CN201664343U - Operating microscope system with angiographic function - Google Patents
Operating microscope system with angiographic function Download PDFInfo
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- CN201664343U CN201664343U CN2008900000067U CN200890000006U CN201664343U CN 201664343 U CN201664343 U CN 201664343U CN 2008900000067 U CN2008900000067 U CN 2008900000067U CN 200890000006 U CN200890000006 U CN 200890000006U CN 201664343 U CN201664343 U CN 201664343U
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/0012—Surgical microscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/20—Surgical microscopes characterised by non-optical aspects
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
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Abstract
The utility model discloses an operating microscope system with the angiographic function, which comprises a microscope module and an angiogram module, wherein the microscope module comprises an illuminating light source and an illuminating optical microscope system, wherein the illuminating optical microscope system comprises a first spectroscope, and the angiogram module comprises an excitation light source and a fluorescence shooting unit; and a light path is formed according to the following method: at least part of illuminating light reflected by an observed object transmits the first spectroscope and then is imaged microscopically, at least part of the excitation light sent by the excitation light source is reflected by the first spectroscope and then irradiated on the observed object, and fluorescent light of the observed object excited by the excitation light is irradiated back to the angiogram module along the coming path of the excitation light and is shot by the fluorescence shooting unit. The operating microscope system can shoot angiographic vessels in operation, and lead to more objective and accurate implementation of operation.
Description
Technical field
This utility model relates to the optical microphotograph technical field of imaging, specially refers to a kind of operating microscope system with angiography function.
Background technology
Microscope applications directly is used for surgical operation then since nineteen twenty-five with microscope in the biomedical sector history of existing centuries.The generation of operating microscope makes the doctor can see the fine structure of operative site clearly, can carry out the various microsurgerys that can't finish with naked eyes, has expanded the operative treatment scope greatly, has improved operation precision and patient's healing rate.Operating microscope has become a kind of conventional armarium, mainly undergos surgery for each section office of hospital clinical and checks use.
Fig. 1 is the sketch map of traditional operation microscope 10.The light that sends from lighting source (for example xenon lamp) 11 sees through object lens 13 and converges on the sample 14 through spectroscope 12 total reflection, passes through object lens 13,16 again through the light of sample 14 backscatterings, enters observer's (operator) human eye 17 at last.
But traditional operating microscope is felt simply helpless for many difficult and complicated illness such as brain liver tumor, cardiovascular, fundus oculi diseases, and these diseases often are positioned at the intensive place of blood vessel, are difficult to distinguish the fine structure and the dynamics state of blood vessel.
In addition, known angiography technology mainly contains: fluorescein angiography (fundus fluorescein angiography is called for short FFA), the dark green angiography of indole (indocyanine green angiography is called for short ICGA).Both inspection steps are basic identical, and just the contrast agent that adopts is different with optical filter.The conventional apparatus of angiographic instrument as shown in Figure 2.The excitation light irradiation that excitation source 31 sends is to the detected person 32 who injected contrast agent, and this detected person 32 is subjected to the irradiation of exciting light and has produced fluorescence, and this fluorescence projects imaging on the camera head 34 after the mating plate 33 after filtration.Existing shadowgraph technique is used for the detected person is checked and diagnoses more.
Summary of the invention
Main purpose of the present utility model solves the problems of the prior art exactly, and a kind of operating microscope system with angiography function is provided, and it can make the enforcement of operation more objective, more accurate.
For achieving the above object, this utility model is by the following technical solutions:
A kind of operating microscope system with angiography function, comprise microscope module, described microscope module comprises lighting source and is positioned on the illumination light light path and utilizes the light optics microscopic system of illumination light to the observing object amplification imaging, the characteristics of described operating microscope system are, also comprise the blood vessel visualization module, described light optics microscopic system comprises first spectroscope, described blood vessel visualization module comprises excitation source and fluorescence image unit, described first spectroscope, described excitation source and described fluorescence image unit constitute light path in the following manner, cross micro-imaging behind described first spectroscope from illumination light to the small part transmission of observing object reflection, the exciting light that described excitation source sends to small part is penetrated on observing object after described first spectroscope reflection, observing object is penetrated along the incoming road of described exciting light by the fluorescence of described excitation and is back to described blood vessel visualization module, and by described fluorescence image unit picked-up.
