CN201767971U - Anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes - Google Patents
Anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes Download PDFInfo
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- CN201767971U CN201767971U CN2010291510148U CN201029151014U CN201767971U CN 201767971 U CN201767971 U CN 201767971U CN 2010291510148 U CN2010291510148 U CN 2010291510148U CN 201029151014 U CN201029151014 U CN 201029151014U CN 201767971 U CN201767971 U CN 201767971U
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- anticoagulant
- blood sampling
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Abstract
The utility model belongs to the technical field of medical instrument, and particularly to an anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes. The utility model is characterized in that: a venous blood sampling needle is connected with a circular connector; the inner chamber wall of the connector is provided with an anti-coagulant coating; the other end of the connector is connected with a distributing conduit; one access pipe of the distributing conduit is provided with a vacuum valve; the other three access pipes of the distributing conduit are respectively provided with a connector; the inner chamber wall of each connector is provided with an anti-coagulant coating; and the other end of each connector is connected with a blood sample bottle needle. The anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes has the following advantages: capability for simultaneously, continuously and quickly sampling one to three tubes of blood; improved blood sampling speed; simplified blood sampling process; reduced operation element of medical personnel such as nurse in clinic blood drawing; reduced error probability; reduced workload; facilitated quick and concentrated clinic blood drawing operation for a large amount; reduced packaging material; reduced medical garbage; and reduced medical insurance cost of the country.
Description
Technical field
This utility model belongs to technical field of medical instruments, particularly relates to medical disposable hard and connects the parallel multi-tube anticoagulant blood-collecting connector.
Background technology
Because the present medical level development of China is unbalanced, the renewal speed of armarium also is uneven, so there is fast disposable, a large amount of blood sampling operating barrier clinically always.Traditional method is that the nurse cooperates a traditional vacuum blood taking tube (connected mode of this blood taking needle and blood taking tube is a tandem) with a hard blood taking needle that connects, clinical needs are taken a blood sample in a large number, and (according to the clinical examination needs) to tend to occur the blood sampling volume of a traditional vacuum test tube not enough, need to increase by 1～2 blood taking tube, at this moment the process of operation of will occurring drawing blood is slow, complicated, complex operation, occur error easily, cause confusion easily, increase nurse's workload and error rate.Long behind the blood outflow human body with the anticoagulant binding time, be easy to generate the accuracy that haemolysis influences assay, wait a series of problems.
Owing to not adding any anticoagulant in traditional blood taking needle and not linking to each other, so anticoagulant is added in the vacuum test tube with vacuum test tube.The tradition anticoagulant mostly is chemicals, and every kind of chemicals can only be at specific test item, heparin, sodium citrate, potassium oxalate, Na
2EDTA, K
2Traditional anticoagulant such as EDTA can not replenish mutually, can not exchange.Even so on blood taking needle, add heparin, sodium citrate, potassium oxalate, Na
2EDTA, K
2Anticoagulant such as EDTA, do not have in all senses yet and also can make troubles, increase misery (if on traditional blood taking needle, add traditional anticoagulant, patient's inspection item just need be more than 2 kinds) for the patient by many blood taking needles that the add different anticoagulant veins that puncture for clinical blood drawing check.
The People's Republic of China's " Chinese pharmacopoeia version in 2005, first one, the 57th page of record " Hirudo (HIRUDO) ", this product is the dry all of Hirudinidae animal whitmania Whitmania pigra Whitman, Hirudo Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Whitmania wranulata Whitman, summer, Qiu Erji catch, scald extremely with boiling water, dry or the low humidity drying.Concoct: Hirudo is cleaned, cutting, drying.Scald Hirudo: get water purification trematodiasis section, water to little with Pulvis Talci according to the method for scalding and heave.Function with cure mainly: removing blood stasis, removing blood stasis stimulates the menstrual flow.Be used for the blood stasis amenorrhea, injury from falling down.
