CN202376556U - Anticoagulant tube sealer for vein remaining needle - Google Patents
Anticoagulant tube sealer for vein remaining needle Download PDFInfo
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- CN202376556U CN202376556U CN2011205364330U CN201120536433U CN202376556U CN 202376556 U CN202376556 U CN 202376556U CN 2011205364330 U CN2011205364330 U CN 2011205364330U CN 201120536433 U CN201120536433 U CN 201120536433U CN 202376556 U CN202376556 U CN 202376556U
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Abstract
The utility model relates to an anticoagulant tube sealer for a vein remaining needle, which comprises a liquid storage bag arranged in a support frame and a roller arranged between two side walls of the support frame and used for pushing the liquid in the liquid storage bag forward. An inclined surface and a concave are alternately formed on the upper end of the left and the right side walls of the support frame, and the wheel shaft arranged in the center of the roller is connected in the concave and rolls forward along the inclined surface. The liquid in the liquid storage bag is hirudin diluent. The anti-coagulant tube sealer for the vein remaining needle can be connected with the existing remaining needle, and an additional improvement on the remaining needle is not needed. The distance between each two concaves of the tube sealer can be obtained by calculation, thus tube sealing solution can be ensured to fill into a tube cavity of the remaining needle, blocking of the tube caused by back-flowing blood and coagulation is avoided, and the anticoagulant tube sealer is convenient to use for nurses and patients. Hirudin diluent is selected as anti-coagulant in the tube sealing device, compared with other tube sealing liquid, hirudin diluent has outstanding anti-coagulation effect, and the detection of anti-coagulant factors in the blood is not affected, and the anticoagulant tube sealer is suitable for tube sealing in repeatedly discontinuous transfusions and the blood sampling processes.
Description
Technical field
This utility model belongs to technical field of medical instruments, particularly relates to a kind of can the connection with existing venous detaining needle, guarantees the tube sealing effect, does not influence the anticoagulation tube clipper of the venous detaining needle of blood parameters again.
Background technology
In recent years, develop rapidly, can alleviate the painful venous detaining needle of patient's repeated localised puncture and be widely used among critical patient's the patient of rescue transfusion, intravenous hyperalimentation and vein batch applications antibiotic or other medicines along with medical science applied.Venous detaining needle comprises puncture needle and sleeve pipe.After the puncture needle band sleeve pipe and penetrated patient's vein, extract puncture needle, sleeve pipe stays in the body, and the outer end connects infusion set or blood-taking device again.Venous detaining needle not only can be used for conventional venous transfusion, and can be used for repeatedly taking a blood sample discontinuously, and the misery of both having avoided repeated localised puncture to cause to the patient has been protected patient's vein again, can also improve nurse's work efficiency simultaneously.
Fig. 1 is the structural representation of the venous detaining needle of prior art.As shown in Figure 1, the venous detaining needle of prior art comprises by puncture needle 11 guiding and penetrates intravenous sleeve pipe 1, is connected the transparent threeway 2 and the infusion connector 6 that is used to be connected infusion pipeline or take a blood sample pipeline of the built-in isolating seal plug 3 of sleeve pipe 1 rear end.
One end of transparent threeway 2 is connected with sleeve pipe 1, and an end is sealed by isolating seal plug 3, and the 3rd end is connected with infusion connector 6 through prolonging pipe 4.Prolong pipe 4 and be provided with liquid stopping block 5.Sleeve pipe 1 is socketed in outside the puncture needle 11, and stretch out from the front end of sleeve pipe 1 at the tip of puncture needle 11.The rear end of puncture needle 11 is provided with puncture needle handle 10, after sleeve pipe 1 gets into vein for ease, puncture needle 11 is extracted, and a side of puncture needle handle 10 is provided with holds needle handle 9.Infusion connector 6 is double lumen tube two kinds of different drug of infusion simultaneously, and the two ends of double lumen tube are sealed by the first sealing end cap 7 and the second sealing end cap 8 respectively.
