CN205251823U - Infusion device is implanted to eye in artificial retina cytoskeleton - Google Patents
Infusion device is implanted to eye in artificial retina cytoskeleton Download PDFInfo
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- CN205251823U CN205251823U CN201520920503.0U CN201520920503U CN205251823U CN 205251823 U CN205251823 U CN 205251823U CN 201520920503 U CN201520920503 U CN 201520920503U CN 205251823 U CN205251823 U CN 205251823U
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- implanted
- bar
- eye
- cytoskeleton
- artificial retina
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Abstract
The utility model discloses an infusion device is implanted to eye in artificial retina cytoskeleton. Utilize the utility model discloses eye in can implanting the artificial retina cytoskeleton, the eye can reduce retinulae support implantation incision in interior of this artificial retina cytoskeleton was implanted, alleviateed eye disease patient's misery. And the purpose of the utility model is to provide a success rate is implanted to the eye in still lying in improving the retina cytoskeleton, reduces the damage of doctor source nature.
Description
Technical field:
The utility model belongs to medical instruments field, is specifically related to eye in a kind of artificial retina cytoskeleton and implants injector.
Background technology:
Retina cell's wound repair is that common problem in science occurs, develops and lapses to cellularity impaired vision. In recent years along with dryDeveloping rapidly of cell research, induced multi-potent stem cells (inducedpluripotentstemcells, iPSCs) is cellula visualis damageRepair with treatment and brought new hope. Due to iPSCs self-replacation and many differentiation potentials, as repairing retina cellular damageDonor not only can meet required cell concentration while transplanting, and iPSCs can be induced to differentiate into various under certain conditionRetina cell system. Therefore, utilize humanized iPSCs transplantation treatment retina cell damage disease to there is important theory significanceWith good clinical treatment prospect. At present, iPSCs replacement therapy is mainly by following two approach: 1. stem cell transplantation enters viewHypostegal cavity/vitreous chamber; 2. stem cell in vitro is divided into retina specific cells and is implanted into subretinal space/vitreous chamber. Research is sent outNow iPSCs cell is grafted directly to after impaired retinal tissue, more than 90% cell cannot replacement therapy damaged cell;And retinulae and host's retina conformability of application iPSCs induction differentiation are poor. Therefore, how people iPSCs source property is lookedRetinulae in vitro culture, and it is transplanted preferably and is integrated into impaired nethike embrane, be current stem-cell therapy, medical tissue engineeringLearn and the common focus of paying close attention in ophthalmology field.
Inventor is successfully planted in degradable poly PLGA by people iPSCs source property retina seed cell early stage(PLGA) on support, and be all kinds of retina cells by its Induction of committed differentiation, built degradable artificial retina cell and propped upFrame, its institutional framework is circular PLGA biomaterial and the retina cell of adherent support growth.
For eye in artificial retina cytoskeleton is implanted, need to use retina cell's support implanting device of particular design, shouldThe cell that implanting device needs protection on support is not impaired in migration process, patient Wicresoft is implanted to reduce iatrogenic injury simultaneously.By the artificial retina cytoskeleton implanting device of this particular design, can be by artificial retina cytoskeleton by the micro-incision of 2mmBe implanted in human eye, effectively reduce operative incision and easy to use, ensured the success rate of support intraocular transplantation.
Summary of the invention:
The purpose of this utility model is to provide one and reduces artificial retina cytoskeleton implantation otch, alleviates persons suffering from ocular disorders misery,Improve eye in artificial retina cytoskeleton and be implanted to power, reduce the interior eye of artificial retina cytoskeleton of iatrogenic injury and implantInjector.
