CN201516036U - Anti-coagulation blood collecting needle of disposable soft tape splicing collecting container and blood discharge hole - Google Patents
Anti-coagulation blood collecting needle of disposable soft tape splicing collecting container and blood discharge hole Download PDFInfo
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- CN201516036U CN201516036U CN2009202216984U CN200920221698U CN201516036U CN 201516036 U CN201516036 U CN 201516036U CN 2009202216984 U CN2009202216984 U CN 2009202216984U CN 200920221698 U CN200920221698 U CN 200920221698U CN 201516036 U CN201516036 U CN 201516036U
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Abstract
The utility model belongs to the technical field of medical appliances, in particular to an anti-coagulation blood collecting needle of a disposable soft tape splicing collecting container and a blood discharge hole, a biological product anticoagulant coating layer is arranged on an inner cavity wall of a circular connector, one end of the connector is provided with a blood collecting plastic conduit, a vacuum valve is arranged on the plastic conduit, the other end of the plastic conduit is provided with a circular connector, the inner cavity wall of the connector is provided with the biological product anticoagulant coating layer, the other end of the connector is provided with an intra-vascular blood taking needle, the other end of another connector is provided with a blood specimen collecting bottle needle, the blood specimen bottle needle is connected with a blood specimen collecting bottle cap which is connected with a plug, the plug is connected with the blood specimen collecting bottle, and a secondary blood discharge hole is arranged on one side of the blood specimen collecting bottle close to the blood specimen collecting bottle cap. The anti-coagulation blood collecting needle can guarantee blood specimen to avoid blood coagulation and hemolysis for guaranteeing the accuracy of inspection results. The anti-coagulation blood collecting needle can flexibly master the usage of blood specimen when inspecting, and guarantee repeated inspect or increase of new inspection projects at any time.
Description
Technical field
This utility model belongs to technical field of medical instruments, particularly relates to the anticoagulant blood-collecting pin of medical disposable soft connecting band collection container and blood-letting mouth.
Background technology
China's traditional soft interconnection system blood taking needle has following shortcoming at present:
1, traditional soft interconnection system blood taking needle: during clinical blood sampling easily when moment thrombosis and haemolysis occur and particularly suffers from certain disease (as diseases such as hyperlipidemia) patient in blood drawing, blood flows out the external blood coagulation phenomenon that promptly takes place, and thrombosis stops up blood collection needles easily influences quality inspection.
2, traditional soft interconnection system blood taking needle does not link to each other with vacuum test tube, needs medical worker's connections when drawing blood operation such as nurse.Traditional design makes medical worker such as nurse increase operation link when blood drawing; Increase the probability of makeing mistakes; Increase workload; Be unsuitable for clinical blood drawing operation a large amount of, quick, that concentrate.
3, do not have anticoagulant in the traditional soft interconnection system blood taking needle, contain anticoagulant, so after the clinical blood drawing, need put upside down mixing (blood combines with anticoagulant is better for convenience) immediately 5 ~ 8 times at vacuum test tube.
4, packaging material are too much, are unfavorable for environmental protection and reduce medical waste.
5, price height increases national medical insurance.
6, the traditional vacuum blood taking tube does not have secondary blood-letting mouth, may the read data failure during machine test on the blood sample in the whole blood taking tube or the Clinical Laboratory personnel think and be necessary duplicate test, and at this moment because the detection machine probe enters the blood sample in the whole blood taking tube, cause the homogeneous tube blood sample to pollute, go bad, blood samples of patients be need extract again, patient suffering and national medical insurance burden increased; The waste resource; Increase medical waste.
7, because the traditional vacuum blood taking tube uses the variety classes anticoagulant to tackle corresponding inspection item, so can't the separation of blood sample, even the purpose that secondary blood-letting mouth can not reach general detection is set, so in case blood sample goes wrong, or when query appearred in testing result, when maybe needing to increase inspection item, just can't carry out any detection and test once more.
