CN201527365U

CN201527365U - Multilayer synchronous fast sampler for drug dissolution

Info

Publication number: CN201527365U
Application number: CN2009202268777U
Authority: CN
Inventors: 牛其云
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-09-29
Filing date: 2009-09-29
Publication date: 2010-07-14
Anticipated expiration: 2019-09-29

Abstract

The utility model discloses a multilayer synchronous fast sampler for drug dissolution. The sampler comprises six dissolution cups (1), a filter membrane (2), test tubes (3), and a machine frame (4), and is characterized in that the dissolution cups (1) are mounted on one side of the machine frame (4) in rows; the test tubes (3), which are arranged in three rows and six lines, are mounted on the other side of the machine frame (4); a synchronous stratified suction unit (5) is arranged on the upper side of each dissolution cup (1); the heads of the suction needles (6) of each synchronous stratified suction unit (5) are extended into the lower part, the middle part and the bottom part of the liquid level in the dissolution cup (1); and three test tubes (3) in each line correspond to three sampling layers in a dissolution cup (1) respectively, and are respectively communicated with the side walls at the bottoms of three cavities of the synchronous stratified suction unit (5) through corresponding communicating pipes (7). The fast sampler has the advantages of simple structure, convenient operation as well as fast sampling, and can sample from three layers with the same quantity in one step, thereby ensuring that the sampling can further meet the requirements and the sampler can be widely used for drug dissolution test.

Description

Medicine stripping multilayer is sampler simultaneously and rapidly

Technical field

The utility model relates to a kind of sampler that drug dissolution detects that is used for, and particularly a kind of medicine stripping multilayer is sampler simultaneously and rapidly.

Background technology

Drug dissolution is meant that medicine is in the regulation medium, dissolution rate from solid pharmaceutical preparations such as tablet or capsule and stripping degree under certain condition, it is a kind of effective means of checking preparation quality and production technology level, also being the standard of estimating preparation active component bioavilability and preparation uniformity coefficient, is the experiment of simulation oral solid formulation process in leaching in stomach.In the testing process of drug dissolution, sampling is an important step fast.Present sampling method mainly contains two kinds: a kind of is to use the transfer pipet manually-operated, requirement will have 6 personnel that are skilled in technique to take out the soup of equivalent in the same position in 6 stripping rotors in the identical time simultaneously, obviously, manually-operated is not only wasted time and energy, and being difficult to reach unified, accurate and consistent, this must influence the reappearance of dissolution determination; Another kind of fast sampler, comprise that stripping rotor, mechanical arm, peristaltic pump, quantity tube, filtering membrane, test tube constitute, stripping rotor and test tube are established 6 respectively, each corresponding one group of sampling head, mechanical arm, peristaltic pump, quantity tube, filtering membrane and corresponding switch thereof are in sampling of the medicine dissolution fluid in the stripping rotor and injecting tube.This fast sampler with the purpose that has so reached quick sampling, promptly reached " be sampled to certainly filtration cycle finished in 30 seconds regulation ", but complex structure aspect switching manipulation, still is artificial twice operation; In addition, because the liquor strength in the stripping rotor is different along with the difference of the degree of depth, heavy particulate is in the bottom easily, although passed through stirring and evenly mixing, this phenomenon still exists on microcosmic, present solution is, the regulation sampling spot liquid level middle from wall of cup greater than the 10mm place, represent mean value, but still have certain personal error, for the medicine of having relatively high expectations, do not reach accuracy of detection.

Summary of the invention

The purpose of this utility model be to provide a kind of not only take a sample quick, time saving and energy saving, and medicine stripping multilayer simple in structure, easy to operate, as can be simultaneously from different levels, different stripping rotor, once to finish whole sampling process sampler simultaneously and rapidly.

For reaching above purpose, the technical scheme that the utility model adopted is: this medicine stripping multilayer is sampler simultaneously and rapidly, comprise stripping rotor, filtering membrane, test tube and frame constitute, frame is "T"-shaped, on the worktable of frame one side, install 6 stripping rotors side by side, it is characterized in that establishing the aspirator of layering simultaneously at the upside of stripping rotor, the head of the aspiration needle of the aspirator of layering simultaneously extends the liquid level bottom in the stripping rotor respectively, middle part and bottom in the stripping rotor, the wall of layering aspirator is provided with scale at the same time, insert frame at the opposite side of frame by test tube and install three rows, six row test tubes side by side, three sampling layers in the corresponding respectively stripping rotor of three test tubes in each row test tube, be connected with bottom, three chambeies sidewall of the aspirator of layering simultaneously by corresponding communicating pipe respectively, on the mouth of test tube, be provided with filtering membrane.

The utility model is also implemented by following measure: described while layering aspirator, constitute by three lumens, in each chamber, be equipped with piston, its piston rod is connected on the same push-pull handle, on push-pull handle, be provided with and hold handle, on the suction side of suction needle stand portion, establish membrane valve, on the sidewall bottom each chamber of three lumens, be provided with the discharge retaining valve, in the outlet of discharging retaining valve, connect corresponding communicating pipe; The through hole that described communicating pipe all passes on the frame vertical panel is fixed; Described while layering aspirator is fixed on the frame by support; Described test tube inserts frame by test tube and is fixed on the frame; Described discharge retaining valve is a micro ball valve, is prior art; Described while layering aspirator is established 6, and its piston rod all is connected on the same push-pull handle.

