CN211453665U

CN211453665U - Automatic sampling device

Info

Publication number: CN211453665U
Application number: CN201922436869.1U
Authority: CN
Inventors: 祝锦敏
Original assignee: Shenzhen Wahyong Analytical Instrument Co ltd
Current assignee: Shenzhen Wahyong Analytical Instrument Co ltd
Priority date: 2019-12-30
Filing date: 2019-12-30
Publication date: 2020-09-08
Anticipated expiration: 2029-12-30

Abstract

The utility model relates to the technical field of chemistry, and discloses an automatic sampling device, which comprises a dissolving-out cup, a first three-way valve, a liquid supplementing cup, a second three-way valve, an injector device, a third three-way valve and a test tube, wherein the dissolving-out cup, the first three-way valve, the liquid supplementing cup, the second three-way valve, the injector device, the third three-way valve; the normally open end of the first three-way valve is communicated to the dissolving-out cup through a pipeline, and the normally closed end of the first three-way valve is communicated to the liquid replenishing cup through a pipeline; the common end of the second three-way valve is communicated to the injector device, the normally open end of the second three-way valve is communicated to the common end of the first three-way valve through a pipeline, and the normally closed end of the second three-way valve is communicated to the common end of the third three-way valve through a pipeline; the normally open end of the third three-way valve is communicated to the test tube through a pipeline, and the normally closed end is communicated to the dissolution cup through a pipeline. The utility model discloses in the automatic sampling device who provides, the opening of every section pipeline of control respectively or seal, keep a whole set of pipe-line system of whole experimentation all to be full of liquid, can not produce the air.

Description

Automatic sampling device

Technical Field

The utility model relates to a technical field of chemistry especially relates to automatic sampling device.

Background

In the process of dissolution experiments of drugs such as tablets, capsules, granules and the like, samples need to be sampled, and the existing drug taking technology has certain defects in the aspects of sampling accuracy, automation degree, system stability and the like at present and is mainly shown in the following steps: the residual bubbles in the pipeline or the samples can not be completely emptied in the automatic sampling process, so that adjacent sampling cross infection is caused, the samples are inaccurate, and the sampling amount is inaccurate. The automatic sampling process can not filter the filter membrane with the diameter of 0.45 mu m or smaller on line, or the pressure of the air system is increased and exceeds the pressure range of the system when the filter membrane with the diameter of 0.45 mu m or smaller on line is filtered, so that the fault of the instrument is caused.

Particularly, a sample obtained from a dissolution instrument needs to be subjected to content detection of a target object by using a liquid chromatograph, the sample obtained from the dissolution instrument is turbid, water system filter membrane filtration with the diameter of at least 0.45 mu m is needed, and if instant medicines are not subjected to online filtration, secondary dissolution can be formed to cause dissolution errors, or a pipeline system of the liquid chromatograph is blocked, so that liquid chromatography faults are caused.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an automatic sampling device aims at solving and is difficult to the problem of guaranteeing the evacuation air completely among the current technique of getting it filled.

The utility model is realized in such a way, and provides an automatic sampling device, which comprises a dissolving-out cup, a first three-way valve, a fluid infusion cup, a second three-way valve, an injector device, a third three-way valve and a test tube which are mutually communicated through pipelines; wherein: the normally open end of the first three-way valve is communicated to the dissolution cup through a pipeline, and the normally closed end of the first three-way valve is communicated to the fluid infusion cup through a pipeline; the common end of the second three-way valve is communicated to the injector device, the normally open end of the second three-way valve is communicated to the common end of the first three-way valve through a pipeline, and the normally closed end of the second three-way valve is communicated to the common end of the third three-way valve through a pipeline; the normally open end of the third three-way valve is communicated to the test tube through a pipeline, and the normally closed end of the third three-way valve is communicated to the dissolution cup through a pipeline.

Further, the device also comprises a positive filter, and the positive filter is arranged on a pipeline connected with the second three-way valve and the third three-way valve.

Further, still include positive filter, positive filter sets up on the pipeline that third three-way valve and test tube communicate.

Furthermore, the third three-way valve is provided with a sample injection needle used for placing the test tube at the tail end of a pipeline communicated with the test tube.

Further, the injector device includes a plurality of inverted injectors, a drive structure for driving the injectors.

Further, the driving structure comprises a push-pull motor and a screw rod.