Foreign medical science blood transfusion and 1993 the 16th volumes of blood fascicle the 6th phase record Chinese Academy of Medical Sciences Blood Research Institute, Guo Juan summary Wang Hebi examines and revises " progress of lepirudin 023 ludon " Haycraft and found in the Hementaria officianalis extract anticoagulant substances is arranged in 1884.At the end of the fifties, Markwardt isolates pure product first, called after hirudin (Hirudin), and know that it is the special inhibitor of thrombin, be a kind of ideal anticoagulant, antithrombotic preparation.Learn its structure and amino acid sequence the beginning of the eighties.Loaded down with trivial details because of the natural hirudin extraction step, and raise the Hirudo difficulty, the Hirudo source is deficient, is difficult to obtain the pure product of q.s, and research and clinical practice are restricted.In recent years, the development of technique for gene engineering has remedied this defective, utilize chemosynthesis, cDNA library, PCR method to obtain gene clone, express and obtain lepirudin 023 ludon, thereby pharmacology, pharmacodynamics and the toxicity etc. of hirudin have more in depth been studied, a large amount of zooperies and clinic trial have been accelerated hirudin and have been applied to clinical process.
The structure of hirudin: natural hirudin is not contain polysaccharide, by the single chain protein that 65 or 66 amino acid residues are formed, and molecular weight about 7,000, be rich in dicarboxylic amino acid, no Arg, Met and Trp, there are three intramolecular disulfide bonds to be positioned at peptide chain N-end, molecular configuration is played Stabilization; The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged; The peptide chain middle part has one by Pro-Lys
47The special construction that-Pro forms, it plays a part certain in hirudin and thrombin interaction.
In 11 kinds of variants of hirudin, only variant I, II and III have anticoagulating active.
So far, all can obtain active lepirudin 023 ludon through escherichia coli or Yeast system expression, and be desulfurization acidic group hirudin, promptly 63 Tyr do not have sulphation.Reorganization has isomorphic map mutually with natural prodcuts.Further can produce multiple variant.
Along with the molecular biology develop rapidly, external at present existing tens companies develop lepirudin 023 ludon and the plain preparation of functional Hirudo, a large number of experiments show that recombinant products is similar to natural prodcuts, are effective anticoagulant and antithrombotic preparation.
The clinical indication of lepirudin 023 ludon can be summarized as follows: 1) surgery anticoagulant; 2) internal medicine anticoagulant; 3) adjuvant of thrombolytic drug; 4) anticoagulant of angioplasty; 5) anticoagulant etc. in the hemodialysis.On the experimentation basis, carrying out clinical bulge test (as subacute and chronic DIC) at present.
The architectural feature of hirudin:
The single chain protein that natural hirudin is made up of 65 amino acid residues, the about 7000D of molecular weight is rich in dicarboxylic amino acid, no Arg, Met, Trp, peptide chain N-end has 3 intramolecular disulfide bond (Cys6-Cys14; Cys16-Cys28; Cys22-Cys39), molecular configuration is played Stabilization.The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged, and is worked in the interaction of hirudin and thrombin by the special construction that a Pro-Lys47-Pro forms in the peptide chain middle part.
The chemical constitution of hirudin:
Hirudin on sale at present in market.
The utility model content
The purpose of this utility model provides a kind of disposable hard and connects the parallel multi-tube anticoagulant blood-collecting connector, can once adopt 1-3 pipe blood simultaneously, continuously, fast, reach and not only make things convenient for blood sampling but also make blood sample that thrombosis and blood coagulation not take place and can adapt to the clinical required various projects of inspection.
Adopt following technical scheme in order to reach the purpose of this utility model: disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that connecting cylindrical connector 3 by vein blood taking needle 2, adapter 3 internal chamber walls are provided with anticoagulant coating 1, the other end of adapter 3 connects distribution ducts 4, on the path pipe of distribution ducts 4 vacuum pipe valve 5 is set, connect an adapter 3 respectively on three path pipe of other of distribution ducts 4, adapter 3 internal chamber walls are provided with anticoagulant coating 1, in other end connection blood sample bottle pin 6 formations of adapter 3.
Described disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that the anticoagulant of described anticoagulant coating 1 usefulness is: hirudin, 3.2% sodium citrate, heparin, citrate, oxalates.
