CN201897567U - Multichannel photoelectric detection device for dry type chemical analysis - Google Patents
Multichannel photoelectric detection device for dry type chemical analysis Download PDFInfo
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- CN201897567U CN201897567U CN 201020650798 CN201020650798U CN201897567U CN 201897567 U CN201897567 U CN 201897567U CN 201020650798 CN201020650798 CN 201020650798 CN 201020650798 U CN201020650798 U CN 201020650798U CN 201897567 U CN201897567 U CN 201897567U
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Abstract
The utility model discloses a multichannel photoelectric detection device for dry type chemical analysis, which comprises a light source incidence channel and four photoelectric detection channels, wherein the four photoelectric detection channels comprise the first, second, third and fourth detection channels which are symmetrically arranged around the device; a reagent tablet is arranged at one end of the first photoelectric detection channel, a detector is arranged at the other end of the first photoelectric detection channel, and a first focusing lens set is placed on the middle part of the first photoelectric detection channel; the structures of the second, third and fourth photoelectric detection channels are as same as the structure of the first photoelectric detection channel; and the photoelectric detectors and the focusing lens sets are arranged on the second, third and fourth photoelectric detection channels respectively. According to the device provided by the utility model, four photoelectric detectors at symmetrical positions are used for measuring the diffused reflection lights at all positions, thereby overcoming the measuring error caused by uneven diffused reflection lights, and increasing the signal to noise ratio and the accuracy of optical measurement, in particular to the dry type chemical measurement.
Description
Technical field
The utility model relates to a kind of spectral analysis device, is specifically related to a kind of multichannel light electric detection means that dry chemical is analyzed that is used for.
Background technology
In clinical examination is analyzed, utilize blood, urine or other body fluid to carry out the clinical analysis check, can obtain the result of a plurality of clinical examination projects fast, be the most accurate, one of the most direct method that the doctor diagnoses.Carrying out during clinical examination analyzes, the wet chemistry analytic approach of normal employing at present, it has used the method that is called as solution chemistry.Usually, the instrument of employing wet chemistry analytic approach is the colourimetry based on Lambert-Beer's law.This detection method need be passed through following steps: blood blood drawing, centrifugal, configuration reagent solution, Photoelectric Detection.The shortcoming of this type of detection method is: reagent needs to preserve in the liquid mode, need carry out preliminary work during detection, need carry out the centrifugal serum that obtains to whole blood, and whole detection needs the time longer.
The dry chemical analytic approach is for wet chemistry method.Be meant the liquid test sample directly is added on the business-like dried reagent bar into the specific production of disparity items, cause specific chemical reaction with the moisture of sample as solvent, thereby carry out chemico-analytic method.Its adopts reflection photometry or differential electrode method as measurement means, mainly possesses following characteristics: accuracy height, speed are fast, generally can make assay in 3-4min; Easy and simple to handle, do not need daily correction; Need not stock any other reagent or prepare any solution; Sample need not pre-service, and multilayer film has the function of selective filter, thereby reduces the influence of interfering material in the mensuration process; The sample consumption is few, and the moisture during reaction is improved and measured sensitivity by the liquid component supply in the sample.
In the dry chemical analytic approach of clinical examination in the present age, the most representative is exactly the multilayer embrane method.It integrates modern chemistry, optics, enzyme technology, Chemical Measurement and computer technology, reached the level that conventional chemical is measured as quantivative approach, mensuration to some project, even can mention in the same breath with reference method, multilayer film can be divided into three types according to the difference of assay method: a kind of multilayer film that is based on the reflection photometry; A kind of ion-selective electrode multilayer film that is based on differential potentiometry; Also having a kind of is the fluorescence reflection luminosity fado tunic based on fluorescent technique and competition immunological technique that latest developments are got up.
Reflection luminosity ratio juris is according to the reflecting medium difference, occurs following several effects after light enters medium: 1) produce reflection and refraction at irradiating surface; 2) absorbed inside; 3) in inside or irradiating surface produce scattering; The summation of these effects has determined light in ratio that leaves medium and direction, and its final intensity of reflected light is relevant with material on the medium, can obtain the absorbance of dry chemical reagents sheet according to this principle, and then derives testing sample concentration.Therefore in dry chemical analyser, generally by forming: light supply apparatus, collimate monochromatic device, Electro-Optical Sensor Set, signal processing system and device displaying result with lower member based on the reflection photometry.
When utilizing the dry chemical analyser to detect, by sending a branch of light at the instrument internal light source, through shining on the dry chemical reagents sheet after monochromatic and the collimation, certain chromogenic substrate is arranged in the dry chemical reagents sheet, because this chromogenic substrate exists stronger specificity to absorb in the certain wave strong point, after carrying out chemical reaction, can absorb the light of this wavelength, by detecting the reflective light intensity behind the dry chemical reagents sheet chemical reaction, and then can obtain the concentration of testing sample with sample.When carrying out dry chemical method mensuration, because determinand dry chemical reagents sheet is the analoids of multi-layer film structure normally, on the one hand, detected light signal has comprised reflected light, refract light, scattered light and multiple internal reflectance light etc., the existence of parasitic light causes the signal to noise ratio (S/N ratio) of Photoelectric Detection lower in the light signal, causes the influence fluctuation that the testing result precision is lower, repeatability is subjected to different determinands bigger; On the other hand, the inhomogeneity of dry chemical reagents sheet district to be measured chemical reagent and sample component distributing all can cause testing result to depart from actual result.This makes present dry chemical analyser compare gap in addition with the wet chemistry analyser on accuracy and precision.
