CN103901144A - Automatic sampler - Google Patents
Automatic sampler Download PDFInfo
- Publication number
- CN103901144A CN103901144A CN201210585703.6A CN201210585703A CN103901144A CN 103901144 A CN103901144 A CN 103901144A CN 201210585703 A CN201210585703 A CN 201210585703A CN 103901144 A CN103901144 A CN 103901144A
- Authority
- CN
- China
- Prior art keywords
- valve
- retaining valve
- automatic sampler
- retaining
- communicated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention discloses an automatic sampler which is used for guiding sucked samples into an analysis flow path of a liquid chromatographic instrument. The automatic sampler is provided with a switching valve and works through the switching of the switching valve; the automatic sampler also comprises a first one-way valve and a second one-way valve; an outlet of the first one-way valve is connected with a cleaning liquid inlet of the switching valve; the cleaning liquid inlet is communicated with a sample inlet of the switching valve or a cleaning waste liquid outlet by switching; the inlet of the first one-way valve is communicated with the cleaning liquid in a cleaning liquid container; the cleaning waste liquid outlet is connected with an inlet of a metering pump; an outlet of the metering pump is connected with an inlet of the second one-way valve.
Description
Technical field
The present invention relates to sample automatically to inject the automatic sampler of the analysis stream of liquid chromatograph.
Background technology
In prior art, the structure of the automatic sampler using in known liquid chromatograph as shown in Figure 1, comprise high pressure transfer valve and low pressure transfer valve, and sampling needle tubing, volume pump, quantitatively ring waits parts, completes the suction of sample by the switching of the connected relation between each port of transfer valve, import the steps such as cleaning.
Generally, transfer valve is by motor, and the topworkies such as sensor driving control gear and rotor, stator form, and the expense of its use cost and maintenance is higher, and need to take larger space.
Summary of the invention
The present invention is in order to solve the aforementioned problems in the prior, automatic sampler in a kind of liquid chromatograph is proposed, be used for the analysis stream of the Sample introduction liquid chromatograph of drawing, automatic sampler has transfer valve, work is carried out in switching by transfer valve, automatic sampler also comprises, the first retaining valve and the second retaining valve, wherein, the outlet of the first retaining valve is connected with the filter washing water inlet of transfer valve, filter washing water inlet is communicated with by switching with injection port or the cleaning waste liquid escape hole of transfer valve, the entrance of the first retaining valve is communicated with the cleaning fluid in soda liquor container, cleaning waste liquid escape hole is connected with the entrance of volume pump, metering delivery side of pump connects the entrance of the second retaining valve, the outlet of the second retaining valve is communicated with cleans waste liquid returnable, the first retaining valve is controlled at the path direction of carrying in described cleaning fluid process, the second retaining valve can prevent the refluence of cleaning fluid in sample suction process.
According to another embodiment of the present invention, a kind of automatic sampler is proposed, for by the analysis stream of Sample introduction liquid chromatograph of drawing, automatic sampler has transfer valve, work is carried out in switching by transfer valve, and automatic sampler also comprises, the first retaining valve and the second retaining valve, wherein, the outlet of the first retaining valve is connected with the filter washing water inlet of transfer valve, filter washing water inlet is not communicated with the injection port of transfer valve, and be communicated with or be not communicated with by switching with cleaning waste liquid escape hole, the entrance of the first retaining valve is communicated with the cleaning fluid in soda liquor container, cleaning waste liquid escape hole is connected with the entrance of volume pump, metering delivery side of pump connects the entrance of the second retaining valve, the outlet of the second retaining valve is communicated with cleans waste liquid returnable, the first retaining valve is controlled at the path direction of carrying in described cleaning fluid process, the second retaining valve can prevent the refluence of cleaning fluid in sample suction process.
Adopt the automatic sampler of structure of the present invention, owing to having adopted two retaining valves to replace low pressure transfer valve and relevant electric component, thereby can reduce the expense of manufacturing cost and maintenance, the space of simultaneously having saved machine.
