CN109045454A - A kind of middle ear repeat administration device and artificial cave electrode - Google Patents
A kind of middle ear repeat administration device and artificial cave electrode Download PDFInfo
- Publication number
- CN109045454A CN109045454A CN201811248653.6A CN201811248653A CN109045454A CN 109045454 A CN109045454 A CN 109045454A CN 201811248653 A CN201811248653 A CN 201811248653A CN 109045454 A CN109045454 A CN 109045454A
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- CN
- China
- Prior art keywords
- pouch
- middle ear
- administration device
- repeat administration
- electrode
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0541—Cochlear electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
- A61N1/36038—Cochlear stimulation
Abstract
The present invention relates to otology medical instruments fields, and in particular, to a kind of middle ear repeat administration device and artificial cave electrode.Middle ear repeat administration device of the invention, including hollow pouch and the connecting tube being connected to below pouch, the junction of the pouch and connecting tube is equipped with check valve；Wherein, the pouch upper opening and opening be arranged biological semi-permeable film.The pouch is placed between malleus and long limb of incus, and the top of pouch is contacted with eardrum, and a groove is laterally arranged above pouch, and the groove of pouch is stuck on manubrium mallei.The present invention is the response to traume for mitigating cochlear electrode implantation, regeneration induction and substitution auditory nerve cell, optimizes artificial cave effect, and the speech recognition ability for improving patient creates novel technical method extremely conveniently, safely, economic.
Description
Technical field
The present invention relates to otology medical instruments fields, and in particular, to a kind of middle ear repeat administration device and artificial cochlea
Implant electrode.
Background technique
Artificial cave has been widely used for clinic, while opening cochlear implant electrode, gives drug, nerve
Trophic factors, gene and the injection treatment of cell inner ear, can mitigate cochlea damage, promote inner ear neural restoration, supplement and induction
Auditory nerve cell regeneration.So as to improve the effect of artificial cave, patient's speech recognition ability is improved.
From U.S. FDA official approval Cochlear implant in 1984 in adult using so far, the whole world has 300,000 deaf persons
Hearing is regained by being implanted into cochlea.I-coch electrode passes through to nerve fiber (the spiral nerve near electrode contact
Ganglion cell) carry out stimulus of direct current carry out the recovered part sense of hearing.Electro photoluminescence is electrode by being inserted into cochlea tympanic canal and therewith
Connected implanted stimulator is realized.But the insertion of electrode can cause wound different degrees of in cochlea, inner ear wound
It then may cause apoptosis and/or the necrosis of nerve fiber (i.e. hair cell and spiral ganglion cells).
Currently, by open tympanic canal or round window, injecting corticosteroid can reduce when implementing artificial cave
The raising of impedance after operation, in clinic it has been recognised that.There are also some researchs, and neurotrophic factor injection cochlea can be changed
The reaction of kind implant electrode, might have the speech discrimination capacity for being conducive to improve patient.But single administration intervention, no Faville
Hold the effect for the treatment of.It needs repeatedly to be administered, to realize long-term therapeutic effect.
Med El Elektromed Geraete GmbH in 2007, applied a patent of invention " with fluid reservoir can
It is implanted into Neural stimulation electrodes " (number of patent application: CN200780027561.9).The patent of invention is disclosed for cochlear tissue
The implantable cochlear electrode array of electro photoluminescence is carried out, the drug elution portion including polymer material is suitable for releasing at any time
Put the medicament for inner ear of therapeutically effective amount.And the implantable electrode holder containing fluid reservoir, it contains in the reservoir
The medical fluid of certain volume.
Applied drug delivery materials are all disposable in the prior art, and either polymeric medicine elutes, still
Fluid reservoir, entrained medication amount are limited, and can not play therapeutic effect once release finishes.Moreover, stream
Body reservoir is needed to be implanted under scalp or is fixed on cochlea, some needs additionally open a window on cochlea.Increase patient
Wound, have the risk for causing cochlea additional injuries.Drug in fluid reservoir, needs micropump to provide pressure, ability
Drug is sent to inner ear, micropump is also required to be implanted in vivo, and cost is costly.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of middle ear repeat administration devices further to additionally provide
A kind of artificial cave electrode containing the middle ear repeat administration device.
