CN104189008B - A kind of preparation method of Penis et testis cervi micropowder piece - Google Patents
A kind of preparation method of Penis et testis cervi micropowder piece Download PDFInfo
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- CN104189008B CN104189008B CN201410396508.8A CN201410396508A CN104189008B CN 104189008 B CN104189008 B CN 104189008B CN 201410396508 A CN201410396508 A CN 201410396508A CN 104189008 B CN104189008 B CN 104189008B
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Abstract
The present invention provides a kind of preparation method of Penis et testis cervi micropowder piece, comprises the following steps：(1) pilose antler piece is carried out except raw meat is processed；(2) by except the pilose antler piece coarse powder after raw meat, the deep cooling crush at a temperature of subzero 30 DEG C to subzero 20 DEG C is crushed to the micro mist of 10 20 μm of particle diameter；(3) Penis et testis cervi micropowder is subjected to dry granulation, tabletting machine produces Penis et testis cervi micropowder piece.The preparation method of the present invention is only with two kinds of raw materials of jujube and pilose antler, and jujube be able to can be both seasoned again with deodorant, completely without additionally adding unsound sweetener again；Simultaneously using the preparation process of tabletting after dry granulation, beneficial to the air excluded in powder, sliver is reduced, increases the hardness of tablet.Using above-mentioned technical proposal, in the case of any auxiliary material is not added with, obtained tablet appearance is good, and numb piece rate and sliver rate are low, and tablet hardness, disintegration, friability meet tablet quality requirement.
Description
Technical field
The present invention relates to biopharmaceutical technology, more particularly, to a kind of preparation method of Penis et testis cervi micropowder piece.
Background technology
Pilose antler is a kind of rare Chinese medicine, takes from sika deer (CervusnipponTemminck) or red deer (C.Elaohus
L not yet ossified young horn), it can be considered that being a natural growth factor storehouse.Ancient books is recorded：Pilose antler is sweet, warm-natured,
Lead extravesated blood, fever and chills frightened epilepsy, the strong will of QI invigorating, the population is not old, warming kidney and enhancing body, production of sperm benefit blood, strengthening tendons mends marrow.Cure mainly consumptive disease thin
Thin, dizziness due to deficiency of blood, soreness of waist and knee, impotence and premature ejaculation, wound is not cured long, brain tonic, intelligence development, green blood, salubrity, synthetism, improves sexual performance, is promoted
Enter the formula of wound healing preparation based on pilose antler.Modern pharmacology research shows that pilose antler has many pharmacological actions, example
Such as：Angiocarpy, nervous system；Sugar, fat, protein metabolism；Immunological regulation, anti-inflammatory is antitumor, brain tonic, anti-ageing pharmacology work of waiting for a long time
With.
When finding that pilose antler is ground into the micro mist scaled powders that particle diameter is 20 μm of ﹤ in the course of the study, its dissolution rate is high,
And the particle diameter crushed is smaller, dissolution time is faster, can guarantee that within the most short time, and active constituents of medicine reaches treatment disease
Need concentration.If micro mist direct tablet compressing can make full use of the resource and adapt to the characteristics of it belongs to concentration dependent medicine.
But be due to 20 μm of particle diameters of ﹤ micro mist surface tension it is big, space is very big between powder, and direct tablet compressing difference of hardness, numb piece rate are high, therefore
Granulation is needed to solve the above problems.If in wet granulation moisture control it is incorrect, easily occur sticking, shedding, sliver, chip off-falling,
The technical problems such as loose pieces.
There is poor taste, fishy smell weight, the problem of taking inconvenience, it is necessary to find a kind of improvement pilose antler in current pilose antler preparation
Mouthfeel, conveniently takes, and preserves the instructions of taking for whole active ingredients that pilose antler contains.
Chinese patent application (CN1401330A) discloses a kind of Buccal red deer horn tablet, which disclose pilose antler and adds sweet taste
Compacting is formed after agent, forming agent and adhesive.Multiple auxiliary materials perhaps are with the addition of, containing for unit mass pilose antler active composition is reduced
Amount.
The content of the invention
Present invention solves the technical problem that being just to provide a kind of preparation method of Penis et testis cervi micropowder piece, and pass through the method
The Penis et testis cervi micropowder piece being prepared from.The preparation method of the present invention need not add numerous auxiliary materials such as forming agent, adhesive, flavor enhancement,
It is tabletted it is also possible to which Penis et testis cervi micropowder is succeeded, and tablet appearance is good, numb piece rate and sliver rate are low；Simultaneously can be by pilose antler
Active ingredient be fully retained, improve pilose antler take inconvenience, the problem of fishy smell is heavier.
