CN202569651U - Column chromatography system - Google Patents
Column chromatography system Download PDFInfo
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- CN202569651U CN202569651U CN 201220148472 CN201220148472U CN202569651U CN 202569651 U CN202569651 U CN 202569651U CN 201220148472 CN201220148472 CN 201220148472 CN 201220148472 U CN201220148472 U CN 201220148472U CN 202569651 U CN202569651 U CN 202569651U
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- column chromatography
- proportion liquid
- pressure pump
- ingredient
- supply pipe
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Abstract
The utility model discloses a column chromatography system comprising a liquid storage pot storing to-be-separated samples, column chromatography assemblies, and an elution device pouring ingredient-mixing liquid to the column chromatography assemblies. The number of the elution device is one and the elution device comprises an ingredient-mixing liquid input opening and an ingredient-mixing liquid supply pipe which are connected with each other. An ingredient-mixing liquid adjusting valve is arranged between the ingredient-mixing liquid input opening and the ingredient-mixing liquid supply pipe. Each column chromatography assembly comprises a chromatography column and a high-pressure pump pouring the to-be-separated samples and the ingredient-mixing liquid into the chromatography column. A chromatography adjusting valve is arranged between each chromatography column and each high-pressure pump. The number of the column chromatography assemblies is two or more than two. The high-pressure pump of each column chromatography assembly is connected with the ingredient-mixing liquid supply pipe and the liquid storage pot. A liquid storage valve is arranged between the high-pressure pump and the liquid storage pot. As the elution device can supply the ingredient-mixing liquid for more than two chromatography columns, labor ingredient-mixing time is saved, technology operation process is simplified, and production efficiency is improved.
Description
Technical field
The utility model relates to biological technical field, relates in particular to a kind of column chromatography system that is used for the biological components separation.
Background technology
Chromatography, promptly " chromatographic analysis " is a kind of difference of utilizing each component physical property, and multicomponent mixture is carried out the technology of compartment analysis, can be applicable to biology and chemical field.Column chromatography be utilize material fixing mutually with flowing phase between different allocation proportions, will fix being loaded on mutually in the post, make sample move and reach separation along a direction.Column chromatography adopts the pressurization clastotype more, to accelerate the flowing velocity of leacheate, shortens the sample elution time.
When adopting the column chromatography system to separate, need regularly in chromatographic column, to inject leacheate, to improve separating effect, still the once-through operation of existing leacheate feeding mechanism can only be injected in single chromatographic column and be consuming time more, inefficiency.
The utility model content
In order to overcome the deficiency of leacheate supply technology in the existing column chromatography system, the purpose of the utility model is to provide a kind of column chromatography system of supply leacheate in many chromatographic columns simultaneously.
In order to address the above problem, the utility model provides a kind of column chromatography system, comprises that storage treats the fluid reservoir of sample separation, column chromatography assembly and inject the leaching device of proportion liquid to said column chromatography assembly, it is characterized in that,
Said leaching device is one, comprises interconnective proportion liquid input port and proportion liquid supply pipe; Be provided with the proportion liquid control valve between said proportion liquid input port and the proportion liquid supply pipe;
Said column chromatography assembly comprises chromatographic column, will treat that sample separation and proportion liquid inject the high-pressure pump of said chromatographic column; Be provided with the chromatography control valve between said chromatographic column and the said high-pressure pump; Said column chromatography assembly is two or more, and the high-pressure pump of each said column chromatography assembly all is connected with said proportion liquid supply pipe and said fluid reservoir;
Be provided with the liquid storage control valve between said high-pressure pump and the said fluid reservoir.
Wherein, said fluid reservoir is identical with the number of said column chromatography assembly, and the high-pressure pump of said fluid reservoir and said column chromatography assembly connects one to one.
Wherein, Said proportion liquid supply pipe comprises first port and second port of connection; Said first port is one and is connected with said proportion liquid input port; The number of said second port is identical with the number of said column chromatography assembly, and the high-pressure pump of said second port and said column chromatography assembly connects one to one.
Wherein, said proportion liquid control valve is arranged on first port of said proportion liquid supply pipe.
Owing to adopt above architectural feature, the column chromatography system of the utility model can be the chromatographic column supply proportion liquid of two or more column chromatography assemblies simultaneously, saves manual work and batching time, has simplified the technological operation flow process, has improved production efficiency.
Description of drawings
Fig. 1 is the structural representation of the column chromatography system of the utility model embodiment.
The specific embodiment
Be elaborated below in conjunction with the structure and the operation principle of accompanying drawing to the column chromatography system embodiment of the utility model.
As shown in Figure 1, in the utility model column chromatography optimum system choosing embodiment, the leaching device that the column chromatography system comprises that the fluid reservoir 1, column chromatography assembly of sample separation treated in storage and injects proportion liquid to the column chromatography assembly.Wherein, leaching device is one, comprises interconnective proportion liquid input port 4 and proportion liquid supply pipe 3; Be provided with proportion liquid control valve 53 between proportion liquid input port 4 and the proportion liquid supply pipe 3.The column chromatography assembly comprises chromatographic column 6, will treat that sample separation and proportion liquid inject the high-pressure pump 2 of chromatographic column 6, are provided with chromatography control valve 52 between chromatographic column 5 and the high-pressure pump 2, with the chromatography speed of control chromatographic column 6.The column chromatography assembly is two or more, and the high-pressure pump 2 of each column chromatography assembly all is connected with proportion liquid supply pipe 3 and fluid reservoir 1.Be provided with liquid storage control valve 51 between high-pressure pump 2 and the fluid reservoir 1.