Preferably:
Described blood vessel visualization module also comprises second spectroscope, described second spectroscope is provided with in the following manner, after described second spectroscope is crossed in described exciting light to small part transmission, the part that transmits is incident upon described first spectroscope again, described fluorescence to small part after the reflection of described second spectroscope, the part that reflects is again by described fluorescence image unit picked-up.
Described observing object adopts the dark green radiography of indole, described excitation source is that centre wavelength is the light source of 810nm, described first spectroscope is the spectroscope of visible light half-transmitting and half-reflecting and infrared total reflection, described second spectroscope is the spectroscope of the following transmission of wavelength 820nm above reflection 820nm, and described fluorescence image unit comprises the near-infrared image unit.
Described observing object adopts the fluorescein sodium radiography, described excitation source is that centre wavelength is the light source of 490nm, described first spectroscope is the spectroscope of visible light half-transmitting and half-reflecting, described second spectroscope reflects the narrow band pass filter of other wavelength transmissions for wavelength 515nm-525nm, and described fluorescence image unit comprises the green glow image unit.
Described observing object adopts aminoguanidine hydrochloride levulic acid radiography, described excitation source is that centre wavelength is the light source of 400nm, described first spectroscope is the dichroic mirror of visible light half-transmitting and half-reflecting and ultraviolet light total reflection, described second spectroscope reflects the narrow band pass filter of other wavelength transmissions for wavelength 640-650nm, and described fluorescence image unit comprises the HONGGUANG image unit.
Described excitation source is light emitting diode or super-radiance light emitting diode or laser diode.
Described blood vessel visualization module also comprises the 3rd spectroscope and visible image capturing unit, described first spectroscope is the visible light spectroscope of half reflection at least, described the 3rd spectroscope is described exciting light transmission and the visible light spectroscope of half reflection at least, described the 3rd spectroscope and visible image capturing unit are provided with in the following manner, through the visible light of the described first spectroscope reflected back to small part again after described the 3rd spectroscope reflection, the part that reflects is absorbed by described visible image capturing unit again.
More described the 3rd spectroscope of described second spectroscope is nearer and farther from described excitation source from described first spectroscope.
More described the 3rd spectroscope of described second spectroscope is nearer and farther from described first spectroscope from described excitation source.
Described blood vessel visualization module also comprises first collecting lens and close described first spectroscopical second collecting lens that is arranged at close described excitation source on the described exciting light light path.
This utility model beneficial technical effects is:
1, operating microscope of the present utility model system not only has conventional light optics microscopic system, also in the light optics microscopic system, be provided with first spectroscope, simultaneity factor also comprises the blood vessel visualization module that contains excitation source and fluorescence image unit, cross micro-imaging behind first spectroscope from illumination light to the small part transmission of observing object reflection, and the exciting light that excitation source sends to small part is penetrated on observing object after the reflection of first spectroscope, observing object is penetrated along the incoming road of exciting light by the fluorescence of excitation and is back to the blood vessel visualization module, and absorb by the fluorescence image unit, like this, adopt operating microscope of the present utility model system, the radiography blood vessel is taken also when the doctor observes by the operating microscope system in operation process by the operating microscope system, the doctor can be performed the operation more accurately in conjunction with the shooting information that angiography obtains, the efficient of operation can also be improved, and these dynamic operation process information of being absorbed can be kept for follow-up diagnosis and evaluation.
2, according to this utility model, can be in conjunction with the angiographic imaging device on the basis that does not change the traditional operation microscopie unit, so not only lowered production cost, and modular design, visualization module conveniently is combined on other the microscope equipment, embodied the motility of this design, convenient doctor's operation.
Description of drawings
Fig. 1 is the microscopical structural representation of traditional operation;
Fig. 2 is the conventional apparatus structural representation of angiographic instrument;
Fig. 3 is the structural representation of this utility model operating microscope a kind of embodiment of system;
Fig. 4 is the structural representation of the blood vessel visualization module among Fig. 3;
Fig. 5 is the structural representation of the another kind of embodiment of this utility model operating microscope system;
Feature of the present utility model and advantage will be elaborated in conjunction with the accompanying drawings by embodiment.
The specific embodiment
Embodiment one
Please refer to Fig. 3, the operating microscope system with radiography function comprises microscope module 10 and blood vessel visualization module 20.
Wherein, microscope module 10 comprises visible lighting source 11 and illumination light microscopic system.Lighting source 11 can select for use powerful Halogen light or xenon lamp to realize all illuminations of even sufficient intensity.The illumination light microscopic system comprises the 4th spectroscope 12, first object lens 13, first spectroscope 15 and second object lens 16.First spectroscope, the 15 preferred optical filters that adopt infrared total reflection visible light half-transmitting and half-reflecting.
