CN202710575U - Biomedical detection device - Google Patents

Biomedical detection device Download PDF

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Publication number
CN202710575U
CN202710575U CN 201220373020 CN201220373020U CN202710575U CN 202710575 U CN202710575 U CN 202710575U CN 201220373020 CN201220373020 CN 201220373020 CN 201220373020 U CN201220373020 U CN 201220373020U CN 202710575 U CN202710575 U CN 202710575U
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CN
China
Prior art keywords
filter wheel
rotating disk
biomedical
wheel rotating
exit end
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 201220373020
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Chinese (zh)
Inventor
张志忠
刘尊亮
王旗
吴芸
周华东
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SUZHOU LEO BIOTECHNOLOGY CO Ltd
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SUZHOU LEO BIOTECHNOLOGY CO Ltd
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Abstract

The utility model discloses a biomedical detection device, comprising a multi-color light source (1). The biomedical detection device is characterized in that a collecting lens (1-2) is arranged at an exit end of the multi-color light source (1); a filter wheel turntable (2-1) is arranged at the exit end of the collecting lens; a plurality of through holes are arranged on the filter wheel turntable (2-1); a light filter (2-2) is respectively arranged on each through hole; eight paths of light splitters (3-1) are arranged above the through holes; the eight paths of light splitters (3-1) are connected with eight optical fibers (3-2); the exit end of each optical fiber (3-2) corresponds to a corresponding transparent micro-cup (4-1) containing detecting liquid; a corresponding photoelectric receiving tube (5-1) is arranged above each transparent micro-cup (4-1), and the output end of each photoelectric receiving tube (5-1) is connected with a signal collecting and processing device. The biomedical detection device can be multi-purpose, not only can detect immune projects, but also can detect biomedical projects, thereby being beneficial to reducing the use cost of a user.