8, owing to not adding any anticoagulant in traditional blood taking needle and not linking to each other, so anticoagulant is added in the vacuum test tube with vacuum test tube.The tradition anticoagulant mostly is every kind of chemicals of chemicals can only be at specific test item, heparin, sodium citrate, potassium oxalate, Na
2EDTA, K
2Traditional anticoagulant such as EDTA can not replenish mutually, can not exchange.Even so on blood taking needle, add heparin, sodium citrate, potassium oxalate, Na
2EDTA, K
2Anticoagulant such as EDTA, do not have in all senses yet and also can make troubles, increase misery (if on traditional blood taking needle, add traditional anticoagulant, patient's inspection item just need be more than 2 kinds) for the patient by many blood taking needles that the add different anticoagulant veins that puncture for clinical blood drawing check.
9, be inconvenient to add needed other additives of Clinical Laboratory.
The People's Republic of China's " Chinese pharmacopoeia version in 2005, first one, the 57th page of record " Hirudo (HIRUDO) ", this product is the dry all of Hirudinidae animal whitmania Whitmania pigra Whitman, Hirudo Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Whitmania wranulata Whitman, summer, Qiu Erji catch, scald extremely with boiling water, dry or the low humidity drying.Concoct: Hirudo is cleaned, cutting, drying.Scald Hirudo: get water purification trematodiasis section, water to little with Pulvis Talci according to the method for scalding and heave.Function with cure mainly: removing blood stasis, removing blood stasis stimulates the menstrual flow.Be used for the blood stasis amenorrhea, injury from falling down.
Foreign medical science blood transfusion and 1993 the 16th volumes of blood fascicle the 6th phase record Chinese Academy of Medical Sciences Blood Research Institute, Guo Juan summary Wang Hebi examines and revises " progress of lepirudin 023 ludon " Haycraft and found in the Hementaria officianalis extract anticoagulant substances is arranged in 1884.At the end of the fifties, Markwardt isolates pure product first, called after hirudin (Hirudin), and know that it is the special inhibitor of thrombin, be a kind of ideal anticoagulant, antithrombotic preparation.Learn its structure and amino acid sequence the beginning of the eighties.Loaded down with trivial details because of the natural hirudin extraction step, and raise the Hirudo difficulty, the Hirudo source is deficient, is difficult to obtain the pure product of q.s, and research and clinical practice are restricted.In recent years, the development of technique for gene engineering has remedied this defective, utilize chemosynthesis, cDNA library, PCR method to obtain gene clone, express and obtain lepirudin 023 ludon, thereby pharmacology, pharmacodynamics and the toxicity etc. of hirudin have more in depth been studied, a large amount of zooperies and clinic trial have been accelerated hirudin and have been applied to clinical process.At present, our laboratory is carrying out the research of HV1 cloning and expression.
The structure of hirudin: natural hirudin is not contain polysaccharide, by the single chain protein that 65 or 66 amino acid residues are formed, and molecular weight about 7,000, be rich in dicarboxylic amino acid, no Arg, Met and Trp, there are three intramolecular disulfide bonds to be positioned at peptide chain N-end, molecular configuration is played Stabilization; The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged; The peptide chain middle part has one by Pro-Lys
47The special construction that-Pro forms, it plays a part certain in hirudin and thrombin interaction.
In 11 kinds of variants of hirudin, only variant I, II and III have anticoagulating active.
So far, all can obtain active lepirudin 023 ludon through escherichia coli or Yeast system expression, and be desulfurization acidic group hirudin, promptly 63 Tyr do not have sulphation.Reorganization has isomorphic map mutually with natural prodcuts.Further can produce multiple variant.
Along with the molecular biology develop rapidly, external at present existing tens companies develop lepirudin 023 ludon and the plain preparation of functional Hirudo, a large number of experiments show that recombinant products is similar to natural prodcuts, are effective anticoagulant and antithrombotic preparation.
