CN202951005U - Composite artificial skin - Google Patents
Composite artificial skin Download PDFInfo
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- CN202951005U CN202951005U CN 201220583941 CN201220583941U CN202951005U CN 202951005 U CN202951005 U CN 202951005U CN 201220583941 CN201220583941 CN 201220583941 CN 201220583941 U CN201220583941 U CN 201220583941U CN 202951005 U CN202951005 U CN 202951005U
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- chitosan
- diaphragm
- artificial skin
- silicone rubber
- membrane
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Abstract
The utility model provides a composite artificial skin which comprises a silicon rubber membrane and a chitosan membrane, wherein the chitosan membrane is connected on one side face of the silicon rubber membrane. Due to the fact that a composite artificial skin structure is adopted by integrally attaching of the silicon rubber membrane and the chitosan membrane, the chitosan membrane of the composite artificial skin and cells of a human body have strong affinity, can be decomposed and absorbed by enzyme in the human body, and do not have non-toxic and side effect on the human body. The chitosan membrane can effectively achieve aims of bacteria resistance and bacteriostasis, imbibition hemostasis, promoting of wound healing, reducing cicatricose and other effects. Meanwhile, the silicon rubber membrane of the composite artificial skin not only can achieve good air permeability and achieves the aim of bacterial breeding of a wound surface, but also can effectively separate external bacterial invasion, and enables the wound surface to be effectively protected. After the wound surface is healed, the silicon rubber membrane automatically drops, and is not adhered with skin tissue. The composite artificial skin is simple in structure, convenient to manufacture, low in cost, and safe and reliable in use.
Description
Technical field
This utility model relates to a kind of medical composite material, specifically relates to a kind of compound artificial skin.
Background technology
Artificial skin is as the interim skin that substitutes of wound surface, and generally need to meet following function: 1, the flexibility close with human body skin also can keep certain form and intensity when moistening; 2, can be close to wound surface, the effect of resistance bacterium is arranged; 3, can prevent that moisture and body fluid from overflowing from wound surface; 4, can absorb from the transudate of wound surface depths, and can not cause the hydrops between artificial skin and wound surface; 5, there is good biocompatibility; 6, anaphylaxis does not occur; 7, can sterilize and sterilizing, and can store, prevent that antibacterial from infecting; 8, can delay pain, there is certain antibacterial action, promote granulation growth and skin regeneration, promote treatment; 9, preferably transparent, can observe the wound healing situation; 10 once traumatic infection occurs, and can easily from wound surface, take off, and does not damage wound surface.
The tissue engineering artificial skin that Shaanxi Aierfu ActivTissue Engineering Co., Ltd. produces is from getting tissue is digested, be separated into epidermis cell, fibrocyte, and it is carried out to separation and Culture and amplification, reassemble into the double-layered artificial skin tissue after reaching certain cell quantity, the raw material of this artificial skin tissue that has drawn from, there is certain risk, and expensive, general patient is beyond affordability.
And chitosan derives from the organism structure materials such as Crusta Penaeus seu Panulirus, Carapax Eriocheir sinensis, material is increased income extensively, with human body cell, very strong affinity is arranged, but the enzyme in body decompose and absorb, to human body avirulence and side effect.Simultaneously, there is the important biological actions such as antibacterial bacteriostatic, hemostasis, promotion wound healing, the adhesion of prevention histoorgan due to chitosan, thereby, by Application and Development widely, become good biomedicine, pharmaceutical material.
The Chinese patent that the patent No. is ZL200610161520.6 discloses a kind of preparation method of liquid hemostatic silicone rubber dressing, it is by the A of fluid silicone rubber, B component, be equipped with by required viscosity and level and smooth, soft requirement, stir, be squeezed in by acetate fiber non-woven fabrics, medical adhesive-bonded fabric or absorbent carbasus the elastomer formed on the material that is carrier; After waiting for that elastomer solidifies, add again the elastomer superabsorbent bleeding-stopping dressing that carboxymethyl chitosan, calcium alginate and CMC granule form through Co 60 degraded sterilizing on elastomer, this hemostatic silicone rubber dressing can be used for postoperative nursing, short more, hemostasis, remove and absorb a large amount of wound fluids, make the quick absorption of wound fluid and reach hemostasis, antibiotic, the effect that promotes wound healing, minimizing cicatrix.Yet the extexine of this hemostatic silicone rubber dressing is to be made and formed by the mixture of carboxymethyl chitosan, calcium alginate and CMC pressed powder, complicated component, cost is high, and the complex manufacturing technology of this hemostatic silicone rubber dressing, technological requirement is high, and production efficiency is low.
