CN108114314A - A kind of degradable pleura sticking patch and preparation method thereof - Google Patents

A kind of degradable pleura sticking patch and preparation method thereof Download PDF

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Publication number
CN108114314A
CN108114314A CN201710302641.6A CN201710302641A CN108114314A CN 108114314 A CN108114314 A CN 108114314A CN 201710302641 A CN201710302641 A CN 201710302641A CN 108114314 A CN108114314 A CN 108114314A
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pleura
degradable
sticking patch
patch
parts
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曲平波
夏维
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/06—Coatings containing a mixture of two or more compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention belongs to simulated organ technical fields, and in particular to a kind of degradable pleura sticking patch and preparation method thereof, the pleura sticking patch it include following parts by weight of component：15 parts poly- to dioxy cyclohexanone, 15 parts of chitosans, 15 parts of epidermal growth factor and 1 10 parts of Sodium Hyaluronates.The preparation method is：(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；(2) chitosan, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gelling agent；(3) gelling agent is laid on patch；(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.The good biocompatibility, safe of the pleura sticking patch of the present invention, in prevention wall of the chest adhesion, anti-infective aspect significant effect.

Description

A kind of degradable pleura sticking patch and preparation method thereof
Technical field
The invention belongs to simulated organ technical fields, and in particular to a kind of degradable pleura sticking patch and preparation method thereof.
Background technology
Human tissue injury's Regeneration and Repair is always the clinical problem faced, in recent years, with cell biology and tissue The development of engineering technology, biological sticking patch bring dawn as a kind of appearance of emerging wound repair material for people, biology Material cladding sticking patch is the adjustable with stent of natural degradable large biological molecule composite degradable macromolecule braided material formation The patch of section property can promote the reparation of tissue defect as biomaterial scaffolds by spatiall induction and tissue substitute effect, Since it is without the ingredient even seldom containing host immune rejection reaction, there is good histocompatbility, extensively should For the defective tissue reparation in clinical each field, and achieve good application prospect.
Biological-material complex patch thoracic surgery reparation using more mature, especially the situation of concurrent infection is controlled Therapeutic effect is rather good；Application in shaping medical domain in terms of burn, augmentation rhinoplasty and mamaplasty, can be promoted using Biological-material complex patch It is regenerated into body, organized renewing original appearance is made to have more aesthetic values；In terms of gynemetrics.Basin bottom is dissected and reconstruction aspect prospect It is wide.However bone tissue and ligament regeneration in orthopaedics.The reconstruction of bladder, ureter and penis in Urology Surgery.It is cardiovascular Though the application in terms of devices for heart valve treatments congenital heart disease is repaired in neighborhood obtains certain achievement but entirety is still in experiment Exploratory stage.Require further study expansion；Biological composite patch there is now commercialization, and moderate, in wide clinical application.
Surgical incision site infection is most commonly that in surgical infection, wall of the chest infection is one kind of surgical incision site infection Type.Reparation and the reconstruction of chest wall defect are a difficult problems of thoracic surgery under Infection Status.
With the continuous renewal of surgical materials and the continuous improvement of surgical technic level, biology composite patch is wide at present It is general to be applied to breast wall repairing, significantly reduce infection and disease relapse.Being had using artificial synthesized sticking patch increases postoperative infection and some The risk of long-term complications, the biocompatibility of biological composite patch is more preferable, and security higher is also prevented from wall of the chest adhesion etc. Potential danger.
The content of the invention
Invention broadly provides a kind of degradable pleura sticking patch and preparation method thereof, the biocompatibilities of such sticking patch It is good, safe, in prevention wall of the chest adhesion, anti-infective aspect significant effect.Its technical solution is as follows：A kind of degradable pleura is mended Piece, including following parts by weight of component：1-5 parts poly- to dioxy cyclohexanone, 1-5 parts of chitosans, 1-5 parts of epidermal growth factor and 1- 10 parts of Sodium Hyaluronates.
Preferably, the surface layer of the degradable pleura sticking patch is coated with artificial skin.
Preferably, the artificial skin is bonded by porous silicone rubber and knitting nylon fiber.
Preferably, the poly- molecular weight to dioxy cyclohexanone is 9 × 102-2×106Da, the molecular weight of the chitosan For 1 × 103-5×104Da。
Preferably, the poly- molecular weight to dioxy cyclohexanone is 1.1 × 105Da。
Preferably, the epidermal growth factor is selected from fibroblast growth factor, basic fibroblast growth factor One or more of with placenta growth factor, the activity of the epidermal growth factor is 1 × 104-1×105IU。
Preferably, the Sodium Hyaluronate is the middle-molecular-weihydroxyethyl Sodium Hyaluronate or molecule of ten thousand dalton of molecular weight 50-100 Measure the low molecular weight sodium hyaluronate of ten thousand dalton of 5-30.
Preferably, the chitosan is derived from shrimp shell or crab shell.
A kind of preparation method of degradable pleura sticking patch, comprises the following steps：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) chitosan, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gelling agent；
(3) gelling agent is laid on patch；
(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.
Using above-mentioned degradable pleura sticking patch and preparation method thereof, the present invention has the following advantages：
