CN203017419U - Active particles containing no chemical additives as well as capsules, troches and granules containing active particles - Google Patents
Active particles containing no chemical additives as well as capsules, troches and granules containing active particles Download PDFInfo
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- CN203017419U CN203017419U CN 201220379224 CN201220379224U CN203017419U CN 203017419 U CN203017419 U CN 203017419U CN 201220379224 CN201220379224 CN 201220379224 CN 201220379224 U CN201220379224 U CN 201220379224U CN 203017419 U CN203017419 U CN 203017419U
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Abstract
The utility model discloses active particles containing no chemical additives. The active particles containing no chemical additives comprise main bodies and a plurality of lines, wherein each main body is of a quasi-circular particle, and all the lines are formed in the main bodies. The utility model also discloses capsules, troches and granules comprising the active particles containing no chemical additives.
Description
Technical field
This utility model relates to a kind of active particles (active pellet excluding chemical additives) that does not contain chemical additive or excipient.
Background technology
The method of making traditional microgranule includes liquid layered manner, powder layered manner and extrudes spheronization.The liquid layered manner is that active component is dissolved in solvent, and adds polymer binder, then by spray drying method, mucus is sticked to a core, makes microgranule in stacked mode.The powder layered manner is that powder is sprayed polymer binder, makes microgranule in stacked mode equally.Extruding spheronization also needs to use polymer binder and helps molding.Yet polymer binder belongs to the functional chemical additive of demand in processing procedure, to human body without any help.
As for general reactive powder, normally active component extraction drying is got.But the reactive powder size that makes differs, below 100 μ m.Shape mostly is greatly needle-like, splintery, irregular or round shaped grain shape.When running into aqueous vapor, reactive powder easily absorbs aqueous vapor and produces viscosity and mucus, and is difficult for flowing.If follow-uply want to carry out processed, need the extra lubricant that adds help flow of powder.Above-mentioned lubricant such as magnesium stearate can be used to coat reactive powder, make it sliding and easily flow along not sticking.But lubricant also can cause burden to human body except meeting affects the collapsibility and dissolubility of active component in preparation.
In addition, in order to improve the characteristic of preparation, also may add other chemical additive.For example, for improving stability, can add antiseptic.Perhaps, in order to improve local flavor and outward appearance, can add correctives, spice or pigment.Or, can add in order to adjust the loose speed of collapsing of medicine and collapse powder.
From the above, no matter be traditional microgranule or the reactive powder of wanting to make preparation, all unavoidably to use the chemical additives such as polymer binder or lubricant in processing procedure.In addition, in order to improve the preparation characteristic, may also to add the chemical additive of other kind.If but the above-mentioned preparation that contains chemical additive of life-time service probably causes harmful effect to human body.
Therefore, needing a kind of active particles to possess has good processability and preparation characteristic, and avoids using chemical additive can and be processed into preparation in preparation forms the time.
The utility model content
One of the purpose of this utility model is to provide a kind of active particles that does not contain chemical addition agent, basically overcome the defective of prior art, this active particles possesses good processability and preparation characteristic is arranged, and avoids using chemical additive in the time of can and being processed into preparation in preparation forms.
Therefore, an aspect of the present utility model is that a kind of active particles that does not contain chemical addition agent is being provided, and includes main body and several lines.The shape of main body is the similar round graininess.Several lines are arranged in main body.
In one or more embodiment of this utility model, the particle diameter of main body can be approximately 100 to 1200 μ m.
In one or more embodiment of this utility model, the width of each lines can be approximately 0.1 to 10 μ m.
In one or more embodiment of this utility model, several lines are interconnective.
In one or more embodiment of this utility model, main body includes at least one fine powder body, and the particle diameter of fine powder body is 20-160 μ m.
In one or more embodiment of this utility model, the active particles that does not contain chemical addition agent also comprises a liquid, is arranged in lines.
In one or more embodiment of this utility model, the active particle that does not contain chemical addition agent also comprises a clad, is positioned at the surface of main body.
Another aspect of the present utility model is that a kind of capsule is being provided, and includes the above-mentioned capsule that does not contain the active particles of chemical addition agent and coat active particles.
Another aspect of the present utility model is that a kind of lozenge that is made of the above-mentioned active particles that does not contain chemical addition agent is being provided.
Another aspect of the present utility model is that a kind of granule that is made of the above-mentioned active particles that does not contain chemical addition agent is being provided.