Sleeve pipe 1 is to adopt four polyvinyl fluoride materials to process, and transparent threeway 2 is to adopt medical material polythene material to process with the infusion connector 6 that is used to be connected infusion pipeline or to take a blood sample pipeline.
During transfusion, puncture needle 11 is brought sleeve pipe 1 in the human vein into, and puncture needle 11 is extracted from transparent threeway 2 tail ends, and sleeve pipe 1 is stayed in the human vein.
Because the sleeve pipe of venous detaining needle needs the long period to stay in the human vein, after each transfusion is accomplished, cause tube chamber to stop up for preventing that blood from refluxing to condense, all need carry out tube sealing.Usually use common syringe that tube-sealing solution is injected now and carry out tube sealing in the remaining needle tube chamber." 2010 the 26th 1 phases of volume of practical Chinese medicine journal; Put down in writing in " application of venous detaining needle and nursing " literary composition that Zhang Jianrong, the Hou Sifang in the hospital of traditional Chinese hospital, Ninghe County, Tianjin delivers, the tube sealing maneuver is an important ring, adopts slowly injection malleation sealed-tube method usually; Be that the limit is slowly injected the limit and withdrawed from syringe needle; Guarantee that needle tip keeps malleation, avoid causing the blood coagulation plugging in backflow of blood to the blood vessel pin.Above-mentioned blood vessel pin promptly refers to the sleeve pipe of remaining needle.But this use ordinary syringe is carried out pipe sealing method, and to be the nurse push the dosage of tube-sealing solution according to oneself experience decision; The dosage control that does not have strict standard be difficult to guarantee all to be full of tube-sealing solution in each remaining needle tube chamber, and especially the sleeve pipe front end stretches into human body parts and is difficult to observe; If tube sealing does not thoroughly make backflow of blood to sleeve pipe front end; Caused the blood coagulation plugging not come to light again, agglomerative clot is poured in the human vein by liquid when infusing once more, can cause the generation of thrombosis.
" Chinese general family medicine " March in 2010, the 8th volume the 3rd phase 395-396 page or leaf was put down in writing heparin sodium diluent and normal saline that present clinical main tube-sealing solution commonly used is a variable concentrations in " effect of two kinds of tube sealing methods of venous detaining needle relatively ".Normal saline can prevent blood coagulation with the effect of keeping extracellular osmotic pressure, blood volume and water-electrolyte balance, blood circulation, and little to vascular stimulation, its malleation tube sealing is safe and reliable, and clinical practice is extensive than the heparin in sealing method.But the normal saline tube sealing time is shorter, and conventional normal saline needs 3-5 hour tube sealing once, has increased nurse's workload, also bothers patient and has a rest.And the normal saline tube sealing is prone to cause phlebitis; Because normal saline using dosage once probably needs 10-30ml; And generally can only tube sealing 3-5h, the nursing staff need be through normal saline flushing pipeline commonly used, and flushing line need puncture as the calparine cap of sealing end cap; Because calparine cap just is easy to by germ contamination through repeatedly puncturing, flows into human body through transfusion and cause symptoms such as phlebitis.Part calparine cap poor quality is arranged in addition, and repeatedly puncture is passed through infusion pipeline with trickle medical grade rubber chip easily, directly gets into human vas and causes bigger harm.
Therefore, clinically also often the result of use heparin sodium diluent that is superior to normal saline carry out tube sealing.Heparin is a kind of acid mucopolysaccharide; All has stronger anticoagulation when using in vivo and in vitro; The dilution back is widely used in clinical as the remaining needle tube-sealing solution; Use a small amount of Calciparine/sodium salt water sealing (sealing water) pipe, phlebitic incidence rate is starkly lower than the normal saline tube sealing, and tube sealing effect retention time is longer than the normal saline tube sealing.But the heparin sodium tube sealing still has inevitable shortcoming, because heparin sodium has certain side effect to cause anticoagulant easily, is prone to cause bleeding, dosage is difficult for shortcomings such as grasp; So for have, the patient of disturbances of blood coagulation; Ying Shenyong in order to avoid increase the weight of the state of an illness, adverse consequences occurs.The remaining needle operation of can drawing blood in addition avoids the patient by the misery of repeated localised puncture, but uses normal saline and the equal effect of heparin sodium undesirable.Normal saline is because using dosage is big, and dilute blood causes blood each item index on the low side easily, in addition because the characteristics of normal saline make too early the condensing of blood easily.The limitation of heparin sodium itself can't detect hematology's routine, whole blood test, hemorheology test, the experiment of projects such as serum biochemistry, pharmacokinetic experiment, serum biochemistry, blood bank's test, blood sugar test, erythrocyte sedimentation rate experiment fast with the blood that contains heparin sodium.The tube-sealing solution hirudin diluent that this utility model provides just can solve the disadvantage of above-mentioned two kinds of traditional tube-sealing solutions.
