CN101803926B - Disposable soft-connection parallel multi-tube hirudin anticoagulant blood-collecting connector - Google Patents
Disposable soft-connection parallel multi-tube hirudin anticoagulant blood-collecting connector Download PDFInfo
- Publication number
- CN101803926B CN101803926B CN2010191020088A CN201019102008A CN101803926B CN 101803926 B CN101803926 B CN 101803926B CN 2010191020088 A CN2010191020088 A CN 2010191020088A CN 201019102008 A CN201019102008 A CN 201019102008A CN 101803926 B CN101803926 B CN 101803926B
- Authority
- CN
- China
- Prior art keywords
- blood
- adapter
- anticoagulant
- connector
- hirudin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003146 anticoagulant agent Substances 0.000 title claims abstract description 74
- 229940127219 anticoagulant drug Drugs 0.000 title claims abstract description 70
- 102000007625 Hirudins Human genes 0.000 title claims abstract description 40
- 108010007267 Hirudins Proteins 0.000 title claims abstract description 40
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title claims abstract description 40
- 229940006607 hirudin Drugs 0.000 title claims abstract description 40
- 239000008280 blood Substances 0.000 claims abstract description 96
- 210000004369 blood Anatomy 0.000 claims abstract description 96
- 239000011248 coating agent Substances 0.000 claims abstract description 20
- 238000000576 coating method Methods 0.000 claims abstract description 20
- 210000003462 vein Anatomy 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 12
- 230000008569 process Effects 0.000 abstract description 6
- 239000002906 medical waste Substances 0.000 abstract description 3
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 239000010816 packaging waste Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 16
- 241000237903 Hirudo Species 0.000 description 9
- 238000010241 blood sampling Methods 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 5
- OTQCKZUSUGYWBD-BRHMIFOHSA-N lepirudin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 OTQCKZUSUGYWBD-BRHMIFOHSA-N 0.000 description 5
- 229960004408 lepirudin Drugs 0.000 description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 229960002897 heparin Drugs 0.000 description 4
- 229920000669 heparin Polymers 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 150000003891 oxalate salts Chemical class 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- 108090000190 Thrombin Proteins 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- VBIXEXWLHSRNKB-UHFFFAOYSA-N ammonium oxalate Chemical compound [NH4+].[NH4+].[O-]C(=O)C([O-])=O VBIXEXWLHSRNKB-UHFFFAOYSA-N 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229960004072 thrombin Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005755 formation reaction Methods 0.000 description 2
- 230000008588 hemolysis Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000237678 Hirudinidae Species 0.000 description 1
- RVQDZELMXZRSSI-IUCAKERBSA-N Pro-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1 RVQDZELMXZRSSI-IUCAKERBSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000964941 Whitmania Species 0.000 description 1
- 241000258623 Whitmania pigra Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006477 desulfuration reaction Methods 0.000 description 1
- 230000023556 desulfurization Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Images
Abstract
Description
Common blood taking needle cooperates required blood drawing time of general blood collection tube and blood drawing amount | The present invention improves required blood drawing time of back and blood drawing amount |
5-7 blood sampling volume second 5ml | 6-8 blood sampling volume second 15ml |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010191020088A CN101803926B (en) | 2010-02-08 | 2010-02-08 | Disposable soft-connection parallel multi-tube hirudin anticoagulant blood-collecting connector |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010191020088A CN101803926B (en) | 2010-02-08 | 2010-02-08 | Disposable soft-connection parallel multi-tube hirudin anticoagulant blood-collecting connector |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101803926A CN101803926A (en) | 2010-08-18 |
CN101803926B true CN101803926B (en) | 2011-08-31 |
Family
ID=42606001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010191020088A Expired - Fee Related CN101803926B (en) | 2010-02-08 | 2010-02-08 | Disposable soft-connection parallel multi-tube hirudin anticoagulant blood-collecting connector |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101803926B (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5785662A (en) * | 1996-05-30 | 1998-07-28 | Medisys Technologies, Inc. | Blood collection assembly with plurality of vials |