The blood vessel visualization module of present embodiment is for being provided with at the ICG radiography.As shown in Figure 3 and Figure 4, the blood vessel visualization module comprises excitation source 21, excitation optical system and camera head.Excitation source 21 can adopt centre wavelength to be preferably LED (light emitting diode) or SLED (super-radiance light emitting diode) or the LD (laser diode) of 810nm.Excitation optical system comprises second spectroscope 22, the 3rd spectroscope 24, adjustable first collecting lens f1 and the second collecting lens f2 (the alleged lens of this paper are not limited to single lens, also contain the battery of lens that a plurality of lens are formed) that is arranged in the converting interface shell 2.Second spectroscope, the 22 preferred optical filters that adopt the following wavelength transmission of wavelength 820nm above reflection 820nm, the 3rd spectroscope 24 adopts the optical filter of visible light reflective infrared transmission.Camera head comprises near-infrared image unit 23 and visible image capturing unit 25.Near-infrared image unit 23 comprises coupling ring 23b, CCD (charge-coupled image sensor) 23c of camera lens and aperture 23a, camera lens and photographic head, and the unit 23d of the control element through connecting CCD23c.
Operating microscope system works principle is as follows:
The light that lighting source 11 sends is through 12 reflections of the 4th spectroscope, converge on the detected material 14 by first object lens 13, again through first object lens 13, first spectroscope 15 and second object lens 16, enter observer's human eye 17 through the light of detected material 14 backscatterings at last.
When carrying out the ICG development, the light that excitation source 21 sends through the first collecting lens f1 be converged to uniform hot spot 21 ', in succession by becoming directional light behind the 3rd spectroscope 24, second spectroscope 22 and the second collecting lens f2, this directional light shines in the detected biological tissue through first spectroscope 15 and first object lens 13 again.Because the ICG maximum absorption wavelength is 805nm, the maximum excitation wavelength is 835nm, and change has taken place the spectrum of the flashlight that then reflects back.Flashlight is again through behind first object lens 13, first spectroscope 15, part flashlight enters human eye through second object lens 16, another part flashlight is earlier through the second collecting lens f2, after second spectroscope 22 filters reflection, project on the infrared pick-up element 23, and after light the 3rd spectroscope 24 optical filtering reflections that see through, project on the visible image capturing element 25.
Contrast agent is injected detected person's vein fast, can utilize operating microscope of the present utility model system that operation is observed or taken.Because contrast agent moves with blood flow, dynamically touches off the form of blood vessel, adds fluorescent imaging, has improved the contrast and the observability of blood vessel, some trickle blood vessels are changed recognized.Utilize the shooting of fluorescence to take continuously, make surgical outcome more objective, accurate and dynamic, and the information that is obtained has valuable value to clinical diagnosis, prognostic evaluation, treatment, observation of curative effect and discussion pathogeny etc.
Embodiment two
The difference of present embodiment and embodiment is that the blood vessel visualization module is for being provided with as contrast Material Injection Protocols at employing photosensitizer 5-ALA (aminoguanidine hydrochloride levulic acid).5-ALA aminoguanidine hydrochloride levulic acid maximum absorption wavelength is 400nm, excitation wavelength is the HONGGUANG of 645nm, correspondingly, excitation source 21 preferred center wavelength are the ultraviolet light source of 400nm, first spectroscope, 15 preferential dichroic mirror and the 3rd spectroscope 24 preferred short wavelength of the employing transmission filters that adopt visible light half-transmitting and half-reflecting and ultraviolet light total reflection, as ultraviolet light transmission and visible light reflection, second spectroscope, the 22 preferred narrow band pass filters that adopt centre wavelength 645nm, reflect as wavelength 640nm-650nm, its all band transmission, near-infrared image unit 23 replaces with the HONGGUANG image unit, simultaneously, and first, two collecting lens f1, the focal length of f2 has respective change.Because the light source that adopts is a ultraviolet light, so in order to prevent the injury of ultraviolet light to human eye, should set up optical filter 18 to filter ultraviolet light before human eye receives light.The operation principle of present embodiment and embodiment one are similar, do not repeat them here.
Embodiment three
The difference of present embodiment and embodiment is that the blood vessel visualization module is for being provided with as contrast Material Injection Protocols at the employing fluorescein sodium.Fluorescein absorbing wavelength 490nm blue light, the green glow of excitation wavelength 520nm, correspondingly, excitation source 21 preferred center wavelength are the light source of 490nm, first spectroscope 15 and the 3rd spectroscope 24 preferred semi-transparent semi-reflecting optical filters of visible light that adopt, second spectroscope, 22 preferred employing centre wavelengths are 520nm, for example 515nm-525nm reflection, the narrow band pass filter of other wavelength transmissions, near-infrared image unit 23 replaces with the green glow image unit, simultaneously, the focal length of first and second collecting lens f1, f2 has respective change.The operation principle of present embodiment and embodiment one are similar, do not repeat them here.
In various embodiments, the position of the position of second spectroscope 22, imaging apparatus 23 and the 3rd spectroscope 24, visible image capturing element 25 can correspondingly be changed.Because it is aforesaid embodiment is paid the utmost attention in be easy to do height reflection of spectroscope generally speaking, promptly nearer and be provided with than the 3rd spectroscope 24 from excitation source 21 farther modes from first spectroscope 15 according to second spectroscope 22.
In addition, as shown in Figure 5, in the embodiment of accommodation, can also save the 3rd spectroscope 24 and visible image capturing unit 2 in the blood vessel visualization module.Should be appreciated that though as preferred examples, set up the 3rd spectroscope 24 and visible image capturing unit 2 and can make the shooting capacity of native system increase for visible light, these improve features is not necessary for this utility model.
Above content be in conjunction with concrete preferred implementation to further describing that this utility model is done, can not assert that concrete enforcement of the present utility model is confined to these explanations.For this utility model person of an ordinary skill in the technical field, under the prerequisite that does not break away from this utility model design, can also make some simple deduction or replace, all should be considered as belonging to protection domain of the present utility model.
Claims (10)
1. operating microscope system with angiography function, comprise microscope module, described microscope module comprises lighting source and is positioned on the illumination light light path and utilizes the light optics microscopic system of illumination light to the observing object amplification imaging, it is characterized in that, also comprise the blood vessel visualization module, described light optics microscopic system comprises first spectroscope, described blood vessel visualization module comprises excitation source and fluorescence image unit, described first spectroscope, described excitation source and described fluorescence image unit constitute light path in the following manner, cross micro-imaging behind described first spectroscope from illumination light to the small part transmission of observing object reflection, the exciting light that described excitation source sends to small part is penetrated on observing object after described first spectroscope reflection, observing object is penetrated along the incoming road of described exciting light by the fluorescence of described excitation and is back to described blood vessel visualization module, and by described fluorescence image unit picked-up.
2. operating microscope as claimed in claim 1 system, it is characterized in that, described blood vessel visualization module also comprises second spectroscope, described second spectroscope is provided with in the following manner, after described second spectroscope is crossed in described exciting light to small part transmission, the part that transmits is incident upon described first spectroscope again, described fluorescence to small part after the reflection of described second spectroscope, the part that reflects is again by described fluorescence image unit picked-up.
3. operating microscope as claimed in claim 2 system, it is characterized in that, described observing object adopts the dark green radiography of indole, described excitation source is that centre wavelength is the light source of 810nm, described first spectroscope is the spectroscope of visible light half-transmitting and half-reflecting and infrared total reflection, described second spectroscope is the spectroscope of the following transmission of wavelength 820nm above reflection 820nm, and described fluorescence image unit comprises the near-infrared image unit.
4. operating microscope as claimed in claim 2 system, it is characterized in that, described observing object adopts the fluorescein sodium radiography, described first spectroscope is the spectroscope of visible light half-transmitting and half-reflecting, described excitation source is that centre wavelength is the light source of 490nm, described second spectroscope reflects the narrow band pass filter of other wavelength transmissions for wavelength 515nm-525nm, and described fluorescence image unit comprises the green glow image unit.
5. operating microscope as claimed in claim 2 system, it is characterized in that, described observing object adopts aminoguanidine hydrochloride levulic acid photosensitizer radiography, described excitation source is that centre wavelength is the light source of 400nm, described first spectroscope is the dichroic mirror of visible light half-transmitting and half-reflecting and ultraviolet light total reflection, described second spectroscope reflects the narrow band pass filter of other wavelength transmissions for wavelength 640-650nm, and described fluorescence image unit comprises the HONGGUANG image unit.
6. as any described operating microscope system of claim 1 to 5, it is characterized in that described excitation source is light emitting diode or super-radiance light emitting diode or laser diode.