Description

Biomedical pick-up unit
Technical field
The utility model relates to a kind of medical detecting Instrument, especially a kind of Biological indicators device for fast detecting, and specifically a kind of trace level (μ l level) sample and reagent of only needing just can fast qualitative and the quantitative biomedical pick-up unit that detects required biochemical indicator.
Background technology
At present, enzyme micro-plate reader and Biochemical Analyzer are generally being adopted by the check section office of situation of all-level hospitals with good conditionsi and other medical and health organizations at present, have brought facility for to a certain extent these reviewers, have improved their robotization detection level.But the self Biochemical Analyzer has the characteristics of obvious deficiency: the one, and sample and reagent dosage are large, need ml level liquid measure; The 2nd, the single pattern detection time is long, especially can cause the deviation that waits for a long time and cause test result when the patient of collective detects.And the enzyme micro-plate reader of self does not have a biochemical measuring ability on the market, has increased thus user's purchase cost.Therefore, a kind of multi-functional medical science pick-up unit that is compounded with biochemical class and the detection of immune intermediate item of design just seems very necessary.
Summary of the invention
The purpose of this utility model is for existing microplate reader and the single problem of biochemical instruments detection technique, designs a kind of multi-functional biomedical pick-up unit that is compounded with immune class and biochemical intermediate item qualitative, quantitative chemical examination detection.
The technical solution of the utility model is:
A kind of biomedical pick-up unit, it comprises secondary color light source 1, the exit end that it is characterized in that described secondary color light source 1 is equipped with condenser 1-2, exit end at condenser is equipped with filter wheel rotating disk 2-1, filter wheel rotating disk 2-1 is provided with several through holes, optical filter 2-2 all is installed on each through hole, No. eight optical splitter 3-1 are installed above through hole, No. eight optical splitter 3-1 are connected with eight optical fiber 3-2, the exit end of every optical fiber 3-2 is corresponding with the transparent trace cup 4-1 that corresponding being equipped with detects liquid, directly over every transparent trace cup 4-1 corresponding photoelectric receiving tube 5-1 is installed, the output terminal of photoelectric receiving tube 5-1 links to each other with signal acquisition and processing apparatus.
Described secondary color light source 1 is halogen tungsten lamp.
Described transparent trace cup 4-1 is installed on the mobile microwell plate.
Described filter wheel rotating disk 2-1 is connected with the stepper motor 6 that drives its rotation, at the periphery of filter wheel rotating disk 2-1 filter wheel projection 2-3 is installed, and in the side of filter wheel rotating disk 2-1 the contact detecting device 7 that matches with filter wheel projection 2-3 is installed.
The beneficial effects of the utility model:
1, a tractor serves several purposes not only can detect immune intermediate item, can also detect biochemical intermediate item, thereby has reduced customer using cost.
2, the biochemistry required sample of roughly the same immune class and reagent only reach trace level (μ l level) consumption, and therefore available finger blood method substitutes the vein haemospasia method, thereby have alleviated the painful of patient and reduced the reagent use cost.
3, detection speed is fast high with accuracy, is because adopted ARM micro-chip processor and LVDS data-interface, and the sample of 96 person-portions only need can detect complete and printout in 90 seconds.
Description of drawings
Fig. 1 is system of the present utility model detecting unit FB(flow block).
Fig. 2 is composition structural representation of the present utility model.
Fig. 3 is the sectional view of filter wheel rotating disk of the present utility model.
Among the figure 1, the secondary color light source, 1-2, condenser, 2, the monochromatic light shaper, 2-1, filter wheel rotating disk, the 2-2 optical filter, 2-3, filter wheel projection, 3, eight tunnel optical signal transmission, 3-1, No. eight optical splitters, 3-2, optical fiber, 3-3, eight tunnel detects incident light I i, 3-4, eight tunnel detects emergent light I o, 4, microwell plate, 4-1, transparent trace cup, 5, No. eight photoelectric detectors, 5-1, photoelectric receiving tube, 6, stepper motor, 6-1, motor signal wire, 6-2, motor shaft, 7, the contact detecting device, 8, eight road electric signal amplifiers, 9, eight road A/D converters, 10, log-compressed and converter unit, 11, immunity and a biochemical computing unit, 12, LVDS data-interface, 13, the output report print unit.
Embodiment
Below in conjunction with drawings and Examples the utility model is further described.
Shown in Fig. 2-3.
A kind of biomedical pick-up unit, it comprises that secondary color light source 1(can adopt halogen tungsten lamp), the exit end of described secondary color light source 1 is equipped with condenser 1-2, exit end at condenser is equipped with filter wheel rotating disk 2-1, filter wheel rotating disk 2-1 is provided with several through holes, optical filter 2-2 all is installed on each through hole, described filter wheel rotating disk 2-1 is connected with the stepper motor 6 that drives its rotation, periphery at filter wheel rotating disk 2-1 is equipped with filter wheel projection 2-3, side at filter wheel rotating disk 2-1 is equipped with the contact detecting device 7 that matches with filter wheel projection 2-3, as shown in Figure 3, No. eight optical splitter 3-1 are installed above through hole, No. eight optical splitter 3-1 are connected with eight optical fiber 3-2, the exit end of every optical fiber 3-2 is corresponding with the transparent trace cup 4-1 that corresponding being equipped with detects liquid, described transparent trace cup 4-1 is installed on the mobile microwell plate, directly over every transparent trace cup 4-1, corresponding photoelectric receiving tube 5-1 is installed, the output terminal of photoelectric receiving tube 5-1 links to each other with signal acquisition and processing apparatus, as shown in Figure 1.
System's detecting unit FB(flow block) as shown in Figure 1, it indicates the signal flow between each functional unit in the system detecting device.It is comprised of 11 big units altogether, is respectively secondary color light source 1, monochromatic light shaper 2, eight tunnel optical signal transmission 3, microwell plate 4, No. eight photoelectric detectors 5, eight road electric signal amplifiers 8, eight road A/D converters 9, log-compressed and converter unit 10, immunity item and a biochemical computing unit 11, LVDS data-interface 12, output report printing 13.Monochromatic light wherein forms the unit, is by consisting of such as the halogen tungsten lamp 1-1 in the accompanying drawing 2, condenser 1-2.The wavelength coverage that halogen tungsten lamp 1-1 sends after condenser assembly 1-2 optically focused, deflection, forms a branch of direct projection polychromatic light from 340nm~780 nm visible lights, enters monochromatic light shaper 2, thereby forms a certain monochrome (specific wavelength) light.
