CN103405306B - Subretinal space stem cell transplanter - Google Patents
Subretinal space stem cell transplanter Download PDFInfo
- Publication number
- CN103405306B CN103405306B CN201310338635.8A CN201310338635A CN103405306B CN 103405306 B CN103405306 B CN 103405306B CN 201310338635 A CN201310338635 A CN 201310338635A CN 103405306 B CN103405306 B CN 103405306B
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- China
- Prior art keywords
- stem cell
- subretinal space
- syringe needle
- pipe
- electric motors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to a kind of Subretinal space stem cell transplanter.Be intended to solve existing Subretinal space stem cell transplanter complicated operation, technical problem that potential safety hazard is large.It is by syringe needle, sleeve pipe, injection power propulsion tube, spiral cover, described syringe needle, sleeve pipe, injection power propulsion tube, spiral cover, linear electric motors, power supply, gauge tap, quantitative storage pipe, the formations such as positioning limiting fixator, pilot hole is provided with in positioning limiting fixator, the elementary of linear electric motors is mounted in injection power propulsion tube, its secondary one end is fixedly connected with thrust piece through after the pilot hole of positioning limiting fixator, quantitative storage pipe one end is communicated in syringe needle accordingly, its other end is equipped with piston, and this piston corresponds to thrust piece, gauge tap is arranged on the leading portion region near syringe needle on described sleeve pipe.Grafting device of the present invention is simple to operate, safe and reliable, overcome two people operate inharmonious bring wear out amphiblestroid risk, significantly reduce transplanting difficulty, improve subretinal space and transplant the effect of stem cell.
Description
Technical field
The invention belongs to area of medical devices, particularly relate to the Subretinal space stem cell transplanter of performing the operation in clinical and experimental eye science.
Background technology
Current modal blinding oculopathy comprises cataract, keratopathy, glaucoma and retinal degenerative disease (comprising senile degeneration of macula, retinitis pigmentosa, the retinal degeneration etc. that diabetic renal papillary necrosis and high myopia cause).The cataract wherein accounting for leading cause of blindness (60%) can be extractd Intraocular implantation operation through day by day perfect modern day cataract and recover lost eyesight; Glaucoma is controlled mainly through early prevention and later stage medicine or operation, and part meets the life quality of patient.Retinal degenerative disease is the most common cause (more than 50%) of developed country's blinding, and China, every year because of the patient nearly 200,000 that this type of disease is blind, is the serious blinding oculopathy that there is no effective treatment means at present in the world.Therefore, for this kind of sickness rate of retinal degenerative disease is high, the heavy diseases causing blindness of harm finds treatment means, is the great demand of China's economy, society and people ' s health.Research finds, in retinal degenerative disease generation evolution, is first that the degeneration of retinal pigment epithelium (RPE) and photoreceptor cell，photosensory cell is dead.Therefore, the replacement therapy of photoreceptor cell，photosensory cell and RPE is the critical cellular target rebuilding retinal function.Research shows, the regenerative therapy that the operability of stem cell replacement therapy and the easy observation of transplanting back vision function make stem cell mediate is becoming the clinical management strategy of serious blinding oculopathy.
At present, domestic and international ophthalmologic clinician and research worker are commonly used microsyringe and are carried out subretinal space stem cell transplantation, due to longer (the long 30mm of common metal syringe needle of microsyringe, glass needle pipe range 85mm, the long 128mm of whole syringe), after operator inserts subretinal space injection needle, hand syringes, needs assistant's pressing handle stem cell injection to subretinal space.The complication that the application of this microsyringe is common has:
(1) operator is difficult to and assistant's cooperation, micro-have careless syringe needle very easily to wear out retina to enter vitreous chamber, wear out retinal vessel and cause retinal hemorrhage, hematophthalmia is caused time serious, cause subretinal space graft failure, carry out the success rate of subretinal space stem cell transplantation greatly about 40 ~ 50% with microsyringe.