Eye is implanted injector in artificial retina cytoskeleton of the present utility model, it is characterized in that, comprise hollow tubular sleeve,Vitreous cavity head, spring, the support be made up of flexible material are implanted bar, contiguous block and inject bar, before and after described sleeve comprisesWhat be flexibly connected injects head and bolus tube, is provided with annular stop piece at the middle part of the hollow tube of bolus tube, and establish at annular stop piece middle partHave for support and implant the hole passed of bar, on the right-hand member inwall of bolus tube, be provided with fixture block, described bar, contiguous block, the support of injectingImplant bar and Vitreous cavity head and be sequentially fixedly linked, described contiguous block middle part has groove, implants bar side at groove near supportEdge be provided with the draw-in groove corresponding with fixture block, draw-in groove is connected with maintenance slide plate near the edge of injecting bar side, this maintenance slide plate anotherOne end is provided with banking stop, and described contiguous block, support implantation bar and Vitreous cavity head is positioned at the hollow tube of sleeve, described bulletSpring is placed on support and implants on bar, and its one end props up contiguous block and is connected piece and stops and fix, and one end props up annular stop piece in additionAnd stopped and fix by annular stop piece, the periphery ancient piece of jade, round, flat and with a hole in its centre shape size of described contiguous block and the interior hollow pipe shape phase of bolus tube right-hand memberAdapt to, corresponding the propping up of fixture block on the right-hand member inwall of the draw-in groove on contiguous block and maintenance slide plate and bolus tube, described intraocular is plantedThe front end that enters head is provided with can place the cytoskeletal placement groove of artificial retina.
Preferably, the described Vitreous cavity head of being made up of flexible material is the Vitreous cavity head of being made up of silica gel.
On described bolus tube right-hand member outer wall, be preferably also provided with the relative a pair of handle in upper and lower both sides.
The described head of injecting is preferably connected by cutting ferrule with bolus tube, injects head and snaps in the hollow pipeline of bolus tube.
In artificial retina cytoskeleton of the present utility model, eye implantation injector is to use like this: take off and inject head, and will be artificialRetina cell's support is put in that in the placement groove of front end of Vitreous cavity head, (the Vitreous cavity head of flexible material can make contact eyeWhen eyeball, be flexible, not damaged), then set up and inject head, move to eyes front and (in this process, inject head and can protectProtect artificial retina cell's support, avoid impaired in migration process, patient Wicresoft is implanted to reduce iatrogenic injury simultaneously),Hold handle, inject bar, Compress Spring, fixture block skids off and enters maintenance slide plate from draw-in groove, and Vitreous cavity head is stretched from injecting headGo out, continue to inject bar, make fixture block prop up the banking stop on maintenance slide plate, Vitreous cavity head has just reached assigned address, soAfter by the artificial retina cytoskeleton of the placement groove of the front end of Vitreous cavity head the micro-incision by 2mm implant in eye, like thisJust can effectively reduce operative incision and easy to use, ensure the success rate of support intraocular transplantation. Fixture block, draw-in groove and maintenanceSlide plate can limit the displacement of Vitreous cavity head, has limit and pushes away effect, thereby can be good at artificial retina cell to prop upFrame is implanted interior eye. After implantation, unclamp and inject bar, under the effect of spring, Vitreous cavity head, support are implanted bar, connectionPiece and inject bar and shrink back, until fixture block snaps in draw-in groove.
Utilize the utility model artificial retina cytoskeleton can be implanted to interior eye, in this artificial retina cytoskeleton, eye is implantedInterior eye can reduce retinulae support and implant otch, alleviates persons suffering from ocular disorders misery. And the purpose of this utility model is also to improveIn retina cell's support, eye is implanted to power, reduces iatrogenic injury.