Accompanying drawing explanation
Fig. 1 is the structural representation of automatic sampler in prior art;
Fig. 2 a-2d is according to the schematic diagram of the sample introduction process of the automatic sampler of the embodiment of the present invention;
Fig. 3 a and Fig. 3 b are the structural representations of automatic sampler according to another embodiment of the present invention.
Embodiment
Referring to accompanying drawing 2a-2d, the sample introduction process according to the automatic sampler of the embodiment of the present invention is described.
For simplicity, be 1-6 by the port number consecutively of transfer valve, the chromatographic column of port one connecting fluid facies analysis instrument, port 2 connects high pressure and moves phase stream, and port 3 connects quantitatively ring, and port 4 connects volume pump, port 5 connects the outlet of retaining valve A, and port 6 is injection ports of sample.As shown in Figure 2 a, the now port one of transfer valve and 2,3 and 4,5 and 6 are communicated with respectively, and the needle tubing of sampling inserts sample bottle, volume pump starts suction action, due to the non-return effect of retaining valve B, the circulating direction of whole stream as shown by arrows, from sampling needle tubing to quantitative ring, through port 3 and 4, volume pump sucks sample.
Then, carry out the conveying of sample feeding and cleaning fluid.As shown in Figure 2 b, now, transfer valve is rotated counterclockwise 60 degree, port one and 6,2 and 3, and 4 and 5 be communicated with respectively, and sampling needle tubing is inserted to the injection port 6 of transfer valve, the mobile phase stream of high pressure is by port 2 and 3, by the sample delivery in quantitative ring to chromatographic column.
Due to the non-return effect of retaining valve A, volume pump sucks cleaning fluid through port 5 and 4 from soda liquor container, and due to the non-return effect of retaining valve B, volume pump is sent the cleaning fluid of suction into Butterworth Hatch, and so perseveration, completes the conveying of cleaning fluid.
Then, transfer valve 60 degree that turn clockwise, now the port one of transfer valve and 2,3 and 4,5 and 6 is communicated with respectively.Due to the non-return effect of retaining valve, quantitatively the highly pressurised liquid in ring passes through port 3 and 4, and flows to Butterworth Hatch through retaining valve B, completes the process of releasing the pressure, as shown in Figure 2 c.And now,, due to the suction action of volume pump, the cleaning fluid in soda liquor container sucks through the measured pump of port 5 and 6 by retaining valve A, then passes through retaining valve B, finally discharges from Butterworth Hatch.Volume pump perseveration, can also complete the cleaning of stream inside.
The cleaning of sampling needle tubing as shown in Figure 2 d, is extracted sampling needle tubing from injection port 6, insert Butterworth Hatch, completes cleaning process.
As shown in Figure 2 a-2d, just completed the process of whole sample feeding.The cleaning of sampling needle tubing and stream inside not only can be carried out in the time not analyzing, also can be in analysis time from sample injects on once sample sucking action starting, carry out, be so more conducive to the stable and accurate of analysis result.
Describe according to another embodiment of the present invention referring to accompanying drawing 3a and 3b.Shown in Fig. 2 a in the situation that, injection port does not insert sampling needle tubing, and cleaning fluid likely flows out from injection port along port 5 from retaining valve A.For fear of the generation of this situation, as shown in Figure 3 a, another embodiment of the present invention is adjusted the interface angle of sampling valve.Interface angle between 6 ports of original sampling valve is all 60 degree, and the angle between the port 5 and 6 of the sampling valve shown in Fig. 3 a is greater than 60 degree, for example, can be set to 65 degree, and angle between other ports is 59 degree.In the time switching action, the anglec of rotation becomes 59 degree, guarantees that port 5 and 6 is not communicated with.But the absorption of carrying out cleaning fluid in this case, as shown in Figure 2 c and the cleaning of stream inside just can not realize.
Although the present invention discloses as above with preferred embodiment; but be not for limiting the present invention, any person of ordinary skill in the field, without departing from the spirit and scope of the present invention; can do a little change and retouching, therefore protection scope of the present invention is with being as the criterion that claim was defined.
