringe is grown (the long 30mm of common metal syringe needle, glass needle pipe range 85mm, the long 128mm of whole syringe), after operator inserted subretinal space to injection needle, hand syringes, needed assistant's pressing handle stem cell to be expelled to subretinal space.The common complication of the application of this microsyringe has:
(1) operator is difficult to and assistant's cooperation, micro-have careless syringe needle very easily to wear out retina to enter vitreous chamber, wear out retinal vessel and cause retinal hemorrhage, when serious, cause hematophthalmia, cause the subretinal space graft failure, carry out the success rate of subretinal space stem cell transplantation greatly about 40～50% with microsyringe.
When (2) microsyringe carries out the subretinal space injection, can not control injection volume and the scope of cell, in injection site, form the koppie of transplanted cells, the accumulation of cell can cause unbalanced, the serious survival rate that affects the subretinal space transplanted cells that nutrition, secretion, metabolism, the cell polarity of cell distribute.
(3) design due to the glass microsyringe is that syringe needle and syringe are integrated, expensive, injection needle is very thin, syringe needle external diameter commonly used is 0.184～0.36mm, internal diameter is 0.0826～0.184mm, the medicining liquid dipping method is often adopted in the sterilization of syringe, and autoclave sterilization can cause the acutance of injection needle to descend.
(4) very thin due to the syringe needle internal diameter, easy cleaning not after use, solution soaking causes that easily sterilization is not thorough, can cause the pollution of operation.
Summary of the invention
For existing problem in the above-mentioned prior art of better solution, the invention provides a kind of simple to operate, safe and reliable subretinal space stem cell transplantation device.
In order to realize the foregoing invention purpose, the present invention by the following technical solutions:
Design a kind of subretinal space stem cell transplantation device, comprise syringe needle, sleeve pipe, the injection power propulsion tube, spiral cover, described syringe needle, sleeve pipe, the injection power propulsion tube, spiral cover is installed connection successively, this grafting device also comprises linear electric motors, drive the power supply of these linear electric motors, control the gauge tap of these linear electric motors start and stop, be installed in this sleeve pipe be used to pre-installing the quantitative storage pipe of stem cell, be installed on the positioning limiting fixator in described injection power propulsion tube, in described positioning limiting fixator, be provided with pilot hole, the elementary of described linear electric motors is mounted in described injection power propulsion tube, a secondary end of described linear electric motors is fixedly connected with thrust piece after passing the pilot hole of described positioning limiting fixator, described quantitative storage Guan Yiduan is communicated in described syringe needle accordingly, its other end is equipped with piston, and this piston is corresponding to described thrust piece, described gauge tap is arranged on the leading portion zone of close syringe needle on described sleeve pipe.
Described storage pipe-in-pipe antimere is provided with long and narrow window, and quantitatively stores on the longitudinal axis of managing outer tube wall and be provided with scale at this.
Described gauge tap is apart from quantitatively storing pipe-in-pipe front end 10～20mm.
Described quantitatively storage pipe is made by medical glass;
The model of described syringe needle is any in 28G, 30G, 31G, 32G, 34G.
In described spiral cover, be provided with and butt up against the secondary spring of described linear electric motors.
Described gauge tap is contact witch, is respectively equipped with and advances, stops, retreating button.
Described spiral cover is provided with the strip projection.
The power supply that drives described linear electric motors is the built-in power be arranged in described spiral cover, or is external power supply.
The present invention has actively useful effect:
Subretinal space stem cell transplantation device of the present invention overcome two people operate inharmonious bring wear out amphiblestroid risk, created simple, easy to operate, as to be difficult for pollution grafting device, obviously reduce the transplanting difficulty, improved the effect that subretinal space is transplanted stem cell.
The syringe needle of the subretinal space stem cell transplantation device in the present invention and syringe can for split and syringe needle can be disposable, can overcome autoclave sterilization causes the acutance of injection needle to descend, and avoid very thin because of the syringe needle internal diameter, easy cleaning not after use, solution soaking causes that easily sterilization is not thorough, thereby causes the problem of the pollution of operation.