The beneficial effects of the utility model are: compare with the fast sampler of present use, not only sample rate is fast, and simple in structure, and is easy to operate, can be disposable from the equivalent sampling simultaneously of three levels, and sampling is met the requirements more.

Description of drawings

Fig. 1, look synoptic diagram for structure master of the present utility model.

Fig. 2, look synoptic diagram for the left side of the utility model Fig. 1.

Fig. 3, look synoptic diagram for the right side of the utility model Fig. 1.

Fig. 4, for the utility model simultaneously the layering aspirator axially analyse and observe enlarged diagram.

Embodiment

Make the utility model with reference to Fig. 1,2,3,4.This medicine stripping multilayer is sampler simultaneously and rapidly, comprise stripping rotor 1, filtering membrane 2, test tube 3, frame 4 constitutes, frame 4 is "T"-shaped, on the worktable 8 of frame 4 one sides, install 6 stripping rotors 1 side by side, it is characterized in that establishing the aspirator of layering simultaneously 5 at the upside of stripping rotor 1, the head of the aspiration needle 6 of the aspirator of layering simultaneously 5 extends the liquid level bottom in the stripping rotor 1 respectively, middle part and bottom in the stripping rotor 1, the wall of layering aspirator 5 is provided with scale at the same time, can be from equivalent sampling simultaneously on three aspects, insert frame 9 at the opposite side of frame 4 by test tube and install three rows, six row test tubes 3 side by side, three sampling layers in the corresponding respectively stripping rotor 1 of three test tubes in each row test tube 3, be connected with bottom, three chambeies sidewall of the aspirator of layering simultaneously 5 by corresponding communicating pipe 7 respectively, on the mouth of test tube 3, be provided with filtering membrane 2.

Described while layering aspirator 5, constitute by three lumens 51, in each chamber, be equipped with piston 52, its piston rod 53 is connected on the same push-pull handle 54, on push-pull handle 54, be provided with and hold handle 55, on the suction side of 6 portions of aspiration needle, establish membrane valve 56, on the sidewall bottom each chamber of three lumens 51, be provided with and discharge retaining valve 57, in the outlet of discharging retaining valve 57, connect corresponding communicating pipe 7, when upwards handle 55 was held in pulling, membrane valve 56 was opened, and got rid of retaining valve 57 and was closed, three layers of soup in the stripping rotor 1 are drawn in the corresponding cavity of three lumens 51 simultaneously, after taking out enough amounts from scale observation, handle 55 is held in recompression, and membrane valve 56 is closed, discharge retaining valve 57 and be opened, three intraluminal soups are pressed in the corresponding test tube 3 simultaneously; The through hole 10 that all passes described communicating pipe 7 on frame 4 vertical panels is fixing; Described while layering aspirator 5 is fixed on the frame 4 by support 11; Described test tube 3 inserts frame 9 by test tube and is fixed on the frame 4; Described discharge retaining valve 57 is a micro ball valve, is prior art; Described while layering aspirator 5 is established 6, and its piston rod 53 all is connected on the same push-pull handle 54, like this, can control 18 pistons simultaneously by push-pull handle 54 and move simultaneously.

Claims

1. medicine stripping multilayer sampler simultaneously and rapidly, comprise stripping rotor (1), filtering membrane (2), test tube (3) and frame (4) constitute, frame (4) is "T"-shaped, on the worktable (8) of frame (4) one sides, install 6 stripping rotors (1) side by side, it is characterized in that establishing layering aspirator (5) simultaneously at the upside of stripping rotor (1), the head of the aspiration needle (6) of layering aspirator (5) extends the liquid level bottom in the stripping rotor (1) respectively simultaneously, middle part and bottom in the stripping rotor (1), the wall of layering aspirator (5) is provided with scale at the same time, insert frame (9) at the opposite side of frame (4) by test tube and install three rows, six row test tubes (3) side by side, three sampling layers in the respectively corresponding stripping rotors of three test tubes (1) in each row test tube (3), be connected with bottom, three chambeies sidewall of while layering aspirator (5) by corresponding communicating pipe (7) respectively, on the mouth of test tube (3), be provided with filtering membrane (2).

2. medicine stripping multilayer according to claim 1 is sampler simultaneously and rapidly, it is characterized in that described while layering aspirator (5), constitute by three lumens (51), in each chamber, be equipped with piston (52), its piston rod (53) is connected on the same push-pull handle (54), on push-pull handle (54), be provided with and hold handle (55), on the suction side of aspiration needle (6) seat portion, establish membrane valve (56), on the sidewall bottom each chamber of three lumens (51), be provided with and discharge retaining valve (57), in the outlet of discharging retaining valve (57), connect corresponding communicating pipe (7).

3. medicine stripping multilayer according to claim 1 and 2 is sampler simultaneously and rapidly, and the through hole (10) that it is characterized in that all passing described communicating pipe (7) on frame (4) vertical panel is fixing; Described while layering aspirator (5) is fixed on the frame (4) by support (11); Described while layering aspirator (5) is established 6, and its piston rod (53) all is connected on the same push-pull handle (54).