CN202814874U - Near-infrared fluorescent scanner - Google Patents
Near-infrared fluorescent scanner Download PDFInfo
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- CN202814874U CN202814874U CN 201220372662 CN201220372662U CN202814874U CN 202814874 U CN202814874 U CN 202814874U CN 201220372662 CN201220372662 CN 201220372662 CN 201220372662 U CN201220372662 U CN 201220372662U CN 202814874 U CN202814874 U CN 202814874U
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- light
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- infrared fluorescent
- light source
- timing unit
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Abstract
The utility model provides a near-infrared fluorescent scanner which comprises a light source, a light splitter, a focusing lens, a moving device, a timing unit, a near-infrared detector and a controller, wherein the controller triggers the timing unit to time the chromatography time of a test strip; when the timing unit exceeds the time, the moving device is triggered to move the test strip; a near-infrared light emitted from the light source is focused and subsequently projected to a test strip (with a near-infrared fluorescent mark) of a sample, so as to generate a bounce light; the near-infrared detector acquires the bounce light, converts the bounce light into an electric signal and transmits the electric signal to the controller; and the controller analyzes the concentration of a target object in the sample according to the electric signal. Whether the sample is positive or negative can be judged according to the concentration of the target object, the sensitivity in diagnosis can be effectively improved, and the quantitative analysis on the concentration of the target object can be carried out.
Description
Technical field
The utility model relates to a kind of diagnostic instrments, relates in particular to a kind of near-infrared fluorescent scanner.
Background technology
Immunochromatographic method is a kind of quick diagnosis technology of rising in recent years, its principle is a certain region of special antibody being fixed in first specific test paper, after test paper is invaded sample (urine or serum), corresponding antigen and this antibody generation specific binding in the sample, utilize the collaurum developing technology can make test paper show certain color, can be negative or the positive by judgement sample by color.
But there is defective in this technology: the one, and sensitivity is low, then can't develop the color if sample concentration is low; The 2nd, can't quantitative test.
The utility model content
And defective that can't quantitative low for present immunochromatographic method sensitivity, the utility model provides a kind of near-infrared fluorescent scanner, sensitivity that can the Effective Raise diagnosis, and can carry out quantitative test.
A kind of near-infrared fluorescent scanner comprises:
Light source, controller, timing unit, light splitting piece, focus lamp, mobile device and near infrared detector;
Light source is used for providing near infrared light;
Timing unit is used for the chromatography time of test strips is carried out timing;
Light splitting piece is arranged on the light path of described light source, and focus lamp is arranged on the light splitting optical path of light splitting piece, and light splitting piece is used near infrared light light splitting with light source to focus lamp, and focus lamp is used for the light splitting of light splitting piece is focused on;
Mobile device is used for mobile test strips;
Near infrared detector is used for the reflected light of the near-infrared fluorescent mark generation of the sample on the collection test strips, converts reflected light to electric signal and output electrical signals;
Controller is connected with light source, timing unit, mobile device and near infrared detector respectively, be used for the control light source and send near infrared light, trigger the timing unit timing, move test strips at the overtime triggering mobile device of timing unit, and according to the concentration vector of target detection thing in the electric signal analytic sample.
A kind of near-infrared fluorescent scanner that the utility model provides, controller triggers the chromatography time of timing unit timing control test strips, move test strips at the overtime triggering mobile device of timing unit, after focusing on, near infrared light that light source sends projects to on the test paper of the sample of near-infrared fluorescent mark and produce reflected light, near infrared detector gathers reflected light and converts electric signal to and send to controller, controller is by the concentration of object in this electric signal analytic sample, concentration by object can be positive or feminine gender by judgement sample, can effectively improve the sensitivity of diagnosis, and can carry out quantitative test to the target detection substrate concentration, in addition, timing unit can automatically be controlled the chromatography time of test strips and can automatically start mobile device, and automaticity is higher.
Description of drawings
The structural representation of a kind of near-infrared fluorescent scanner the first embodiment that Fig. 1 provides for the utility model.
