CN105361997B - Eye is implanted into injector in a kind of artificial retina cytoskeleton - Google Patents
Eye is implanted into injector in a kind of artificial retina cytoskeleton Download PDFInfo
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- CN105361997B CN105361997B CN201510795027.9A CN201510795027A CN105361997B CN 105361997 B CN105361997 B CN 105361997B CN 201510795027 A CN201510795027 A CN 201510795027A CN 105361997 B CN105361997 B CN 105361997B
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Abstract
The invention discloses eye in a kind of artificial retina cytoskeleton to be implanted into injector.Using the present invention artificial retina cytoskeleton can be implanted into eye, eye can reduce retinulae stenter to implant otch in eye implantation in the artificial retina cytoskeleton, mitigate persons suffering from ocular disorders pain.And power is implanted to the present invention also aims to improve eye in retina cell's support, reduces iatrogenic injury.
Description
Technical field：
The invention belongs to medical instruments field, and in particular to eye is implanted into injector in a kind of artificial retina cytoskeleton.
Background technology：
Retina cell's injury repair is that cellularity impaired vision occurs, develops and lapse to common problem in science.In recent years
With developing rapidly for stem-cell research, induced multi-potent stem cell (induced pluripotent stem cells, iPSCs)
Reparation for cellula visualis damage brings new hope with treatment.Due to iPSCs self-replacations and more differentiation potentials, as repairing
The donor of diplopia retinulae damage can not only meet cell concentration required during transplanting, and iPSCs can be lured under certain condition
Lead and be divided into a variety of retina cell systems.Therefore, humanized's iPSCs transplantation treatment retina cell's damage diseases are utilized
With important theory significance and good clinical treatment prospect.At present, iPSCs replacement therapies mainly pass through following two ways
Footpath：1. stem cell transplantation enters subretinal space/vitreous chamber；2. stem cell in vitro, which is divided into retina specific cells, to be implanted into and regards
Nethike embrane cavity of resorption/vitreous chamber.Research found after iPSCs cells are grafted directly into impaired retinal tissue, more than 90%
Cell can not replacement therapy damaged cell；And apply the retinulae of iPSCs induction differentiation and host retina conformability poor.
Therefore, how by people iPSCs sources property retina cell's in vitro culture, and it is preferably transplanted and is integrated into impaired nethike embrane, be to work as
Preceding stem-cell therapy, medical tissue engineering and the common focus of attention of field of ophthalmology.
People iPSCs sources property retina seed cell is successfully planted in degradable poly lactic-co-glycolic acid early stage by inventor
On polymer (PLGA) support, and direct it and be induced to differentiate into all kinds of retina cells, construct degradable artificial retina
Cytoskeleton, the retina cell that its institutional framework grows for circular PLGA biomaterials and adherent support.
In order to by eye in the implantation of artificial retina cytoskeleton, it is necessary to retina cell's stenter to implant using particular design
Device, the implanting device need the cell on protective cradle not to be damaged in migration process, while the minimally invasive implantation of patient is cured with reducing
Source property is damaged.By the artificial retina cytoskeleton implanting device of this particular design, artificial retina cytoskeleton can be passed through
2mm micro-incision is implanted in human eye, is effectively reduced operative incision and easy to use, be ensure that the success of support intraocular transplantation
Rate.
The content of the invention：
It is an object of the invention to provide one kind to reduce artificial retina cytoskeleton implantation otch, mitigates persons suffering from ocular disorders pain
Hardship, improve eye in artificial retina cytoskeleton and be implanted to power, reduce in the artificial retina cytoskeleton of iatrogenic injury
Eye implantation injector.