The technical scheme is that：A kind of preparation method of Penis et testis cervi micropowder piece, comprises the following steps：
(1) pilose antler piece is carried out except raw meat is processed：50-100 parts by weight jujube or red date powder or red date slices are weighed, are added
30-40 times of weight water boils 30min-60min, crosses 300-100 mesh sieves, obtains jujube water；This jujube is water-cooled to 60-70 DEG C, plus
Enter 400-500 parts by weight pilose antler piece infiltration 20min, be then heated to boiling and boil 15-20 seconds, take out pilose antler and drain the water；Again
Pilose antler is put into above-mentioned jujube water and boiled again 15-20 seconds, is taken the dish out of the pot, is placed in after draining the water in 50-60 DEG C of aeration cabinet
Drying to moisture is 5%-10%, obtains pilose antler piece coarse powder；
(2) by except the pilose antler piece coarse powder after raw meat, the deep cooling crush at a temperature of subzero 30 DEG C to subzero 20 DEG C is crushed to
The micro mist of 10-20 μm of particle diameter；
(3) Penis et testis cervi micropowder is subjected to dry granulation, tabletting machine produces Penis et testis cervi micropowder piece.
The preparation method of the Penis et testis cervi micropowder piece of the present invention, wherein dry granulation is to use dry granulating machine in the step (3)
Through overcompression, shaping, coarse crushing, whole grain, pressure is 70kN, and shearing granulates after Penis et testis cervi micropowder is suppressed, and crosses 200 mesh sieves, keeps
The part by weight of grain and micro mist is 6:4-7:3.
The preparation method of the Penis et testis cervi micropowder piece of the present invention, wherein in the step (4) during tabletting, first in 20-30kN pressure
Lower precompressed, then the main pressure under 30-50kN pressure.
The herbal medicine books of China《This warp》Described in arrive, sweet warm-natured, the returns spleen stomach of jujube, have tonifying middle-Jiao and Qi, blood-nourishing peace
God, the function of relaxing the property of medicine；And modern pharmacology then finds that jujube contains protein, fat, carbohydrate, organic acid, vitamin
The nutritional ingredients such as A, vitamin C, trace element, several amino acids.Inventor has found that processing fishy smell after pilose antler with jujube mitigates,
And the active ingredient in jujube can also promote the performance of the clinical drug effect of pilose antler.
The preparation method of the present invention is only with two kinds of raw materials of jujube and pilose antler, and jujube be able to can both be carried out again with deodorant
Seasoning, completely without additionally adding unsound sweetener again；Simultaneously using the preparation process of tabletting after dry granulation, it is beneficial to
The air in powder is excluded, sliver is reduced, increases the hardness of tablet.Using above-mentioned technical proposal, any auxiliary material is being not added with
Under situation, obtained tablet appearance is good, and numb piece rate and sliver rate are low, and tablet hardness, disintegration, friability meet tablet quality will
Ask, and the hardness can also ensure the later stage tablet is coated, aluminum coated steel, be unlikely to the fragmentation in preparation process.
Active ingredient in pilose antler can be fully retained by the preparation method of the present invention, improved pilose antler and taken inconvenience,
The problem of fishy smell is heavier, and the nutritional ingredient elite such as the protein of jujube, trace element is drawn, be conducive to effective constituent of pilose antler
Preferably play clinical drug effect.Pure natural components of the invention containing pilose antler and jujube, its local flavor is natural, convenient to take, absorption
It is good, it is not added with any auxiliary material.User need not take the auxiliary material of no drug effect more, can ensure pilose antler high concentration as far as possible to fill
The activity of medicine is waved in distribution.
The present invention is low than the extraction preparation cost of pilose antler protein peptides with Penis et testis cervi micropowder direct tablet compressing, and is also prevented from
The loss of active ingredient during extraction, preparation technology is simple.Penis et testis cervi micropowder piece prepared by the present invention is combined oral by mucous membrane of mouth
The absorption features of intestines and stomach, make the active ingredient in Penis et testis cervi micropowder quickly enter in vivo, can overcome the first pass effect of liver, carry
High curative effect, and it is convenient to take, the meaning of its clinical meaning and the utilization of resources is very great.
Brief description of the drawings
Fig. 1-4 is the scanning electron microscope (SEM) photograph of the Penis et testis cervi micropowder of the present invention.
Embodiment
Embodiments of the invention are described in detail below in conjunction with accompanying drawing.It should be noted that not conflicting
In the case of, the feature in embodiment and embodiment in the application can be mutually combined.