In the present embodiment, particularly, the column chromatography assembly is two, and fluid reservoir 1 is identical with the number of column chromatography assembly, also is two, and fluid reservoir 1 connects one to one with the high-pressure pump 2 of column chromatography assembly.Be equipped with liquid storage control valve 51 between each fluid reservoir 1 and the high-pressure pump 2, treat the flow of sample separation with control.Certainly, fluid reservoir 1 also can be one here, and the high-pressure pump 2 of two column chromatography assemblies all is connected to a fluid reservoir, is that two chromatographic columns 6 provide and treat sample separation through a fluid reservoir 1.
Preferably; Proportion liquid supply pipe 3 comprises first port 31 and second port 32 of connection; First port 31 is one and is connected with proportion liquid input port 4; The number of second port 32 is identical with the number of column chromatography assembly, also is two, and second port 32 connects one to one with the high-pressure pump 2 of column chromatography assembly.
Further, proportion liquid control valve 53 is arranged on first port 31 of proportion liquid supply pipe 3.Promptly can be the delivery rate that control flows to all high-pressure pumps 2 through a proportion liquid control valve 53.As another kind of embodiment, proportion liquid control valve 53 also can be arranged on second port 32 of proportion liquid supply pipe 3 here, and certainly correspondingly, proportion liquid control valve 53 also is two.
In the above-described embodiments, adopted proportion liquid supply pipe 3, certainly with a plurality of ports; As another kind of embodiment; Also can adopt the proportion liquid supply pipe 3 that only has two ports, proportion liquid supply pipe 3 is a plurality of, respectively high-pressure pump is connected with proportion liquid input port 4.Simultaneously, the number of column chromatography assembly also is not limited to two of the foregoing description, also can be three or four or more.
During work, inject the drip washing proportion liquid that configures by proportion liquid input port 4, proportion liquid injects in the chromatographic column 6 through high-pressure pump 2 from proportion liquid supply pipe 3; Open high-pressure pump 2, open liquid storage control valve 51 after, the sample separation of treating in the receiver 1 in high-pressure pump 2 effects down, is separated in the inflow chromatographic column 6.
Because the structure of the leaching device of the column chromatography system of the utility model is a proportion liquid input port 4 is controlled two chromatographic columns 6 simultaneously through proportion liquid supply pipe 3 drip washing proportion liquid supply; So can save artificial and batching time; Simplify the technological operation flow process, for the positive effect of having enhanced productivity.
Claims (4)
1. column chromatography system comprises that storage treats the fluid reservoir of sample separation, column chromatography assembly and inject the leaching device of proportion liquid to said column chromatography assembly, it is characterized in that:
Said leaching device is one, comprises interconnective proportion liquid input port and proportion liquid supply pipe; Be provided with the proportion liquid control valve between said proportion liquid input port and the proportion liquid supply pipe;
Said column chromatography assembly comprises chromatographic column, will treat that sample separation and proportion liquid inject the high-pressure pump of said chromatographic column; Be provided with the chromatography control valve between said chromatographic column and the said high-pressure pump; Said column chromatography assembly is two or more, and the high-pressure pump of each said column chromatography assembly all is connected with said proportion liquid supply pipe and said fluid reservoir;
Be provided with the liquid storage control valve between said high-pressure pump and the said fluid reservoir.
2. column chromatography according to claim 1 system is characterized in that said fluid reservoir is identical with the number of said column chromatography assembly, and the high-pressure pump of said fluid reservoir and said column chromatography assembly connects one to one.
3. column chromatography according to claim 1 system; It is characterized in that; Said proportion liquid supply pipe comprises first end and second end of connection; Said first end is one and is connected with said proportion liquid input port that the number of said second end is identical with the number of said column chromatography assembly, and the high-pressure pump of said second end and said column chromatography assembly connects one to one.
4. column chromatography according to claim 3 system is characterized in that said proportion liquid control valve is arranged on first end of said proportion liquid supply pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220148472 CN202569651U (en) | 2012-04-10 | 2012-04-10 | Column chromatography system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220148472 CN202569651U (en) | 2012-04-10 | 2012-04-10 | Column chromatography system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202569651U true CN202569651U (en) | 2012-12-05 |
Family
ID=47239108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220148472 Expired - Fee Related CN202569651U (en) | 2012-04-10 | 2012-04-10 | Column chromatography system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202569651U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194905A (en) * | 2015-10-22 | 2015-12-30 | 宁波荣安生物药业有限公司 | Chromatography system |
| CN107249709A (en) * | 2014-12-18 | 2017-10-13 | 通用电气健康护理生物科学股份公司 | Automation chromatographic column switching control based on pressure detection |
-
2012
- 2012-04-10 CN CN 201220148472 patent/CN202569651U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107249709A (en) * | 2014-12-18 | 2017-10-13 | 通用电气健康护理生物科学股份公司 | Automation chromatographic column switching control based on pressure detection |
| CN107249709B (en) * | 2014-12-18 | 2020-07-14 | 通用电气健康护理生物科学股份公司 | Automated chromatography column switching control based on pressure detection |
| CN105194905A (en) * | 2015-10-22 | 2015-12-30 | 宁波荣安生物药业有限公司 | Chromatography system |
| CN105194905B (en) * | 2015-10-22 | 2017-04-12 | 宁波荣安生物药业有限公司 | Chromatography system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20200410 |