The above-mentioned embodiment of this utility model, compared following advantages with known prior art:
(1) the above-mentioned embodiment of this utility model does not contain chemical additive and excipient, can reduce that the user is reached actual healthy effects psychologically.
(2) density of the active particles of the above-mentioned embodiment of this utility model is higher and the uniform particle diameter degree is better, has to control the effect that discharges.
(3) main body of the above-mentioned embodiment of this utility model is the round shaped grain shape and can not produces mucus and have a good physical flow, does not therefore need additionally to add lubricant in the process that is processed into preparation such as capsule or lozenge.
(4) include lines in the active particles of the above-mentioned embodiment of this utility model, have better collapsibility.
Above-mentioned utility model content aims to provide the simplification summary of this disclosure, so that the reader possesses basic understanding to this disclosure.This utility model content is not the complete overview of this disclosure, and its purpose is not at the key/critical element of pointing out this utility model embodiment or defines scope of the present utility model.After consulting hereinafter embodiment, have in technical field under this utility model and know that usually the knowledgeable is when can understanding easily technological means that essence spirit of the present utility model and this utility model adopt and implementing aspect.
Description of drawings
For above-mentioned and other purpose of the present utility model, feature, advantage and embodiment can be become apparent, appended the description of the drawings is as follows:
Figure 1A-1B is the cross-sectional view that illustrates according to a kind of active particles of this utility model one embodiment;
Fig. 2 is the cross-sectional view that illustrates according to a kind of capsule of this utility model one embodiment;
Fig. 3 is the cross-sectional view that illustrates according to a kind of lozenge of this utility model one embodiment;
Fig. 4 is the cross-sectional view that illustrates according to a kind of granule of this utility model one embodiment;
Wherein, main element symbol description:
100,210,310,410,510: active particles
110: main body 112: the fine powder body
114: liquid 120,320,420: the cloud form lines
130,430,530: clad 140,240,540: ice shape lines
200: capsule 250: capsule
300: lozenge 400: granule
D: width.
The specific embodiment
Below will disclose a plurality of embodiment of the present utility model with accompanying drawing, as clearly stated, the details on many practices will be explained in the following description.Yet, should be appreciated that, the details on these practices does not use to limit this utility model.That is to say, in this utility model part embodiment, the details on these practices is non-essential.In addition, for the purpose of simplifying accompanying drawing, some known habitual structures and element will illustrate it in the mode of simple signal in the accompanying drawings.
Figure 1A-1B is the cross-sectional view that illustrates according to a kind of active particles 100 of this utility model one embodiment.As shown in the figure, a kind of active particles 100 comprises main body 110 and several lines.The shape of main body 110 is the similar round graininess.Several lines are arranged in main body 110, and these lines are cloud form lines 120 or ice shape lines 140.
The textured active particles 100 of above-mentioned tool can be made of the extrusion molding spheronization of arranging in pairs or groups.Wherein when carrying out extrusion molding, can adjust the cohesive of active component by aperture, extrusion stress and the speed of controlling moisture, die hole version, therefore not need additionally to add chemical additive or excipient.
Specifically, the particle diameter of main body 110 is about 100 to 1200 μ m, and shape is the similar round graininess.The particle diameter of main body 110 can be adjusted according to the demand on using.For instance, can according to the collapsibility of active particles 100 and the rate of release of demand, design the particle diameter of active particles 100.In addition, because the more general reactive powder of density of main body 110 is high, and the uniform particle diameter degree is better, therefore has to control the effect that discharges.Above-mentioned similar round graininess refers to main body 110 can be ball, oval ball, or near ball or oval ball.And easily roll because of its profile, and be not subject to the aqueous vapor impact and produce mucus, therefore can show better mobility in the course of processing, and do not need additionally to add lubricant.Main body 110 can be comprised of active component fully, does not contain chemical additive or excipient, and can reduce, the user is reached actual healthy effects psychologically.In one embodiment, main body 110 can include fine powder body 112, therefore main body 110 can include the structure of seriality or noncontinuity.Above-mentioned fine powder body 112 can be active component after extracting drying, then obtains by pulverizing process.The particle diameter of fine powder body 112 can be 20-160 μ m, and shape is similar round, fixedly body or irregular shape body.