Embodiment 1：The preparation method of Penis et testis cervi micropowder piece
Comprise the following steps that：
(1) pilose antler piece is carried out except raw meat is processed：Red date powder or red date slices 1Kg are taken, is placed in 30L water and boils 30 minutes,
200 mesh sieves are crossed, jujube water is obtained, waits to be water-cooled to 70 DEG C, adds 10kg pilose antler pieces, infiltrate 20min, then heating boils 20
Second, pilose antler is taken out, drained；Pilose antler is added in above-mentioned jujube water again and boils 20s, takes the dish out of the pot and drains away the water, 60 DEG C is placed in and leads to
Dried in wind drying box, be 5%-6% to moisture.
(2) by except the pilose antler piece coarse powder after raw meat, then deep cooling crush (temperature is maintained at subzero 30 DEG C to subzero 20 DEG C)
It is crushed to the micro mist of 10-20 μm of particle diameter；
(3) Penis et testis cervi micropowder is subjected to dry granulation, i.e., with dry granulating machine through overcompression, shaping, coarse crushing, whole grain, dry method
During granulation, temperature is 20-25 DEG C, and humidity is 40-50%, and pressure is 70kN, and shearing granulates after Penis et testis cervi micropowder is suppressed, mistake
200 mesh sieves, the ratio for keeping grain and micro mist is 6:4；
(4) the pilose antler particle after granulation is subjected to tabletting, carries out tabletting using Fitow P2020 tablet press machines, be in tabletting
The air in powder after granulation is excluded, sliver increase hardness is reduced, increases pressing step, wherein, temperature is 20-25 DEG C, humidity
For 40-50%, preload pressure is 20-30kN, and principal pressure is 30-50kN.
(5) dress is first wrapped inside in the product after film-making with Aluminium-coating Packer, then outer packing is carried out with complex pocket and carton.
Test example 1 is scanned electron microscope experiment to the Penis et testis cervi micropowder in embodiment 1
Micropowder samples of the pilose antler after deep cooling crush in Example 1, are scanned electron microscope experiment, i.e., are chosen with ophthalmic tweezers
A little sample carries out critical point drying metal spraying on sample platform of scanning electronic microscope.Swept in S-520 types Hitachi electron scanning Electronic Speculum
Retouch, amplify corresponding multiple, take pictures and determine.Observe the particle diameter and form of Penis et testis cervi micropowder piece.According to Penis et testis cervi micropowder piece ESEM
Scheme (Fig. 1-4) analysis, the four width electron microscope is respectively ESEM of the pilose antler powder under 500X, 1000X, 2000X, 5000X
Show that pilose antler powder is mostly irregular rectangle particle in figure, figure, particle diameter distribution is distributed on 10-50 μm, Pilose Antler particle
Some bulk particles.Meanwhile, find there are some elongated fibrous materials in Pilose Antler.According to the scanning electron microscope (SEM) photograph of pilose antler powder
The performance of pilose antler powder tabletting is analyzed, powder is in granular form good fluidity, but poor compressibility is, it is necessary to than larger pressure tabletting.
The tablet suppressed without any auxiliary material, difference of hardness is fugitive frangible, therefore we use dry granulation after carry out tabletting again, into
Product rate is high, and numb piece rate and sliver rate are low, and tablet hardness, disintegration, friability meet tablet quality requirement.
The quality of Penis et testis cervi micropowder piece prepared by the embodiment 1 of test example 2 is as shown in table 1 below：
Table 1
Embodiment 2：The preparation method of Penis et testis cervi micropowder piece
Comprise the following steps that：
(1) pilose antler piece is carried out except raw meat is processed：Red date powder or red date slices 2Kg are taken, is placed in 80L water and boils 60 minutes,
Jujube water is filtered to obtain, waits to be water-cooled to 70 DEG C, adds 10kg pilose antler pieces, infiltrate 20min, 30s is boiled in then heating, by pilose antler
Take out, drain；Pilose antler is added in above-mentioned jujube water again and boils 30s, takes the dish out of the pot and drains away the water, is placed in 60 DEG C of aeration cabinets
Drying, is 5%-6% to moisture.
(2) by except the pilose antler piece coarse powder after raw meat, then deep cooling crush (temperature is maintained at subzero 30 DEG C to subzero 20 DEG C)
It is crushed to the micro mist of 10-20 μm of particle diameter；
(3) Penis et testis cervi micropowder is subjected to dry granulation, i.e., with dry granulating machine through overcompression, shaping, coarse crushing, whole grain, dry method
During granulation, temperature is 20-25 DEG C, and humidity is 40-50%, and pressure is 70kN, and shearing granulates after Penis et testis cervi micropowder is suppressed, mistake
200 mesh sieves, the ratio for keeping grain and micro mist is 7:3；
(4) the pilose antler particle after granulation is subjected to tabletting, carries out tabletting using Fitow P2020 tablet press machines, be in tabletting
The air in powder after granulation is excluded, sliver increase hardness is reduced, increases pressing step, wherein, temperature is 20-25 DEG C, humidity
For 40-50%, preload pressure is 20-30kN, and principal pressure is 30-50kN.