(2) when microsyringe carries out subretinal space injection, injection volume and the scope of cell can not be controlled, the koppie of transplanted cells is formed in injection site, the accumulation of cell can cause the nutrition of cell, secretion, metabolism, cell polarity distribution unbalanced, the serious survival rate affecting subretinal space transplanted cells.
(3) because the design of glass microsyringe is that syringe needle and syringe are integrated, expensive, injection needle is very thin, conventional syringe needle external diameter is 0.184 ~ 0.36mm, internal diameter is 0.0826 ~ 0.184mm, the sterilization of syringe often adopts medicining liquid dipping method, and autoclave sterilization can cause the acutance of injection needle to decline.
(4) very thin due to syringe needle internal diameter, not easy cleaning after using, solution soaking easily causes sterilization thorough, can cause the pollution of operation.
Summary of the invention
In order to better solve problem existing in above-mentioned prior art, the invention provides a kind of simple to operate, safe and reliable Subretinal space stem cell transplanter.
In order to realize foregoing invention object, the present invention by the following technical solutions:
Design a kind of Subretinal space stem cell transplanter, comprise syringe needle, sleeve pipe, injection power propulsion tube, spiral cover, described syringe needle, sleeve pipe, injection power propulsion tube, spiral cover installs connection successively, this grafting device also comprises linear electric motors, drive the power supply of these linear electric motors, control the gauge tap of these linear electric motors start and stop, be installed in this sleeve pipe for pre-installing the quantitative storage pipe of stem cell, be installed on the positioning limiting fixator in described injection power propulsion tube, pilot hole is provided with in described positioning limiting fixator, the elementary of described linear electric motors is mounted in described injection power propulsion tube, secondary one end of described linear electric motors is fixedly connected with thrust piece through after the pilot hole of described positioning limiting fixator, described quantitative storage pipe one end is communicated in described syringe needle accordingly, its other end is equipped with piston, and this piston corresponds to described thrust piece, described gauge tap is arranged on the leading portion region near syringe needle on described sleeve pipe.
Described storage pipe-in-pipe antimere is provided with long and narrow window, and is provided with scale on the longitudinal axis that this quantitatively stores pipe outer tube wall.
Described gauge tap is apart from quantitatively storing pipe-in-pipe front end 10 ~ 20mm.
Described quantitatively storage pipe is made up of medical glass;
The model of described syringe needle is any one in 28G, 30G, 31G, 32G, 34G.
Be provided with in described spiral cover and butt up against the secondary spring of described linear electric motors.
Described gauge tap is contact witch, is respectively equipped with advance, stopping, Reverse keys.
Described spiral cover is provided with strip projection.
Drive the power supply of described linear electric motors to be arranged at the built-in power in described spiral cover, or be external power supply.
The present invention has actively useful effect:
1. Subretinal space stem cell transplanter of the present invention overcome two people operate inharmonious bring wear out amphiblestroid risk, create grafting device that is simple, easy to operate, that not easily pollute, significantly reduce transplanting difficulty, improve the effect that subretinal space transplants stem cell.
2. the syringe needle of the Subretinal space stem cell transplanter in the present invention and syringe can for split and syringe needle can be disposable, can overcome autoclave sterilization causes the acutance of injection needle to decline, and that avoids because of syringe needle internal diameter is very thin, not easy cleaning after using, solution soaking easily causes sterilization not thorough, thus causes the problem of the pollution of operation.
3. the Subretinal space stem cell transplanter in the present invention, operator oneself can operate injection process, do not need to coordinate with assistant, avoid in engagement process micro-have careless syringe needle very easily wear out retina enter vitreous chamber situation occur, wear out retinal vessel and cause retinal hemorrhage, hematophthalmia is caused time serious, cause subretinal space graft failure, carry out the success rate of subretinal space stem cell transplantation greatly about 40 ~ 50% with microsyringe, Subretinal space stem cell transplanter of the present invention improves the success rate of subretinal space stem cell transplantation.
Accompanying drawing explanation
The axonometric chart of the Subretinal space stem cell transplanter in Fig. 1 the present invention;
The sectional view of the Subretinal space stem cell transplanter in Fig. 2 the present invention.
