CN103784487A - Ginseng micro-powder tablet and preparation method thereof - Google Patents
Ginseng micro-powder tablet and preparation method thereof Download PDFInfo
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- CN103784487A CN103784487A CN201410084452.2A CN201410084452A CN103784487A CN 103784487 A CN103784487 A CN 103784487A CN 201410084452 A CN201410084452 A CN 201410084452A CN 103784487 A CN103784487 A CN 103784487A
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Abstract
The invention relates to a preparation method of a ginseng micro-powder tablet. The method includes the following steps of selecting raw materials, conducting drying, sterilizing, freezing grinding, dry granulating and tabletting, and obtaining the ginseng micro-powder tablet. The invention further provides the ginseng micro-powder tablet prepared through the method. The ginseng micro-powder tablet is attractive in appearance and low in surface pitting rate and fracture rate, and the hardness, the disintegration degree and friability of the ginseng micro-powder tablet meet the requirements for tablet quality. According to the method, the extraction process is omitted, a large amount of ethyl alcohol for extraction solvent can be saved, the production cycle is greatly shortened, and production cost can be greatly reduced. Most importantly, all natural ingredients of ginseng are kept.
Description
Technical field
The present invention relates to a kind of Radix Ginseng micropowder's sheet, and preparation method thereof, biomedicine field belonged to.
Background technology
Radix Ginseng is the traditional rare Chinese medicine of China, has the laudatory title of " the BAICAO king of medicine ", and its property is flat, sweet in the mouth, micro-hardship, tepor, has strongly invigorating primordial QI, and multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, effect of the Fructus Alpiniae Oxyphyllae of calming the nerves.Radix Ginseng is applied to the tcm clinical practice history of existing more than 2000 year, and its pharmacological action widely and medicinal approaches have been subject to the attention of Chinese scholars.In recent years, chemistry, pharmacology and clinical research prove: the multiple pharmacological effect such as Radix Ginseng has memory reinforcing, improves immunity, improves cardiovascular, slow down aging and antitumor.Be used for the treatment of clinically the treatment of the diseases such as cardiovascular, harmonization of the stomach hepatic disease, neurasthenia, antitumor, antioxidation.
While finding that in the process of research Radix Ginseng is ground into particle diameter and is the micropowder rank powder of ﹤ 10 μ m, its dissolution rate is high, and the particle diameter of pulverizing is less, and dissolution time is faster, can guarantee within the shortest time, and active constituents of medicine reaches the concentration that needs for the treatment of disease.If micropowder direct compression can make full use of this resource and adapt to the feature that it belongs to concentration dependent medicine.But because the micropowder surface tension of ﹤ 10 μ m particle diameters is large, between powder, space is very large, direct compression difference of hardness, numb sheet rate are high, therefore need to granulate to solve the problems referred to above.If moisture Control is incorrect in wet granulation, be prone to sticking, shedding, sliver, fall the technical problem such as piece, loose sheet, and Radix Ginseng micropowder of the present invention adopts after dry granulation, compressibility, good fluidity, the qualification rate of Radix Ginseng micropowder's sheet is high, fiber crops sheet rate, sliver rate are low, and hardness, disintegration meet the prescription of tablet.
Chinese patent application (CN102077946A) nano American ginseng buccal tablet, this patent discloses Radix Panacis Quinquefolii powder and has added sweeting agent, forming agent and binding agent to suppress and form after wet granulation.At present, only there is not yet Radix Ginseng powder is broken into after micropowder, in the situation that not adding any adjuvant, be pressed into the report of tablet.
Summary of the invention
The present invention is directed to the problems of the prior art provides a kind of preparation method of Radix Ginseng micropowder's sheet, and the Radix Ginseng micropowder's sheet being prepared from by the method.The present invention can remain the effective ingredient in Radix Ginseng completely, and the present invention contains Radix Ginseng pure natural components, and its local flavor is natural, and taking convenience, good absorbing are not added any adjuvant.
A preparation method for Radix Ginseng micropowder's sheet, comprises the following steps:
(1) choose raw material Radix Ginseng, Radix Ginseng is cleaned, cook dry in the sun;
(2) Radix Ginseng after dry in the sun is dried in the ventilated drying oven of 60 ℃, to the content of moisture be 4-14%;
(3) Radix Ginseng after drying is carried out to ozone sterilization, wherein, when ozone sterilization, the concentration of ozone is 50-60mg/m
3, sterilization time is 4-6h.