The structural representation of a kind of near-infrared fluorescent scanner the second embodiment that Fig. 2 provides for the utility model.
Embodiment
Embodiment of the present utility model is described with reference to the accompanying drawings.The element of describing in an accompanying drawing of the present utility model or a kind of embodiment and feature can combine with element and the feature shown in one or more other accompanying drawings or the embodiment.Should be noted that in order to know purpose, omitted in accompanying drawing and the explanation and the utility model expression and description irrelevant, parts known to persons of ordinary skill in the art and processing.
As shown in Figure 1, the structural representation of near infrared point fluorescent scanning instrument the first embodiment that the utility model provides comprises:
Light splitting piece 15 is arranged on the light path of light source 11, and focus lamp 16 is arranged on the light splitting optical path of light splitting piece 15, and light splitting piece 15 is used near infrared light light splitting with light source 11 to focus lamp 16, and focus lamp 16 is used for the light splitting of light splitting piece 15 is focused on;
Near infrared detector 17 is used for the reflected light of the near-infrared fluorescent mark generation of the sample on the collection test strips 14, converts reflected light to electric signal and output electrical signals; Controller 12 is connected with near infrared detector with light source 11, timing unit 13, mobile device 18 respectively and is connected, be used for control light source 11 and send near infrared light, trigger timing unit 13 timing, when timing unit 13 is overtime, trigger mobile device 18 and move test strips 24, and according to the concentration vector of target detection thing in the electric signal analytic sample.
Near infrared light is the electromagnetic wave between visible light and mid-infrared light, and wavelength is between 650-1500nm, and this concept is as well known to those skilled in the art.
Target detection thing near infrared light mark in the sample, the target detection substrate concentration characterizes by intensity of reflected light.
As shown in Figure 2, the structural representation of near-infrared fluorescent scanner the second embodiment of providing of the utility model.
Mobile device comprises stepper motor 27, screw mandrel 28, base plate 29 and the sample stage 210 that is used for carrying test strips 24, stepper motor 27 and sample stage 210 are arranged on the base plate 29, stepper motor 27 links to each other with sample stage 210 by screw mandrel 28, and controller 22 rotates the displacement that produces on the horizontal direction with Quality control platform 210 and near infrared detector 211 by control step motor 27.
Alternatively, timing unit 23 is arranged on the sample stage 210, when induction installation 231 is sensed test strips 24 and is put into, send induced signal to controller 22, controller 22 receives that sending triggering command control timer 232 behind this signal begins timing according to setting-up time, sample in setting-up time on the test strips 24 carries out the chromatography reaction, produce a down trigger stepper motor 27 at overtime rear controller 22 and move test strips 24, the chromatography time can set up on their own according to actual needs, after setting-up time, automatically open near infrared detector 211, need not manual operation and start.
Alternatively, the near-infrared fluorescent scanner comprises that also the first optical filter 212, the first optical filters 212 are arranged between light source 21 and the light splitting piece 25, and mating plate 212 can obtain the near infrared light of required wavelength after filtration.
Alternatively, near infrared point fluorescent scanning instrument comprises that also the second optical filter 213, the second optical filters 213 are arranged between light splitting piece 25 and the near infrared detector 211.
Alternatively, controller 22 comprises the USB interface 214 of carrying out data transmission for external computing machine.
Alternatively, controller 22 also comprises the printer interface 215 for external printer, and external printer is used in real time output measurement data.
Alternatively, controller 22 also comprises for carrying out the network port 216 of real-time Communication for Power with external system.
Alternatively, adopt cable to be connected between light source 21 and the controller 22.
Detecting unit 222 is connected with near infrared detector 211, is used for obtaining the fluorescence vector according to the electric signal that receives, and obtains the concentration vector of target detection thing by the conversion relation of fluorescence vector and mapping matrix.
Below further set forth the principle of work of present embodiment.