Compared with the prior art, the utility model provides an automatic sampling device controls opening or sealing of every section pipeline respectively through setting up a plurality of relatively independent pipelines, can realize keeping a whole set of pipe-line system of whole experimentation to be full of liquid, can not produce the air, in high automation simultaneously, has guaranteed the stability of system.

Drawings

Fig. 1 is a schematic structural pipeline diagram of an automatic sampling device according to an embodiment of the present invention;

fig. 2 is a schematic structural diagram of an automatic sampling device according to an embodiment of the present invention;

fig. 3 is a schematic structural view of an automatic sampling device according to another embodiment of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

The implementation of the present embodiment is described in detail below with reference to specific drawings.

As shown in fig. 1 to 2, the present embodiment provides an automatic sampling apparatus that switches the opening and closing of a line by three-way valves, hereinafter, a common end a of each three-way valve is simultaneously communicated with a normally open end B, which is opened by default, and a normally closed end C, which is closed by default, and only one of the normally open end B and the normally closed end C is opened at the same time. The automatic sampling device specifically comprises a dissolving-out cup 1, a first three-way valve 2, a liquid supplementing cup 3, a second three-way valve 4, an injector device 5, a third three-way valve 6 and a test tube 9 which are mutually communicated through pipelines; wherein: the normally open end B of the first three-way valve 2 is communicated to the dissolution cup 1 through a pipeline, and the normally closed end C thereof is communicated to the fluid infusion cup 3 through a pipeline; the common end A of the second three-way valve 4 is communicated to the injector device 5, the normally open end B thereof is communicated to the common end A of the first three-way valve 2 through a pipeline, and the normally closed end C thereof is communicated to the common end A of the third three-way valve 6 through a pipeline; the normally open end B of the third three-way valve 6 is communicated to the test tube 9 through a pipeline, and the normally closed end C is communicated to the dissolution cup 1 through a pipeline.

In the automatic sampling device, a pipeline between the dissolution cup 1 and the first three-way valve 2 is a sampling pipeline and is responsible for sucking a sample from the dissolution cup 1 to the injector device 5; a pipeline between the liquid supplementing cup 3 and the first three-way valve 2 is a liquid supplementing pipeline and is responsible for supplementing liquid to the injector device 5; a pipeline between the third three-way valve 6 and the test tube 9 is a sample injection pipeline, and the final sample injection is copied; the line between the third three-way valve 6 and the dissolution cup 1 is a loop responsible for returning the sample left in the injector device 5 to the dissolution cup 1.

Because sample pipeline, fluid infusion pipeline, notes appearance pipeline, return circuit communicate each other through three-way valve and independent respectively again, do not have the dead volume and connect to can the independent control wherein the switching of arbitrary pipeline, can carry out by stage, keep whole experimentation whole set of pipe-line system all to be full of liquid, can not produce the air, in high automation, guaranteed the stability of system.

Preferably, as shown in fig. 2, the automatic sampling device further includes a forward filter 7, and the forward filter 7 is disposed on a pipeline connecting the second three-way valve 4 and the third three-way valve 6, so that online filtration can be achieved. In other embodiments, as shown in fig. 3, the forward filter 7 is provided on a conduit (i.e., a sample injection line) through which the third three-way valve 6 communicates with the test tube 9. The forward filter 7 is specifically a 0.45 μm water system filter membrane, which can only pass liquid but not air.

Preferably, the pipeline that third three-way valve 6 and test tube 9 communicate, annotate the sample pipeline end promptly and be equipped with the notes appearance needle 8 that is used for putting into test tube 9, annotate appearance needle 8 and need control position to guarantee to annotate the appearance, avoid being contaminated simultaneously. When necessary, the sample injection needle 8 may be positioned in the waste liquid tank to discharge the waste liquid therein.

The injector device 5 includes a plurality of inverted injectors 52, and a drive structure for driving the injectors 52. The driving structure includes a push-pull motor 51 and a lead screw 53. The push-pull motor 51 outputs torque to drive the screw 53 to rotate, thereby realizing the pumping (suction) and the pumping (discharge) of the syringe 52.

As shown in fig. 1 and fig. 2, the present embodiment further provides a sampling method, which uses the above automatic sampling device to perform sampling, and includes the following steps:

the syringe device 5 starts to draw, and the sample is sucked into the syringe device 5 from the dissolution cup 1 through the pipe via the first three-way valve 2 and the second three-way valve 4.