(5) dress is first wrapped inside in the product after film-making with Aluminium-coating Packer, then outer packing is carried out with complex pocket and carton.
The preparation method technology of the present invention is simple and easy to apply, and feasibility is strong, and Penis et testis cervi micropowder piece is convenient to take, easily absorbs, completely
The pure natural active ingredient of pilose antler is remained, while jujube has invigorating spleen and reinforcing stomach, benefiting qi and nourishing blood, the effect of antitoxic heart-soothing and sedative, jujube
Mutually auxiliary with pilose antler is to use, and not only improves the mouthfeel of pilose antler, has reached except raw meat effect, and has been conducive to pilose antler preferably to play and has faced
Bed curative effect, is inconvenient to have great importance overcoming pilose antler traditionally to take.
The Penis et testis cervi micropowder piece of the present invention is used after dry granulation, compressibility, good fluidity, the qualification rate of Penis et testis cervi micropowder piece
Height, numb piece rate, sliver rate are low, and hardness, disintegration meet the quality requirement of tablet.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (2)
1. a kind of preparation method of Penis et testis cervi micropowder piece, it is characterised in that：Comprise the following steps：
(1) pilose antler piece is carried out except raw meat is processed：50-100 parts by weight jujube or red date powder or red date slices are weighed, 30-40 is added
Times of weight water boils 30min-60min, crosses 300-100 mesh sieves, obtains jujube water；This jujube is water-cooled to 60-70 DEG C, adds 400-
500 parts by weight pilose antler pieces infiltrate 20min, are then heated to boiling and boil 15-20 seconds, take out pilose antler and drain the water；Again by pilose antler
Be put into above-mentioned jujube water and boil again 15-20 seconds, take the dish out of the pot, dried in the aeration cabinet that 50-60 DEG C is placed in after draining the water to
Moisture is 5%-10%, obtains pilose antler piece coarse powder；
(2) by except the pilose antler piece coarse powder after raw meat, the deep cooling crush at a temperature of subzero 30 DEG C to subzero 20 DEG C is crushed to particle diameter
10-20 μm of micro mist；
(3) Penis et testis cervi micropowder is subjected to dry granulation, tabletting machine produces Penis et testis cervi micropowder piece；
The dry granulation is that pressure is 70kN through overcompression, shaping, coarse crushing, whole grain with dry granulating machine, Penis et testis cervi micropowder pressure
Shearing granulates after system, crosses 200 mesh sieves, and the part by weight for keeping grain and micro mist is 6:4-7:3；During tabletting, first in 20-30kN pressures
Precompressed under power, then the main pressure under 30-50kN pressure.
2. the Penis et testis cervi micropowder piece that the preparation method of the Penis et testis cervi micropowder piece described in claim 1 is prepared.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2722033C1 (en) * | 2019-11-22 | 2020-05-26 | Алексей Николаевич Осинцев | Method of preserving deer antlers |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886558B (en) * | 2015-05-06 | 2020-10-09 | 山东东阿阿胶股份有限公司 | Donkey-hide gelatin and pilose antler double-component tablet and preparation method thereof |
| CN105535052B (en) * | 2015-12-29 | 2019-03-15 | 东阿阿胶股份有限公司 | A kind of donkey-hide gelatin Radix Panacis Quinquefolii micropowder piece and preparation method thereof |
| CN109619560A (en) * | 2018-12-22 | 2019-04-16 | 郭伟 | A kind of spotted deer antler chewable tablets and preparation method thereof |
| CN112715935B (en) * | 2020-12-30 | 2022-08-23 | 苏州红冠庄国药股份有限公司 | Pilose antler buccal tablet and preparation method thereof |
| CN114042047A (en) * | 2021-10-22 | 2022-02-15 | 甘肃创兴生物工程有限责任公司 | Preparation method of cornu cervi pantotrichum ultrafine freeze-dried powder |
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| CN103844158A (en) * | 2012-12-07 | 2014-06-11 | 牛彩风 | Jujube-cornu cervi oral tablet and preparation method thereof |
| CN103784487A (en) * | 2014-03-07 | 2014-05-14 | 山东东阿阿胶股份有限公司 | Ginseng micro-powder tablet and preparation method thereof |
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| RU2722033C1 (en) * | 2019-11-22 | 2020-05-26 | Алексей Николаевич Осинцев | Method of preserving deer antlers |
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