3. the subretinal space stem cell transplantation device in the present invention, operator can oneself operate injection process, do not need to coordinate with the assistant, having avoided micro-in the engagement process has careless syringe needle very easily to wear out the situation generation that retina enters vitreous chamber, wear out retinal vessel and cause retinal hemorrhage, when serious, cause hematophthalmia, cause the subretinal space graft failure, the success rate of carrying out the subretinal space stem cell transplantation with microsyringe is greatly about 40～50%, and subretinal space stem cell transplantation device of the present invention has improved the success rate of subretinal space stem cell transplantation.
The accompanying drawing explanation
The axonometric chart of the subretinal space stem cell transplantation device in Fig. 1 the present invention;
The cutaway view of the subretinal space stem cell transplantation device in Fig. 2 the present invention.
In the drawings, 1 be syringe needle, 2 for quantitative storage pipe, 3 for sleeve pipe, 4 for piston, 5 for thrust piece, 6 for positioning limiting fixator, 7 for injection power propulsion tube, 8 for linear electric motor primary, 9 for linear electric motors are secondary, 10 be pilot hole for gauge tap, 13 for spring, 12 for spiral cover, 11.
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing and specific embodiment.
Embodiment 1: a kind of subretinal space stem cell transplantation device, referring to Fig. 1, Fig. 2, comprise syringe needle (30G) 1, built-in piston 4 has also been pre-installed the storage pipe 2 of quantitative stem cell, the sleeve pipe 3 of suit storage pipe, positioning limiting fixator 6, injection power propulsion tube 7, spiral cover 10, line inductance electromotor, the gauge tap 12 of line inductance electromotor, described syringe needle 1 is threaded with storage pipe-in-pipe 3, described quantitative stem cell storage pipe 2 and 3 clampings of storage pipe-in-pipe, described sleeve pipe 3 is connected with injection power propulsion tube 7 threaded one ends, described positioning limiting fixator 6 is fixedly mounted on injection power propulsion tube 7 inwalls, in described positioning limiting fixator 6, be provided with pilot hole 13, elementary 8 of described line inductance electromotor is fixed on injection power propulsion tube 7, secondary 9 one ends of described line inductance electromotor pass the pilot hole 13 of positioning limiting fixator 6, and in its termination, thrust piece 5 is housed, described spiral cover 10 is threaded with injection power propulsion tube 7, described gauge tap 12 is arranged on sleeve pipe 3 leading portions.
Offer to described sleeve pipe 3 lateral symmetry long and narrow window, be provided with scale on the outer tube wall longitudinal axis of storage pipe-in-pipe 3.Described gauge tap 12 is apart from sleeve pipe 3 front end 15mm, long 10mm, wide 4mm.
Described quantitative storage pipe 2 is made by medical glass; Described spiral cover 10 is placed in injection power propulsion tube 7 one ends spring 11 is housed.Described spiral cover 10 is provided with for anti-skidding strip projection.
The using method of above-mentioned subretinal space stem cell transplantation device is as follows:
During use, the storage pipe clamp that quantitative stem cell is housed is contained in the storage pipe-in-pipe, syringe needle is contained in storage pipe-in-pipe front end, finger Push switch during injection, piston advances forward with the quantitative stem cell storage of the secondary promotion of the line inductance electromotor of piston pipe, the stem cell quantitatively stored in pipe is injected to subretinal space, by reset switch, make secondary the resetting in linear electric motors when finishing using.Because the storage pipe-in-pipe is provided with scale, the injector can be closed down linear electric motors and be controlled injection volume.In addition, quantitatively the storage pipe also can be according to the difference of transplanting the stem cell volume, and the stem cell that manufactures different volumes is carried memotron, then selects the quantitative storage pipe that will use according to the size of injection volume, can control like this degree of accuracy of injection volume.
Claims (10)
1. subretinal space stem cell transplantation device, comprise the syringe needle connected is installed successively, sleeve pipe, the injection power propulsion tube, spiral cover, it is characterized in that: this grafting device also comprises linear electric motors, drive the power supply of these linear electric motors, control the gauge tap of these linear electric motors start and stop, be installed on this sleeve pipe be used to pre-installing the quantitative storage pipe of stem cell, be installed on the positioning limiting fixator in described injection power propulsion tube, described positioning limiting fixator is provided with pilot hole, the elementary of described linear electric motors is mounted in described injection power propulsion tube, a secondary end of described linear electric motors passes after the pilot hole of described positioning limiting fixator fixedly thrust piece, described quantitative storage Guan Yiduan is communicated in described syringe needle accordingly, its other end is equipped with piston, and this piston is corresponding to described thrust piece, described gauge tap is arranged on the leading portion zone of close syringe needle on described sleeve pipe.
2. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described sleeve pipe lateral symmetry position is provided with long and narrow window, and is provided with scale along the longitudinal axis that should quantitatively store the pipe outer tube wall.
3. according to the subretinal space stem cell transplantation device of claim 1, it is characterized in that: described gauge tap is apart from quantitatively storing pipe-in-pipe front end 10～20mm.
4. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described quantitative storage pipe is made by medical glass.
5. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: the model of described syringe needle is 28G, 30G, 31G, 32G or 34G.
6. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: in described spiral cover, be provided with and butt up against the secondary spring of described linear electric motors.
7. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described spiral cover is provided with the strip projection.
8. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described gauge tap is contact witch, is respectively equipped with and advances, stops, retreating button.
9. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: in described spiral cover, be provided with the built-in power that drives described linear electric motors.
10. according to the subretinal space stem cell transplantation device in claim 1, it is characterized in that: described power supply is external power supply.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310338635.8A CN103405306B (en) | 2013-08-06 | 2013-08-06 | Subretinal space stem cell transplanter |
| PCT/CN2014/083389 WO2015018294A1 (en) | 2013-08-06 | 2014-07-31 | Subretinal space stem cell transplanter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310338635.8A CN103405306B (en) | 2013-08-06 | 2013-08-06 | Subretinal space stem cell transplanter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103405306A true CN103405306A (en) | 2013-11-27 |
| CN103405306B CN103405306B (en) | 2015-11-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310338635.8A Active CN103405306B (en) | 2013-08-06 | 2013-08-06 | Subretinal space stem cell transplanter |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103405306B (en) |
| WO (1) | WO2015018294A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015018294A1 (en) * | 2013-08-06 | 2015-02-12 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023546412A (en) * | 2020-10-15 | 2023-11-02 | アルコン インコーポレイティド | wireless injector |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862489A (en) * | 2010-06-13 | 2010-10-20 | 江苏华阳电器有限公司 | Medicament injector and control method thereof |
| CN201668723U (en) * | 2010-06-07 | 2010-12-15 | 陈仕勇 | Medical liquid distributor |
| US20130006218A1 (en) * | 2009-09-26 | 2013-01-03 | Anteis Sa | Assisted Injection Device |
| EP2623146A1 (en) * | 2012-01-31 | 2013-08-07 | TrichoScience Innovations Inc. | Injection devices |
| CN203425104U (en) * | 2013-08-06 | 2014-02-12 | 中国人民解放军总医院 | Sub-retinal space stem cell transplantation device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003180828A (en) * | 2001-12-21 | 2003-07-02 | Matsushita Electric Ind Co Ltd | Electric fluid discharging apparatus |
| CN201481927U (en) * | 2009-08-17 | 2010-05-26 | 北京航空航天大学 | Piezoelectrically-driven portable insulin injection pump |
| CN101628138A (en) * | 2009-08-17 | 2010-01-20 | 北京航空航天大学 | Piezoelectric-driven portable insulin infusion pump |
| CN102614565B (en) * | 2012-04-01 | 2013-12-25 | 上海大学 | Automatic micro-injection device |
| CN103405306B (en) * | 2013-08-06 | 2015-11-18 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
-
2013
- 2013-08-06 CN CN201310338635.8A patent/CN103405306B/en active Active
-
2014
- 2014-07-31 WO PCT/CN2014/083389 patent/WO2015018294A1/en active Application Filing
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130006218A1 (en) * | 2009-09-26 | 2013-01-03 | Anteis Sa | Assisted Injection Device |
| CN201668723U (en) * | 2010-06-07 | 2010-12-15 | 陈仕勇 | Medical liquid distributor |
| CN101862489A (en) * | 2010-06-13 | 2010-10-20 | 江苏华阳电器有限公司 | Medicament injector and control method thereof |
| EP2623146A1 (en) * | 2012-01-31 | 2013-08-07 | TrichoScience Innovations Inc. | Injection devices |
| CN203425104U (en) * | 2013-08-06 | 2014-02-12 | 中国人民解放军总医院 | Sub-retinal space stem cell transplantation device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015018294A1 (en) * | 2013-08-06 | 2015-02-12 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103405306B (en) | 2015-11-18 |
| WO2015018294A1 (en) | 2015-02-12 |
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