The second three-way valve 4 is switched to the normally closed end C, the injector device 5 starts to be opened, and the waste liquid is primarily filtered through the third three-way valve 6.

The syringe device 5 withdraws the anti-snag beads.

The injector device 5 is again primed and the test tube 9 is filled.

After completion, the injector device 5 withdraws the anti-snag bead and switches the third three-way valve 6 to the normally closed end C.

The injector device 5 is driven to finally discharge the volume of the anti-hanging beads pumped back to the dissolution cup 1.

The second three-way valve 4 and the third three-way valve 6 are switched back to the normal opening end B.

As shown in fig. 1 and fig. 2, preferably, the sampling method further includes rinsing the pipeline before sampling, and specifically includes the following steps:

after the injector device 5 pumps a certain amount of sample, the second three-way valve 4 and the third three-way valve 6 are both switched to the normally closed end C;

the injector device 5 is driven, and after the driving is finished, the second three-way valve 4 and the third three-way valve 6 are both switched to the normally opened end B;

and (5) recycling the steps again, and finishing the circular rinsing. In the rinsing circuit of this embodiment, the injector device 5 draws 5ml each time.

As shown in fig. 1 and fig. 2, preferably, the sampling method further includes fluid infusion, specifically including the following steps:

the first three-way valve 2 is switched to a normally closed end C, and the injector device 5 is pumped;

the first three-way valve 2 is switched to a normally open end B, the second three-way valve 4 and the third three-way valve 6 are switched to a normally closed end C, and the injector device 5 is opened;

and the second three-way valve 4 and the third three-way valve 6 are switched to the normally open end B, and liquid supplementing is completed.

Preferably, the sampling method further comprises a cleaning evacuation after sampling, and specifically comprises the following steps:

the normally open end B of the third three-way valve 6 is positioned to the waste liquid tank through a pipeline;

the first three-way valve 2 is switched to a normally closed end C, the injector device 5 is pumped, after the pumping, the first three-way valve 2 is switched to a normally open end B, and the injector device 5 is opened to finish cleaning the sampling pipeline;

the first three-way valve 2 is switched to a normally closed end C, the injector device 5 is pumped, after the pumping, the first three-way valve 2 is switched to a normally open end B, the injector 52 is opened, and the second three-way valve 4 is switched to the normally open end B, so that the sample injection pipeline is cleaned;

the first three-way valve 2 is switched to a normally closed end C, the injector device 5 is pumped, after the pumping is finished, the first three-way valve 2 is switched to a normally open end B, the second three-way valve 4 and the third three-way valve 6 are switched to the normally closed end C, and the injector device 5 is opened to finish cleaning a loop pipeline;

the second three-way valve 4 and the third three-way valve 6 are both switched to the normally open end B. In the wash drain of this embodiment, the syringe device 5 draws 10ml each time.

The above description is only exemplary of the present invention and should not be construed as limiting the present invention, and any modifications, equivalents and improvements made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.

Claims

1. The automatic sampling device is characterized by comprising a dissolving-out cup, a first three-way valve, a fluid infusion cup, a second three-way valve, an injector device, a third three-way valve and a test tube which are mutually communicated through pipelines; wherein:

the normally open end of the first three-way valve is communicated to the dissolution cup through a pipeline, and the normally closed end of the first three-way valve is communicated to the fluid infusion cup through a pipeline;

the common end of the second three-way valve is communicated to the injector device, the normally open end of the second three-way valve is communicated to the common end of the first three-way valve through a pipeline, and the normally closed end of the second three-way valve is communicated to the common end of the third three-way valve through a pipeline;

the normally open end of the third three-way valve is communicated to the test tube through a pipeline, and the normally closed end of the third three-way valve is communicated to the dissolution cup through a pipeline.

2. The automatic sampling device of claim 1, further comprising a forward filter disposed on a conduit connecting the second three-way valve and the third three-way valve.

3. The automatic sampling device of claim 1, further comprising a positive filter disposed on a conduit through which the third three-way valve communicates with the test tube.

4. The automatic sampling device according to claim 1, wherein the end of the conduit of the third three-way valve communicating with the test tube is provided with a sample injection needle for inserting the test tube.

5. An automatic sampling device according to any one of claims 1 to 4, wherein the injector device comprises a plurality of inverted injectors, drive means for driving the injectors.

6. The automatic sampling device of claim 5, wherein the drive mechanism comprises a push-pull motor and a lead screw.