Eye implantation injector in the artificial retina cytoskeleton of the present invention, it is characterised in that the set including hollow tubular
Cylinder, the Vitreous cavity head being fabricated from a flexible material, spring, stenter to implant bar, contiguous block and bar is injected, before described sleeve includes
What is be flexibly connected afterwards injects head and bolus tube, is provided with ring limit block at the middle part of the hollow tube of bolus tube, in ring limit block
Portion is provided with the hole passed through for stenter to implant bar, is provided with fixture block on the right-hand member inwall of bolus tube, it is described inject bar, contiguous block,
Stenter to implant bar and Vitreous cavity head order are fixedly linked, and are provided with groove in the middle part of described contiguous block, are planted in groove close to support
The edge for entering bar side is provided with the neck corresponding with fixture block, and neck is connected with maintenance slide plate close to the edge for injecting bar side, the maintenance
The other end of slide plate is provided with banking stop, and described contiguous block, stenter to implant bar and Vitreous cavity head are located in the hollow tube of sleeve,
Described spring is placed on stenter to implant bar, and its one end props up contiguous block and is connected block stop and fixes, and other end props up
Ring limit block is simultaneously fixed by ring limit block stop, in the periphery wall shape size and bolus tube right-hand member of described contiguous block
Hollow pipe shape is adapted, and the neck and maintenance slide plate on contiguous block are corresponding with the fixture block on the right-hand member inwall of bolus tube to be supported
Firmly, the front end of described Vitreous cavity head is provided with the placement groove that can place artificial retina cytoskeleton.
It is preferred that the described Vitreous cavity head being fabricated from a flexible material is the Vitreous cavity head made of silica gel.
A pair of relative handles of upper and lower both sides are preferably also provided with described bolus tube right-hand member outer wall.
Described head of injecting preferably is connected with bolus tube by cutting ferrule, is injected head and is caught in the hollow pipeline of bolus tube.
Eye implantation injector so uses in the artificial retina cytoskeleton of the present invention：Remove and inject head, by people
Work retina cell's support is put in the placement groove of the front end of Vitreous cavity head that (the Vitreous cavity head of flexible material can make to connect
It is flexible, not damaged when eye-catching eyeball), then set up and inject head, moving to drawing axis, (in the process, injecting head can be with
Artificial retina cytoskeleton is protected, avoids being damaged in migration process, at the same it is iatrogenic to reduce to the minimally invasive implantation of patient
Damage), handle is held, injects bar, compression spring, fixture block is skidded off from neck into maintenance slide plate, and Vitreous cavity head is from pushing away
Head stretches out, and continues to inject bar, fixture block is propped up the banking stop on maintenance slide plate, Vitreous cavity head has just reached specific bit
Put, in the micro-incision implantation that the artificial retina cytoskeleton of the placement groove of the front end of Vitreous cavity head then is passed through into 2mm
Eye, it thus can effectively reduce operative incision and easy to use, ensure that the success rate of support intraocular transplantation.Fixture block, card
Groove and maintenance slide plate can limit the displacement of Vitreous cavity head, there is limit to push away effect, so as to will manually regard well
Eye in retinulae stenter to implant.After implantation, bar is injected in release, under the action of the spring, Vitreous cavity head, stenter to implant
Bar, contiguous block and inject bar and shrink back, until fixture block is caught in neck.
Using the present invention artificial retina cytoskeleton can be implanted into eye, eye is planted in the artificial retina cytoskeleton
Retinulae stenter to implant otch can be reduced by entering interior eye, mitigate persons suffering from ocular disorders pain.And the present invention also aims to improve
Eye is implanted to power in retina cell's support, reduces iatrogenic injury.
Brief description of the drawings：
Fig. 1 is the stereoscopic appearance figure of eye implantation injector in the artificial retina cytoskeleton of the present invention；
Fig. 2 is the three-dimensional external structure and internal junction of eye implantation injector in the artificial retina cytoskeleton of the present invention
Structure exploded view；
Fig. 3 is that the section view of the sleeve (main-vision surface) of eye implantation injector in the artificial retina cytoskeleton of the present invention is decomposed
Figure, and internal structure main-vision surface exploded view；
Fig. 4 is the sectional view of eye implantation injector in the artificial retina cytoskeleton of the present invention；
Fig. 5 is contiguous block in Fig. 3 and injects the enlarged drawing of bar；
Fig. 6 is the enlarged drawing of Vitreous cavity head；
Wherein：1st, head is injected；2nd, bolus tube；3rd, bar, 4, contiguous block are injected；5th, stenter to implant bar；6th, Vitreous cavity head；7、
Neck；8th, maintenance slide plate；9th, groove；10th, ring limit block；11st, fixture block；12nd, groove is placed；13rd, handle；14th, hole；15th, limit
Bit slice；16th, spring.