The specific technical solution of the present invention is as follows:
Middle ear repeat administration device provided by the invention, including hollow pouch and the connection being connected to below pouch
The junction of pipe, the pouch and connecting tube is equipped with check valve；
Wherein, the pouch upper opening and opening be arranged biological semi-permeable film, it is recessed that one is laterally arranged above pouch
Slot.
Middle ear repeat administration device according to the present invention, wherein the pouch is placed between malleus and long limb of incus,
The top of pouch is contacted with eardrum, and a groove is laterally arranged above pouch, and the groove of pouch is stuck on manubrium mallei.
Middle ear repeat administration device according to the present invention, wherein preferably, the pouch is telescopic cylindric
Structure, such as, but not limited to the bellows structure with organ is cylindric.
Middle ear repeat administration device according to the present invention, wherein it is further preferred that the race diameter of the pouch
For 3~5mm, 1.5mm is highly no more than when being compressed to most close, 2.5mm is no more than under natural relaxed state.
Middle ear repeat administration device according to the present invention, wherein preferably, the length of the connecting tube is 10~
15mm。
Middle ear repeat administration device according to the present invention, preferably, at the pouch upper center opening and
Laterally one groove of setting is hit exactly above pouch.
The present invention also provides a kind of artificial cave electrode, the artificial cave electrode includes any of the above institute
The middle ear repeat administration device stated.
Artificial cave electrode according to the present invention, wherein the artificial cave electrode is in artificial cochlea
The last one interior stimulating electrode sheet metal rear, which is equipped with, expands place, in the connecting tube for expanding place Yu middle ear repeat administration device
End is connected.
Artificial cave electrode according to the present invention, wherein have at least on the stimulating electrode in artificial cochlea
One drug delivery port.
The novel artificial cave electrode of one kind provided by the invention, its main feature is that: 1. have one can repeat to
The biocompatibility storage facilities (middle ear repeat administration device i.e. of the present invention) of medicine, this equipment can plant middle ear lacuna
It is interior；It is connect by the connecting tube with one-way cock with artificial cave electrode；2. implant electrode has at least one medicine
Object delivers port, and the storage facilities is connected to the outer surface of the electrode holder, for that will come from the storage facilities
Curative drug be shipped to the implant electrode outer surface.
The present invention by eardrum, the natural physiological structure of auditory ossicular chain, the fluid reservoir of repeatable administration is fixed and
Positioning.The pressure twitched by vibrophone and cochleostapedial reflex, by biological therapies liquid such as drugs in fluid reservoir
It is injected into cochlea.The devices such as additional implantable miniature pump are not needed, reduce the wound of patient, and low cost, patient is without economy
Burden.The conventional treat-and-release of auripuncture can be passed through, injected in treatment medication or gene, stem cell etc. repeatedly, repeatedly
Ear biological therapy fluid.For the response to traume for mitigating cochlear electrode implantation, regeneration induction and substitution auditory nerve cell optimize people
Work cochlea implantation effect, the speech recognition ability for improving patient create novel technical method extremely conveniently, safely, economic.
Detailed description of the invention
Fig. 1 is middle ear repeat administration schematic device of the invention, wherein left side is device top view, and right side is device
Main view；
Fig. 2 is the artificial cave electrode schematic diagram of the device of repeat administration containing middle ear of the invention；
Fig. 3 is that the middle ear of the artificial cave electrode of the device of repeat administration containing middle ear of the invention are implanted into schematic diagram.
Appended drawing reference
1, pouch, 11, biological semi-permeable film, 12, groove, 2, connecting tube, 3, implant electrode, 31, expand place, 4, implant.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.
As shown in Figure 1, middle ear repeat administration device of the invention, including hollow pouch 1 and is connected to below pouch
Connecting tube 2, the junction of the pouch and connecting tube is equipped with check valve；Wherein, the pouch upper opening and in opening
Biological semi-permeable film 11 is set, a groove 12 is laterally set above pouch, can be convenient and connect with manubrium mallei.Middle ear of the invention
Repeat administration device (including pouch and connecting tube etc.) uses biocompatibility identical with artificial cochlear implant outer surface
Material (such as silica gel, polyethylene, Teflon etc.).
The biological semi-permeable film (collodion film, glassine paper etc.) that the present invention is arranged at pouch upper opening, can be covered on
Overthe openings interior can also be lining in opening inner side.
As shown in figure 3, the pouch is placed between malleus and long limb of incus, the top of pouch is contacted with eardrum, pouch
Groove is stuck on manubrium mallei.
Wherein preferably, the telescopic cylindrical-shaped structure of the pouch, thus make pouch that there is certain extendable room, it is excellent
Choosing is using cylindric with organ bellows structure.It is further preferred that the race diameter of the pouch is 3~5mm, highly exist
It is no more than 1.5mm when being compressed to most close, 2.5mm is no more than under natural relaxed state.Preferably, the length of the connecting tube
Degree is 10mm.
Further preferably, opening and one groove of the lateral setting in center above pouch at the pouch upper center,
The opening can be, but not limited to be circular port.
As shown in Fig. 2 and 3, the present invention also provides a kind of artificial cave electrode, the artificial cave electrode
Including any of the above middle ear repeat administration device.Last in artificial cochlea of the artificial cave electrode 3
A stimulating electrode sheet metal rear be equipped with expands place 31, herein for electrode be implanted into cochlea when with connect at round window or scala tympani fenestration
Contact portion point, is connected expanding place with the connection pipe end of middle ear repeat administration device.Have on stimulating electrode in artificial cochlea
At least one drug delivery port.Artificial cave electrode signal receiving end is connected with well known implant 4, the plant
Enter body for receiving signal and signal being passed to implant electrode.
Specific use process is as follows for middle ear repeat administration device and artificial cave electrode of the invention:
(1) production of novel implant electrode: as shown in figs. 1 and 2, cochlear implant electrode of the invention has and conventional electrodes
Identical implant, electrod-array.Unlike, in the junction of electrode cable and electrod-array, connection one can be repeated
The biocompatibility storage facilities (middle ear repeat administration device i.e. of the invention) of administration, this equipment can plant in middle ear lacuna.
The outer surface of implant electrode array has at least one drug delivery port, for will be from the therapeutic medicine of the storage facilities
Object is shipped to the implant electrode outer surface.
(2) the specific implantation of the artificial cave electrode with middle ear repeat administration device: as shown in figure 3,
After completing conventional manual's cochlea implantation, it will be connected to the middle ear repeat administration device of cochlear electrode, it is long with incus to be placed in malleus
Between foot, notice that the front (i.e. above) of pouch is contacted with eardrum, positive groove is stuck on manubrium mallei.Then use biological organic
Glue bonds the ear bones for being implanted into capsule band and two sides, and the biological organic glue can be, but not limited to as cyanoacrylate gluing
Agent, the Instant cement series that can such as select Permabond company to produce.
(3) pressure producing method is administered: as shown in figure 3, the drug being stored in the pouch of implantation middle ear or biological therapy
Liquid is that cannot open the one-way cock of pouch end to enter cochlea in the absence of stress.Drug is promoted to enter ear
The pressure of snail moves from eardrum and drives the movable power of auditory ossicular chain, provides pressure completely without replanting into micro pump,
Electric power maintenance is not needed.By the eardrum pressurizing device of wide clinical application (such as pressurization otoscope, politzer's bag or
The plum nit instrument of frequency and pressure controllable), eardrum can be pushed to move, squeeze pouch and generate pressure, this pressure is enough to open valve
Door, liquid medicine injection is entered in cochlea.Another method is, by the electro photoluminescence of cochlear electrode, to induce cochleostapedial reflex, musculus stapedius band
Dynamic stapes movement is transferred to the pouch between implantation ear bones by auditory ossicular chain, squeezes pouch and generate pressure, this pressure is enough to open valve
Door, liquid medicine injection is entered in cochlea.Or by the two connected applications, have reached optimal administration pressure.