Lines can be positioned at main body 110, also can be positioned at the surface of main body 110.The width D of lines can be approximately 0.1-10 μ m, and shape can be cloud form lines 120 or ice shape lines 140.Due to the width of lines and the variation of the degree of depth, generally lines can be considered as interface or space.One end of cloud form lines 120 is curling shape usually.Ice shape lines 140 is usually linearly, when splitting as ice cube, and the state that its crack presents.Can interconnect between lines.Owing to having several lines in active particles 100, so collapsibility is better.Make the method for lines, can utilize extrude and round as a ball forming process in the internal stress that produces make active particles produce lines.In one embodiment, active particles 100 also can comprise a liquid 114 and is arranged in lines.As shown in Figure 1A-1B, liquid 114 can be arranged in cloud form lines 120 or ice shape lines 140.Aforesaid liquid 114 can be the active component that is in a liquid state.
In addition, active particles 100 can be in order to be processed into preparation.The form of preparation for example can be capsule 200, lozenge 300 or granule 400.
Fig. 2 is the cross-sectional view that illustrates according to a kind of capsule of this utility model one embodiment.Above-mentioned capsule 200 can be made of active particles 210 and capsule 250.As shown in the figure, can include ice shape lines 240 in active particles 210.Because the main body 110 of active particles 100 is the round shaped grain shape and can produce mucus because absorbing aqueous vapor, therefore when being filled to capsule 250, active particles 100 do not need additionally to add lubricant.
Fig. 3 system is the cross-sectional view that illustrates according to a kind of lozenge of this utility model one embodiment.The active particles 310 that can comprise as shown in the figure, tool cloud form lines 320 in lozenge 300.Lozenge can utilize wet granulation manufacturing, as active particles 100 is first mixed with water or ethanol, then carries out drying process, then plays ingot to form lozenge.Because active particles 100 has higher density, therefore do not need additionally to add excipient in manufacture process.
Fig. 4 is the cross-sectional view that illustrates according to a kind of granule of this utility model one embodiment.As shown in the figure, can comprise the active particles 410 of tool cloud form lines 420 and the active particles 510 of tool ice shape lines 540 in granule 400.And two kinds of active particles all include clad 530.The manufacture method of granule for example can be microgranule 100 is made into diameter as the granule 400 of 300-1500 μ m strip or class circle shape again take extrusion way or granulate mode.
From the above, contain in the process of capsule 200, lozenge 300 and granule 400 of active particles in manufacturing, do not need additionally to add chemical additive or excipient.
The composition of active particles
The active particles 100 that main body 110 and lines consist of can be entirely active component, and does not contain chemical additive and additional excipients, and can reduce the healthy effects to the user.Above-mentioned chemical additive refers to binding agent, collapses powder, diluent, fluidizer, lubricant, correctives, emulsifying agent, antiseptic, spice or pigment.
Above-mentioned active component can be the active component that is applied to food or medicine.Distinguish according to activity, can be divided into the active substance of active substance or adjuvanticity.Above-mentioned active substance can be organic acid, fatty acid, polypeptide or protein, probiotic bacteria, fungus, alkaloid, flavonoid or chemical compound.The active substance of above-mentioned adjuvanticity can be polysaccharides or carbohydrate.
Above-mentioned organic acid can be citric acid, malic acid, lactic acid, fruit fermented product or other can be applicable to the organic acid that food adds.
The carbon number that above-mentioned fatty acid can be carbochain is less than 50 unsaturated fatty acid.For example, Omega3 fatty acid, Omega6 fatty acid, Omega9 fatty acid, lecithin or phosphoric acid silk amino acid.
Aforementioned polypeptides or protein can be polypeptide or the protein with physiological regulatory action.
Above-mentioned probiotic bacteria can be Lactobacillus, Bifidobacterium, spore Pseudomonas, bacillus subtilis, Streptococcus, Enterococcus or Saccharomycodes.
Above-mentioned fungus can be edible or medicinal fungal mycelia, edible or medicinal fungus sporophore, Ascomycetes fungus or list Gammaproteobacteria fungus.For instance, fungal material can be Antrodia Camphorata, Cordyceps, Ganoderma, Cordyceps militaris (L.) Link., Coriolous Dersicolor (Fr.) Quel or splits the folding bacterium.
Above-mentioned alkaloid can be the extract of the plant, animal or the fungus that can be applicable to food additives.For example piperine, trigonelline, theophylline and caffeine, resveratrol, serotonin, ergotin and derivant thereof, carnitine or choline.
Above-mentioned flavonoid can be the flavonoid from fruit, vegetable, tea, wine, seed or plant roots, or other can be applicable to the flavonoid of food additives.For instance, flavonoid can be rutin, hesperidin, Quercetin, green tea polyphenol, red wine polyphenols or olive polyphenol.