The clinical indication of lepirudin 023 ludon can be summarized as follows: 1) surgery anticoagulant; 2) internal medicine anticoagulant; 3) adjuvant of thrombolytic drug; 4) anticoagulant of angioplasty reaches; 5) anticoagulant etc. in the hemodialysis.On the experimentation basis, carrying out clinical bulge test (as subacute and chronic DIC) at present.The architectural feature of hirudin:
The single chain protein that natural hirudin is made up of 65 amino acid residues, the about 7000D of molecular weight is rich in dicarboxylic amino acid, no Arg, Met, Trp, peptide chain N-end has 3 intramolecular disulfide bond (Cys6-Cys14; Cys16-Cys28; Cys22-Cys39), molecular configuration is played Stabilization.The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged, and is worked in the interaction of hirudin and thrombin by the special construction that a Pro-Lys47-Pro forms in the peptide chain middle part.
The chemical constitution of hirudin:
In a word, hirudin on sale is lepirudin 023 ludon (Hirudin) in market at present.
Summary of the invention
In order to solve as above problem, the purpose of this utility model provides the anticoagulant blood-collecting pin of a kind of disposable soft connecting band collection container and blood-letting mouth, promptly makes things convenient for blood sampling to make blood sample that thrombosis and blood coagulation do not take place again and can adapt to the clinical required various projects of inspection.
This utility model adopts following technical scheme to achieve the above object: the anticoagulant blood-collecting pin of a kind of disposable soft connecting band collection container and blood-letting mouth, it is characterized in that biological product anticoagulant coating 1 being set by the internal chamber wall of cylindrical connector 9, end at adapter 9 is provided with blood sampling plastic catheter 8, on plastic catheter 8, place vacuum valve 11, the other end at conduit 8 is provided with cylindrical connector 10, internal chamber wall at adapter 10 is provided with biological product anticoagulant coating 1, at adapter 10 other ends vein blood taking needle 2 is set; At the other end of adapter 9 collection blood sample bottle pin 3 is set, collection blood sample bottle pin 3 connects collection blood sample valve protection caps 5, and collection blood sample valve protection cap 5 connects plugs 4, and plug 4 connects collection blood sample bottles 6, closes on collection blood sample valve protection cap 5 one sides and secondary blood-letting mouth 7 is set constitutes on collection blood sample bottle 6.
The anticoagulant blood-collecting pin of described disposable soft connecting band collection container and blood-letting mouth is characterized in that the anticoagulant of described biological product anticoagulant coating 1 usefulness is: hirudin.
The anticoagulant blood-collecting pin of described disposable soft connecting band collection container and blood-letting mouth is characterized in that vein blood taking needle 2, collection blood sample bottle pin 3 are to adopt the medical stainless steel material to make; Adapter 9, adapter 10, secondary blood-letting mouth 7, conduit 8, vacuum valve 11, collection blood sample valve protection cap 5 are to adopt the medical polyethylene material to make; Plug 4 is to adopt medical butyl rubber plug material to make; Collection blood sample bottle 6 is made by pure polyethylene terephthalate (PET) material.
The anticoagulant blood-collecting pin of this utility model disposable soft connecting band collection container and blood-letting mouth has the following advantages: increased the anticoagulant coating on the basis of traditional soft interconnection system blood taking needle, made blood flow out and externally just can touch anticoagulant.Blood can blood coagulation, thrombosis, haemolysis, guarantees that the blood drawing blood sample meets the Clinical Laboratory requirement, makes assay accurate, improves the clinical treatment level.Because used biological anticoagulant hirudin, according to its characteristics: do not destroy the active ingredient of blood, do not disturb the blood regime values, so can detect about 300 kinds of test items in the blood.Hirudin does not have any heavy metal, antibacterial, impurity or the like interference test blood unfavorable factor aborning in addition, so post-production, make the misgivings yet do not have any Interference Detection project.To sum up, hirudin can substitute the anticoagulant of present clinical use, really reaches a kind of anticoagulant and substitutes multiple anticoagulant.Increase secondary blood-letting mouth, make the Clinical Laboratory personnel can grasp blood consumption when checking flexibly, economize on blood volume to greatest extent, guarantee duplicate test at any time or increase new inspection item.At blood taking needle the anticoagulant coating is set, during clinical blood drawing, because the blood pressure of human body is higher than atmospheric pressure, so the blood backflow phenomenon can not occur.