Summary of the invention
The purpose of this utility model is for above-mentioned existing problems and deficiency, and a kind of simple in structure, easily manufactured, compound artificial skin that cost is low, safe and reliable is provided.
The technical solution of the utility model is achieved in that
Compound artificial skin described in the utility model, be characterized in comprising silicone rubber diaphragm and chitosan diaphragm, and described chitosan diaphragm is connected on a side of silicone rubber diaphragm.
In order to make working strength of the present utility model high, in above-mentioned silicone rubber diaphragm, be provided with enhancement Layer.Described enhancement Layer is non-woven fabrics or nylon net cloth or cotton cloth.
In order to make structure of the present utility model varied, above-mentioned silicone rubber diaphragm can connect as one by multiple different mode from the chitosan diaphragm, can be both above-mentioned silicone rubber diaphragm be the silicon rubber cement for making this silicone rubber diaphragm still during toughness and above-mentioned chitosan diaphragm be bonded as one, can be also that above-mentioned silicone rubber diaphragm and chitosan diaphragm are bonded as one by the medical silica-gel bonding agent.
In order to make the utlity model has multiple different result of use, to meet easily the different instructions for use of user, above-mentioned chitosan diaphragm is common chitosan non-woven fabrics or water-soluble chitosan non-woven fabrics or chitosan quaternary ammonium salt non-woven fabrics or using carboxyl chitosan non-woven fabrics or chitosan diaphragm or chitin fiber diaphragm or chitosan foam diaphragm.
This utility model is owing to having adopted silicone rubber diaphragm and chitosan diaphragm to fit into the structure that is made into integration compound artificial skin, this compound artificial skin has the flexibility close with human body skin, also can keep certain form and intensity when moistening, and the chitosan diaphragm on it and human body cell have very strong affinity, can be decomposed by the enzyme in human body and absorb, to human body avirulence and side effect, can effectively realize antibacterial bacteriostatic by this chitosan diaphragm, liquid-absorbent hemostatic, the effects such as wound healing and minimizing cicatrix, can realize good breathability by the silicone rubber diaphragm on this compound artificial skin simultaneously, reach the purpose that prevents the wound surface bacteria breed, can effectively intercept the intrusion of outside antibacterial again, wound surface is effectively protected, and the silicone rubber diaphragm is transparent, user can be observed the situation of wound healing at any time, thereby bring great convenience to user, and after wound healing, silicone rubber membrane sector-meeting Automatic-falling, can not stick together with skin histology, thereby effectively avoided causing the problem of secondary insult.Of the present utility model simple in structure, easily manufactured, cost is low, safe and reliable.
Below in conjunction with accompanying drawing, this utility model is further described.
The accompanying drawing explanation
Fig. 1 is perspective view of the present utility model.
Fig. 2 is the perspective view of chitosan diaphragm described in the utility model while starting one jiao.
The cross-sectional view that Fig. 3 is this utility model embodiment 1.
The cross-sectional view that Fig. 4 is this utility model embodiment 2.