Object in the sample is carried out the near infrared mark by the near infrared labelling technique, afterwards with sample drop on test strips 24, test strips 24 is fixed on the sample stage 210, when induction installation 231 is sensed test strips, to controller 22 feedback-induced signals; Controller 22 sends triggering command according to induced signal, timer 2 32 is when receiving the triggering command that controller 22 sends, begin the chromatography time of test strips is carried out timing, move test strips 24 until overtime rear controller control step motor 27, controller 22 control light sources 21 send near infrared light, near infrared light is successively through the first optical filter 212, get to the near-infrared fluorescent mark of test strips 7 after light splitting piece 25 and the focus lamp 26, produce reflected light, reflected light passes through focus lamp 26 successively, received by near infrared detector 211 after light splitting piece 25 and the second optical filter 213, near infrared detector 211 produces test strips 24 in mobile process reflected light converts electric signal to and sends to controller 22, described electric signal is fluorescent pulse, controller 22 obtains the fluorescence vector of target detection thing according to the fluorescent pulse analysis that receives, conversion relation by fluorescence vector and mapping matrix can draw the concentration vector of object in the sample on the test strips 24, mapping matrix is to obtain by a large amount of related experiment data accumulations, can be negative or the positive by judgement sample according to object concentration vector size, the data such as object concentration vector size can show by external printer output.
A kind of near-infrared fluorescent scanner that the utility model provides, controller triggers the chromatography time of timing unit timing control test strips, move test strips at the overtime triggering mobile device of timing unit, after focusing on, near infrared light that light source sends projects to on the test paper of the sample of near-infrared fluorescent mark and produce reflected light, near infrared detector gathers reflected light and converts electric signal to and send to controller, controller is by the concentration of object in this electric signal analytic sample, concentration by object can be positive or feminine gender by judgement sample, can effectively improve the sensitivity of diagnosis, and can carry out quantitative test to the target detection substrate concentration, in addition, timing unit can automatically be controlled the chromatography time of test strips and can automatically start mobile device, automaticity is higher, and can carry out quantitative test to the target detection substrate concentration, thereby can be early warning and the fast detecting of some disease, checking on and import and export inspection and quarantine in the scene of food security provides technical guarantee.
Although described the utility model and advantage thereof in detail, be to be understood that and in the situation that does not exceed the spirit and scope of the present utility model that limited by appended claim, can carry out various changes, alternative and conversion.And the application's scope is not limited only to the specific embodiment of the described process of instructions, equipment, means, method and step.The one of ordinary skilled in the art will readily appreciate that from disclosure of the present utility model, according to the utility model can use carry out with the essentially identical function of corresponding embodiment described herein or obtain result essentially identical with it, existing and want exploited process, equipment, means, method or step future.Therefore, appended claim is intended to comprise such process, equipment, means, method or step in their scope.
Claims (10)
1. a near-infrared fluorescent scanner is characterized in that, described near-infrared fluorescent scanner comprises:
Light source, controller, timing unit, light splitting piece, focus lamp, mobile device and near infrared detector;
Described light source is used for providing near infrared light;
Described timing unit is used for the chromatography time of test strips is carried out timing;
Described light splitting piece is arranged on the light path of described light source, described focus lamp is arranged on the light splitting optical path of described light splitting piece, described light splitting piece is used near infrared light light splitting with described light source to described focus lamp, and described focus lamp is used for the light splitting of described light splitting piece is focused on;
Described mobile device is used for mobile described test strips;
Described near infrared detector is used for the reflected light of the near-infrared fluorescent mark generation of the sample on the collection test strips, converts reflected light to electric signal and output electrical signals;
Described controller is connected with described light source, described timing unit, described mobile device and the near infrared detector of being connected respectively, be used for controlling described light source and send near infrared light, trigger described timing unit timing, when described timing unit is overtime, trigger described mobile device and move described test strips, and analyze the concentration vector of target detection thing in the described sample according to described electric signal.