The formula blood taking needle that is flexible coupling that increases after the anticoagulant coating is directly connected on the blood taking tube, makes medical worker such as nurse when clinical blood drawing, reduce operation link; Reduce the probability of makeing mistakes; Reduce workload; Help clinical blood drawing operation a large amount of, quick, that concentrate.Reduce packaging material, reduce medical waste, lower national medical insurance.In addition owing in the formula blood taking needle that is flexible coupling, having increased the anticoagulant coating, so after the clinical blood drawing, do not need to put upside down mixing (blood flow just combines with anticoagulant uniformly) after the anticoagulant coating.
Improve the back owing to increase secondary blood-letting mouth, make the Clinical Laboratory personnel can grasp blood consumption when checking flexibly, economize on blood volume to greatest extent, guarantee duplicate test at any time or increase new inspection item.In addition owing to can carry out the secondary blood-letting at any time, even wherein one bottle of blood sample is rotten or solidify, the blood sample that does not also influence other makes the Clinical Laboratory personnel detect once more and test.
Anticoagulant blood-collecting pin through animal experiment and clinical trial proof this utility model disposable soft connecting band collection container and blood-letting mouth can produce the huge social benefit:
1, reduces patient suffering's (project of the every check of general blood collection tube need be drawn blood about 5ml, as detects 8 sample 40ml that then need draw blood, and white medicated cap vacuum test tube only needs the 5ml blood sample can reach above-mentioned detection effect).
2, zero defect in clinical blood drawing.
3, the medical insurance of saving 20-30% is submitted an expense account.
4, help blood drawing crowd use in a large number, for example: infant, weak patients and other special body constitution patients etc.
5, for example help soft accident: blood sampling is concentrated in three chlorocyanamide incidents and rigid accident, for example: earthquake, war etc.
Complicated procedures when 6, simplifying the clinical blood drawing of nurse.Avoid the mistake of later stage clinical laboratory when chemical examination.Assurance medical test blood sample specimen quality is provided convenience for further realizing the detection of chemical examination automatization.
7, heparin, sodium citrate, potassium oxalate, Na
2EDTA, K
2The blood taking tube that anticoagulant such as EDTA use is only checked the about 100 kinds of compositions in the blood in clinical, use the hirudin anticoagulant agent can detect about 300 kinds of detection compositions in the blood.Improve the Clinical Laboratory level, increase the hospital economy benefit.
8, increase secondary blood-letting mouth, make the Clinical Laboratory personnel can grasp blood consumption when checking flexibly, economize on blood volume to greatest extent, guarantee duplicate test at any time or increase new inspection item.Thereby guarantee less medical waste, save cost, reduce the patient suffering, make things convenient for the Clinical Laboratory personnel.
9, increase secondary blood-letting mouth, convenient other the required additives of Clinical Laboratory that add.
Description of drawings
Fig. 1 is the front view of the anticoagulant blood-collecting pin of this utility model disposable soft connecting band collection container and blood-letting mouth.
