CN105943509A - Radix angelicae sinensis and tangerine peel chewable tablet capable of reducing fever and causing dieresis and preparation method of Chinese angelica and tangerine peel chewable tablet - Google Patents
Radix angelicae sinensis and tangerine peel chewable tablet capable of reducing fever and causing dieresis and preparation method of Chinese angelica and tangerine peel chewable tablet Download PDFInfo
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- 239000007910 chewable tablet Substances 0.000 title claims abstract description 24
- 229940068682 chewable tablet Drugs 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims description 7
- 241000675108 Citrus tangerina Species 0.000 title abstract 7
- 241000213006 Angelica dahurica Species 0.000 title abstract 3
- 206010037660 Pyrexia Diseases 0.000 title abstract 2
- 239000000843 powder Substances 0.000 claims abstract description 22
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 13
- 241000233866 Fungi Species 0.000 claims abstract description 8
- 229920002472 Starch Polymers 0.000 claims abstract description 8
- 240000001085 Trapa natans Species 0.000 claims abstract description 8
- 235000009165 saligot Nutrition 0.000 claims abstract description 8
- 239000008107 starch Substances 0.000 claims abstract description 8
- 235000019698 starch Nutrition 0.000 claims abstract description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000001543 Corylus americana Nutrition 0.000 claims abstract description 7
- 235000007466 Corylus avellana Nutrition 0.000 claims abstract description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 7
- 229930195725 Mannitol Natural products 0.000 claims abstract description 7
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 7
- 239000000594 mannitol Substances 0.000 claims abstract description 7
- 235000010355 mannitol Nutrition 0.000 claims abstract description 7
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 7
- 239000000661 sodium alginate Substances 0.000 claims abstract description 7
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 7
- 238000000855 fermentation Methods 0.000 claims abstract description 5
- 230000004151 fermentation Effects 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 240000009226 Corylus americana Species 0.000 claims abstract 3
- 241000125175 Angelica Species 0.000 claims description 35
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 230000001737 promoting effect Effects 0.000 claims description 15
- 208000004880 Polyuria Diseases 0.000 claims description 13
- 230000035619 diuresis Effects 0.000 claims description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000004005 microsphere Substances 0.000 claims description 7
- 244000242564 Osmanthus fragrans Species 0.000 claims description 6
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- 238000003756 stirring Methods 0.000 claims description 6
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- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 3
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 3
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- 108010080698 Peptones Proteins 0.000 claims description 3
- 230000033228 biological regulation Effects 0.000 claims description 3
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- 238000000227 grinding Methods 0.000 claims description 3
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- 235000019319 peptone Nutrition 0.000 claims description 3
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- 239000006228 supernatant Substances 0.000 claims description 3
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- 240000002853 Nelumbo nucifera Species 0.000 abstract 1
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- 241000333181 Osmanthus Species 0.000 abstract 1
- 235000003283 Pachira macrocarpa Nutrition 0.000 abstract 1
- 244000179684 Passiflora quadrangularis Species 0.000 abstract 1
- 235000011266 Passiflora quadrangularis Nutrition 0.000 abstract 1
- 235000014364 Trapa natans Nutrition 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
- 241000723382 Corylus Species 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
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- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
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- QYZBCWXZSYTIOY-UHFFFAOYSA-N Mercuric oxide Chemical compound [O-2].[Hg+2] QYZBCWXZSYTIOY-UHFFFAOYSA-N 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
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- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a Chinese angelica and tangerine peel chewable tablet capable of reducing fever and causing dieresis. The Chinese angelica and tangerine peel chewable tablet is prepared from the following raw materials: 60 to 70 parts of radix angelicae sinensis, 20 to 25 parts of tangerine peel, 4 to 6 parts of black fungus powder, 14 to 15 parts of cucumber, 20 to 24 parts of water chestnut starch, 5 to 7 parts of stem and leaf of cabbage, 7 to 10 parts of grenadine juice, 3 to 5 parts of lotus leaves, 2 to 4 parts of coix seed, 0.5 to 0.6 part of sweet-scented osmanthus powder, 6 to 9 parts of hazelnut kernel powder, 8 to 10 parts of mannitol, 6 to 8 parts of magnesium stearate, 50 to 60 parts of chitosan, and an appropriate amount of sodium alginate solution. The radix angelicae sinensis and the tangerine peel are combined to prepare a chewable tablet, a very good blood replenishing effect is achieved, the anemia crowd is convenient to take the chewable tablet when being in an anaemic symptom, the harm brought by the anaemic symptom can be reduced, the radix angelicae sinensis and the tangerine peel are prepared into enzymes through fermentation, the drug effect can be enhanced, rapid absorption is facilitated, the chewable tablet is wrapped in a microballoon, pungent odor and taste can be effectively covered, and chewable tablet taking is facilitated.