Claims (4)
1. an automatic sampler, for by the analysis stream of Sample introduction liquid chromatograph of drawing, described automatic sampler has transfer valve, carries out work by the switching of described transfer valve, it is characterized in that,
Described automatic sampler also comprises,
The first retaining valve and the second retaining valve;
Wherein, the outlet of described the first retaining valve is connected with the filter washing water inlet of described transfer valve, described filter washing water inlet is communicated with by switching with injection port or the cleaning waste liquid escape hole of described transfer valve, the entrance of described the first retaining valve is communicated with the cleaning fluid in soda liquor container, described cleaning waste liquid escape hole is connected with the entrance of volume pump, described metering delivery side of pump connects the entrance of described the second retaining valve, the outlet of described the second retaining valve is communicated with cleans waste liquid returnable, described the first retaining valve is controlled at the path direction of carrying in described cleaning fluid process, described the second retaining valve can prevent the refluence of cleaning fluid in sample suction process.
2. an automatic sampler, for by the analysis stream of Sample introduction liquid chromatograph of drawing, described automatic sampler has transfer valve, carries out work by the switching of described transfer valve, it is characterized in that,
Described automatic sampler also comprises,
The first retaining valve and the second retaining valve;
Wherein, the outlet of described the first retaining valve is connected with the filter washing water inlet of described transfer valve, described filter washing water inlet is not communicated with the injection port of described transfer valve, and be communicated with or be not communicated with by switching with cleaning waste liquid escape hole, the entrance of described the first retaining valve connects the cleaning fluid in soda liquor container, described cleaning waste liquid escape hole is connected with the entrance of volume pump, described metering delivery side of pump connects the entrance of described the second retaining valve, the outlet of described the second retaining valve is communicated with cleans waste liquid returnable, described the first retaining valve is controlled at the path direction of carrying in described cleaning fluid process, described the second retaining valve can prevent the refluence of cleaning fluid in sampling process.
3. automatic sampler as claimed in claim 1 or 2, wherein said the first and second retaining valves are switch valve or solenoid valve.
4. automatic sampler as claimed in claim 2, wherein said transfer valve is six-way valve, and interface angle between described injection port and the described filter washing water inlet of described transfer valve is greater than 60 degree.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210585703.6A CN103901144B (en) | 2012-12-28 | 2012-12-28 | Automatic sampler |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210585703.6A CN103901144B (en) | 2012-12-28 | 2012-12-28 | Automatic sampler |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103901144A true CN103901144A (en) | 2014-07-02 |
| CN103901144B CN103901144B (en) | 2015-08-12 |
Family
ID=50992603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210585703.6A Expired - Fee Related CN103901144B (en) | 2012-12-28 | 2012-12-28 | Automatic sampler |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103901144B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105784883A (en) * | 2016-04-28 | 2016-07-20 | 中国科学院寒区旱区环境与工程研究所 | Online sample diluting experiment device |
| CN114609312A (en) * | 2022-03-22 | 2022-06-10 | 苏州艾迪迈医疗科技有限公司 | Sample introduction structure and method for sample pretreatment device to chromatographic analysis device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1407337A (en) * | 2001-09-03 | 2003-04-02 | 株式会社资生堂 | Liquid chromatographic system, sampler, cleaning device and method |
| US20040020542A1 (en) * | 2000-11-13 | 2004-02-05 | Cueni Hansjorg Emil | Sample injection valve for high-performacne liquid chromatography (hplc) devices |
