CN114397412A - Medicine intermediate each hierarchy detecting system - Google Patents
Medicine intermediate each hierarchy detecting system Download PDFInfo
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- CN114397412A CN114397412A CN202111655550.3A CN202111655550A CN114397412A CN 114397412 A CN114397412 A CN 114397412A CN 202111655550 A CN202111655550 A CN 202111655550A CN 114397412 A CN114397412 A CN 114397412A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/16—Devices for withdrawing samples in the liquid or fluent state with provision for intake at several levels
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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Abstract
The invention relates to the field of sampling detection in drug production, in particular to a drug intermediate detection system in each level. A detection system for detecting each layer of a drug intermediate through a fixed distance and sampling in batches at one time. A medicine intermediate detection system of each level comprises a storage tank, a sampling driving mechanism, a communicating sampling mechanism, a sampler, a sampling storage mechanism and the like; the sampling driving mechanism, the communicating sampling mechanism and the sampling storage mechanism are arranged in the storage tank, and the sampler is connected with the communicating sampling mechanism and the sampling storage mechanism in a sliding manner. The sampler is conveyed to different heights by matching the sampling driving mechanism with the sampling storage mechanism, the sampler is moved to a sampling position by matching the sampling driving mechanism with the communicating sampling mechanism, the medicine intermediates in the storage tank at the same distance from the center are sampled by matching the communicating sampling mechanism with the sampler, and the influence of external impurities during mixing and sampling is reduced among the medicine intermediates by replacing the used sampler.
Description
Technical Field
The invention relates to the field of sampling detection in drug production, in particular to a drug intermediate detection system in each level.
Background
The drug intermediate is used as a chemical raw material or a chemical product in the drug synthesis process as the name implies, and the chemical product is required to reach the drug synthesis level. The drug intermediate can be produced in a common chemical plant without the production license of the drug, the pharmaceutical plant can set up corresponding intermediate production and storage processes and methods according to the requirements, and then the finished drug intermediate is directly applied to the pharmaceutical process of the finished drug.
In the process of producing the pharmaceutical intermediates in the existing chemical plant and large-scale pharmaceutical enterprise, firstly, the quantity of preparing the pharmaceutical intermediates is large, secondly, the pharmaceutical intermediates in various states can exist, the detection of the pharmaceutical intermediates for the solid is convenient, the detection of the pharmaceutical intermediates for the liquid is very inconvenient and easily causes the mixing or pollution of the pharmaceutical intermediates, the data which causes the final sample detection is inaccurate, a large amount of liquid pharmaceutical intermediates are generally stored in a storage tower or a storage tank, the sampling and positioning of the pharmaceutical intermediates for the lower layer are difficult in the sampling process, and the position environment of the uncertain sampling during the sample comparison and detection is the same, the manual operation is that the pharmaceutical intermediates at different height sampling positions are not mixed and the sampling difficulty is high.
In order to solve the technical problem, a detection system for detecting the levels of the drug intermediates in batches at one time through fixed distance is developed.
Disclosure of Invention
In order to overcome the defects of easy mixing of drug intermediate samples and inaccurate positioning of sampling height, the invention has the technical problems that: provides a detection system for each level of a drug intermediate through a fixed distance and sampling in batches at one time.
The technical scheme is as follows: a medicine intermediate level detection system comprises a storage tank, a liquid through pipe, a sensing control module, a first separation pipe, a second separation pipe, a sampling driving mechanism, a communicating sampling mechanism, a sampler and a sampling storage mechanism, wherein the storage tank is internally filled with a liquid medicine intermediate, the upper surface of the storage tank is provided with a through hole, the upper end and the lower end of the storage tank are respectively provided with the liquid through pipe, the sensing control module is arranged on the upper surface of the storage tank, the upper end of the first separation pipe is fixedly connected in the through hole of the storage tank, the second separation pipe is arranged in the first separation pipe, the front and the back of the second separation pipe are symmetrically provided with sliding grooves, the sampling driving mechanism is arranged in the storage tank, the sampling driving mechanism is electrically connected with the sensing control module, the communicating sampling mechanism is arranged on the first separation pipe and the second separation pipe in a penetrating manner, the sampler is provided with a plurality of sampling mechanisms, and the sampler is connected with the communicating sampling mechanism in a sliding manner, the sampling and storing mechanism is arranged in the second partition pipe in a vertically sliding mode, the sampler is connected with the sampling and storing mechanism in a sliding mode, and the sampling and storing mechanism is electrically connected with the induction control module.