Description
Technical field
The present invention relates to food processing technology field, particularly relate to a kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet and preparation method thereof.
Background technology
Radix Angelicae Sinensis, for the dry root of umbelliferae angelica.Main product the southeast of Gansu, is secondly that Yunnan, Sichuan, Shaanxi, Hubei etc. save, is cultivation.There is replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.It is usually used in blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis weighs due to its sweet in the mouth, therefore specially can enrich blood, and its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, has benefit in row, is the panacea enriched blood of circulation of qi promoting.
Pericarpium Citri Reticulatae is conventional Chinese medicine, has regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Ming Dynasty's Li Shizhen (1518-1593 A.D.) cloud: " then mend with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then drop with fall medicine.Spleen is the mother of Primordial Qi, is the label taking the photograph gas, therefore Pericarpium Citri tangerinae is two through the medicine of edema caused by disorder of QI, but with join and reinforcing and reducing lift also." Pericarpium Citri Reticulatae can significantly reduce blood fat, significantly alleviates hepatocellular esterified degree, there are obvious blood fat reducing, prevention of arterial hardening and anti-high blood coagulation state effect, and Pericarpium Citri Reticulatae can suppress platelet aggregation, and there is reduction erythrocyte aggregation.
Anemia refers to that human peripheral blood erythrocyte volume reduces, less than a kind of common clinical symptoms of lower limit normal range.Pericarpium Citri Reticulatae and Radix Angelicae Sinensis collocation have effect of well enriching blood, and daily can have some improvement anemia.But owing to inconvenience taken by Chinese medicine, need to be processed making it easy to carry and take to them.The chewable tablet occurred on market can meet requirement, therefore they can be made chewable tablet, the most easy to carry, conveniently takes, and can quantitatively take, it is to avoid disposably takes and damage human body too much.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that a kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet and preparation method thereof.
The present invention is achieved by the following technical solutions:
A kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet, is made up of the raw material of following weight portion: Radix Angelicae Sinensis 60-70, Pericarpium Citri Reticulatae 20-25, black fungus powder 4-6, Fructus Cucumidis sativi 14-15, water caltrop starch 20-24, Caulis et Folium Brassicae capitatae 5-7, Sucus Granati 7-10, Folium Nelumbinis 3-5, Semen Coicis 2-4, pollen powder of sweet osmanthus 0.5-0.6, hazelnut kernel powder 6-9, mannitol 8-10, magnesium stearate 6-8, chitosan 50-60, sodium alginate soln are appropriate.
The preparation method of described a kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet, comprises the following steps:
(1) the soak by water 60-70min of 5-6 times is added after Radix Angelicae Sinensis, Pericarpium Citri Reticulatae being cleaned together, after filtration, medicinal residues are pulverized standby, filtrate adds ethanol stirring after being concentrated into the 20-30% of volume be 65-70% to alcohol content, take supernatant after standing 20-24h and reclaim ethanol, after spray drying, obtain angelica and dried orange peel water extract；
(2) it is ground into 40-50 mesh after draining moisture after Fructus Cucumidis sativi, Caulis et Folium Brassicae capitatae, Folium Nelumbinis, Semen Coicis being cleaned roguing, the water of the weight such as addition and the peptone of 2-3%, through 110-120 DEG C of autoclave sterilization 25-30min, then first regulating mixture pH after being cooled to 35-37 DEG C is 5.5-6, then the bacillus acidophilus after overactivation accessing 4-5% is fermented 20-25h, then the medicinal residues adding angelica and dried orange peel continue fermentation 8-12h, and dried ultramicronising is pulverized and obtained angelica and dried orange peel ferment；
(3) add chitosan in 1% acetum of certain mass and dissolve, then with after sodium hydroxide solution regulation pH to 6.0, obtain chitosan solution standby, angelica and dried orange peel ferment is added in the sodium alginate soln of appropriate 15g/L and dissolve, it is then added in certain density calcium chloride solution, continuously stirred 25-30min, bead is collected after filtration, bead is put in chitosan solution, continuously stirred crosslinking 50-60min, at a temperature of 40 DEG C, it is dried 20-24h after sucking filtration washing, obtains angelica and dried orange peel ferment microsphere；
(4) angelica and dried orange peel ferment microsphere, the water extract of angelica and dried orange peel, black fungus powder, water caltrop starch, Sucus Granati, pollen powder of sweet osmanthus, hazelnut kernel powder, mannitol co-grinding are crossed 60 mesh sieves, it is subsequently adding the water of 10% weight portion, stir and be placed in the vacuum drying oven of 55-65 DEG C that to be dried to water content be 2.5-3.5%, obtain mixing soft material；
(5) will mix after soft material is pulverized and cross 14-18 mesh sieve, and be subsequently adding magnesium stearate, after mix homogeneously, carry out tabletting, obtain clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet.