(4) Radix Ginseng after sterilizing is soaked in liquid nitrogen, the Radix Ginseng after soaking is carried out to deep cooling crush, the particle diameter being ground into is the micropowder of 1-10 μ m;
(5) Radix Ginseng micropowder who step (4) is made carries out dry granulation, through overcompression, molding, coarse crushing, granulate and get final product, and makes the particle diameter after dry granulation be less than or equal to 80 orders Radix Ginseng micropowder;
(6) ginseng granules after granulating is carried out to tabletting, to obtain final product.
After dry granulation refers to drug powder (adding if desired diluent etc.) is mixed, be directly pressed into piece with suitable equipment, then be broken into the method for required size particles.This method makes to produce between particle adhesion by the effect of compression stress.Can be divided into double compression and rolling process.
Further, in above-mentioned steps (5), when dry granulation, temperature is 20-25 ℃, and humidity is 40-50%, and pressure is 10-20kN;
Further, in step (6), when the ginseng granules after granulating is carried out to tabletting, temperature is 20-25 ℃, and humidity is 40-50%, and tablet machine precompression is 20-30kN, and principal pressure is 30-50kN.
In the preparation method of above-mentioned Radix Ginseng micropowder's sheet, after dry granulation, adopt precompressed step when tabletting, be beneficial to the air of getting rid of in powder, reduce sliver, increase the hardness of tablet.Adopt this technical scheme, under the situation of not adding any adjuvant, the tablet appearance making is good, fiber crops sheet rate and sliver rate are low, tablet hardness, disintegration, friability meet tablet quality requirement, and this hardness can also guarantee that the later stage carries out coating, overlay film processing to this tablet, be unlikely to cracked in preparation process.
Meanwhile, preparation is because of without interpolation adjuvant when micropowder tablet of the present invention, and user needn't be taken the adjuvant without drug effect more, can guarantee as much as possible that Radix Ginseng high concentration is to give full play to the activity of medicine.
Low compared with the preparation cost of Radix Ginseng extract tabletting with Radix Ginseng micropowder's tabletting, but also the loss of effective ingredient can prevent from extracting time, preparation technology is simple.Radix Ginseng micropowder tablet of the present invention absorbs approach by oral mucosa in conjunction with oral gastrointestinal, effective ingredient in Radix Ginseng micropowder is entered rapidly in body, can overcome the first pass effect of liver, improve curative effect, and taking convenience, the meaning of its clinical meaning and the utilization of resources is very great.
Accompanying drawing explanation
Fig. 1 is 2000 times of scanning electron microscope (SEM) photographs of Radix Ginseng micropowder in Radix Ginseng micropowder tablet of the present invention;
Fig. 2 is 7000 times of scanning electron microscope (SEM) photographs of Radix Ginseng micropowder in Radix Ginseng micropowder tablet of the present invention;
Fig. 3 is 7000 times of scanning electron microscope (SEM) photographs of Radix Ginseng micropowder in Radix Ginseng micropowder tablet of the present invention;
Fig. 4 is 5000 times of scanning electron microscope (SEM) photographs of Radix Ginseng micropowder in Radix Ginseng micropowder tablet of the present invention.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But embodiment is only exemplary, scope of the present invention is not formed to any restriction.It will be understood by those skilled in the art that lower without departing from the spirit and scope of the present invention and can the details of technical solution of the present invention and form be modified or be replaced, but these modifications and replacement all fall within the scope of protection of the present invention.
The preparation method of embodiment 1 Radix Ginseng micropowder's sheet
Concrete steps are as follows:
(1) get Radix Ginseng 10Kg, clean twice by purified water, after Radix Ginseng is cooked, dry, be placed in 60 ℃ of heated-air circulation ovens oven dry to mass fractions that contain moisture and be about 10%.
(2) Radix Ginseng after drying is carried out to ozone sterilization, wherein, when ozone sterilization, the concentration of ozone is 50-60mg/m
3, sterilization time is 4-6h.