The utility model content
In order to overcome the deficiencies in the prior art, the purpose of this utility model is to provide a kind of multichannel light electric detection means that dry chemical is analyzed that is used for, and this Device Testing result has pin-point accuracy and high precision.
In order to solve the problems of the technologies described above, realize above-mentioned purpose, the utility model is achieved through the following technical solutions:
A kind of multichannel light electric detection means that is used for the dry chemical analysis, comprise that equally product detect mouth, place analoids on the described sample detection mouth, described sample detection mouth below is provided with a light source incident passage, described light source incident passage one end is provided with light source, the other end is provided with incident passage lens combination, also comprise and be symmetrically distributed in this device first photodetection passage all around, the second photodetection passage, the 3rd photodetection passage and the 4th photodetection passage, the described first photodetection passage, the second photodetection passage, the 3rd photodetection passage and the 4th photodetection passage one end are described analoids, the other end is respectively arranged with first, second, the 3rd, the 4th photodetector, the centre is placed the first convergent lens group respectively, the second convergent lens group, the 3rd convergent lens group and the 4th convergent lens group.
Further, the optical axis of described light source incident passage is 30 °～60 ° with the optical axis included angle of the described first photodetection passage, the second photodetection passage, the 3rd photodetection passage and described the 4th photodetection passage respectively.
Compared with prior art, the multichannel light electric detection means that is used for the dry chemical analysis of the present utility model, utilize the photodetector of four symmetric positions, overcome and diffused each, improved especially signal to noise ratio (S/N ratio) and the degree of accuracy measured of dry chemical of optical measurement to the measuring error that unevenness caused.
Above-mentioned explanation only is the general introduction of technical solutions of the utility model, for can clearer understanding technological means of the present utility model, and can be implemented according to the content of instructions, below with preferred embodiment of the present utility model and conjunction with figs. describe in detail as after.Embodiment of the present utility model is provided in detail by following examples and accompanying drawing thereof.
Description of drawings
Below in conjunction with drawings and embodiments the utility model is described in further detail.
Fig. 1 is the schematic diagram that is used for the multichannel light electric detection means of dry chemical analysis of the present utility model.
Fig. 2 is the vertical view that is used for an embodiment of the multichannel light electric detection means that dry chemical analyzes of the present utility model.
Fig. 3 is the A-A cut-open view of embodiment among Fig. 2.
Number in the figure explanation: number in the figure explanation: 10, light source incident passage, 101, light source, 102, incident passage lens combination, 11, first detection channels, 111, the first photodetectors, 112, first lens combination, 12, second detection channels, 121, second photodetector, 13, the 3rd detection channels, the 131, the 3rd photodetector, the 132, the 3rd lens combination, 14, the four detection channels, the 141, the 4th photodetector, 4, sample detection mouth, 5, analoids, 51, detection zone.
Embodiment
Referring to Fig. 1, Fig. 2 and shown in Figure 3, a kind of multichannel light electric detection means that is used for the dry chemical analysis, comprise that equally product detect mouth 4, place analoids 5 on the described sample detection mouth 4, described sample detection mouth 4 belows are provided with a light source incident path 10, described light source incident path 10 one end is provided with light source 101, the other end is provided with incident passage lens combination 102, also comprise and be symmetrically distributed in this device first photodetection passage 11 all around, the second photodetection passage 12, the 3rd photodetection passage 13 and the 4th photodetection passage 14, the described first photodetection passage 11, the second photodetection passage 12, the 3rd photodetection passage 13 and the 4th photodetection passage 14 1 ends are described analoids 5, the other end is respectively arranged with first, second, the 3rd, the 4th photodetector 111,121,131,141, the centre is placed the first convergent lens group, 112, the second convergent lens groups respectively, the 3rd convergent lens group 132 and the 4th convergent lens group.
Further, the optical axis of described light source incident path 10 is 30 °～60 ° with the optical axis included angle of the described first photodetection passage 11, the second photodetection passage 12, the 3rd photodetection passage 13 and described the 4th photodetection passage 14 respectively.
The light that light source 101 sends incides on the detection zone 51 of the test agent sheet 5 that is placed on the sample detection mouth 4 through incident passage lens combination 102, produce diffusing of all directions, through the meeting first convergent lens group 112, the second convergent lens group, trimerization lens combination 132, after the 4th poly-lens combination is assembled, by first, second, the 3rd, the 4th photodetector 111,121,131,141 detect, electric signal after four photodetectors conversions that calculated by microprocessor is transferred into the back end signal processing module, calculate by microprocessor, can get testing concentration value to the end.