The People's Republic of China's " Chinese pharmacopoeia version in 2010; First one; The 57th page of record " Hirudo (HIRUDO) ", these article are the dry all of Hirudinidae animal whitmania Whitmania pigra Whitman, Hirudo Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Whitmania wranulata Whitman, and summer, Qiu Erji catch; Scald extremely with boiling water, dry or the low humidity drying.Concoct: Hirudo is cleaned, cutting, drying.Scald Hirudo: get water purification trematodiasis section, water to little with Pulvis Talci according to the method for scalding and heave.Function with cure mainly: removing blood stasis, removing blood stasis stimulates the menstrual flow.Be used for the blood stasis amenorrhea, injury from falling down.
Foreign medical science blood transfusion and 993 years the 16th volumes of blood fascicle the 6th phase record Chinese Academy of Medical Sciences Blood Research Institute, Guo Juan summary Wang Hebi examines and revises " progress of lepirudin 023 ludon " Haycraft and found in the Hementaria officianalis extract anticoagulant substances is arranged in 1084.At the end of the fifties, Markwardt isolates pure article first, called after hirudin (Hirudin), and know that it is the special inhibitor of thrombin, be a kind of ideal anticoagulant, antithrombotic preparation.Learn its structure and amino acid sequence the beginning of the eighties.Loaded down with trivial details because of the natural hirudin extraction step, and raise the Hirudo difficulty, the Hirudo source is deficient, is difficult to obtain the pure article of q.s, and research and clinical practice are restricted.In recent years; The development of technique for gene engineering has remedied this defective; Utilize chemosynthesis, cDNA library, PCR method to obtain gene clone, express obtaining lepirudin 023 ludon, thereby more in depth studied pharmacology, pharmacodynamics and the toxicity etc. of hirudin; A large amount of zooperies and clinic trial have been accelerated hirudin and have been applied to clinical process.
The structure of hirudin: natural hirudin is not contain polysaccharide, by the single chain protein that 65 or 66 amino acid residues are formed, and molecular weight about 7; 000, be rich in dicarboxylic amino acid, no Arg, Met and Trp; There are three intramolecular disulfide bonds to be positioned at peptide chain N-end, molecular configuration is played Stabilization; The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged; The peptide chain middle part has one by Pro-Lys
47The special construction that-Pro forms, it plays certain function in hirudin and thrombin interaction.
In 11 kinds of variants of hirudin, only variant I, II and III have anticoagulating active.
So far, all can obtain active lepirudin 023 ludon through escherichia coli or Yeast system expression, and be desulfurization acidic group hirudin, promptly 63 Tyr do not have sulphation.Reorganization has isomorphic map mutually with natural prodcuts.Further can produce multiple variant.
Along with the molecular biology develop rapidly, external at present existing tens companies develop lepirudin 023 ludon and the plain preparation of functional Hirudo, and a large amount of tests show that recombinant products is similar with natural prodcuts, are effective anticoagulant and antithrombotic preparation.
The clinical indication of lepirudin 023 ludon can be summarized as follows: 1) surgery anticoagulant; 2) internal medicine anticoagulant; 3) adjuvant of thrombolytic drug; 4) anticoagulant of angioplasty; 5) anticoagulant etc. in the hemodialysis.On the experimentation basis, carrying out clinical bulge test (like subacute and chronic DIC) at present.