The manufacture method of active particles
At first, can first do pre-treatment for active component, as with the first mix and blend of active component and water, then push with bonding processing procedure and can obtain mixture.
Then, with the high-pressure spiral bar radially extrusion molding mixture is extruded, to form the granule of strip.When carrying out extrusion molding, can adjust cohesive and the connectivity of active component by aperture, extrusion stress and the speed of controlling moisture, die hole version, therefore do not need additionally to add chemical additive or excipient.
Come again, use centrifugal quarter dish and auxiliary equipment carry out spheronization, strip particle is cut off, and because of under apocarpy between granule or granule can collide with the board inwall, make it molding formation similar round granule.When carrying out spheronization, also can improve by the cutting plate of controlling round as a ball speed and time and additional machine the outward appearance of active particles 100.
At last, then carry out drying process, and can obtain the textured active particles 100 of tool.
Above-mentioned active particles can be applicable to physiology and pharmacological use.For instance, can be applicable to regulate physiological change or the indication that causes because of disorder.As dyssomnias, comprise insomnia, shallow dormancy, anxiety etc.; Environmental pollution comprises absorption and the absorption of heavy metal, Environmental Hormone, pesticide, Aflatoxin etc.; The imbalance of intestines and stomach physiological status comprises constipation, flatulence, diarrhoea etc.; Metabolic syndrome comprises obesity, hyperlipidemia, fatty liver, diabetes etc.
Although this utility model discloses as above with embodiment; so it is not to limit this utility model; anyly have the knack of this skill person; within not breaking away from spirit and scope of the present utility model; when can be used for a variety of modifications and variations, therefore protection domain of the present utility model is as the criterion when looking accompanying the scope that claims define.
Claims (10)
1. active particles that does not contain chemical addition agent comprises:
One main body, the shape of described main body is the similar round graininess; And
A plurality of lines are arranged in described main body.
2. the active particles that does not contain chemical addition agent as claimed in claim 1, the particle diameter of wherein said main body is 100 to 1200 μ m.
3. the active particles that does not contain chemical addition agent as claimed in claim 1, wherein the width of each described lines is 0.1 to 10 μ m.
4. the active particles that does not contain chemical addition agent as claimed in claim 1, wherein said lines interconnects.
5. the active particles that does not contain chemical addition agent as claimed in claim 1, wherein said main body comprises at least one fine powder body, and the particle diameter of described fine powder body is 20-160 μ m.
6. the active particles that does not contain chemical addition agent as claimed in claim 1, also comprise a liquid and be arranged in described lines.
7. the active particles that does not contain chemical addition agent as claimed in claim 1, also comprise a clad, is positioned at the surface of described main body.
8. capsule comprises:
The active particles that does not contain chemical addition agent as described in claim 1 to 7 any one; And
One capsule coats described active particles.
9. lozenge that is consisted of by the described active particles that does not contain chemical addition agent of claim 1 to 7 any one.
10. granule that is consisted of by the described active particles that does not contain chemical addition agent of claim 1 to 7 any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220379224 CN203017419U (en) | 2012-08-01 | 2012-08-01 | Active particles containing no chemical additives as well as capsules, troches and granules containing active particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220379224 CN203017419U (en) | 2012-08-01 | 2012-08-01 | Active particles containing no chemical additives as well as capsules, troches and granules containing active particles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203017419U true CN203017419U (en) | 2013-06-26 |
Family
ID=48641440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220379224 Expired - Fee Related CN203017419U (en) | 2012-08-01 | 2012-08-01 | Active particles containing no chemical additives as well as capsules, troches and granules containing active particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203017419U (en) |
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2012
- 2012-08-01 CN CN 201220379224 patent/CN203017419U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JISHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ANSHENG BIOTECHNOLOGY CO., LTD. Effective date: 20130910 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20130910 Address after: China Taiwan Taipei Zhongzheng District Ross road section of No. 46 5 floor 1 Patentee after: Basic biotechnology Limited by Share Ltd Address before: 285, Lane 15, 4 Wuxing street, Xinyi District, Taipei, Taiwan, China Patentee before: Ansheng Biological Technology Co., Ltd. |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20151223 Address after: Songshan District, Taipei, China Nanjing East Road, No. 248, No. 17, building three, Taiwan Patentee after: Asian fashion Limited by Share Ltd Address before: China Taiwan Taipei Zhongzheng District Ross road section of No. 46 5 floor 1 Patentee before: Basic biotechnology Limited by Share Ltd |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130626 Termination date: 20190801 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |