CN108272984A - A kind of hypoglycemic drug and preparation method thereof - Google Patents
A kind of hypoglycemic drug and preparation method thereof Download PDFInfo
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- CN108272984A CN108272984A CN201810325806.6A CN201810325806A CN108272984A CN 108272984 A CN108272984 A CN 108272984A CN 201810325806 A CN201810325806 A CN 201810325806A CN 108272984 A CN108272984 A CN 108272984A
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- 239000003472 antidiabetic agent Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 240000008067 Cucumis sativus Species 0.000 claims abstract description 40
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 40
- 241000124033 Salix Species 0.000 claims abstract description 29
- 235000005340 Asparagus officinalis Nutrition 0.000 claims abstract description 17
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 17
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 17
- 244000046052 Phaseolus vulgaris Species 0.000 claims abstract description 17
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims abstract description 17
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 17
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 17
- 244000302512 Momordica charantia Species 0.000 claims abstract description 15
- 235000009811 Momordica charantia Nutrition 0.000 claims abstract description 15
- 235000009812 Momordica cochinchinensis Nutrition 0.000 claims abstract description 15
- 235000018365 Momordica dioica Nutrition 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 244000003416 Asparagus officinalis Species 0.000 claims abstract 5
- 238000000605 extraction Methods 0.000 claims description 56
- 238000010992 reflux Methods 0.000 claims description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- 238000009835 boiling Methods 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 238000001914 filtration Methods 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 13
- 239000002552 dosage form Substances 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 6
- 239000003513 alkali Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 6
- 150000007524 organic acids Chemical class 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000000108 ultra-filtration Methods 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 241000219112 Cucumis Species 0.000 claims description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 15
- 210000004369 blood Anatomy 0.000 abstract description 15
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 13
- 239000008103 glucose Substances 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 230000009467 reduction Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 73
- 241000234427 Asparagus Species 0.000 description 12
- 235000019441 ethanol Nutrition 0.000 description 10
- 239000007788 liquid Substances 0.000 description 9
- 230000036541 health Effects 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 2
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 229940096919 glycogen Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000405414 Rehmannia Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
- 229960004346 glimepiride Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of hypoglycemic drugs and preparation method thereof, include the raw material of following parts by weight：48 parts of 16 22 parts of blue or green money willow, 6 10 parts of pueraria lobata, 35 parts of rde bean, 58 parts of radix rehmanniae recen, 46 parts of asparagus, 10 15 parts of cucumber, 8 14 parts of balsam pear, 1.8 4 parts of grandmother's fourth and the coptis.Raw material sources of the present invention are extensive, use different technique by different material, then mutually cooperate with the product of different process, the finished product of preparation has the function of good reduction blood glucose, can meet the use demand of people.
Description
Technical field
The present invention relates to blood glucose to reduce field, specifically a kind of hypoglycemic drug.
Background technology
Glucose in blood is known as blood glucose, and glucose is the important composition ingredient of human body and the important sources of energy.Just
Ordinary person's body needs many sugar to provide energy daily, and the normal operation for various tissues, internal organs provides power.So blood glucose must
It must keep certain level that could maintain the needs of internal each organ and tissue.The generation and utilization of normal person's blood glucose are in dynamic
The state of balance maintains a metastable level, this is because the result that the source and outlet of blood glucose are roughly the same.Blood
The source of sugar includes：1. food digestion, absorption；2. the decomposition of glycogen stored in liver；3. the conversion of fat and protein.Blood glucose
Outlet includes：1. oxidation transformation is energy；2. being converted into glycogen storage in liver, kidney and muscle；3. be changed into fat and
Other nutritional ingredients such as protein are stored.
Diabetes be with insulin secretion absolutely or relative deficiency, carbohydrate metabolism disturbance be the endocrine metabolism mainly showed
Disease is the common disease for currently endangering human health, it has also become the 5th of the mankind dead killer shows as weight loss, tired
Powerless and easily hungry more foods, are easy to happen the chronic disease of angiocarpy, the cerebrovascular, kidney, eye ground and nervous system, or even make
At blinding and disable, it may occur however that complication spread whole body, seriously affect health and work, viability.China has been at present
As most one of the country of diabetes number in the world.Diabetes will have a direct impact on the health of people, lead to daily life
Living, working and learning obstacle.So rationally and efficiently control blood glucose, safeguard that health is most important, hypoglycemic drug
Research just becomes a hot spot.
Invention content
The purpose of the present invention is to provide a kind of hypoglycemic drugs, to solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides the following technical solutions：
A kind of hypoglycemic drug, includes the raw material of following parts by weight：16-22 parts of blue or green money willow, 6-10 parts of pueraria lobata, rde bean
3-5 parts, 5-8 parts of radix rehmanniae recen, 4-6 parts of asparagus, 10-15 parts of cucumber, 8-14 parts of balsam pear, 1.8-4 parts of grandmother's fourth and coptis 4-8
Part.
As a further solution of the present invention：The hypoglycemic drug, includes the raw material of following parts by weight：Blue or green money willow
18-22 parts, it is 7.5-10 parts of pueraria lobata, 3.8-5 parts of rde bean, 6.6-8 parts of radix rehmanniae recen, 4.5-6 parts of asparagus, 12-15 parts of cucumber, bitter
5.5-8 parts of 10-14 parts of melon, 2.5-4 parts of grandmother's fourth and the coptis.
As a further solution of the present invention：The hypoglycemic drug, includes the raw material of following parts by weight：Blue or green money willow 21
Part, 9 parts of pueraria lobata, 4.5 parts of rde bean, 7.4 parts of radix rehmanniae recen, 5.2 parts of asparagus, 14 parts of cucumber, 13 parts of balsam pear, 3.6 parts of grandmother's fourth
With 7 parts of the coptis.
The preparation method of the hypoglycemic drug, is as follows：
Step 1, cucumber is cleaned, is ground into fritter and dries, and 6-8 times of its weight is added in the cucumber after crushing
In deionized water, it is heated to starting timing after boiling, refluxing extraction 2-3 hours, after first time refluxing extraction, second of reflux
Extraction operation is with for the first time, and after the completion of second of refluxing extraction, the amount of water of third time refluxing extraction is the 4-6 of Cucumber weight
Times, start timing after being heated to boiling, refluxing extraction 1-1.5 hours merges the filtrate of refluxing extraction and reduced pressure three times, obtains
To cucumber extract；
Grandmother's fourth is dried and is crushed by step 2, and grandmother's fourth powder is added in organic acid and is extracted, and is then used in alkali
With filter residue and first time extracting solution is obtained by filtration, filter residue is subjected to ultrasonic wave extraction in water, second of extraction is obtained by filtration
First time extracting solution and second of extracting solution are merged and carry out ultrafiltration, obtain grandmother's fourth extracting solution by liquid；
20-30 mesh is dried and be crushed to blue or green money willow by step 3, and the mass fraction that 3-4 times of its weight is added is 60-
75% ethanol solution, slightly boiling are extracted 3-4 hours, first time extracting solution and filter residue are obtained by filtration, filter residue is put into its weight 8-
10 times of mass fraction is the ethanol solution of 70-90%, the timing since being heated to after boiling, and refluxing extraction 1.5-3 hours obtains
First time extracting solution and second of extracting solution are merged, obtain blue or green money willow extracting solution by second of extracting solution；
The clear water of 3-5 times of its total weight is added in pueraria lobata, rde bean, radix rehmanniae recen, asparagus, balsam pear and the coptis by step 4,
It is cooked by slow fire 3-5 times, it is 50-75 minutes each, merge decoction liquor, obtains the first mixture；
First mixture, cucumber extract, grandmother's fourth extracting solution and blue or green money willow extracting solution are uniformly mixed, are dry by step 5
Dry and crushing is added customary adjuvant and is prepared into corresponding dosage form.
As a further solution of the present invention：Be crushed to 120-150 mesh in step 5, dosage form include pill, granule and
Capsule.
Compared with prior art, the beneficial effects of the invention are as follows：Raw material sources of the present invention are extensive, used by different material
Then different technique mutually cooperates with the product of different process, the finished product of preparation has the function of good reduction blood glucose, can
To meet the use demand of people.
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of hypoglycemic drug, includes the raw material of following parts by weight：16 parts of blue or green money willow, 6 parts of pueraria lobata, 3 parts of rde bean, life
4 parts of 5 parts of glutinous rehmannia, 4 parts of asparagus, 10 parts of cucumber, 8 parts of balsam pear, 1.8 parts of grandmother's fourth and the coptis.