The architectural feature of hirudin:
The single chain protein that natural hirudin is made up of 65 amino acid residues, the about 7000D of molecular weight is rich in dicarboxylic amino acid, no Arg, Met, Trp, peptide chain N-end has 3 intramolecular disulfide bond (Cys6-Cys14; Cys16-Cys28; Cys18-Cys39), molecular configuration is played Stabilization.The C-end has more acidic amino acid residue, and a sulphation Tyr is arranged, and is worked in the interaction of hirudin and thrombin by the special construction that a Pro-Lys47-Pro forms in the peptide chain middle part.
Summary of the invention
This utility model is to provide a kind of in order to solve the variety of issue that exists in the prior art can be connected with existing venous detaining needle, guarantees the tube sealing effect, does not influence the anticoagulation tube clipper of the venous detaining needle of blood parameters again.
The technical scheme that this utility model is taked for the technical problem that exists in the solution known technology is:
The anticoagulation tube clipper of the venous detaining needle of this utility model comprises being arranged on the liquid storing bag in the support and being arranged on the roller that between the support two side liquid in the liquid storing bag is promoted forward.
The compartment of terrain, wall upper end, the left and right sides of described support forms inclined-plane and depression, and the wheel shaft that roller central authorities are provided with is connected in the depression and along the inclined-plane and rolls forward.
The liquid storing bag front end of described tube clipper stretches out from the front side wall of support, is provided with union joint, the inner cavity that forms of union joint; Stretch out from the rear wall of support the rear end of liquid storing bag, and the rear end is by the end cap sealing with sealing function.
The front end of described union joint is connected with syringe needle.
The liquid of splendid attire is the hirudin diluent in the described liquid storing bag.
Advantage and the good effect that the utlity model has are:
The anticoagulation tube clipper of the venous detaining needle of this utility model can be connected with existing remaining needle, and need not to transform in addition remaining needle.Distance between per two depressions of tube clipper can guarantee that tube-sealing solution is full of the tube chamber of remaining needle through calculating, and avoids backflow of blood and the blood coagulation plugging has made things convenient for nurse and patient's use.Anticoagulant in the pipe sealing device is selected the hirudin diluent for use, compares with other tube-sealing solution, and hirudin had both had good anticoagulation, can not influence the detection of anticoagulin in the blood again, suits repeatedly be used for tube sealing in discontinuity transfusion and the blood collection procedure.
Description of drawings
Fig. 1 is the structural representation of the venous detaining needle of prior art;
Fig. 2 is the structural representation of tube clipper of the venous detaining needle of this utility model;
Critical piece symbol description in the accompanying drawing:
1: sleeve pipe 2: transparent threeway 3: isolating seal plug
4: prolong pipe 5: liquid stopping block 6: infusion connector
7: the first sealing end caps sealing in 8: the second end cap 9: hold needle handle
10: puncture needle handle 11: puncture needle 12: inclined-plane
13: roller 14: wheel shaft 15: end cap
16: liquid storing bag 17: depression 18: support
19: union joint 20: syringe needle.
The specific embodiment
Followingly this utility model is carried out detailed explanation with reference to accompanying drawing and embodiment.The parts identical with prior art have used identical symbol in this utility model.
Fig. 2 is the structural representation of tube clipper of the venous detaining needle of this utility model.As shown in Figure 2, the anticoagulation tube clipper of the venous detaining needle of this utility model comprises being arranged on the liquid storing bag 16 in the support 18 and being arranged on the roller 13 that between support 18 two sides liquid in the liquid storing bag 16 is promoted forward.The compartment of terrain, wall upper end, the left and right sides of support 18 forms inclined-plane 12 and caves in 11, and the roller 13 central wheel shafts 14 that are provided with are connected also can 12 rollings forward along the inclined-plane in the depression 11.
Be loaded with the hirudin diluent in the liquid storing bag 16.The concentration of hirudin is 0.03mg/ml-10mg/ml in the hirudin diluent.Use according to the about 1ml-15ml of different needs at every turn.