Described disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that described citrate is citrate, 2-hydroxy propane tricarboxylic acid salt; Described oxalates is 40% potassium oxalate, 60% ammonium oxalate.
Described disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that vein blood taking needle 2, blood sample bottle pin 6 are to adopt the medical stainless steel material to make; Distribution ducts 4, adapter 3, vacuum pipe valve 5 are to adopt the medical polyethylene material to make.
This utility model disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector and has the following advantages: increased the anticoagulant coating on the basis of traditional rigid connecting type blood taking needle, made blood flow out and externally just can touch anticoagulant.Blood blood coagulation, thrombosis, haemolysis can not occur, guarantees that the blood drawing blood sample meets the Clinical Laboratory requirement, makes assay accurate, improves the clinical treatment level.
A supporting distribution ducts 4 on traditional hard connection blood taking needle, so can once adopt 1-3 pipe blood simultaneously, continuously, fast, both promote blood sampling speed, also simplified blood collection procedure, and made medical workers such as nurse when clinical blood drawing, reduce operation link; Reduce the probability of makeing mistakes; Reduce workload; Help clinical blood drawing operation a large amount of, quick, that concentrate; Reduce packaging material; Reduce medical waste; Lower national medical insurance.
Description of drawings
Fig. 1 is the front view that this utility model disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector.
Explanation to the drawing symbol:
1: anticoagulant coating 2: vein blood taking needle
3: adapter 4: distribution ducts
5: vacuum pipe valve 6: blood sample bottle pin
The specific embodiment
Below in conjunction with accompanying drawing, describe the embodiment 1 that this utility model disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector in detail.Fig. 1 is the front view that this utility model disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector.As shown in Figure 1, this utility model disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that connecting cylindrical connector 3 by vein blood taking needle 2, adapter 3 internal chamber walls are provided with anticoagulant coating 1, the other end of adapter 3 connects distribution ducts 4, on the path pipe of distribution ducts 4 vacuum pipe valve 5 is set, and connects an adapter 3 respectively on three path pipe of other of distribution ducts 4, adapter 3 internal chamber walls are provided with anticoagulant coating 1, in other end connection blood sample bottle pin 6 formations of adapter 3.
The anticoagulant of anticoagulant coating 1 usefulness is: the hirudin amount is: 0.01 milligram～10 milligrams/every pin, the hirudin loading amount can make 5 milliliters of blood anticoagulants more than 7 days at 1 milligram in the blood taking needle at present; 10 milligrams of loading amounts can make 50 milliliters of blood anticoagulants more than 7 days.Preferred plan is to use the hirudin anticoagulant agent can detect about 300 kinds of test items in the blood.1, reduces operation link and stop mistake; 2, the convenient use; 3, testing data is more accurate; 4, test range is extensive; 5, increase the hospital economy benefit; 6, reduce environmental pollution; 7, save medical treatment cost; 8, improve the clinical treatment level; 9, help the early discovery of various diseases and for treatment in time provides foundation, healthy.
The anticoagulant of anticoagulant coating 1 usefulness also comprises: 3.2% sodium citrate, heparin, citrate (citrate, 2-hydroxy propane tricarboxylic acid salt), oxalates (40% potassium oxalate/60% ammonium oxalate) etc.
Above-mentioned vein blood taking needle 2, blood sample bottle pin 6 are to adopt the medical stainless steel material to make; Distribution ducts 4, adapter 3, vacuum pipe valve 5 are to adopt the medical polyethylene material to make.
Because this utility model design can combine with anticoagulant so intravenous needle rear portion increase anticoagulant coating blood is flowed through intravenous needle from patient's vein after, after flowing to the blood sample collection device, blood sample combines with anticoagulant is good, so after blood drawing is finished, needn't put upside down repeatedly clinically, mixing blood sample collection device, thus loaded down with trivial details step in the blood drawing process saved greatly.Anticoagulant can combine with blood is good when flowing through the anticoagulant coating owing to blood sample in addition, the problem that the blood sample premature set is stopped up syringe needle can not occur.In addition, when needs of patients detects multiple project or test item simultaneously and needs a large amount of blood parallel structural design can satisfy medical worker such as nurse simultaneously, quick, a large amount of blood drawing.Both made things convenient for medical personnel, saved clinical blood sampling time again, be very suitable for concentrating, fast, a large amount of blood drawing.