CN200963140Y (en) * | 2006-10-19 | 2007-10-24 | 高凤玲 | Disposable micro blood-taking device |
CN101248998A (en) * | 2008-03-31 | 2008-08-27 | 天津超然生物技术有限公司 | Vacuum hemostix |
-
2010
- 2010-02-08 CN CN2010191020088A patent/CN101803926B/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5785662A (en) * | 1996-05-30 | 1998-07-28 | Medisys Technologies, Inc. | Blood collection assembly with plurality of vials |
CN200963140Y (en) * | 2006-10-19 | 2007-10-24 | 高凤玲 | Disposable micro blood-taking device |
CN101248998A (en) * | 2008-03-31 | 2008-08-27 | 天津超然生物技术有限公司 | Vacuum hemostix |
Also Published As
Publication number | Publication date |
---|---|
CN101803926A (en) | 2010-08-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101695446B (en) | Disposable soft connecting band collection container and anti-freezing vacuum blood taking needle of bleeding opening | |
AU2014340221B2 (en) | Double barrel syringe and method to use same for placement confirmation and joint space injection | |
CN101695447B (en) | Disposable hard connecting band collection container and anti-freezing vacuum blood taking needle of bleeding opening | |
CN102068731B (en) | Venous retention needle suite with hirudin anticoagulation tube sealing device | |
CN201631207U (en) | Disposable hard-connected parallel multi-tube anticoagulant vacuum blood sampling matched set | |
CN202185013U (en) | Anti-coagulation sealing tube suite | |
CN101785676B (en) | Disposable flexible connection hirudin anti-coagulation transverse vacuum blood collection kit | |
CN101785677B (en) | Disposable hard connection hirudin anti-coagulation transverse vacuum blood collection kit | |
CN202028026U (en) | Venous remaining needle with pipe sealing device | |
CN102068730B (en) | Hirudin anticoagulation seal tube kit for vein detained needle | |
CN201524083U (en) | Disposable flexibly connected anticoagulant blood taking needle | |
CN201516035U (en) | Anti-coagulation vacuum blood collecting needle of disposable soft tape splicing collecting container | |
CN201691937U (en) | Disposable flexible parallel connection multi-pipe anticoagulant vacuum blood collecting set | |
CN101803926B (en) | Disposable soft-connection parallel multi-tube hirudin anticoagulant blood-collecting connector | |
CN201516036U (en) | Anti-coagulation blood collecting needle of disposable soft tape splicing collecting container and blood discharge hole | |
CN201516037U (en) | Anti-coagulation vacuum blood collecting needle of disposable hard tape splicing collecting container | |
CN101803927B (en) | Disposable hard-connection parallel multi-tube hirudin anticoagulant blood-collecting connector | |
CN201519153U (en) | Disposable hard-wired type anti-coagulation blood taking needle | |
CN201631201U (en) | Disposable flexibly connected parallel multi-tube anti-coagulation hemostix | |
CN201767971U (en) | Anti-coagulation blood sampling connector with multiple disposable hard parallel connected pipes | |
CN201516034U (en) | Anti-coagulation vacuum blood collecting needle of disposable hard connecting belt blood specimen collecting container | |
Lorber et al. | Entero-Hepatic Circulation of Bromsulphalein: I. Studies on Man with Special Reference to the Clinical BSP Test | |
CN201978319U (en) | Body cavity one-way negative pressure drainage device with scales | |
CN103876752B (en) | Venous indwelling channel hemostix | |
CN202027990U (en) | Venous retention needle sleeve element with pipe sealing device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PP01 | Preservation of patent right |
Effective date of registration: 20160817 Granted publication date: 20110831 |
|
RINS | Preservation of patent right or utility model and its discharge | ||
PD01 | Discharge of preservation of patent | ||
PD01 | Discharge of preservation of patent |
Date of cancellation: 20170607 Granted publication date: 20110831 |
|
TR01 | Transfer of patent right |
Effective date of registration: 20170630 Address after: Tianjin Development Zone 300450 Fifth Avenue Taihua Road No. 12 TEDA SME development center room 3024 Patentee after: Tianjin hundred new biotechnology research and Development Co., Ltd. Address before: 300384 Tianjin Huayuan Industrial Park Torch Hotel 501 Patentee before: Tianjin Baili Kangtai Biological Technology Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110831 Termination date: 20210208 |