Brief description of the drawings:
Fig. 1 is the three-dimensional outline drawing that in artificial retina cytoskeleton of the present utility model, eye is implanted injector;
Fig. 2 is three-dimensional external structure and the internal structure decomposition that in artificial retina cytoskeleton of the present utility model, eye is implanted injectorFigure;
Fig. 3 is the sectional exploded view that in artificial retina cytoskeleton of the present utility model, eye is implanted the sleeve (main-vision surface) of injector,And inner structure main-vision surface exploded view;
Fig. 4 is the cutaway view that in artificial retina cytoskeleton of the present utility model, eye is implanted injector;
Fig. 5 is the contiguous block in Fig. 3 and the enlarged drawing of injecting bar;
Fig. 6 is the enlarged drawing of Vitreous cavity head;
Wherein: 1, inject head; 2, bolus tube; 3, inject bar, 4, contiguous block; 5, support is implanted bar; 6, Vitreous cavity head; 7,Draw-in groove; 8, maintenance slide plate; 9, groove; 10, annular stop piece; 11, fixture block; 12, place groove; 13, handle; 14,Hole; 15, banking stop; 16, spring.
Detailed description of the invention:
Following examples are to further illustrate of the present utility model, instead of to restriction of the present utility model.
Unless special circumstances have other restrictions, otherwise the term that following definition is applicable to use in this description.
Term definition:
The term " support " using in this application refers to the medical bio PLGA of artificial synthesized degradableCompound (PLGA) support, this support can supportint cell Growth and Differentiation.
The term " retina cell " using in this application refers to the specific retina cell through stem cell induction differentiation, comprisesBut do not refer in particular to retinal ganglial cells, retinal pigment epithelium, retina cone cell, retina rod cell, lookNethike embrane Beale's ganglion cells etc.
The term " retina cell's support " using in this application refers to plants medical in artificial synthesized degradable by stem cellOn biological PLGA compound (PLGA) support, be induced to differentiate into specific retina cell, comprise but notRefer in particular to retinal ganglial cells, retinal pigment epithelium, retina cone cell, retina rod cell, retinaBeale's ganglion cells etc.
Embodiment 1:
As shown in Fig. 1,2,3,4,5 and 6, in the artificial retina cytoskeleton of the present embodiment, eye is implanted injector, comprisesThe sleeve of hollow tubular, the Vitreous cavity head 6 of being made up of silica gel, spring 16, support are implanted bar 5, and (it is elongated stemPart, its diameter range is at about 1.3mm to 1.7mm, the diameter in the present embodiment is about 1.5mm), contiguous block 4 and inject bar3, what before and after described sleeve comprises, be flexibly connected injects 1 and bolus tube 2, is provided with ring at the middle part of the hollow tube of bolus tube 2Shape limited block 10, annular stop piece middle part is provided with for support implants the hole 14 that bar 5 passes, and on the right-hand member inwall of bolus tube, is provided withFixture block 11, described inject bar 3, contiguous block 4, support implantation bar 5 and Vitreous cavity head 6 orders are fixedly linked, describedContiguous block 3 middle parts have groove 9, and the edge of implanting bar side near support at groove is provided with the draw-in groove corresponding with fixture block 7, draw-in grooveBe connected with maintenance slide plate 8 near the edge of injecting bar side, the other end of this maintenance slide plate is provided with banking stop 15, described contiguous block 4,Support implantation bar 5 and Vitreous cavity head 6 are positioned at the hollow tube of sleeve, and described spring 16 is placed on support and implants on bar 5, itsOne end props up contiguous block 4 and is connected piece and stops and fix, and one end props up annular stop piece 10 and stopped by annular stop piece in additionFix, in the periphery ancient piece of jade, round, flat and with a hole in its centre shape size of described contiguous block and bolus tube right-hand member, hollow pipe shape adapts, the card on contiguous blockCorresponding the propping up of fixture block 11 on the right-hand member inwall of groove 7 and maintenance slide plate 8 and bolus tube, the front end of described Vitreous cavity head is establishedHave and can place the cytoskeletal placement groove 12 of artificial retina, be relatively provided with one in the described upper and lower both sides of bolus tube right-hand member outer wallTo handle 13, described inject 1 and be connected by cutting ferrule with bolus tube 2, inject head and snap in the hollow pipeline of bolus tube.