The preparation method of the hypoglycemic drug, is as follows：
Cucumber is cleaned, is ground into fritter and dries by step 1, and going for 6 times of its weight is added in the cucumber after crushing
It in ionized water, is heated to starting timing after boiling, refluxing extraction 2.5 hours, after first time refluxing extraction, second of reflux carries
Extract operation is with for the first time, and after the completion of second of refluxing extraction, the amount of water of third time refluxing extraction is 4 times of Cucumber weight, is added
Heat starts timing to after boiling, and refluxing extraction 1 hour merges the filtrate of refluxing extraction and reduced pressure three times, obtains cucumber and carry
Take liquid；
Grandmother's fourth is dried and is crushed by step 2, and grandmother's fourth powder is added in organic acid and is extracted, and is then used in alkali
With filter residue and first time extracting solution is obtained by filtration, filter residue is subjected to ultrasonic wave extraction in water, second of extraction is obtained by filtration
First time extracting solution and second of extracting solution are merged and carry out ultrafiltration, obtain grandmother's fourth extracting solution by liquid；
20 mesh are dried and be crushed to blue or green money willow by step 3, and the ethyl alcohol that the mass fraction of 3 times of its weight is 65% is added
Solution, slightly boiling are extracted 3 hours, first time extracting solution and filter residue are obtained by filtration, the mass fraction that filter residue is put into 9 times of its weight is
Since 75% ethanol solution, the timing being heated to after boiling, refluxing extraction 2 hours obtain second of extracting solution, will carry for the first time
It takes liquid and second of extracting solution to merge, obtains blue or green money willow extracting solution；
The clear water of 4 times of its total weight is added in pueraria lobata, rde bean, radix rehmanniae recen, asparagus, balsam pear and the coptis by step 4, text
Fire decocts 3 times, 60 minutes every time, merges decoction liquor, obtains the first mixture；
First mixture, cucumber extract, grandmother's fourth extracting solution and blue or green money willow extracting solution are uniformly mixed, are dry by step 5
Dry and crushing is added customary adjuvant and is prepared into corresponding dosage form.
Embodiment 2
A kind of hypoglycemic drug, includes the raw material of following parts by weight：18 parts of blue or green money willow, 7.5 parts of pueraria lobata, rde bean 3.8
5.5 parts of part, 6.6 parts of radix rehmanniae recen, 4.5 parts of asparagus, 12 parts of cucumber, 10 parts of balsam pear, 2.5 parts of grandmother's fourth and the coptis.
The preparation method of the hypoglycemic drug, is as follows：
Cucumber is cleaned, is ground into fritter and dries by step 1, and going for 8 times of its weight is added in the cucumber after crushing
In ionized water, it is heated to starting timing after boiling, refluxing extraction 2 hours, after first time refluxing extraction, second of refluxing extraction
Operation is with for the first time, and after the completion of second of refluxing extraction, the amount of water of third time refluxing extraction is 5 times of Cucumber weight, heating
Start timing after to boiling, refluxing extraction 1.5 hours merges the filtrate of refluxing extraction and reduced pressure three times, obtains cucumber and carry
Take liquid；
Grandmother's fourth is dried and is crushed by step 2, and grandmother's fourth powder is added in organic acid and is extracted, and is then used in alkali
With filter residue and first time extracting solution is obtained by filtration, filter residue is subjected to ultrasonic wave extraction in water, second of extraction is obtained by filtration
First time extracting solution and second of extracting solution are merged and carry out ultrafiltration, obtain grandmother's fourth extracting solution by liquid；
25 mesh are dried and be crushed to blue or green money willow by step 3, and the ethyl alcohol that the mass fraction of 4 times of its weight is 66% is added
Solution, slightly boiling are extracted 3.5 hours, first time extracting solution and filter residue are obtained by filtration, filter residue is put into the mass fraction of 9 times of its weight
For 80% ethanol solution, since the timing being heated to after boiling, refluxing extraction 2 hours obtain second of extracting solution, will for the first time
Extracting solution and second of extracting solution merge, and obtain blue or green money willow extracting solution；
The clear water of 3 times of its total weight is added in pueraria lobata, rde bean, radix rehmanniae recen, asparagus, balsam pear and the coptis by step 4, text
Fire decocts 4 times, 70 minutes every time, merges decoction liquor, obtains the first mixture；
First mixture, cucumber extract, grandmother's fourth extracting solution and blue or green money willow extracting solution are uniformly mixed, are dry by step 5
It is dry and be crushed to 130 mesh, customary adjuvant is added and is prepared into corresponding dosage form, dosage form includes pill, granule and capsule.
Embodiment 3
A kind of hypoglycemic drug, includes the raw material of following parts by weight：21 parts of blue or green money willow, 9 parts of pueraria lobata, 4.5 parts of rde bean,
7 parts of 7.4 parts of radix rehmanniae recen, 5.2 parts of asparagus, 14 parts of cucumber, 13 parts of balsam pear, 3.6 parts of grandmother's fourth and the coptis.