7. operating microscope as claimed in claim 2 system, it is characterized in that, described blood vessel visualization module also comprises the 3rd spectroscope and visible image capturing unit, described first spectroscope is the visible light spectroscope of half reflection at least, described the 3rd spectroscope is described exciting light transmission and the visible light spectroscope of half reflection at least, described the 3rd spectroscope and visible image capturing unit are provided with in the following manner, through the visible light of the described first spectroscope reflected back to small part again after described the 3rd spectroscope reflection, the part that reflects is absorbed by described visible image capturing unit again.
8. operating microscope as claimed in claim 7 system is characterized in that more described the 3rd spectroscope of described second spectroscope is nearer and farther from described excitation source from described first spectroscope.
9. operating microscope as claimed in claim 7 system is characterized in that more described the 3rd spectroscope of described second spectroscope is nearer and farther from described first spectroscope from described excitation source.
10. operating microscope as claimed in claim 7 system is characterized in that, described blood vessel visualization module also comprises and being arranged on the described exciting light light path near first collecting lens of described excitation source with near described first spectroscopical second collecting lens.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2008/073017 WO2010054510A1 (en) | 2008-11-11 | 2008-11-11 | Surgical microscope system having angiography function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201664343U true CN201664343U (en) | 2010-12-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008900000067U Expired - Fee Related CN201664343U (en) | 2008-11-11 | 2008-11-11 | Operating microscope system with angiographic function |
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| Country | Link |
|---|---|
| CN (1) | CN201664343U (en) |
| WO (1) | WO2010054510A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319059A (en) * | 2011-10-28 | 2012-01-18 | 北京天助基业科技发展有限公司 | Near-infrared fluorescence imaging surgery guide device and application thereof |
| CN108061963A (en) * | 2018-01-17 | 2018-05-22 | 北京燕阳高科医疗技术有限公司 | Ultraluminescence and the optical system of the more performance high-resolution dermoscopies of polarised light |
| CN108175463A (en) * | 2018-01-23 | 2018-06-19 | 中南大学湘雅医院 | Microsurgery sewing system |
| CN113057743A (en) * | 2017-03-16 | 2021-07-02 | 卡尔蔡司医疗技术股份公司 | Operating microscope |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5532873A (en) * | 1993-09-08 | 1996-07-02 | Dixon; Arthur E. | Scanning beam laser microscope with wide range of magnification |
| MXPA02003064A (en) * | 1999-09-24 | 2003-08-20 | Ca Nat Research Council | Method and apparatus for performing intra operative angiography. |
| WO2004081549A1 (en) * | 2003-03-11 | 2004-09-23 | Koninklijke Philips Electronics N.V. | Spectroscopic analysis apparatus and method with excitation system and focus monitoring system |
| US7801589B2 (en) * | 2005-12-22 | 2010-09-21 | Olympus Corporation | In-vivo examination method and in-vivo examination apparatus |
| JP2007225874A (en) * | 2006-02-23 | 2007-09-06 | Olympus Corp | In-vivo examination method and apparatus |
-
2008
- 2008-11-11 WO PCT/CN2008/073017 patent/WO2010054510A1/en active Application Filing
- 2008-11-11 CN CN2008900000067U patent/CN201664343U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319059A (en) * | 2011-10-28 | 2012-01-18 | 北京天助基业科技发展有限公司 | Near-infrared fluorescence imaging surgery guide device and application thereof |
| CN102319059B (en) * | 2011-10-28 | 2013-03-27 | 北京天助基业科技发展有限公司 | Near-infrared fluorescence imaging surgery guide device and application thereof |
| CN113057743A (en) * | 2017-03-16 | 2021-07-02 | 卡尔蔡司医疗技术股份公司 | Operating microscope |
| CN108061963A (en) * | 2018-01-17 | 2018-05-22 | 北京燕阳高科医疗技术有限公司 | Ultraluminescence and the optical system of the more performance high-resolution dermoscopies of polarised light |
| CN108061963B (en) * | 2018-01-17 | 2024-03-01 | 北京燕阳高科医疗技术有限公司 | Optical system of ultraviolet fluorescence and polarized light multi-performance high-resolution dermatoscope |
| CN108175463A (en) * | 2018-01-23 | 2018-06-19 | 中南大学湘雅医院 | Microsurgery sewing system |
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| Publication number | Publication date |
|---|---|
| WO2010054510A1 (en) | 2010-05-20 |
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101208 Termination date: 20171111 |