Claims (4)
1. eye is implanted an injector in artificial retina cytoskeleton, it is characterized in that, comprises the sleeve of hollow tubular, by flexibilityVitreous cavity head, spring, support that material is made are implanted bar, contiguous block and inject bar, before and after described sleeve comprises, liveWhat be dynamically connected injects head and bolus tube, is provided with annular stop piece, annular stop piece middle part at the middle part of the hollow tube of bolus tubeBe provided with for support and implant the hole passed of bar, on the right-hand member inwall of bolus tube, be provided with fixture block, described inject bar, contiguous block,Support is implanted bar and Vitreous cavity head order and is fixedly linked, and described contiguous block middle part has groove, at groove near supportThe edge of implanting bar side is provided with the draw-in groove corresponding with fixture block, and draw-in groove is connected with maintenance slide plate near the edge of injecting bar side, shouldThe other end of maintenance slide plate is provided with banking stop, and described contiguous block, support are implanted bar and Vitreous cavity head and be arranged in sleeveIn blank pipe, described spring is placed on support and implants on bar, and its one end props up contiguous block and is connected piece and stops and fix, anotherOuter one end props up annular stop piece and is stopped and fix by annular stop piece, the periphery ancient piece of jade, round, flat and with a hole in its centre shape size of described contiguous block withIn bolus tube right-hand member, hollow pipe shape adapts, on the right-hand member inwall of the draw-in groove on contiguous block and maintenance slide plate and bolus tubeFixture block is corresponding to be propped up, and the front end of described Vitreous cavity head is provided with can place the cytoskeletal placement groove of artificial retina.
2. eye is implanted injector in artificial retina cytoskeleton according to claim 1, it is characterized in that, described by softThe Vitreous cavity head that property material is made is the Vitreous cavity head of being made up of silica gel.
3. in artificial retina cytoskeleton according to claim 1, eye is implanted injector, it is characterized in that, described pushing awayOn note cylinder right-hand member outer wall, be also provided with the relative a pair of handle in upper and lower both sides.
4. in artificial retina cytoskeleton according to claim 1, eye is implanted injector, it is characterized in that, described injectsHead is connected by cutting ferrule with bolus tube, injects head and snaps in the hollow pipeline of bolus tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520920503.0U CN205251823U (en) | 2015-11-17 | 2015-11-17 | Infusion device is implanted to eye in artificial retina cytoskeleton |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520920503.0U CN205251823U (en) | 2015-11-17 | 2015-11-17 | Infusion device is implanted to eye in artificial retina cytoskeleton |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205251823U true CN205251823U (en) | 2016-05-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520920503.0U Withdrawn - After Issue CN205251823U (en) | 2015-11-17 | 2015-11-17 | Infusion device is implanted to eye in artificial retina cytoskeleton |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205251823U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105361997A (en) * | 2015-11-17 | 2016-03-02 | 中山大学中山眼科中心 | Pushing and injecting device for implanting artificial retina cytoskeleton into inner eye |
| CN107374817A (en) * | 2017-08-23 | 2017-11-24 | 微瞳（武汉）医疗科技有限公司 | Branch rack loading device, eye decompression operation tool and its application method |
-
2015
- 2015-11-17 CN CN201520920503.0U patent/CN205251823U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105361997A (en) * | 2015-11-17 | 2016-03-02 | 中山大学中山眼科中心 | Pushing and injecting device for implanting artificial retina cytoskeleton into inner eye |
| CN105361997B (en) * | 2015-11-17 | 2018-01-09 | 中山大学中山眼科中心 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
| CN107374817A (en) * | 2017-08-23 | 2017-11-24 | 微瞳（武汉）医疗科技有限公司 | Branch rack loading device, eye decompression operation tool and its application method |
| CN107374817B (en) * | 2017-08-23 | 2019-09-20 | 微瞳（武汉）医疗科技有限公司 | Branch rack loading device and eye are depressured operation tool |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20160525 Effective date of abandoning: 20180109 |