Embodiment：
Following examples are to further explanation of the invention, rather than limitation of the present invention.
Unless special circumstances have other limitations, the term that otherwise following definition uses suitable for this specification.
Term defines：
The term " support " used in this application refers to artificial synthesized degradable medical biological polylactic acid-glycolic base
Acetic acid polymer (PLGA) support, the support being capable of sertoli cell Growth and Differentiations.
The term " retina cell " used in this application refers to that the specific retina through stem cell induction differentiation is thin
Born of the same parents, including but it is not specific to retinal ganglial cells, retinal pigment epithelium, retinal cones cell, retina retinal rod
Cell, bipolar retinal cells etc..
The term " retina cell's support " used in this application refers to planting stem cell to drop in artificial synthesized
On medical bio PLGA compound (PLGA) support of solution, specific retina cell is induced to differentiate into, is wrapped
Include but be not specific to retinal ganglial cells, retinal pigment epithelium, retinal cones cell, retina rod cell,
Bipolar retinal cells etc..
Embodiment 1：
As shown in Fig. 1,2,3,4,5 and 6, eye is implanted into injector in the artificial retina cytoskeleton of the present embodiment, including
The sleeve of hollow tubular, Vitreous cavity is first 6 made of silica gel, spring 16, stenter to implant bar 5 (it is elongated rod-like members,
Diameter of its diameter range in about 1.3mm to 1.7mm, the present embodiment is about 1.5mm), contiguous block 4 and inject bar 3, it is described
Sleeve injects first 1 and bolus tube 2 including fore-aft travel connection, and ring limit block is provided with the middle part of the hollow tube of bolus tube 2
10, ring limit block middle part is provided with the hole 14 passed through for stenter to implant bar 5, and fixture block 11 is provided with the right-hand member inwall of bolus tube,
Described inject bar 3, contiguous block 4, stenter to implant bar 5 and first 6 order of Vitreous cavity is fixedly linked, the described middle part of contiguous block 3
Groove 9 is provided with, is provided with the neck 7 corresponding with fixture block close to the edge of stenter to implant bar side in groove, neck is close to inject bar
The edge of side is connected with maintenance slide plate 8, and the other end of the maintenance slide plate is provided with banking stop 15, described contiguous block 4, stenter to implant bar
5 and Vitreous cavity first 6 be located in the hollow tube of sleeve, described spring 16 is placed on stenter to implant bar 5, and its one end props up connection
Block 4 and connected block, which stop, to be fixed, and other end props up ring limit block 10 and stopped by ring limit block and fixes, described
The periphery wall shape size of contiguous block be adapted with hollow pipe shape in bolus tube right-hand member, neck 7 and maintenance on contiguous block
Slide plate 8 is corresponding with the fixture block 11 on the right-hand member inwall of bolus tube to be propped up, and the front end of described Vitreous cavity head is provided with and can placed
The placement groove 12 of artificial retina cytoskeleton, both sides are relative above and below described bolus tube right-hand member outer wall is provided with a pair of handles
13, it is described to inject first 1 and connected with bolus tube 2 by cutting ferrule, inject head and be caught in the hollow pipeline of bolus tube.