Need multinomial check clinically, when for the first time going up machine chemical examination failure or data are inaccurate or when enlarging inspection item, project organization of the present utility model has improved the shortcoming of present Clinical Laboratory blood taking needle, reduces the operating process of Clinical Laboratory, is the Clinical Laboratory condition that provides more convenience.Can realize secondary check, the check of increase project, duplicate test or the like operation.
Test data example 1:
| Reduction viscosity of blood (mPa.S) | 13.056±4.016 | 13.452±3.745 |
| The erythrocyte rigidity index | 8.481±2.997 | 8.414±2.910 |
| Deformable index | 1.144±0.219 | 1.170±0.214 |
Compare with the present invention behind the existing supporting vacuum test tube of conventional vacuum blood taking needle:
Table: compare with the present invention behind the supporting vacuum test tube of conventional vacuum blood taking needle
| Common blood taking needle cooperates required blood drawing time of general blood collection tube and blood drawing amount | The present invention improves required blood drawing time of back and blood drawing amount |
| 5-7 blood sampling volume second 5ml | The 6-8 15ml that takes a blood sample second |
The anticoagulant vacuum blood taking needle adds the hirudin amount: 0.01 milligram～10 milligrams/every pin.For example: the hirudin loading amount can make 5 milliliters of blood anticoagulants more than 7 days at 1 milligram in the blood taking needle at present; 2 milligrams of loading amounts can make 10 milliliters of blood anticoagulants more than 7 days.
Conclusion:
(1) can add anticoagulant flexibly according to the Clinical Laboratory needs.
(2) alleviate medical personnel's labor intensity.
(3) operating process of the clinical a large amount of blood drawings of minimizing.
(4) adopt the parallel way blood drawing, safety, quick, convenient.
(5) be fit to very much in the accident a large amount of personnel needs of taking a blood sample fast.
(6) can be suitable for multiple blood testing project.
(7) use of needed chemical anticoagulant also can be satisfied the application of new bio anticoagulant hirudin in Clinical Laboratory in the time of can satisfying the tradition blood sampling, thereby the fiery width of cloth improves the Clinical Laboratory level.
Claims (2)
1. disposable hard connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that connecting cylindrical connector (3) by vein blood taking needle (2), adapter (3) internal chamber wall is provided with anticoagulant coating (1), the other end of adapter (3) connects distribution ducts (4), on the path pipe of distribution ducts (4) vacuum pipe valve (5) is set, connect an adapter (3) respectively on three path pipe of other of distribution ducts (4), adapter (3) internal chamber wall is provided with anticoagulant coating (1), in other end connection blood sample bottle pin (6) formation of adapter (3).
2. disposable hard according to claim 1 connects the parallel multi-tube anticoagulant blood-collecting connector, it is characterized in that vein blood taking needle (2), blood sample bottle pin (6) are to adopt the medical stainless steel material to make; Distribution ducts (4), adapter (3), vacuum pipe valve (5) are to adopt the medical polyethylene material to make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010291510148U CN201767971U (en) | 2010-02-08 | 2010-02-08 | Anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010291510148U CN201767971U (en) | 2010-02-08 | 2010-02-08 | Anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201767971U true CN201767971U (en) | 2011-03-23 |
Family
ID=43747798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010291510148U Expired - Fee Related CN201767971U (en) | 2010-02-08 | 2010-02-08 | Anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201767971U (en) |
-
2010
- 2010-02-08 CN CN2010291510148U patent/CN201767971U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PP01 | Preservation of patent right |
Effective date of registration: 20160817 Granted publication date: 20110323 |
|
| RINS | Preservation of patent right or utility model and its discharge | ||
| PD01 | Discharge of preservation of patent | ||
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20170607 Granted publication date: 20110323 |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110323 Termination date: 20180208 |