The preferable technical scheme is that the sampling driving mechanism comprises a bidirectional air pump, a gas storage shell, a vent pipe, an electromagnetic valve, a first motor and a lead screw, the bidirectional air pump is arranged on the upper surface of the storage tank and electrically connected with the induction control module, the gas storage shell is arranged between the upper ends of the first partition pipe and the second partition pipe and communicated with the gas storage shell, the lower surface of the gas storage shell is fixedly connected with the vent pipe, the vent pipe is located between the first partition pipe and the second partition pipe, the electromagnetic valve is arranged on the vent pipe and electrically connected with the induction control module, the first motor is arranged on the upper surface of the storage tank and electrically connected with the induction control module, the two lead screws are symmetrically arranged in the front and back direction, the two lead screws are respectively rotatably connected into sliding grooves of the second partition pipe from top to bottom, and the first motor and the lead screws are used for up-and-down sliding of the sampling storage mechanism.
The preferable technical scheme is that the communicating and sampling mechanism comprises a sampling through pipe, a plurality of air inlets, a ventilation cavity, a first sliding cavity, a supporting block, a first communicating hole, a second sliding cavity, a stop block and a sealing cover component, wherein the sampling through pipe is respectively fixedly connected to a first separating pipe and a second separating pipe in a penetrating way, the wall thickness of the outer side end of the sampling through pipe is larger than that of the rest parts of pipes, four mounting grooves are formed in the inner surface of the wall of the outer side end of the sampling through pipe, the air inlets are formed in the inner side end of the sampling through pipe and are positioned between the first separating pipe and the second separating pipe and communicated with the ventilation pipe, the ventilation cavity is formed in the pipe wall of the sampling through pipe, the first sliding cavity is formed in the middle of the sampling through pipe, the supporting block is arranged at the outer side end of the ventilation cavity, the ventilation cavity is communicated with the first sliding cavity through the first communicating hole positioned at the outer side part of the sampling through pipe, four second sliding cavities are formed in the wall of the outer side end of the sampling through pipe, the four second sliding cavities are communicated with the first communication port through the first through hole and the second through hole respectively, the four check blocks are arranged, the check blocks are fixedly connected to the outer side ends of the second sliding cavities respectively, and the outer side end of the sampling through pipe is provided with a sealing cover assembly.
According to the preferable technical scheme, the sampling through pipes are uniformly arranged on the first separating pipe and the second separating pipe from top to bottom, and the included angle between two vertically adjacent sampling through pipes is 45 degrees or 90 degrees.
According to the preferable technical scheme, the diameter of the through hole of the first through hole is far larger than that of the through hole of the second through hole, the first through hole is communicated with the outer side end of the second sliding cavity, and the second through hole is communicated with the inner side end of the second sliding cavity.
The technical scheme who prefers, sealed lid subassembly is including the apron, the ejector pad, U-shaped rubber seal ring, the piston ring, the connecting rod, sealing slide, Z-shaped fixture block and torsional spring, the apron sets up the outside end at the sample siphunculus, ejector pad fixed connection is on the medial surface of apron, the outside of ejector pad is served and is provided with U-shaped rubber seal ring and piston ring, U-shaped rubber seal ring is located the outside of piston ring, four connecting rods of medial surface fixedly connected with of apron, the medial surface rigid coupling respectively of four connecting rods has sealing slide, Z-shaped fixture block rotates the mounting groove of connecting at the sample siphunculus, the medial surface of Z-shaped fixture block is close to the ejector pad and is provided with trapezoidal arch, be provided with two torsional springs between the mounting groove of every Z-shaped fixture block and sample siphunculus respectively.
Preferred technical scheme, the sampler is including the sample shell, the second intercommunication mouth, sample inner shell and first spring, the sample shell slides and sets up in the sample logical pipe, rear portion sets up for the echelonment between the front portion in the sample shell, four second intercommunication mouths have been seted up to sample shell outside end circumference, the side is opened before the sample shell has the through-hole, the inside slip of sample shell is provided with the sample inner shell, sample inner shell outside end circumference is opened has a plurality of feed liquor hole, be provided with first spring in the cavity that leaves between sample shell and the sample inner shell, first spring be in the compression attitude and with sample shell and sample inner shell in close contact with.