The anticoagulation tube clipper of the venous detaining needle of this utility model is connected with existing venous detaining needle, plays the tube sealing effect.As shown in Figure 1, venous detaining needle comprises by puncture needle 11 guiding and penetrates intravenous sleeve pipe 1, is connected the transparent threeway 2 and the infusion connector 6 that is used to be connected infusion pipeline or take a blood sample pipeline of the built-in isolating seal plug 3 of sleeve pipe 1 rear end.
One end of transparent threeway 2 is connected with sleeve pipe 1, and an end is sealed by isolating seal plug 3, and the 3rd end is connected with infusion connector 6 through prolonging pipe 4.Prolong pipe 4 and be provided with liquid stopping block 5.Sleeve pipe 1 is socketed in outside the puncture needle 11, and stretch out from the front end of sleeve pipe 1 at the tip of puncture needle 11.The rear end of puncture needle 11 is provided with puncture needle handle 10, after sleeve pipe 1 gets into vein for ease, puncture needle 11 is extracted, and a side of puncture needle handle 10 is provided with holds needle handle 9.Infusion connector 6 is double lumen tube two kinds of different drug of infusion simultaneously, and the two ends of double lumen tube are sealed by the first sealing end cap 7 and the second sealing end cap 8 respectively.
Sleeve pipe 1 adopts four polyvinyl fluoride materials to process, and transparent threeway 2 adopts medical material polythene material to process with the infusion connector 6 that is used to be connected infusion pipeline or take a blood sample pipeline.Puncture needle 11 materials are medical stainless steel, and isolating seal plug 3 is processed for medical butyl rubber plug, the first sealing end cap 7, second end cover 8, liquid stopping block 5, hold needle handle 9, puncture needle handle 10 is processed for medical plastic.
The anticoagulation tube clipper of the venous detaining needle of this utility model; Its syringe needle 20 is thrust by the first sealing end cap 7 or second end cover, 8 places, also can thrust from isolating seal plug 3, and scroll wheel 13 forward; Hirudin diluent in the liquid storing bag 16 is pushed in the venous detaining needle, carry out tube sealing.Union joint 19 front ends also can not connect syringe needle 20, but with the first sealing end cap 7 or second sealing after end cap 8 pulls out, and directly are connected with the port of the infusion connector 6 of venous detaining needle.
Because the anticoagulation tube clipper of this utility model, the distance between per two depressions can guarantee that through calculating tube-sealing solution is full of the tube chamber of remaining needle, avoids backflow of blood and the blood coagulation plugging has made things convenient for nurse and patient's use.
The relation of hirudin and thrombin is following:
The first, lepirudin 023 ludon and α-thrombin with etc. mole non-covalent combine to form stabilized complex (its dissociation constant is very little, 0.8 * 10
-10Mol or 2.0 * 10
-14Mol).The whole protease hydrolysis functions of thrombin this moment are closed; So hirudin can not only prevent fibrinogenic consolidation; And can block the hemostasis reaction of catalyzed by thrombin, such as the platelet response that the activation and the thrombin of factor V, VIII and III brings out, prevented the activatory feedback of thrombinogen and the thrombin that causes generates; Hirudin does not disturb the biosynthesis of thrombin simultaneously, and antithrombin (AT-III) is not also had influence.
The second, oxidized when hirudin, disulfide bond, or its C-end is shown that by depsipeptides (the C-end reduces by 7 or 18 aminoacid then to the inhibition loss of activity 90% or 100% of thrombin) hirudin is a reversibility to the inhibitory action of thrombin.
Hirudin has following characteristics in practical application:
The first, the agent of gene recombinaton hirudin anticoagulant does not contain heavy metal ion, does not have Sulfated pure biological preparation, and is noiseless to test item, is applicable to detections such as biochemistry, immunology, hematology.Also be applicable to unit blood specimen collections such as medical research mechanism, blood station, health and epidemic prevention.