Microwell plate carrier absorbance detection device schematic diagram as shown in Figure 2 and the filter wheel sectional view shown in the accompanying drawing 3, the filter wheel rotating disk 2-1 among the figure and optical filter 2-2 consist of the monochromatic light shaper 2 in the accompanying drawing 1; The motor shaft 6-2 of stepper motor 6 fixedly is embedded in the central axis of filter wheel rotating disk 2-1, eight optical filter 2-2(monochromatic light) distribute symmetrically and be embedded in the corresponding hole slot of rotating disk 2-1 with the axial line of filter wheel rotating disk 2-1; The separately position of eight optical filter 2-2 determined by program composition, and behind the monochromatic filter of selecting a kind of wavelength wherein, programmed instruction control meeting rotates to the porch of No. eight optical splitter 3-1 with it, thereby the monochromatic light of this wavelength is imported among eight road optical fiber 3-2; Filter wheel rotating disk 2-1 outer rim is inlaid with filter wheel projection 2-3, when motor signal wire 6-1 accepts program control instruction and guides motor shaft 6-2 rotation, thereby drive filter wheel rotating disk 2-1 rotation, after filter wheel projection 2-3 runs into contact detecting device 7, system can send into this detection signal the ARM microprocessor and form reset instruction, forces instrument to return to original state.
Shown in accompanying drawing 1 and accompanying drawing 2, eight tunnel optical signal transmission 3 are comprised of No. eight optical splitter 3-1 and eight road optical fiber 3-2, this element optic path only by monochromatic light shaper 2 formed a certain wavelength (such as 405nm) light, by eight road optical fiber 3-2 leaded lights transmission and behind condenser optically focused, forms eight tunnel detection incident light (I i) 3-3, this light intensity I iDetermine, then enter to inject eight transparent trace cup 4-1 that microwell plate carrier 4 embeds, obtain eight the tunnel through eight transparent trace cup 4-1 outgoing and detect emergent light (I o) 3-4.Because the shade of liquid can have in various degree absorption to incident light 3-3 energy in the cup, so emergent light (I o) the intensity size of 3-4 will be along with the depth degree that whether contains liquid color in liquid and the cup among the transparent trace cup 4-1 difference, thereby the variation that can produce absorbance.
Shown in Fig. 1 and Fig. 2, eight transparent trace cup 4-1 are connected to the Kong Weizhong of a row and embedding microwell plate 4, and the Kong Weike of this microwell plate 4 embeds total amount and reaches the transparent trace cup of 12 rows' (96 cups) 4-1.In the detection, microwell plate 4 need be shelved and put into its special support grillage, be moved by the horizontal stepping of stepper motor drive plate supporting frame of a special use, move thereby drive microwell plate 4 equidirectional steppings; And mobile step pitch number is 1~12, can selectedly in arranging by the operator (be less than 8 people such as the detection number, can select the transparent trace cup of 1 row 4-1; Detection number 9~16 people can select the transparent trace cup of 2 rows 4-1; By that analogy, maximum can be selected 12 rows, detects simultaneously 90 person-portion samples); The rim of a cup that microwell plate 4 each mobile step pitch in detection can be guaranteed eight transparent trace cup 4-1 is just towards the corresponding receiving port direction of photoelectric receiving tube 5-1, detected by the arm processor start-up system again, can guarantee that eight road emergent light 3-4 are received and detect light intensity I by photoelectric receiving tube 5-1 with ceiling capacity o, then can be according to I oIntensity-conversion becomes the corresponding electric signal of size, sends into eight road electric signal amplifiers 8.
Shown in Fig. 1 and Fig. 2, through the electric signal that No. eight photoelectric detectors 5 are converted to, send into eight road electric signal amplifiers, 8, eight roods to implement simultaneously amplification, the electric signal after the amplification is admitted to eight road A/D converters 9, thereby implements simultaneously the A/D conversion with eight the road; Send into log-compressed and converter unit 10 after becoming digital signal by simulating signal, implement log-compressed and transformation for mula algorithm, obtain the parameter item value of absorbance; After this, system can be in conjunction with selected (wavelength value), enter immunity or a biochemical computing unit 11 by ARM microprocessor steering order,, implements immunity or biochemical and calculates as parameter value with absorbance, then obtains the relevant data of immunity or biochemical item.Eight tunnel above-mentioned log-compressed and converter unit 10, immunity item or a biochemical computing unit 11, to be solidificated in the program memory ROM after writing and be compiled with program code, in conjunction with measuring and selected parameter, can control and finish computing by testing requirement by the ARM microprocessor.
LVDS data-interface 12 as shown in Figure 1, as immunity or biochemical calculate 11 and output report print 13 data-interface.Be characterized in: the LVDS(low-voltage differential signal) data-interface has fast, low in energy consumption, the undistorted characteristic of transmission speed.Thus, it can shorten system detection time (less than 15 seconds) greatly, and can in 90 seconds, will calculate and data result instantaneous transmission and the printout processed, can be according to the difference of test event in the output print report, demonstrate corresponding item argument, absorbance and all have set the test data of standard items, sample product and blank hole slot in the trace cup to be measured, every data result is objective and accurate, can make things convenient for the clinician that the patient is diagnosed exactly and treats.
The utility model device has diverse in function, a tractor serves several purposes, not only can detect immune intermediate item, but also can detect biochemical intermediate item, thereby has reduced customer using cost; In addition, this device has advantages of also that detection speed is fast, accuracy is high, sample and reagent dosage be few.
The utility model does not relate to partly all, and the prior art that maybe can adopt same as the prior art is realized.