The invention have the advantage that the present invention is by making chewable tablet and have, by Radix Angelicae Sinensis and Pericarpium Citri Reticulatae combination, effect of well enriching blood, anemia crowd can be made conveniently to take when Anemia, reduce its harm brought, angelica and dried orange peel is made ferment by fermentation and can strengthen drug effect, contribute to quickly absorbing, it is wrapped in microsphere and can effectively be covered its irritating abnormal smells from the patient and mouthfeel, be conducive to taking.The black fungus powder of interpolation, water caltrop starch etc. are nutritious, enrich the trophic structure of chewable tablet, and the Fructus Cucumidis sativi of use, Folium Nelumbinis have the health-care effecies such as clearing away heat and promoting diuresis.
Detailed description of the invention
A kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet, is made up of the raw material of following weight portion (kg): Radix Angelicae Sinensis 60, Pericarpium Citri Reticulatae 20, black fungus powder 4, Fructus Cucumidis sativi 14, water caltrop starch 20, Caulis et Folium Brassicae capitatae 5, Sucus Granati 7, Folium Nelumbinis 3, Semen Coicis 2, pollen powder of sweet osmanthus 0.5, hazelnut kernel powder 6, mannitol 8, magnesium stearate 6, chitosan 50, sodium alginate soln are appropriate.
The preparation method of described a kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet, comprises the following steps:
(1) the soak by water 60min of 5 times is added after Radix Angelicae Sinensis, Pericarpium Citri Reticulatae being cleaned together, after filtration, medicinal residues are pulverized standby, filtrate be concentrated into volume 20% after to add ethanol stirring be 65% to alcohol content, stand and take supernatant after 20h and reclaim ethanol, after spray drying, obtain angelica and dried orange peel water extract；
(2) it is ground into 40 mesh after draining moisture after Fructus Cucumidis sativi, Caulis et Folium Brassicae capitatae, Folium Nelumbinis, Semen Coicis being cleaned roguing, the water of the weight such as addition and the peptone of 2%, through 110 DEG C of autoclave sterilization 25min, then first regulating mixture pH after being cooled to 35 DEG C is 5.5, then access the bacillus acidophilus after overactivation of 4% to ferment 20h, then the medicinal residues adding angelica and dried orange peel continue fermentation 8h, and dried ultramicronising is pulverized and obtained angelica and dried orange peel ferment；
(3) add chitosan in 1% acetum of certain mass and dissolve, then with after sodium hydroxide solution regulation pH to 6.0, obtain chitosan solution standby, angelica and dried orange peel ferment is added in the sodium alginate soln of appropriate 15g/L and dissolve, it is then added in certain density calcium chloride solution, continuously stirred 25min, bead is collected after filtration, bead is put in chitosan solution, continuously stirred crosslinking 50min, at a temperature of 40 DEG C, it is dried 20h after sucking filtration washing, obtains angelica and dried orange peel ferment microsphere；
(4) angelica and dried orange peel ferment microsphere, the water extract of angelica and dried orange peel, black fungus powder, water caltrop starch, Sucus Granati, pollen powder of sweet osmanthus, hazelnut kernel powder, mannitol co-grinding are crossed 60 mesh sieves, it is subsequently adding the water of 10% weight portion, stir and be placed in the vacuum drying oven of 55 DEG C that to be dried to water content be 2.5%, obtain mixing soft material；
(5) will mix after soft material is pulverized and cross 14 mesh sieves, and be subsequently adding magnesium stearate, after mix homogeneously, carry out tabletting, obtain clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet.