| WO2007125023A1 (en) * | 2006-04-28 | 2007-11-08 | Technische Universität Berlin | Apparatus for obtaining samples of a fluid and method for cleaning such apparatus |
| CN101196497A (en) * | 2006-12-06 | 2008-06-11 | 株式会社岛津制作所 | Auto-sampler cleaning mechanism |
| US20090078031A1 (en) * | 2007-09-26 | 2009-03-26 | Hitachi High-Technology Corporation | Liquid chromatograph and sample introducing apparatus |
| CN201859140U (en) * | 2010-09-19 | 2011-06-08 | 浙江福立分析仪器有限公司 | Sample injection device of liquid phase automatic sample injector |
-
2012
- 2012-12-28 CN CN201210585703.6A patent/CN103901144B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040020542A1 (en) * | 2000-11-13 | 2004-02-05 | Cueni Hansjorg Emil | Sample injection valve for high-performacne liquid chromatography (hplc) devices |
| CN1407337A (en) * | 2001-09-03 | 2003-04-02 | 株式会社资生堂 | Liquid chromatographic system, sampler, cleaning device and method |
| WO2007125023A1 (en) * | 2006-04-28 | 2007-11-08 | Technische Universität Berlin | Apparatus for obtaining samples of a fluid and method for cleaning such apparatus |
| CN101196497A (en) * | 2006-12-06 | 2008-06-11 | 株式会社岛津制作所 | Auto-sampler cleaning mechanism |
| US20080134804A1 (en) * | 2006-12-06 | 2008-06-12 | Shimadzu Corporation | Auto-sampler cleaning mechanism |
| US20090078031A1 (en) * | 2007-09-26 | 2009-03-26 | Hitachi High-Technology Corporation | Liquid chromatograph and sample introducing apparatus |
| CN201859140U (en) * | 2010-09-19 | 2011-06-08 | 浙江福立分析仪器有限公司 | Sample injection device of liquid phase automatic sample injector |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105784883A (en) * | 2016-04-28 | 2016-07-20 | 中国科学院寒区旱区环境与工程研究所 | Online sample diluting experiment device |
| CN114609312A (en) * | 2022-03-22 | 2022-06-10 | 苏州艾迪迈医疗科技有限公司 | Sample introduction structure and method for sample pretreatment device to chromatographic analysis device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103901144B (en) | 2015-08-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106199032B (en) | A kind of sample injection method of no cross contamination | |
| JP6309439B2 (en) | Hemoglobin analyzer | |
| CN105745535B (en) | Gradient liquid transporting apparatus for sample analyser | |
| CN101869894B (en) | Clean device, purging system, cleaning method and particle analyzer | |
| JP6870741B2 (en) | Autosampler and liquid chromatograph | |
| JP2015092166A5 (en) | ||
| CN103852587B (en) | Liquid sample introduction system and control method thereof | |
| JP5643340B2 (en) | Automatic analyzer with low-pressure in-line filter action | |
| CN107561198A (en) | A kind of liquid chromatograph automatic sampler | |
| CN102794273B (en) | Plate washing machine cleaning head and plate washing machine assembly | |
| CN104062170A (en) | Automatic online micro-scale sample dilution and mixing system and mixing method | |
| CN201543626U (en) | Capillary tube cleaning device | |
| CN103901144A (en) | Automatic sampler | |
| CN206177912U (en) | Go up appearance device in low -voltage tube | |
| CN202330373U (en) | Automatic dilution device for ion chromatography solution | |
| CN202599841U (en) | Sampling device of atomic fluorescence instrument | |
| CN104062167A (en) | Automatic online sample dilution and mixing device and mixing method | |
| CN203908855U (en) | Diluting and mixing device of automatic online sample and chromatographic analysis instrument | |
| CN102049397A (en) | Method and device for cleaning capillary of automatic sampler | |
| CN204214822U (en) | The tomographic system of the positive reflux of chromatographic column and bypass functionality is realized based on three seven logical valves | |
| CN202599840U (en) | Sample injection device of two-injection-pump contrast ventriculography (CVG) system | |
| CN203908852U (en) | Automatic online micro sample diluting and mixing system | |
| CN203908854U (en) | Automatic online sample diluting and mixing device | |
| CN211453665U (en) | Automatic sampling device | |
| CN103969349A (en) | A washing method of inspection equipment and the inspection equipment thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150812 Termination date: 20151228 |
|
| EXPY | Termination of patent right or utility model |