Claims (4)
1. eye is implanted into injector in a kind of artificial retina cytoskeleton, it is characterised in that the sleeve including hollow tubular, by soft
Property Vitreous cavity head, spring, stenter to implant bar, contiguous block made of material and bar is injected, described sleeve includes fore-aft travel
Head and bolus tube are injected in connection, and ring limit block is provided with the middle part of the hollow tube of bolus tube, is provided with the middle part of ring limit block
The hole passed through for stenter to implant bar, is provided with fixture block on the right-hand member inwall of bolus tube, and described inject bar, contiguous block, support are planted
Enter bar and Vitreous cavity head order is fixedly linked, groove is provided with the middle part of described contiguous block, in groove close to stenter to implant bar side
Edge be provided with the neck corresponding with fixture block, neck is connected with maintenance slide plate close to the edge for injecting bar side, the maintenance slide plate
The other end is provided with banking stop, and described contiguous block, stenter to implant bar and Vitreous cavity head are located in the hollow tube of sleeve, described
Spring is placed on stenter to implant bar, and its one end props up contiguous block and is connected block stop and fixes, and other end props up annular limit
Position block is simultaneously fixed by ring limit block stop, periphery wall shape size and the hollow tube in bolus tube right-hand member of described contiguous block
Shape is adapted, and the neck and maintenance slide plate on contiguous block are corresponding with the fixture block on the right-hand member inwall of bolus tube to be propped up, described
The front end of Vitreous cavity head be provided with and can place the placement groove of artificial retina cytoskeleton.
2. in artificial retina cytoskeleton according to claim 1 eye be implanted into injector, it is characterised in that it is described by
Vitreous cavity head made of flexible material is the Vitreous cavity head made of silica gel.
3. eye is implanted into injector in artificial retina cytoskeleton according to claim 1, it is characterised in that described
Both sides are provided with a pair of handles to bolus tube right-hand member outer wall relatively up and down.
4. eye is implanted into injector in artificial retina cytoskeleton according to claim 1, it is characterised in that described pushes away
Head is connected with bolus tube by cutting ferrule, is injected head and is caught in the hollow pipeline of bolus tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510795027.9A CN105361997B (en) | 2015-11-17 | 2015-11-17 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510795027.9A CN105361997B (en) | 2015-11-17 | 2015-11-17 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
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| Publication Number | Publication Date |
|---|---|
| CN105361997A CN105361997A (en) | 2016-03-02 |
| CN105361997B true CN105361997B (en) | 2018-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510795027.9A Active CN105361997B (en) | 2015-11-17 | 2015-11-17 | Eye is implanted into injector in a kind of artificial retina cytoskeleton |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110507477A (en) * | 2019-09-27 | 2019-11-29 | 安徽国泰国瑞医疗科技有限公司 | A kind of device for the implantation of ophthalmology drainage tube |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205251823U (en) * | 2015-11-17 | 2016-05-25 | 中山大学中山眼科中心 | Infusion device is implanted to eye in artificial retina cytoskeleton |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766181A (en) * | 1996-08-02 | 1998-06-16 | Staar Surgical Company, Inc. | Spring biased deformable intraocular injecting apparatus |
| GB2408456A (en) * | 2003-11-28 | 2005-06-01 | Mohamed Naguib Abdel-Khalek | Fluid evacuation syringe |
| US20060235430A1 (en) * | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
| JP4947484B2 (en) * | 2006-02-22 | 2012-06-06 | Ｈｏｙａ株式会社 | Intraocular lens insertion device |
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2015
- 2015-11-17 CN CN201510795027.9A patent/CN105361997B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205251823U (en) * | 2015-11-17 | 2016-05-25 | 中山大学中山眼科中心 | Infusion device is implanted to eye in artificial retina cytoskeleton |
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| Publication number | Publication date |
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| CN105361997A (en) | 2016-03-02 |
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Address after: 510060 No. 54 martyrs South Road, Guangzhou, Guangdong, Yuexiu District Co-patentee after: Shandong baiduoan Medical Equipment Co.,Ltd. Patentee after: ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN University Address before: 510060 No. 54 martyrs South Road, Guangzhou, Guangdong, Yuexiu District Co-patentee before: Shandong Branden Medical Device Co.,Ltd. Patentee before: ZHONGSHAN OPHTHALMIC CENTER, SUN YAT-SEN University |
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