Explanation to the drawing symbol:
1: biological product anticoagulant coating 2: vein blood taking needle
3: collection blood sample bottle pin 4: plug
5: collection blood sample valve protection cap 6: collection blood sample bottle
7: secondary blood-letting mouth 8: conduit
9: adapter 10: adapter
11: vacuum valve
The specific embodiment
Below in conjunction with accompanying drawing, describe the embodiment of the anticoagulant blood-collecting pin of this utility model disposable soft connecting band collection container and blood-letting mouth in detail.Fig. 1 is the front view of the anticoagulant blood-collecting pin of this utility model disposable soft connecting band collection container and blood-letting mouth.As shown in Figure 1, the anticoagulant blood-collecting pin of this utility model disposable soft connecting band collection container and blood-letting mouth, be that internal chamber wall by cylindrical connector 9 is provided with biological product anticoagulant coating 1, end at adapter 9 is provided with blood sampling plastic catheter 8, on plastic catheter 8, place vacuum valve 11, the other end at conduit 8 is provided with cylindrical connector 10, at the internal chamber wall of adapter 10 biological product anticoagulant coating 1 is set, and at adapter 10 other ends vein blood taking needle 2 is set; At the other end of adapter 9 collection blood sample bottle pin 3 is set, collection blood sample bottle pin 3 connects collection blood sample valve protection caps 5, and collection blood sample valve protection cap 5 connects plugs 4, and plug 4 connects collection blood sample bottles 6, closes on collection blood sample valve protection cap 5 one sides and secondary blood-letting mouth 7 is set constitutes on collection blood sample bottle 6.
The anticoagulant of biological product anticoagulant coating 1 usefulness is: hirudin.Preferred plan is to use the hirudin anticoagulant agent can detect about 300 kinds of test items in the blood.1, reduces the link and stop mistake; 2, the convenient use; 3, testing data is more accurate; 4, test range is extensive; 5, increase the hospital economy benefit; 6, reduce environmental pollution; 7, save medical treatment cost; 8, improve the clinical treatment level; 9, the early discovery of various diseases is in time treated, foundation is provided, healthy.
Vein blood taking needle 2, collection blood sample bottle pin 3 are to adopt the medical stainless steel material to make; Adapter 9, adapter 10, secondary blood-letting mouth 7, conduit 8, vacuum valve 11, collection blood sample valve protection cap 5 are to adopt the medical polyethylene material to make; Plug 4 is to adopt medical butyl rubber plug material to make; Collection blood sample bottle 6 is made by pure polyethylene terephthalate (PET) material.
Because this utility model design can combine with anticoagulant so intravenous needle rear portion increase anticoagulant coating blood is flowed through intravenous needle from patient's vein after, after flowing to the blood sample collection device, blood sample combines with anticoagulant is good, so after blood drawing is finished, needn't put upside down repeatedly clinically, mixing blood sample collection device (being traditional blood taking tube), thus loaded down with trivial details step in the blood drawing process saved greatly.Anticoagulant can combine with blood is good when flowing through the anticoagulant coating owing to blood sample in addition, the problem that the blood sample premature set is stopped up syringe needle can not occur.
Secondary blood-letting mouth is applied to clinically: when blood drawing for the first time go up the machine chemical examination or data are inaccurate, when enlarging inspection item, can detect from machine chemical examination in the salty new blood drawing of blood-letting, after also can preserving a period of time, thereby once more from the blood-letting mouth blood drawing go up the machine chemical examination and detect the shortcoming of having improved present Clinical Laboratory---if the blood drawing back goes up that the machine test is unsuccessful just must extract patient's blood sample once more again, and dripping appears in blood drawing easily from present blood taking tube in addition, leakage pollutes environment and disease propagation.Test data sees Table 1.
Table 1: test data
Anticoagulant blood-collecting pin with disposable soft connecting band collection container and blood-letting mouth behind the embodiment 2 existing supporting vacuum test tubes of conventional vacuum blood taking needle relatively sees Table 2:
Conclusion:
(1) the hirudin consumption is few.
(2) response speed is fast.
(3) can be suitable for multiple blood testing project.
(4) can be littler to the interference of blood than other anticoagulant.
(5) operating process of the clinical blood drawing of minimizing.
(6) increase secondary blood-letting mouth, reduce the operating process of Clinical Laboratory, be the Clinical Laboratory condition that provides more convenience.Can realize secondary check, the check of increase project, duplicate test or the like operation.