The preferred technical scheme is that the sampling and storing mechanism comprises fixed sliding blocks, a platform base, a circular baffle, a fixed frame, a second motor, a gear set, a limiting ring, a rotating platform, a supporting frame, an electric push rod, a first fixed block and a sampler fixing component, wherein two fixed sliding blocks are arranged, the two fixed sliding blocks are respectively arranged on a lead screw in a sliding manner, the platform base is fixedly connected between the two fixed sliding blocks, the circular baffle is fixedly connected to the periphery of the platform base, the fixed frame is fixedly connected to the upper surface of the front part of the platform base, the second motor is fixedly connected to the fixed frame, the gear set is arranged at the front part of the platform base, the output shaft of the second motor is connected with the gear set, the limiting ring and the rotating platform are rotatably arranged on the platform base, the limiting ring is provided with a limiting block, the inner side surface of the limiting ring is provided with a toothed ring, the outer side surface of the rotating platform is provided with a toothed ring, the limiting ring and the toothed ring of the rotating platform are respectively meshed with the gear set, the upper rigid coupling of rotating platform has the support frame, and the rigid coupling has electric putter on the support frame, and the inboard circumference rigid coupling in circular baffle upper end has the first fixed block of a plurality of, and it has a sampler fixed subassembly to articulate on every first fixed block.
According to the preferred technical scheme, the transmission ratio of the gear set is set, the rotating angular speeds of the limiting ring and the rotating platform are the same, and the limiting block of the limiting ring and the electric push rod are located in the same direction.
The preferred technical scheme, sampler fixed subassembly is including fixed stop, electromagnetism fixing base, support the slip table, the second fixed block, the second spring, third fixed block and slide bar, fixed stop is provided with two, two fixed stop lower extreme rigid couplings have the electromagnetism fixing base, be the through-hole setting in the middle of the electromagnetism fixing base, the electromagnetism fixing base is connected with the induction control module electricity, it slides and sets up between two fixed stop to support the slip table, the symmetry rigid coupling has two second fixed blocks around between two fixed stop, be provided with the second spring between two second fixed blocks and the support slip table respectively, when supporting the slip table and electromagnetism fixing base locking, the second spring is in tensile state, the rigid coupling has the third fixed block on the fixed stop adjacent with circular baffle, the third fixed block articulates there is the slide bar, the slide bar lower extreme is located the spacing ring upper surface.
The invention has the beneficial effects that: the invention separates the center of the storage tank by the first separation pipe and the second separation pipe, the sampling drive mechanism is matched with the sampling storage mechanism to send the sampling device to different heights, the sampling device is moved to a sampling position under the matching of the sampling drive mechanism and the communicating sampling mechanism, the medicine intermediates which are at the same distance from the center in the storage tank are sampled under the matching of the communicating sampling mechanism and the sampling device, the position of the communicating sampling mechanism is set to ensure that the samples are not mixed, the used sampling device is replaced to reduce the influence of external impurities during mixing and sampling among the medicine intermediates, and the sampling drive mechanism, the communicating sampling mechanism, the sampling device and the sampling storage mechanism are connected in series through the induction control module to realize the automatic sampling process.
Drawings
Fig. 1 is a schematic perspective view of the present invention.
Fig. 2 is a schematic cross-sectional view of the three-dimensional structure of the present invention.
Fig. 3 is a sectional view of a part of the three-dimensional structure of the present invention.
FIG. 4 is a sectional view of the connection sampling mechanism of the present invention.
Fig. 5 is an enlarged schematic view of the three-dimensional structure at the position A of the present invention.
Fig. 6 is a schematic perspective view of the sealing cap assembly of the present invention.
Fig. 7 is a schematic perspective view of the sampler of the present invention.
FIG. 8 is a cross-sectional view of a portion of the three-dimensional construction of the sample retention mechanism of the present invention.
Fig. 9 is a sectional view showing the three-dimensional structure of the sampler fixing member of the present invention.