The preparation method of the hypoglycemic drug, is as follows：
Cucumber is cleaned, is ground into fritter and dries by step 1, and going for 6 times of its weight is added in the cucumber after crushing
It in ionized water, is heated to starting timing after boiling, refluxing extraction 2.2 hours, after first time refluxing extraction, second of reflux carries
Extract operation is with for the first time, and after the completion of second of refluxing extraction, the amount of water of third time refluxing extraction is 5 times of Cucumber weight, is added
Heat starts timing to after boiling, and refluxing extraction 1.5 hours merges the filtrate of refluxing extraction and reduced pressure three times, obtains cucumber
Extracting solution；
Grandmother's fourth is dried and is crushed by step 2, and grandmother's fourth powder is added in organic acid and is extracted, and is then used in alkali
With filter residue and first time extracting solution is obtained by filtration, filter residue is subjected to ultrasonic wave extraction in water, second of extraction is obtained by filtration
First time extracting solution and second of extracting solution are merged and carry out ultrafiltration, obtain grandmother's fourth extracting solution by liquid；
30 mesh are dried and be crushed to blue or green money willow by step 3, and the ethyl alcohol that the mass fraction of 4 times of its weight is 72% is added
Solution, slightly boiling are extracted 4 hours, first time extracting solution and filter residue are obtained by filtration, the mass fraction that filter residue is put into 9 times of its weight is
Since 75% ethanol solution, the timing being heated to after boiling, refluxing extraction 2 hours obtain second of extracting solution, will carry for the first time
It takes liquid and second of extracting solution to merge, obtains blue or green money willow extracting solution；
The clear water of 5 times of its total weight is added in pueraria lobata, rde bean, radix rehmanniae recen, asparagus, balsam pear and the coptis by step 4, text
Fire decocts 3 times, 50 minutes every time, merges decoction liquor, obtains the first mixture；
First mixture, cucumber extract, grandmother's fourth extracting solution and blue or green money willow extracting solution are uniformly mixed, are dry by step 5
Dry and crushing is added customary adjuvant and is prepared into corresponding dosage form.
Embodiment 4
A kind of hypoglycemic drug, includes the raw material of following parts by weight：22 parts of blue or green money willow, 10 parts of pueraria lobata, 5 parts of rde bean,
8 parts of 8 parts of radix rehmanniae recen, 6 parts of asparagus, 15 parts of cucumber, 14 parts of balsam pear, 4 parts of grandmother's fourth and the coptis.
The preparation method of the hypoglycemic drug, is as follows：
Cucumber is cleaned, is ground into fritter and dries by step 1, and going for 7 times of its weight is added in the cucumber after crushing
It in ionized water, is heated to starting timing after boiling, refluxing extraction 2.5 hours, after first time refluxing extraction, second of reflux carries
Extract operation is with for the first time, and after the completion of second of refluxing extraction, the amount of water of third time refluxing extraction is 5 times of Cucumber weight, is added
Heat starts timing to after boiling, and refluxing extraction 1.4 hours merges the filtrate of refluxing extraction and reduced pressure three times, obtains cucumber
Extracting solution；
Grandmother's fourth is dried and is crushed by step 2, and grandmother's fourth powder is added in organic acid and is extracted, and is then used in alkali
With filter residue and first time extracting solution is obtained by filtration, filter residue is subjected to ultrasonic wave extraction in water, second of extraction is obtained by filtration
First time extracting solution and second of extracting solution are merged and carry out ultrafiltration, obtain grandmother's fourth extracting solution by liquid；
20 mesh are dried and be crushed to blue or green money willow by step 3, and the ethyl alcohol that the mass fraction of 4 times of its weight is 72% is added
Solution, slightly boiling are extracted 3 hours, first time extracting solution and filter residue are obtained by filtration, the mass fraction that filter residue is put into 9 times of its weight is
Since 88% ethanol solution, the timing being heated to after boiling, refluxing extraction 2.5 hours obtain second of extracting solution, will for the first time
Extracting solution and second of extracting solution merge, and obtain blue or green money willow extracting solution；
The clear water of 5 times of its total weight is added in pueraria lobata, rde bean, radix rehmanniae recen, asparagus, balsam pear and the coptis by step 4, text
Fire decocts 4 times, 75 minutes every time, merges decoction liquor, obtains the first mixture；
First mixture, cucumber extract, grandmother's fourth extracting solution and blue or green money willow extracting solution are uniformly mixed, are dry by step 5
It is dry and be crushed to 150 mesh, customary adjuvant is added and is prepared into corresponding dosage form, dosage form includes pill, granule and capsule.