Claims (2)
1. a clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet, it is characterized in that, be made up of the raw material of following weight portion: Radix Angelicae Sinensis 60-70, Pericarpium Citri Reticulatae 20-25, black fungus powder 4-6, Fructus Cucumidis sativi 14-15, water caltrop starch 20-24, Caulis et Folium Brassicae capitatae 5-7, Sucus Granati 7-10, Folium Nelumbinis 3-5, Semen Coicis 2-4, pollen powder of sweet osmanthus 0.5-0.6, hazelnut kernel powder 6-9, mannitol 8-10, magnesium stearate 6-8, chitosan 50-60, sodium alginate soln are appropriate.
The preparation method of a kind of clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet the most according to claim 1, it is characterised in that comprise the following steps:
(1) the soak by water 60-70min of 5-6 times is added after Radix Angelicae Sinensis, Pericarpium Citri Reticulatae being cleaned together, after filtration, medicinal residues are pulverized standby, filtrate adds ethanol stirring after being concentrated into the 20-30% of volume be 65-70% to alcohol content, take supernatant after standing 20-24h and reclaim ethanol, after spray drying, obtain angelica and dried orange peel water extract；
(2) it is ground into 40-50 mesh after draining moisture after Fructus Cucumidis sativi, Caulis et Folium Brassicae capitatae, Folium Nelumbinis, Semen Coicis being cleaned roguing, the water of the weight such as addition and the peptone of 2-3%, through 110-120 DEG C of autoclave sterilization 25-30min, then first regulating mixture pH after being cooled to 35-37 DEG C is 5.5-6, then the bacillus acidophilus after overactivation accessing 4-5% is fermented 20-25h, then the medicinal residues adding angelica and dried orange peel continue fermentation 8-12h, and dried ultramicronising is pulverized and obtained angelica and dried orange peel ferment；
(3) add chitosan in 1% acetum of certain mass and dissolve, then with after sodium hydroxide solution regulation pH to 6.0, obtain chitosan solution standby, angelica and dried orange peel ferment is added in the sodium alginate soln of appropriate 15g/L and dissolve, it is then added in certain density calcium chloride solution, continuously stirred 25-30min, bead is collected after filtration, bead is put in chitosan solution, continuously stirred crosslinking 50-60min, at a temperature of 40 DEG C, it is dried 20-24h after sucking filtration washing, obtains angelica and dried orange peel ferment microsphere；
(4) angelica and dried orange peel ferment microsphere, the water extract of angelica and dried orange peel, black fungus powder, water caltrop starch, Sucus Granati, pollen powder of sweet osmanthus, hazelnut kernel powder, mannitol co-grinding are crossed 60 mesh sieves, it is subsequently adding the water of 10% weight portion, stir and be placed in the vacuum drying oven of 55-65 DEG C that to be dried to water content be 2.5-3.5%, obtain mixing soft material；
(5) will mix after soft material is pulverized and cross 14-18 mesh sieve, and be subsequently adding magnesium stearate, after mix homogeneously, carry out tabletting, obtain clearing away heat and promoting diuresis angelica and dried orange peel chewable tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610371726.5A CN105943509A (en) | 2016-05-31 | 2016-05-31 | Radix angelicae sinensis and tangerine peel chewable tablet capable of reducing fever and causing dieresis and preparation method of Chinese angelica and tangerine peel chewable tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610371726.5A CN105943509A (en) | 2016-05-31 | 2016-05-31 | Radix angelicae sinensis and tangerine peel chewable tablet capable of reducing fever and causing dieresis and preparation method of Chinese angelica and tangerine peel chewable tablet |
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| CN105943509A true CN105943509A (en) | 2016-09-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2619509A (en) * | 2022-06-06 | 2023-12-13 | Plant Mat Limited | Fungal materials |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2619509A (en) * | 2022-06-06 | 2023-12-13 | Plant Mat Limited | Fungal materials |
| US12031266B2 (en) | 2022-06-06 | 2024-07-09 | Plant Material Limited | Fungal materials |
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Application publication date: 20160921 |
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