The light intensity R that measures by first, second, third, fourth photodetector 111,121,131,141 that obtains
1, R
2, R
3, R
4Draw R
t=(R
1+ R
2+ R
3+ R
4)/4 can calculate reflection density according to the Williams-Clapper formula, further can calculate the concentration of testing sample according to the proportionate relationship between reflection density and the sample concentration.
Preferably, test by using the multichannel light electric detection means that is used for dry analysis of the present utility model, light source is selected the LED of 580nm, detects the dry chemical reagents sheet of corresponding GLU type.
Embodiment 1: for opening the first photodetection passage 11;
Embodiment 2: for opening first, second photodetection passage 11,12;
Embodiment 3: for opening first, second, third photodetection passage 11,12,13;
Embodiment 4: for opening the first, second, third and the 4th photodetection passage 11,12,13,14.
It is as shown in table 1 below to detect the result who obtains under four kinds of situations.
The detection limit of glucose, precision and degree of accuracy contrast among table 1 embodiment 1,2,3,4
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 |
| Assay method | Prior art | |||
| Glucose detection limit (mmol/L) | 0.05 | 0.05 | 0.05 | 0.05 |
| Precision (coefficient of variation CV) | ≤5.0％ | ≤4.0％ | ≤3.5％ | ?≤3％ |
| Degree of accuracy (target value) | ±9％ | ±7％ | ±6％ | ?±4％ |
Testing result shows, along with the increase of detection channels, its result's degree of accuracy is in being up to of target value ± 4%, and the coefficient of variation CV of precision＜3% is higher than common testing result, has improved signal to noise ratio (S/N ratio) and accuracy.
The foregoing description just is to allow the one of ordinary skilled in the art can understand content of the present utility model and enforcement according to this for technical conceive of the present utility model and characteristics being described, its objective is, can not limit protection domain of the present utility model with this.The variation or the modification of every equivalence of having done according to the essence of the utility model content all should be encompassed in the protection domain of the present utility model.
Claims (2)
1. one kind is used for the multichannel light electric detection means that dry chemical is analyzed, comprise that equally product detect mouthful (4), described sample detection mouth (4) is gone up and is placed analoids (5), described sample detection mouth (4) below is provided with a light source incident passage (10), described light source incident passage (10) one ends are provided with light source (101), the other end is provided with incident passage lens combination (102), it is characterized in that: also comprise being symmetrically distributed in this device first photodetection passage (11) all around, the second photodetection passage (12), the 3rd photodetection passage (13) and the 4th photodetection passage (14), the described first photodetection passage (11), the second photodetection passage (12), the 3rd photodetection passage (13) and the 4th photodetection passage (14) one ends are described analoids (5), the other end is respectively arranged with first, second, the 3rd, the 4th photodetector (111), (121), (131), (141), the centre is placed the first convergent lens group (112), the second convergent lens group respectively, the 3rd convergent lens group (132) and the 4th convergent lens group.
2. according to claim 1ly be used for the multichannel light electric detection means that dry chemical is analyzed, it is characterized in that: the optical axis of described light source incident passage (10) is 30 °～60 ° with the optical axis included angle of the described first photodetection passage (11), the second photodetection passage (12), the 3rd photodetection passage (13) and described the 4th photodetection passage (14) respectively.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201020650798 CN201897567U (en) | 2010-12-09 | 2010-12-09 | Multichannel photoelectric detection device for dry type chemical analysis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201020650798 CN201897567U (en) | 2010-12-09 | 2010-12-09 | Multichannel photoelectric detection device for dry type chemical analysis |
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| CN201897567U true CN201897567U (en) | 2011-07-13 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102564954A (en) * | 2010-12-09 | 2012-07-11 | 苏州生物医学工程技术研究所 | Multi-channel photoelectric detection device for dry type chemical analysis |
| CN105974142A (en) * | 2016-05-13 | 2016-09-28 | 长春迪瑞医疗科技股份有限公司 | {0><}0{>Multi-light path coagulation analysis system |
| CN109709041A (en) * | 2018-12-27 | 2019-05-03 | 天津昌和生物医药技术有限公司 | Dry analysis monochromatic light road Multichannel photoelectric detection device |
-
2010
- 2010-12-09 CN CN 201020650798 patent/CN201897567U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102564954A (en) * | 2010-12-09 | 2012-07-11 | 苏州生物医学工程技术研究所 | Multi-channel photoelectric detection device for dry type chemical analysis |
| CN105974142A (en) * | 2016-05-13 | 2016-09-28 | 长春迪瑞医疗科技股份有限公司 | {0><}0{>Multi-light path coagulation analysis system |
| CN109709041A (en) * | 2018-12-27 | 2019-05-03 | 天津昌和生物医药技术有限公司 | Dry analysis monochromatic light road Multichannel photoelectric detection device |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110713 Termination date: 20161209 |
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| CF01 | Termination of patent right due to non-payment of annual fee |