Labeled as: 1-a storage tank, 2-a liquid through pipe, 3-a sensing control module, 4-a first partition pipe, 5-a second partition pipe, 6-a bidirectional air pump, 7-an air storage shell, 8-an air through pipe, 9-an electromagnetic valve, 10-a first motor, 11-a lead screw, 12-a sampling through pipe, 13-an air inlet, 14-an air vent cavity, 15-a first sliding cavity, 16-a supporting block, 17-a first communication port, 18-a second sliding cavity, 19-a first through hole, 20-a second through hole, 21-a stop block, 22-a cover plate, 23-a push block, 24-a U-shaped rubber sealing ring, 25-a piston ring, 26-a connecting rod, 27-a sealing slide block, 28-a Z-shaped clamping block, 29-a torsion spring and 30-a sampling shell, 31-a second communication port, 32-a sampling inner shell, 33-a first spring, 34-a fixed sliding block, 35-a platform base, 36-a circular baffle, 37-a fixed frame, 38-a second motor, 39-a gear set, 40-a limiting ring, 41-a rotating platform, 42-a supporting frame, 43-an electric push rod, 44-a first fixed block, 45-a fixed baffle, 46-an electromagnetic fixed seat, 47-a supporting sliding table, 48-a second fixed block, 49-a second spring, 50-a third fixed block and 51-a sliding rod.
Detailed Description
The technical scheme of the invention is further explained by combining the attached drawings.
Example 1
A medicine intermediate level detection system comprises a storage tank 1, a liquid through pipe 2, a sensing control module 3, a first separation pipe 4, a second separation pipe 5, a sampling driving mechanism, a communicated sampling mechanism, a sampler and a sampling storage mechanism, wherein the storage tank 1 is internally filled with a liquid medicine intermediate, the upper surface of the storage tank 1 is provided with a through hole, the upper end and the lower end of the storage tank 1 are respectively provided with the liquid through pipe 2, the sensing control module 3 is fixedly arranged on the upper surface of the storage tank 1, the upper end of the first separation pipe 4 is fixedly connected in the through hole of the storage tank 1, the second separation pipe 5 is arranged inside the first separation pipe 4, the front part and the rear part of the second separation pipe 5 are symmetrically provided with sliding grooves, the sampling driving mechanism is arranged in the storage tank 1, the sampling driving mechanism is electrically connected with the sensing control module 3, the communicated sampling mechanism is arranged on the first separation pipe 4 and the second separation pipe 5, the sampler is provided with a plurality of, sampler and intercommunication sampling mechanism sliding connection, and the sample is preserved the mechanism and is slided from top to bottom and set up in second separator tube 5, and the sampler is preserved mechanism sliding connection with the sample, and the sample is preserved the mechanism and is connected with the 3 electricity of response control module.
Because the intermediates stored in the storage tank 1 can be layered, the detection is carried out after the sampling of the drug intermediates of different levels is needed, when the device is used for carrying out the sampling detection on the drug intermediates of different heights in the storage tank 1, firstly, an operator starts the sampling driving mechanism by controlling the induction control module 3, so that the sampling storage mechanism storing an empty sampler moves to a specified height, the induction control module 3 stops the height adjustment of the sampling driving mechanism, controls the sampler to enter the communicating sampling mechanism by the sampling storage mechanism, the sampler samples the drug intermediates in the storage tank 1 by the communicating sampling mechanism under the driving of the sampling driving mechanism, the induction control module 3 controls the sampling driving mechanism to reversely rotate after the sampling is finished, so that the sampler returns to the sampling storage mechanism from the communicating sampling mechanism, and the sampling of the drug intermediates of one height is finished by the processes, then induction control module 3 starts the next high removal of sample actuating mechanism and carries out the sample operation, and all samplers need to return to storage tank 1 upper portion manual work and change the sampler after all taking a sample in the mechanism is preserved in the sample, realize through this device to a certain height or all high samplings in storage tank 1 to the sample of taking is the medicine midbody sample of mid portion in storage tank 1.
Example 2
On the basis of embodiment 1, as shown in fig. 3, the sampling driving mechanism includes a bidirectional air pump 6, a gas storage housing 7, a vent pipe 8, an electromagnetic valve 9, a first motor 10 and a lead screw 11, the bidirectional air pump 6 is disposed on the upper surface of the storage tank 1, the bidirectional air pump 6 is electrically connected to the sensing control module 3, the gas storage housing 7 is disposed between the upper ends of the first separation pipe 4 and the second separation pipe 5, the bidirectional air pump 6 is communicated with the gas storage housing 7, the lower surface of the gas storage housing 7 is fixedly connected to the vent pipe 8, the vent pipe 8 is disposed between the first separation pipe 4 and the second separation pipe 5, the vent pipe 8 is provided with the electromagnetic valve 9, the electromagnetic valve 9 is electrically connected to the sensing control module 3, the first motor 10 is disposed on the upper surface of the storage tank 1, the first motor 10 is electrically connected to the sensing control module 3, the lead screws 11 are symmetrically disposed in front and back, the two lead screws 11 are respectively rotatably connected to the chutes of the second separation pipe 5 up and down, the first motor 10 and the lead screw 11 are used for sliding the sampling and holding mechanism up and down.
In the sampling driving mechanism of the device, a bidirectional air pump 6 is used for inflating and pressurizing or exhausting and depressurizing a gas storage shell 7, a vent pipe 8 is used for enabling the gas environment communicated with the sampling mechanism to be high pressure or negative pressure, so that the power source of a sampler and the sampling action are realized, a screw rod 11 is driven by a first motor 10, the sampling and storing mechanism is enabled to slide up and down in a second separating pipe 5, when an induction control module 3 starts the first motor 10 to enable the sampling and storing mechanism to reach a specified height along the screw rod 11, the induction control module 3 closes the first motor 10 and starts an electromagnetic valve 9 to enable the gas storage shell 7 to be communicated with the communicating sampling mechanism with the specified height, then the induction control module 3 starts the bidirectional air pump 6 to exhaust air to enable the communicating sampling mechanism to be changed into negative pressure, at the moment, the sampler moves to the outer side end communicated with the sampling mechanism, when the sampler moves to the outer side end communicated with the sampling mechanism, the sampler can be opened to take a sample under the action of pressure, the induction control module 3 controls the bidirectional air pump 6 to reversely pressurize and supply air after the sampling is finished, so that the sampler moves to the inner side end and is stored in the sampling storage mechanism, when the pressure of the gas storage shell 7 is reduced, the sampler is separated from the sampling storage mechanism, and finally the induction control module 3 controls the bidirectional air pump 6 and the electromagnetic valve 9 to be closed, so that the sampling process with the specified height is finished.
As shown in fig. 4 and 5, the communicating sampling mechanism includes a sampling pipe 12, an air inlet 13, a ventilation cavity 14, a first sliding cavity 15, a supporting block 16, a first communicating opening 17, a second sliding cavity 18, a stop block 21 and a sealing cover component, the sampling pipe 12 is provided with a plurality of sampling pipes 12, the sampling pipes 12 are respectively fixedly connected to the first separating pipe 4 and the second separating pipe 5 in a penetrating manner, the sampling pipe 12 is uniformly arranged on the first separating pipe 4 and the second separating pipe 5 from top to bottom, wherein an included angle between two adjacent sampling pipes 12 is 45 ° or 90 °, as the purpose of the communicating sampling mechanism is to extract samples at middle parts of each layer in the storage tank 1, the plurality of sampling pipes 12 are provided, in the continuous sampling process, the flow of samples at the upper and lower adjacent layers of the communicating sampling mechanism, which can be driven by sampling, in order to avoid the influence of liquid flow change brought by sampling, arranging upper and lower adjacent sampling through pipes 12 in a staggered manner, wherein the pipe wall of the outer side end of each sampling through pipe 12 is thicker than the pipe walls of the rest parts, the pipe wall of the outer side end of each sampling through pipe 12 is used for limiting a sampler, four mounting grooves are formed in the inner surface of the pipe wall of the outer side end of each sampling through pipe 12, an air inlet 13 is arranged at the inner side end of each sampling through pipe 12, the air inlet 13 is positioned between a first partition pipe 4 and a second partition pipe 5, the air inlet 13 is communicated with an air pipe 8, a ventilation cavity 14 is formed in the pipe wall of each sampling through pipe 12, a first sliding cavity 15 is formed in the middle of each sampling through pipe 12, a supporting block 16 is arranged at the outer side end of each ventilation cavity 14, the ventilation cavity 14 is communicated with the first sliding cavity 15 through a first communication hole 17 positioned at the outer side part, four second sliding cavities 18 are arranged in the pipe wall of the outer side end of each sampling through pipe 12, and the four second sliding cavities 18 are respectively communicated with the first communication holes 17 through a first through hole 19 and a second through hole 20, the diameter of the through hole of the first through hole 19 is far greater than that of the through hole of the second through hole 20, the first through hole 19 is communicated with the outer side end of the second sliding cavity 18, the second through hole 20 is communicated with the inner side end of the second sliding cavity 18, four stoppers 21 are arranged, the stoppers 21 are respectively and fixedly connected to the outer side end of the second sliding cavity 18, and a sealing cover assembly is arranged at the outer side end of the sampling through pipe 12.