In the drawings, 1 be syringe needle, 2 be sleeve pipe for quantitatively storing pipe, 3,4 be piston, 5 be thrust piece, 6 be positioning limiting fixator, 7 be injection power propulsion tube, 8 be linear electric motor primary, 9 for linear electric motors are secondary, 10 be spiral cover, 11 be spring, 12 be gauge tap, 13 be pilot hole.
Detailed description of the invention
Below in conjunction with accompanying drawing and specific embodiment, the present invention is described in further detail.
Embodiment 1: a kind of Subretinal space stem cell transplanter, see Fig. 1, Fig. 2, comprise syringe needle (30G) 1, built-in piston 4 has also pre-installed the storage pipe 2 of quantitative stem cell, the sleeve pipe 3 of suit storage pipe, positioning limiting fixator 6, injection power propulsion tube 7, spiral cover 10, line inductance electromotor, the gauge tap 12 of line inductance electromotor, described syringe needle 1 is threaded with storage pipe-in-pipe 3, described quantitative stem cell storage pipe 2 and the clamping of storage pipe-in-pipe 3, described sleeve pipe 3 is connected with injection power propulsion tube 7 threaded one end, described positioning limiting fixator 6 is fixedly mounted on injection power propulsion tube 7 inwall, pilot hole 13 is provided with in described positioning limiting fixator 6, elementary 8 of described line inductance electromotor is fixed on injection power propulsion tube 7, the pilot hole 13 of positioning limiting fixator 6 is passed in secondary 9 one end of described line inductance electromotor, and in its termination, thrust piece 5 is housed, described spiral cover 10 is threaded with injection power propulsion tube 7, described gauge tap 12 is arranged on sleeve pipe 3 leading portion.
Offer long and narrow window to described sleeve pipe 3 lateral symmetry, the outer tube wall longitudinal axis of storage pipe-in-pipe 3 is provided with scale.Described gauge tap 12 is apart from sleeve pipe 3 front end 15mm, long 10mm, wide 4mm.
Described quantitative storage pipe 2 is made up of medical glass; Described spiral cover 10 is placed in injection power propulsion tube 7 one end and spring 11 is housed.Described spiral cover 10 is provided with for anti-skidding strip projection.
The using method of above-mentioned Subretinal space stem cell transplanter is as follows:
During use, the storage pipe clamp that quantitative stem cell is housed is contained in storage pipe-in-pipe, syringe needle is contained in storage pipe-in-pipe front end, Push switch is pointed during injection, the piston advances forward of the secondary promotion of the line inductance electromotor with piston quantitative stem cell storage pipe, stem cell in quantitative storage pipe being injected subretinal space, to make the secondary reset in linear electric motors when finishing using by reset switch.Because storage pipe-in-pipe is provided with scale, injector can close down linear electric motors to control injection volume.In addition, quantitatively storage pipe also can according to the difference of transplanting stem cell volume, and the stem cell manufacturing different volumes carries memotron, then according to the quantitative storage pipe that the size selection of injection volume will use, can control the degree of accuracy of injection volume like this.
Claims (9)
1. a Subretinal space stem cell transplanter, comprise the syringe needle installing connection successively, sleeve pipe, injection power propulsion tube, spiral cover, it is characterized in that: this grafting device also comprises linear electric motors, drive the power supply of these linear electric motors, control the gauge tap of these linear electric motors start and stop, be installed on the quantitative storage pipe for pre-installing stem cell of this sleeve pipe, be installed on the positioning limiting fixator in described injection power propulsion tube, described positioning limiting fixator is provided with pilot hole, the elementary of described linear electric motors is mounted in described injection power propulsion tube, thrust piece is fixed through after the pilot hole of described positioning limiting fixator in secondary one end of described linear electric motors, described quantitative storage pipe one end is communicated in described syringe needle accordingly, its other end is equipped with piston, and this piston corresponds to described thrust piece
,described gauge tap is arranged on the leading portion region near syringe needle on described sleeve pipe, and described sleeve pipe lateral symmetry position is provided with long and narrow window, and is provided with scale along this longitudinal axis quantitatively storing pipe outer tube wall, and described syringe needle 1 is threaded with storage pipe-in-pipe 3.