(3) Radix Ginseng after sterilizing is soaked in liquid nitrogen, the Radix Ginseng after soaking is carried out to deep cooling crush, the particle diameter being ground into is the micropowder of 1-10 μ m;
(4) Radix Ginseng micropowder who step (4) is made carries out dry granulation; by Radix Ginseng micropowder through overcompression, molding, coarse crushing, granulate and get final product; and make the particle diameter after dry granulation be less than or equal to 80 orders; wherein; when dry granulation; temperature is 20-25 ℃, and humidity is 40-50%, and pressure is 10-20kN(Japan friendship dry granulating machine IF-MINI).
(5) ginseng granules after granulating is carried out to tabletting, utilize Fitow P2020 tablet machine to carry out tabletting, in the time of tabletting for get rid of granulate after air in powder, reduce sliver and increase hardness, increase precompressed step, wherein, temperature is 20-25 ℃, humidity is 40-50%, and preload pressure is 20-30KN, and principal pressure is 30-50KN.
(6) product after film-making is first carried out to inner packing with Aluminium-coating Packer, then carry out outer package with complex pocket and carton.
Test example 1 is carried out scanning electron microscope experiment to Radix Ginseng micropowder in the present invention
Get the micropowder sample of Radix Ginseng of the present invention after deep cooling crush, carry out scanning electron microscope experiment, choose a little sample on sample platform of scanning electronic microscope with ophthalmic tweezers, carry out critical point drying metal spraying.In S-520 type Hitachi electron scanning Electronic Speculum, scan, amplify corresponding multiple, take pictures and measure.Observe particle diameter and the form of Radix Ginseng micropowder tablet.Analyze according to Radix Ginseng micropowder's sheet scanning electron microscope (SEM) photograph (Fig. 1-4), Radix Ginseng powder has lamellar, circle and irregularly shaped, and below particle size distribution 10 μ m, mean diameter degree is at 5 μ m.The performance of analyzing Radix Ginseng powder's tabletting according to Radix Ginseng powder's scanning electron microscope (SEM) photograph, powder is good with circular flow in the form of sheets, but poor compressibility, the sheet of extrusion is easily broken.Do not add the tablet of any adjuvant compacting, difference of hardness, fugitive frangible, therefore we carry out tabletting after adopting dry granulation again, yield rate is high, and numb sheet rate and sliver rate low, tablet hardness, disintegration, friability meet tablet quality requirement.
The quality of Radix Ginseng micropowder's sheet of test example 2 preparation technology parameter of the present invention and preparation thereof is as shown in table 1:
It is simple that the present invention prepares tablet technology, feasibility is strong, Radix Ginseng micropowder's tablets is convenient, easily absorb, retain Radix Ginseng pure natural components completely as various ginsenosides, panax acid, oleanolic acid, plurality of inorganic salt (zinc, selenium, manganese, molybdenum, strontium, copper, ferrum, potassium, magnesium), several amino acids and vitamin (B1, B2, C) and volatile ingredient etc., retained the natural flavour mountaineous of Radix Ginseng.
Claims (4)
1. a preparation method for Radix Ginseng micropowder's sheet, is characterized in that, comprises the following steps:
(1) choose raw material Radix Ginseng, Radix Ginseng is cleaned, cook dry in the sun;
(2) Radix Ginseng after steaming and decocting is dried in the ventilated drying oven of 60 ℃, to the content of moisture be 4-14%;
(3) Radix Ginseng after drying is carried out to ozone sterilization, wherein, when ozone sterilization, the concentration of ozone is 50-60mg/m
3, sterilization time is 4-6h.
(4) Radix Ginseng after sterilizing is soaked in liquid nitrogen, the Radix Ginseng after soaking is carried out to deep cooling crush, the particle diameter being ground into is the micropowder of 1-10 μ m;
(5) Radix Ginseng micropowder who step (4) is made carries out dry granulation, through overcompression, molding, coarse crushing, granulate and get final product, and makes the particle diameter after dry granulation be less than or equal to 80 orders Radix Ginseng micropowder;
(6) ginseng granules after granulating is carried out to tabletting, to obtain final product.
After dry granulation refers to drug powder (adding if desired diluent etc.) is mixed, be directly pressed into piece with suitable equipment, then be broken into the method for required size particles.This method makes to produce between particle adhesion by the effect of compression stress.Can be divided into double compression and rolling process.
2. the preparation method of Radix Ginseng micropowder's sheet according to claim 1, is characterized in that, in described step (5), when dry granulation, temperature is 20-25 ℃, and humidity is 40-50%, and pressure is 10-20kN.