Induction promoting epidermization is stimulated by adding Multiple components in the pleura sticking patch of this case, fiber finer can also be inhibited into The overexpression of born of the same parents recovers the original composition of reduction skin histology, while does not cause cicatricial tissue, makes good fast of the wall of the chest, does not stay scar. The degradable pleura sticking patch histocompatbility of this case is good, degree of safety is high, can be rapidly used for body wound repair and reconstruction.
Specific embodiment
Embodiment 1
1. a kind of degradable pleura sticking patch, including following parts by weight of component：2 part 1.1 × 105Da's gathers to dioxy ring Ketone, 3 part 1 × 103The chitosan of Da, 2 parts of activity are 5 × 104The fibroblast growth factor of IU and 5 part of 1,000,000 dalton Sodium Hyaluronate, the surface layer of the pleura sticking patch are coated with the artificial skin being bonded by porous silicone rubber and knitting nylon fiber Skin.
2. the preparation method of above-mentioned degradable pleura sticking patch is：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) chitosan from shrimp shell, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gel Agent；
(3) gelling agent is laid on patch；
(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.
Embodiment 2
1. a kind of degradable pleura sticking patch, including following parts by weight of component：5 part 9 × 102Da's gathers to dioxy ring Ketone, 1 part 5 × 104The chitosan of Da, 5 parts of activity are 1 × 104The fibroblast growth factor of IU and 1 part of 500,000 dalton Sodium Hyaluronate, the surface layer of the pleura sticking patch are coated with the artificial skin being bonded by porous silicone rubber and knitting nylon fiber Skin.
2. the preparation method of above-mentioned degradable pleura sticking patch is：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) chitosan from crab shell, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gel Agent；
(3) gelling agent is laid on patch；
(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.
Embodiment 3
1. a kind of degradable pleura sticking patch, including following parts by weight of component：1 part 1 × 104Da's gathers to dioxy ring Ketone, 5 part 1 × 104The chitosan of Da, 1 part of activity are 1 × 105The fibroblast growth factor of IU and 10 part of 800,000 dalton Sodium Hyaluronate, the surface layer of the pleura sticking patch are coated with the artificial skin being bonded by porous silicone rubber and knitting nylon fiber Skin.
2. the preparation method of above-mentioned degradable pleura sticking patch is：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) chitosan from crab shell, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gel Agent；
(3) gelling agent is laid on patch；
(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.
Embodiment 4
1. a kind of degradable pleura sticking patch, including following parts by weight of component：2 part 9 × 105Da's gathers to dioxy ring Ketone, 5 part 1 × 104The chitosan of Da, 2 parts of activity are 5 × 104The fibroblast growth factor of IU and 8 part of 1,000,000 dalton Sodium Hyaluronate, the surface layer of the pleura sticking patch are coated with the artificial skin being bonded by porous silicone rubber and knitting nylon fiber Skin.
2. the preparation method of above-mentioned degradable pleura sticking patch is：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) chitosan from shrimp shell, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gel Agent；
(3) gelling agent is laid on patch；
(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.
Comparative example 1
1. a kind of degradable pleura sticking patch, including following parts by weight of component：2 part 2 × 106Da's is poly- to dioxy cyclohexanone With 3 part 1 × 103The chitosan of Da.
2. the preparation method of above-mentioned degradable pleura sticking patch is：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) weigh the chitosan from shrimp shell by formula ratio and be prepared into gelling agent；
(3) gelling agent is laid on patch, envelope after fitting.
Comparative example 2
1. a kind of degradable pleura sticking patch, including following parts by weight of component：2 part 2 × 106Da's gathers to dioxy ring Ketone, 3 part 1 × 103The chitosan of Da, 2 parts of activity are 5 × 104The fibroblast growth factor of IU and 5 part of 1,000,000 dalton Sodium Hyaluronate.
2. the preparation method of above-mentioned degradable pleura sticking patch is：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2) chitosan from shrimp shell, epidermal growth factor and Sodium Hyaluronate are weighed by formula ratio, is prepared into gel Agent；
(3) gelling agent is laid on patch, envelope after fitting.
Pleura reparative experiment
1. test material：Using the wall of the chest of rabbit as subjects, wound repair model is made, is randomly divided into 4 groups, every group 10 Only, i.e. A, B, C, D group.
2.A groups apply the pleura sticking patch prepared in embodiment 1, B groups apply the pleura sticking patch prepared in embodiment 2, C groups are applied The pleura sticking patch for preparing in comparative example 2 is applied with the pleura sticking patch that is prepared in comparative example 1, D groups, observes wound repair situation.
3. experimental result observes time, pleura sticking patch and surrounding that the paradoxical breathing that each rabbit is average in every group weakens The time of tissue tight's combination, the complete healing time of the wall of the chest.
1 four groups of pleura sticking patch effects of table compare
As shown in Table 1, A groups are compared with D groups, and because of the uncoated artificial skin of D groups, effect has very big difference, manually Skin provides Moist healing environment for pleura sticking patch, is conducive to the healing of the wall of the chest.For A groups compared with C groups, the healing effect of C groups is poor, A groups tool improves significantly.Finally, during actual experiment, it is found that pleura sticking patch degradable time and the wall of the chest are cured completely It closes that the time is close, and pleura sticking patch is also degradable after wall of the chest healing, ensures that pleura sticking patch is also degraded and finished while wound healing.
It will be apparent to those skilled in the art that technical solution that can be as described above and design, make other various Corresponding change and deformation, and all these changes and deformation should all belong to the protection domain of the claims in the present invention Within.