2. Subretinal space stem cell transplanter according to claim 1, is characterized in that: described gauge tap is apart from quantitatively storing pipe-in-pipe front end 10 ~ 20mm.
3. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: described quantitative storage pipe is made up of medical glass.
4. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: the model of described syringe needle is 28G, 30G, 31G, 32G or 34G.
5. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: be provided with in described spiral cover and butt up against the secondary spring of described linear electric motors.
6. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: described spiral cover is provided with strip projection.
7. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: described gauge tap is contact witch, be respectively equipped with advance, stopping, Reverse keys.
8. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: in described spiral cover, be provided with the built-in power driving described linear electric motors.
9. according to the Subretinal space stem cell transplanter in claim 1, it is characterized in that: described power supply is external power supply.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310338635.8A CN103405306B (en) | 2013-08-06 | 2013-08-06 | Subretinal space stem cell transplanter |
| PCT/CN2014/083389 WO2015018294A1 (en) | 2013-08-06 | 2014-07-31 | Subretinal space stem cell transplanter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310338635.8A CN103405306B (en) | 2013-08-06 | 2013-08-06 | Subretinal space stem cell transplanter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103405306A CN103405306A (en) | 2013-11-27 |
| CN103405306B true CN103405306B (en) | 2015-11-18 |
Family
ID=49598384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310338635.8A Active CN103405306B (en) | 2013-08-06 | 2013-08-06 | Subretinal space stem cell transplanter |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103405306B (en) |
| WO (1) | WO2015018294A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103405306B (en) * | 2013-08-06 | 2015-11-18 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
| US20220117781A1 (en) * | 2020-10-15 | 2022-04-21 | Alcon Inc. | Wireless injector |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862489A (en) * | 2010-06-13 | 2010-10-20 | 江苏华阳电器有限公司 | Medicament injector and control method thereof |
| CN201668723U (en) * | 2010-06-07 | 2010-12-15 | 陈仕勇 | Medical liquid distributor |
| EP2623146A1 (en) * | 2012-01-31 | 2013-08-07 | TrichoScience Innovations Inc. | Injection devices |
| CN203425104U (en) * | 2013-08-06 | 2014-02-12 | 中国人民解放军总医院 | Sub-retinal space stem cell transplantation device |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003180828A (en) * | 2001-12-21 | 2003-07-02 | Matsushita Electric Ind Co Ltd | Electric fluid discharging apparatus |
| CN101628138A (en) * | 2009-08-17 | 2010-01-20 | 北京航空航天大学 | Piezoelectric-driven portable insulin infusion pump |
| CN201481927U (en) * | 2009-08-17 | 2010-05-26 | 北京航空航天大学 | Piezoelectrically-driven portable insulin injection pump |
| WO2011036285A2 (en) * | 2009-09-26 | 2011-03-31 | Anteis Sa | Assisted injection device |
| CN102614565B (en) * | 2012-04-01 | 2013-12-25 | 上海大学 | Automatic micro-injection device |
| CN103405306B (en) * | 2013-08-06 | 2015-11-18 | 中国人民解放军总医院 | Subretinal space stem cell transplanter |
-
2013
- 2013-08-06 CN CN201310338635.8A patent/CN103405306B/en active Active
-
2014
- 2014-07-31 WO PCT/CN2014/083389 patent/WO2015018294A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201668723U (en) * | 2010-06-07 | 2010-12-15 | 陈仕勇 | Medical liquid distributor |
| CN101862489A (en) * | 2010-06-13 | 2010-10-20 | 江苏华阳电器有限公司 | Medicament injector and control method thereof |
| EP2623146A1 (en) * | 2012-01-31 | 2013-08-07 | TrichoScience Innovations Inc. | Injection devices |
| CN203425104U (en) * | 2013-08-06 | 2014-02-12 | 中国人民解放军总医院 | Sub-retinal space stem cell transplantation device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103405306A (en) | 2013-11-27 |
| WO2015018294A1 (en) | 2015-02-12 |
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