The specific embodiment
As Figure 1-Figure 4, compound artificial skin described in the utility model, comprise silicone rubber diaphragm 1 and chitosan diaphragm 2, and described chitosan diaphragm 2 is connected on a side of silicone rubber diaphragm 1.In order to make working strength of the present utility model high, even can not affect its working strength when moistening, in above-mentioned silicone rubber diaphragm 1, be provided with enhancement Layer 3, the enhancement Layer that described enhancement Layer 3 is made for non-woven fabrics or nylon net cloth or cotton cloth or other material.In order to make structure of the present utility model varied, above-mentioned silicone rubber diaphragm 1 can connect as one by multiple different mode from chitosan diaphragm 2, can be both above-mentioned silicone rubber diaphragm 1 be the silicon rubber cement for making this silicone rubber diaphragm 1 still during toughness and above-mentioned chitosan diaphragm 2 be bonded as one, can be also that above-mentioned silicone rubber diaphragm 1 is bonded as one (as shown in Figure 4) by medical silica-gel bonding agent 4 with chitosan diaphragm 2.And above-mentioned silicone rubber diaphragm 1 is transparent, user can be observed the situation of wound healing at any time, thereby brings great convenience to user.As shown in Figure 3, if above-mentioned silicone rubber diaphragm 1 be the silicon rubber cement for making this silicone rubber diaphragm 1 still during toughness and above-mentioned chitosan diaphragm 2 be bonded as one, and while in silicone rubber diaphragm 1, being provided with enhancement Layer 3, its concrete manufacture method is so: first uncrosslinked silicone rubber is dissolved in to petroleum ether, butyl acetate and dimethylbenzene form silicon rubber cement, then the enhancement Layer of non-woven fabrics or nylon net cloth or cotton cloth or other material being made flattens and is immersed in silicon rubber cement, solidify the regular hour, at silicon rubber cement still during toughness, the chitosan diaphragm is laid on the enhancement Layer that the non-woven fabrics that contains silicon rubber cement or nylon net cloth or cotton cloth or other material make, make compound artificial skin described in the utility model after solidifying fully.In order to make the utlity model has multiple different result of use, to meet easily the different instructions for use of user, above-mentioned chitosan diaphragm 2 is common chitosan non-woven fabrics or water-soluble chitosan non-woven fabrics or chitosan quaternary ammonium salt non-woven fabrics or using carboxyl chitosan non-woven fabrics or chitosan diaphragm or chitin fiber diaphragm or chitosan foam diaphragm.
This utility model is described by embodiment, but this utility model is not construed as limiting, with reference to description of the present utility model, other variations of the disclosed embodiments, as the professional person for this area easily expects, within such variation should belong to the scope of this utility model claim restriction.
Claims (6)
1. a compound artificial skin, is characterized in that comprising silicone rubber diaphragm (1) and chitosan diaphragm (2), and described chitosan diaphragm (2) is connected on a side of silicone rubber diaphragm (1).
2. compound artificial skin according to claim 1, is characterized in that in above-mentioned silicone rubber diaphragm (1) being provided with enhancement Layer (3).
3. compound artificial skin according to claim 2, is characterized in that above-mentioned enhancement Layer (3) is non-woven fabrics or nylon net cloth or cotton cloth.
4. compound artificial skin according to claim 1, it is characterized in that above-mentioned silicone rubber diaphragm (1) be the silicon rubber cement for making this silicone rubber diaphragm (1) still during toughness and above-mentioned chitosan diaphragm (2) be bonded as one.
5. compound artificial skin according to claim 1, is characterized in that above-mentioned silicone rubber diaphragm (1) and chitosan diaphragm (2) are bonded as one by medical silica-gel bonding agent (4).
6. compound artificial skin according to claim 1, is characterized in that above-mentioned chitosan diaphragm (2) is common chitosan non-woven fabrics or water-soluble chitosan non-woven fabrics or chitosan quaternary ammonium salt non-woven fabrics or using carboxyl chitosan non-woven fabrics or chitin fiber diaphragm or chitosan foam diaphragm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220583941 CN202951005U (en) | 2012-11-08 | 2012-11-08 | Composite artificial skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220583941 CN202951005U (en) | 2012-11-08 | 2012-11-08 | Composite artificial skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202951005U true CN202951005U (en) | 2013-05-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220583941 Expired - Fee Related CN202951005U (en) | 2012-11-08 | 2012-11-08 | Composite artificial skin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202951005U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107412841A (en) * | 2017-08-09 | 2017-12-01 | 江西高大生物医疗科技有限公司 | A kind of production method of medical tea oil dressing |
| CN108114314A (en) * | 2017-05-03 | 2018-06-05 | 曲平波 | A kind of degradable pleura sticking patch and preparation method thereof |
| CN108175875A (en) * | 2018-03-27 | 2018-06-19 | 四川大学华西医院 | A kind of Repair of tissue defect film carrier and preparation method thereof |
-
2012
- 2012-11-08 CN CN 201220583941 patent/CN202951005U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108114314A (en) * | 2017-05-03 | 2018-06-05 | 曲平波 | A kind of degradable pleura sticking patch and preparation method thereof |
| CN107412841A (en) * | 2017-08-09 | 2017-12-01 | 江西高大生物医疗科技有限公司 | A kind of production method of medical tea oil dressing |
| CN108175875A (en) * | 2018-03-27 | 2018-06-19 | 四川大学华西医院 | A kind of Repair of tissue defect film carrier and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130529 Termination date: 20131108 |