3. the preparation method of Radix Ginseng micropowder's sheet according to claim 1, is characterized in that, in described step (6), when ginseng granules after granulating is carried out to tabletting, temperature is 20-25 ℃, and humidity is 40-50%, tablet machine precompression is 20-30kN, and principal pressure is 30-50kN.
4. Radix Ginseng micropowder's sheet that the preparation method of the Radix Ginseng micropowder's sheet as described in claim 1-3 any one makes.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055936A (en) * | 2014-07-11 | 2014-09-24 | 郭海涛 | Method for preparing lycium barbarum tablet |
| CN104107192A (en) * | 2014-06-27 | 2014-10-22 | 山东东阿阿胶股份有限公司 | Small molecular donkey-hide gelatin pure powder tablet and preparation method thereof |
| CN104189008A (en) * | 2014-08-13 | 2014-12-10 | 山东东阿阿胶股份有限公司 | Preparation method of micronized corn cervi pantotrichum tablet |
| CN104783162A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
| CN104783163A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
| CN105832791A (en) * | 2015-08-13 | 2016-08-10 | 吉林长白绿叶人参产业有限公司 | Pure under-forest ginseng powder tablet and preparation method thereof |
| CN106109506A (en) * | 2016-07-19 | 2016-11-16 | 湖州新驰医药科技有限公司 | A kind of Periostracum cicadae micropowder tablet and preparation method thereof |
| CN106109505A (en) * | 2016-07-19 | 2016-11-16 | 湖州新驰医药科技有限公司 | A kind of Cordyceps cicadae Shing micropowder tablet and preparation method thereof |
| CN106472749A (en) * | 2016-10-25 | 2017-03-08 | 广东省农业科学院茶叶研究所 | A kind of purple bud ginseng tea and preparation method thereof |
| CN109329347A (en) * | 2018-12-03 | 2019-02-15 | 江西省农业科学院农产品质量安全与标准研究所 | Processing method and the flour cake containing rape seed powder of a kind of rape seed powder and preparation method thereof |
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| CN103316060A (en) * | 2013-06-06 | 2013-09-25 | 黑龙江省农业科学院食品加工研究所 | Preparation method of ginseng powder and American ginseng powder |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104107192A (en) * | 2014-06-27 | 2014-10-22 | 山东东阿阿胶股份有限公司 | Small molecular donkey-hide gelatin pure powder tablet and preparation method thereof |
| CN104107192B (en) * | 2014-06-27 | 2018-06-22 | 山东东阿阿胶股份有限公司 | A kind of small molecule colla asini pure powder piece and preparation method thereof |
| CN104055936A (en) * | 2014-07-11 | 2014-09-24 | 郭海涛 | Method for preparing lycium barbarum tablet |
| CN104189008A (en) * | 2014-08-13 | 2014-12-10 | 山东东阿阿胶股份有限公司 | Preparation method of micronized corn cervi pantotrichum tablet |
| CN104189008B (en) * | 2014-08-13 | 2017-11-03 | 山东东阿阿胶股份有限公司 | A kind of preparation method of Penis et testis cervi micropowder piece |
| CN104783162A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
| CN104783163A (en) * | 2015-04-27 | 2015-07-22 | 威海环翠楼红参科技有限公司 | Preparation method of novel resource food Korean red ginseng wall-broken micron particles |
| CN105832791A (en) * | 2015-08-13 | 2016-08-10 | 吉林长白绿叶人参产业有限公司 | Pure under-forest ginseng powder tablet and preparation method thereof |
| CN106109506A (en) * | 2016-07-19 | 2016-11-16 | 湖州新驰医药科技有限公司 | A kind of Periostracum cicadae micropowder tablet and preparation method thereof |
| CN106109505A (en) * | 2016-07-19 | 2016-11-16 | 湖州新驰医药科技有限公司 | A kind of Cordyceps cicadae Shing micropowder tablet and preparation method thereof |
| CN106472749A (en) * | 2016-10-25 | 2017-03-08 | 广东省农业科学院茶叶研究所 | A kind of purple bud ginseng tea and preparation method thereof |
| CN109329347A (en) * | 2018-12-03 | 2019-02-15 | 江西省农业科学院农产品质量安全与标准研究所 | Processing method and the flour cake containing rape seed powder of a kind of rape seed powder and preparation method thereof |
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Application publication date: 20140514 |