The identical mouse of 240 situations of selection and 6 groups are equally divided into, to every mouse mainline after fasting 15 hours
Alloxan so that the blood glucose of mouse reaches 17.5mmol/L or more, and giving plastic injection quality score daily to 1 group of mouse is
0.85 sodium cellulose glycolate solution 0.5ml, 2 groups of mouse give Glimepiride, 3-6 groups according to the amount of 60mg/kg daily
The product of embodiment 1-4 is given, dosage is 40mg/kg, is dissected mouse after continuing 10 days, and average blood sugar value is measured, and is measured
It the results are shown in Table 1.
Table 1
The blood glucose of 3-6 groups decreases drastically compared to 1-2 groups as can be seen from Table 1, shows that blood sugar decreasing effect is good.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (5)
1. a kind of hypoglycemic drug, which is characterized in that include the raw material of following parts by weight：16-22 parts of blue or green money willow, pueraria lobata 6-10
Part, 3-5 parts of rde bean, 5-8 parts of radix rehmanniae recen, 4-6 parts of asparagus, 10-15 parts of cucumber, 8-14 parts of balsam pear, 1.8-4 parts of grandmother's fourth and
4-8 parts of the coptis.
2. hypoglycemic drug according to claim 1, which is characterized in that include the raw material of following parts by weight：Blue or green money willow
18-22 parts, it is 7.5-10 parts of pueraria lobata, 3.8-5 parts of rde bean, 6.6-8 parts of radix rehmanniae recen, 4.5-6 parts of asparagus, 12-15 parts of cucumber, bitter
5.5-8 parts of 10-14 parts of melon, 2.5-4 parts of grandmother's fourth and the coptis.
3. hypoglycemic drug according to claim 1, which is characterized in that include the raw material of following parts by weight：Blue or green money willow
21 parts, 9 parts of pueraria lobata, 4.5 parts of rde bean, 7.4 parts of radix rehmanniae recen, 5.2 parts of asparagus, 14 parts of cucumber, 13 parts of balsam pear, grandmother's fourth 3.6
7 parts of part and the coptis.
4. a kind of preparation method of hypoglycemic drug as described in any one of claims 1-3, which is characterized in that specific steps are such as
Under：
Cucumber is cleaned, is ground into fritter and dries by step 1, by the cucumber after crushing be added 6-8 times of its weight go from
In sub- water, it is heated to starting timing after boiling, refluxing extraction 2-3 hours, after first time refluxing extraction, second of refluxing extraction
Operation is with for the first time, and after the completion of second of refluxing extraction, the amount of water of third time refluxing extraction is 4-6 times of Cucumber weight, is added
Heat starts timing to after boiling, and refluxing extraction 1-1.5 hours merges the filtrate of refluxing extraction and reduced pressure three times, obtains Huang
Melon extracting solution；
Grandmother's fourth is dried and is crushed by step 2, and grandmother's fourth powder is added in organic acid and is extracted, and then uses alkali neutralization, mistake
Filter obtains filter residue and first time extracting solution, and filter residue is carried out ultrasonic wave extraction in water, second of extracting solution is obtained by filtration, by the
Extracting solution and second of extracting solution, which merge, carries out ultrafiltration, obtains grandmother's fourth extracting solution；
20-30 mesh is dried and be crushed to blue or green money willow by step 3, and the mass fraction that 3-4 times of its weight is added is 60-75%'s
Ethanol solution, slightly boiling are extracted 3-4 hours, first time extracting solution and filter residue are obtained by filtration, filter residue is put into 8-10 times of its weight
Mass fraction is the ethanol solution of 70-90%, the timing since being heated to after boiling, refluxing extraction 1.5-3 hours, obtains second
First time extracting solution and second of extracting solution are merged, obtain blue or green money willow extracting solution by extracting solution；
The clear water of 3-5 times of its total weight, slow boiling is added in pueraria lobata, rde bean, radix rehmanniae recen, asparagus, balsam pear and the coptis by step 4
It decocts 3-5 times, it is 50-75 minutes each, merge decoction liquor, obtains the first mixture；
Step 5, the first mixture, cucumber extract, grandmother's fourth extracting solution and blue or green money willow extracting solution are uniformly mixed, it is dry and
It crushes, customary adjuvant is added and is prepared into corresponding dosage form.
5. the preparation method of hypoglycemic drug according to claim 4, which is characterized in that be crushed in the step 5
120-150 mesh, dosage form include pill, granule and capsule.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112717071A (en) * | 2021-01-26 | 2021-04-30 | 张天亮 | Medicament for treating diabetes |
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