The second, the Tyr peptide chain structure of hirudin can suppress the thrombin specificity, but this effect is reversible, and when the reaction of Tyr peptide chain warp depsipeptides, after the hirudin forfeiture suppressed activity, blood preparation also can be done hemagglutination test again.
The 3rd, haemachrome hematocrit and leukocyte etc. all there are not influence, can not only be used for the research of Physiological Experiment and clotting mechanism, and on clinical medicine, also can be used as the anticoagulant when transfusing blood.
The 4th, can reduce surface activity of blood platelet to platelet, anticoagulant reduces platelet adhesion property.Hirudin can suppress the adhesive attraction of platelet to silication glass, and this is not direct interaction to hematoblastic effect, and it does not disturb hematoblastic function.
The 5th; The blood coagulation resisting function of hirudin in different animals and blood plasma its anticoagulation that confirms different with heparin; It does not rely on anticoagulant factor, does not disturb the detection of anticoagulant factor yet, does not receive influence of platelet CA++ (PF4) and rich histidine protein or the like yet.It is the safest, the most effective natural antithrombase anticoagulant in the known anticoagulative substance in the present world.
Claims (5)
1. the anticoagulation tube clipper of a venous detaining needle is characterized in that: this tube clipper comprises the liquid storing bag (16) that is arranged in the support (18) and is arranged on the roller (13) that liquid between support (18) two side that liquid storing bag (16) is interior promotes forward.
2. the anticoagulation tube clipper of venous detaining needle according to claim 1; It is characterized in that: the compartment of terrain, left and right sides wall upper end of support (18) forms inclined-plane (12) and depression (17), the wheel shaft (14) that roller (13) central authorities are provided be connected depression (17) interior and along the inclined-plane (12) roll forward.
3. the anticoagulation tube clipper of venous detaining needle according to claim 1, it is characterized in that: the liquid storing bag of tube clipper (16) front end stretches out from the front side wall of support (18), is provided with union joint (19), the inner cavity that forms of union joint (19); Stretch out from the rear wall of support (18) rear end of liquid storing bag (16), and the rear end is sealed by the end cap with sealing function (15).
4. the anticoagulation tube clipper of venous detaining needle according to claim 3, it is characterized in that: the front end of union joint (19) is connected with syringe needle (20).
5. the anticoagulation tube clipper of venous detaining needle according to claim 3, it is characterized in that: the liquid of the interior splendid attire of liquid storing bag (16) is the hirudin diluent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011205364330U CN202376556U (en) | 2011-12-20 | 2011-12-20 | Anticoagulant tube sealer for vein remaining needle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011205364330U CN202376556U (en) | 2011-12-20 | 2011-12-20 | Anticoagulant tube sealer for vein remaining needle |
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| Publication Number | Publication Date |
|---|---|
| CN202376556U true CN202376556U (en) | 2012-08-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011205364330U Expired - Fee Related CN202376556U (en) | 2011-12-20 | 2011-12-20 | Anticoagulant tube sealer for vein remaining needle |
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| CN (1) | CN202376556U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488939A (en) * | 2011-12-20 | 2012-06-13 | 天津市百利康泰生物技术有限公司 | Anticoagulation pipe sealing device of venous indwelling needle |
| CN103861205A (en) * | 2014-03-13 | 2014-06-18 | 李林风 | Thrombus prevention device with indwelling catheter |
-
2011
- 2011-12-20 CN CN2011205364330U patent/CN202376556U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102488939A (en) * | 2011-12-20 | 2012-06-13 | 天津市百利康泰生物技术有限公司 | Anticoagulation pipe sealing device of venous indwelling needle |
| CN103861205A (en) * | 2014-03-13 | 2014-06-18 | 李林风 | Thrombus prevention device with indwelling catheter |
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Effective date of registration: 20160817 Granted publication date: 20120815 |
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| RINS | Preservation of patent right or utility model and its discharge | ||
| PD01 | Discharge of preservation of patent |
Date of cancellation: 20170607 Granted publication date: 20120815 |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120815 Termination date: 20191220 |
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| CF01 | Termination of patent right due to non-payment of annual fee |