Claims (9)

1. a kind of degradable pleura sticking patch, it is characterised in that：It includes following parts by weight of component：1-5 parts it is poly- to dioxy cyclohexanone, 1-5 parts of chitosans, 1-5 parts of epidermal growth factor and 1-10 parts of Sodium Hyaluronates.
2. degradable pleura sticking patch according to claim 1, it is characterised in that：The surface layer of the degradable pleura sticking patch applies It is covered with artificial skin.
3. degradable pleura sticking patch according to claim 2, it is characterised in that：The artificial skin by porous silicone rubber with Knitting nylon fiber is bonded.
4. degradable pleura sticking patch according to claim 1, it is characterised in that：The poly- molecular weight to dioxy cyclohexanone For 9 × 102-2×106Da, the molecular weight of the chitosan is 1 × 103-5×104Da。
5. degradable pleura sticking patch according to claim 4, it is characterised in that：The poly- molecular weight to dioxy cyclohexanone For 1.1 × 105Da。
6. degradable pleura sticking patch according to claim 1, it is characterised in that：The epidermal growth factor is selected from into fiber One or more of Porcine HGF, basic fibroblast growth factor and placenta growth factor, the epidermal growth The activity of the factor is 1 × 104-1×105IU。
7. degradable pleura sticking patch according to claim 1, it is characterised in that：The Sodium Hyaluronate is molecular weight 50- The low molecular weight sodium hyaluronate of ten thousand dalton of middle-molecular-weihydroxyethyl Sodium Hyaluronate or molecular weight 5-30 of 1000000 dalton.
8. degradable pleura sticking patch according to claim 1, it is characterised in that：The chitosan is derived from shrimp shell or crab shell.
A kind of 9. method for preparing degradable pleura sticking patch as claimed in claim 2, it is characterised in that：Comprise the following steps：
(1) weigh and gather to dioxy cyclohexanone by formula ratio, patch is woven by textile instrument；
(2 weigh chitosan, epidermal growth factor and Sodium Hyaluronate by formula ratio, are prepared into gelling agent；
(3) gelling agent is laid on patch；
(4) artificial skin, envelope after fitting are coated on the patch for be covered with gelling agent.
CN201710302641.6A 2017-05-03 2017-05-03 A kind of degradable pleura sticking patch and preparation method thereof Pending CN108114314A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1312727A (en) * 1998-06-18 2001-09-12 澳大利亚微研究基金会 Method of tissue repair II
US7252832B1 (en) * 2004-12-13 2007-08-07 Biomet Sports Medicine, Inc. Composite collagen material and method of forming same
CN102316823A (en) * 2009-02-11 2012-01-11 新加坡南洋理工大学 Multi-layered surgical prosthesis
CN202951005U (en) * 2012-11-08 2013-05-29 李国明 Composite artificial skin
US20160067031A1 (en) * 2014-09-08 2016-03-10 Ghassan S. Kassab Methods and uses of mediastinal pleura tissue for various stent and other medical applications

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1312727A (en) * 1998-06-18 2001-09-12 澳大利亚微研究基金会 Method of tissue repair II
US7252832B1 (en) * 2004-12-13 2007-08-07 Biomet Sports Medicine, Inc. Composite collagen material and method of forming same
CN102316823A (en) * 2009-02-11 2012-01-11 新加坡南洋理工大学 Multi-layered surgical prosthesis
CN202951005U (en) * 2012-11-08 2013-05-29 李国明 Composite artificial skin
US20160067031A1 (en) * 2014-09-08 2016-03-10 Ghassan S. Kassab Methods and uses of mediastinal pleura tissue for various stent and other medical applications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
范虹等: "胸壁缺损的重建修复", 《中国综合临床》 *
龚志云等: "可降解聚对二氧环己酮网的制备、优化及体内降解研究", 《第二军医大学学报》 *

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Application publication date: 20180605