2. near-infrared fluorescent scanner according to claim 1, it is characterized in that, described timing unit comprises induction installation and timer, and described induction installation all links to each other with described controller with timer, and described induction installation is for the induction test strips and to described controller feedback-induced signal; Described timer is used for beginning the chromatography time of test strips is carried out timing when receiving the triggering command that described controller sends according to described induced signal.
3. near-infrared fluorescent scanner according to claim 1, it is characterized in that, described mobile device comprises stepper motor, screw mandrel, base plate and the sample stage that is used for the carrying test strips, described stepper motor and described sample stage are arranged on the described base plate, described stepper motor links to each other with sample stage by screw mandrel, and described controller rotates with the displacement on Quality control platform and the near infrared detector generation horizontal direction by the described stepper motor of control.
4. arbitrary described near-infrared fluorescent scanner is characterized in that according to claim 1-3, and described near-infrared fluorescent scanner also comprises the first optical filter, and described the first optical filter is arranged between described light source and the described light splitting piece.
5. arbitrary described near-infrared fluorescent scanner is characterized in that according to claim 1-3, and described near-infrared fluorescent scanner also comprises the second optical filter, and described the second optical filter is arranged between described light splitting piece and the described near infrared detector.
6. arbitrary described near-infrared fluorescent scanner is characterized in that described controller comprises the USB interface of carrying out data transmission for external computing machine according to claim 1-3.
7. arbitrary described near-infrared fluorescent scanner is characterized in that described controller also comprises the printer interface for external printer according to claim 1-3.
8. arbitrary described near-infrared fluorescent scanner is characterized in that according to claim 1-3, and described controller also comprises for carrying out the network port of real-time Communication for Power with external system.
9. arbitrary described near-infrared fluorescent scanner is characterized in that according to claim 1-3, adopts cable to be connected between described light source and the described controller.
10. arbitrary described near-infrared fluorescent scanner according to claim 1-3 is characterized in that described controller comprises:
Trigger control unit, be connected with described light source, described timing unit and the mobile device of being connected respectively, be used for controlling described light source and send near infrared light, trigger described timing unit timing, when described timing unit is overtime, trigger described mobile device and move described test strips;
Detecting unit is connected with described near infrared detector, is used for obtaining the fluorescence vector according to the described electric signal that receives, and obtains the concentration vector of target detection thing by the conversion relation of fluorescence vector and mapping matrix.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220372662 CN202814874U (en) | 2012-06-01 | 2012-07-30 | Near-infrared fluorescent scanner |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220259062 | 2012-06-01 | ||
| CN201220259062.0 | 2012-06-01 | ||
| CN 201220372662 CN202814874U (en) | 2012-06-01 | 2012-07-30 | Near-infrared fluorescent scanner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202814874U true CN202814874U (en) | 2013-03-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220372662 Withdrawn - After Issue CN202814874U (en) | 2012-06-01 | 2012-07-30 | Near-infrared fluorescent scanner |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202814874U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103454256A (en) * | 2012-06-01 | 2013-12-18 | 北京润博福得生物科技发展有限公司 | Near infrared fluorescence scanner |
| CN116297289A (en) * | 2022-12-29 | 2023-06-23 | 蓝冰河(常州)精密测量技术有限责任公司 | Near-infrared film quality on-line monitoring system based on InGaAs array detector |
-
2012
- 2012-07-30 CN CN 201220372662 patent/CN202814874U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103454256A (en) * | 2012-06-01 | 2013-12-18 | 北京润博福得生物科技发展有限公司 | Near infrared fluorescence scanner |
| CN103454256B (en) * | 2012-06-01 | 2015-11-25 | 北京润博福得生物科技发展有限公司 | Near-infrared fluorescent scanner |
| CN116297289A (en) * | 2022-12-29 | 2023-06-23 | 蓝冰河(常州)精密测量技术有限责任公司 | Near-infrared film quality on-line monitoring system based on InGaAs array detector |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20130320 Effective date of abandoning: 20151125 |
|
| C25 | Abandonment of patent right or utility model to avoid double patenting |