Claims (4)

1. biomedical pick-up unit, it comprises secondary color light source (1), the exit end that it is characterized in that described secondary color light source (1) is equipped with condenser (1-2), exit end at condenser is equipped with filter wheel rotating disk (2-1), filter wheel rotating disk (2-1) is provided with several through holes, optical filter (2-2) all is installed on each through hole, No. eight optical splitters (3-1) are installed above through hole, No. eight optical splitters (3-1) are connected with eight optical fiber (3-2), the exit end of every optical fiber (3-2) is corresponding with the transparent trace cup (4-1) that corresponding being equipped with detects liquid, corresponding photoelectric receiving tube (5-1) is installed directly over every transparent trace cup (4-1), and the output terminal of photoelectric receiving tube (5-1) links to each other with signal acquisition and processing apparatus.
2. biomedical pick-up unit according to claim 1 is characterized in that described secondary color light source (1) is halogen tungsten lamp.
3. biomedical pick-up unit according to claim 1 is characterized in that described transparent trace cup (4-1) is installed on the mobile microwell plate.
4. biomedical pick-up unit according to claim 1, it is characterized in that described filter wheel rotating disk (2-1) is connected with the stepper motor (6) that drives its rotation, periphery at filter wheel rotating disk (2-1) is equipped with filter wheel projection (2-3), in a side of filter wheel rotating disk (2-1) the contact detecting device (7) that matches with filter wheel projection (2-3) is installed.
CN 201220373020 2012-07-31 2012-07-31 Biomedical detection device Expired - Fee Related CN202710575U (en)

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Application Number Priority Date Filing Date Title
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105548020A (en) * 2015-12-09 2016-05-04 苏州德沃生物技术有限公司 Full-automatic multichannel biochemical detector and detection method thereof
CN105548010A (en) * 2015-12-31 2016-05-04 天津微纳芯科技有限公司 LED light source coupling and integrating module
CN109597390A (en) * 2017-09-30 2019-04-09 深圳迈瑞生物医疗电子股份有限公司 Motion control method, movement failure analysis methods and the Biochemical Analyzer of carrier

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105548020A (en) * 2015-12-09 2016-05-04 苏州德沃生物技术有限公司 Full-automatic multichannel biochemical detector and detection method thereof
CN105548020B (en) * 2015-12-09 2018-09-18 苏州德沃生物技术有限公司 Fully-automatic multi-channel biochemical detection device and its detection method
CN105548010A (en) * 2015-12-31 2016-05-04 天津微纳芯科技有限公司 LED light source coupling and integrating module
CN109597390A (en) * 2017-09-30 2019-04-09 深圳迈瑞生物医疗电子股份有限公司 Motion control method, movement failure analysis methods and the Biochemical Analyzer of carrier

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CF01 Termination of patent right due to non-payment of annual fee
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Granted publication date: 20130130

Termination date: 20170731