(4) repeat administration mode: the middle ear that the present invention makes are implanted into equipment, after connecting with malleus and eardrum, in eardrum
Umbilical region forms a mark region.It, can be by fine needle puncture, accurately by medicine around the umbilical region in the circular scope of 1mm radius
Object and the liquid of biological therapy are injected into the pouch between implantation ear bones.
It should be noted last that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting.Although ginseng
It is described the invention in detail according to embodiment, it will be apparent to an ordinarily skilled person in the art that technical side of the invention
Case is modified or replaced equivalently, and without departure from the spirit and scope of technical solution of the present invention, should all be covered in the present invention
Scope of the claims in.
Claims (9)
1. a kind of middle ear repeat administration device, which is characterized in that the middle ear repeat administration device include hollow pouch and
The junction of the connecting tube being connected to below pouch, the pouch and connecting tube is equipped with check valve；
Wherein, the pouch upper opening and opening be arranged biological semi-permeable film.
2. middle ear repeat administration device according to claim 1, which is characterized in that it is long with incus that the pouch is placed in malleus
Between foot, the top of pouch is contacted with eardrum, and a groove is laterally arranged above pouch, and the groove of pouch is stuck on manubrium mallei.
3. middle ear repeat administration device according to claim 1 or 2, which is characterized in that the pouch is telescopic circle
Column structure.
4. middle ear repeat administration device according to claim 3, which is characterized in that the race diameter of the pouch be 3~
5mm is highly no more than 1.5mm when being compressed to most close, and 2.5mm is no more than under natural relaxed state.
5. middle ear repeat administration device according to claim 1 or 2, which is characterized in that the length of the connecting tube is 10
~15mm.
6. middle ear repeat administration device according to claim 1 or 2, which is characterized in that opened at the pouch upper center
Mouth and one groove of the lateral setting in center above pouch.
7. a kind of artificial cave electrode, which is characterized in that the artificial cave electrode includes claim 1-6 any
The middle ear repeat administration device.
8. artificial cave electrode according to claim 7, which is characterized in that the artificial cave electrode is in people
The last one i-coch stimulating electrode sheet metal rear of work, which is equipped with, expands place, is expanding place and middle ear repeat administration device
Pipe end is connected to be connected.
9. artificial cave electrode according to claim 8, which is characterized in that have on the stimulating electrode in artificial cochlea
There is at least one drug delivery port.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811248653.6A CN109045454B (en) | 2018-10-25 | 2018-10-25 | Middle ear repeated drug delivery device and artificial cochlea implantation electrode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811248653.6A CN109045454B (en) | 2018-10-25 | 2018-10-25 | Middle ear repeated drug delivery device and artificial cochlea implantation electrode |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109045454A true CN109045454A (en) | 2018-12-21 |
| CN109045454B CN109045454B (en) | 2021-02-02 |
Family
ID=64765384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811248653.6A Active CN109045454B (en) | 2018-10-25 | 2018-10-25 | Middle ear repeated drug delivery device and artificial cochlea implantation electrode |
Country Status (1)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022021713A1 (en) * | 2020-07-31 | 2022-02-03 | 黄建民 | Artificial titanium ossicle having cup-shaped top disc |
| CN115430026A (en) * | 2022-09-23 | 2022-12-06 | 南京鼓楼医院 | Integrated artificial cochlea implant repeated delivery dosing electrode and control device |
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| DE19928611A1 (en) * | 1999-06-22 | 2000-12-28 | Lre Technology Partner Gmbh | Portable applicator for supplying fluid medicament continuously to middle ear includes detachable cover and reservoir, with tubing leading to cannula retained in ear drum |
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| CN115430026A (en) * | 2022-09-23 | 2022-12-06 | 南京鼓楼医院 | Integrated artificial cochlea implant repeated delivery dosing electrode and control device |
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| Publication number | Publication date |
|---|---|
| CN109045454B (en) | 2021-02-02 |
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