Table 2: the anticoagulant blood-collecting pin with disposable soft connecting band collection container and blood-letting mouth behind the supporting vacuum test tube of conventional vacuum blood taking needle compares
The anticoagulant vacuum blood taking needle adds the hirudin amount: 0.01 milligram ~ 10 milligrams/every pin
For example: the hirudin loading amount can make 5 milliliters of blood anticoagulants more than 7 days at 1 milligram in the blood taking needle at present; 10 milligrams of loading amounts can make 50 milliliters of blood anticoagulants more than 7 days.
Claims (3)
1. the anticoagulant blood-collecting pin of disposable soft connecting band collection container and blood-letting mouth, its feature is provided with biological product anticoagulant coating (1) by the internal chamber wall of cylindrical connector (9), end at adapter (9) is provided with conduit (8), vacuum valve (11) is set on conduit (8), the other end at conduit 8 is provided with cylindrical connector (10), internal chamber wall at adapter (10) is provided with biological product anticoagulant coating (1), at adapter (10) other end vein blood taking needle (2) is set; The other end at adapter (9) is provided with collection blood sample bottle pin (3), collection blood sample bottle pin (3) connects collection blood sample valve protection cap (5), collection blood sample valve protection cap (5) connects plug (4), plug (4) connects collection blood sample bottle (6), and a side of closing on collection blood sample valve protection cap (5) on collection blood sample bottle (6) is provided with secondary blood-letting mouth (7) and constitutes.
2. the anticoagulant blood-collecting pin of disposable soft connecting band collection container according to claim 1 and blood-letting mouth is characterized in that the anticoagulant of described biological product anticoagulant coating (1) usefulness is: hirudin.
3. the anticoagulant blood-collecting pin of disposable soft connecting band collection container according to claim 1 and blood-letting mouth is characterized in that vein blood taking needle (2), collection blood sample bottle pin (3) are to adopt the medical stainless steel material to make; Adapter (9), adapter (10), secondary blood-letting mouth (7), conduit (8), vacuum valve (11), collection blood sample valve protection cap (5) are to adopt the medical polyethylene material to make; Plug (4) is to adopt medical butyl rubber plug material to make; Collection blood sample bottle (6) is made by pure pet material.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202216984U CN201516036U (en) | 2009-10-30 | 2009-10-30 | Anti-coagulation blood collecting needle of disposable soft tape splicing collecting container and blood discharge hole |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009202216984U CN201516036U (en) | 2009-10-30 | 2009-10-30 | Anti-coagulation blood collecting needle of disposable soft tape splicing collecting container and blood discharge hole |
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| CN201516036U true CN201516036U (en) | 2010-06-30 |
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| CN2009202216984U Expired - Lifetime CN201516036U (en) | 2009-10-30 | 2009-10-30 | Anti-coagulation blood collecting needle of disposable soft tape splicing collecting container and blood discharge hole |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011050562A1 (en) * | 2009-10-30 | 2011-05-05 | 天津市百利康泰生物技术有限公司 | Anticoagulation vacuum blood collection needle whit disposable flexible-connecting collection container and bleeding port |
| WO2011050561A1 (en) * | 2009-10-30 | 2011-05-05 | 天津市百利康泰生物技术有限公司 | Disposable rigidly-connected anticoagulant vacuum blood collection needle with collection container and blood outlet |
-
2009
- 2009-10-30 CN CN2009202216984U patent/CN201516036U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011050562A1 (en) * | 2009-10-30 | 2011-05-05 | 天津市百利康泰生物技术有限公司 | Anticoagulation vacuum blood collection needle whit disposable flexible-connecting collection container and bleeding port |
| WO2011050561A1 (en) * | 2009-10-30 | 2011-05-05 | 天津市百利康泰生物技术有限公司 | Disposable rigidly-connected anticoagulant vacuum blood collection needle with collection container and blood outlet |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20100630 Effective date of abandoning: 20091030 |