When the sampler enters the sampling through pipe 12, the inner end of the sampling through pipe 12 is blocked by the sampler, the inside of the sampling through pipe 12 becomes a negative pressure environment through the bidirectional air pump 6, the gas in the first sliding chamber 15 enters the ventilation chamber 14 from the first communicating port 17, the gas in the second sliding chamber 18 enters the ventilation chamber 14 through the first through hole 19 and the second through hole 20, the gas in the ventilation chamber 14 is pumped away through the air inlet 13, the gas in the first sliding chamber 15 is continuously pumped away through the first communicating port 17 at the outer side of the sampling through pipe 12, so that the sampler moves towards the outer side end in the first sliding chamber 15, when the sampler moves to the outer side end, the sealing cover assembly is opened and opened towards the outer side, at the moment, the negative pressure environment can pump the gas in the second sliding chamber 18, the action of opening the sealing cover assembly towards the outer side is assisted, in order to open or close the sealing cover assembly smoothly, therefore, the gas in the second sliding chamber 18 is communicated with the first communicating port 17, the second through hole 20 is used for balancing the air pressure change caused in the second sliding chamber 18 during the sliding process of the sealing cover assembly, however, since the first through hole 19 and the second through hole 20 are respectively communicated with both sides of the second sliding chamber 18, in order to simultaneously realize the ventilation effect in the second sliding chamber 18 and the sliding of the sealing cover assembly, the diameter of the through hole of the first through hole 19 is set to be much larger than that of the through hole of the second through hole 20, so that the second through hole 20 cannot resist the main pressure change brought by the first through hole 19 while ensuring ventilation, after the sampler finishes sampling, the bidirectional air pump 6 pumps air from the air inlet 13 to the inside of the sampling through pipe 12, the air resets the sampler through the first communication port 17, and at the same time, the second sliding cavity 18 is inflated to reset the sealing cover assembly, and after the sampler is reset internally, the gas pushes the sampler to slide outwards along the sampling through pipe 12.
As shown in fig. 5 and 6, the sealing cover assembly includes a cover plate 22, a push block 23, a U-shaped rubber sealing ring 24, a piston ring 25, a connecting rod 26, a sealing slider 27, a Z-shaped fixture block 28 and a torsion spring 29, the cover plate 22 is disposed at an outer side end of the sampling through pipe 12, the push block 23 is fixedly connected to an inner side surface of the cover plate 22, the U-shaped rubber sealing ring 24 and the piston ring 25 are disposed at an outer side end of the push block 23, the U-shaped rubber sealing ring 24 is disposed at an outer side of the piston ring 25, the U-shaped rubber sealing ring 24 and the piston ring 25 are used for sealing between the sampling through pipe 12 and the sealing cover assembly, the inner side surface of the cover plate 22 is fixedly connected to four connecting rods 26, inner side ends of the four connecting rods 26 are respectively fixedly connected to the sealing slider 27, the Z-shaped fixture block 28 is rotatably connected to an installation groove of the sampling through pipe 12, a trapezoidal protrusion is disposed near the push block 23 at the inner side surface of the Z-shaped fixture block 28, the trapezoidal protrusion of the Z-shaped fixture block 28 is used for triggering the unlocking of the push block 23, two torsion springs 29 are respectively arranged between each Z-shaped fixture block 28 and the mounting groove of the through-sampling pipe 12.
The sealing cover component is used for sealing the sampling through pipe 12 and sampling by matching with the sampler, when the sampler contacts the trapezoid bulge of the Z-shaped fixture block 28, the Z-shaped fixture block 28 loses the locking of the push block 23, the sealing slide block 27 slides outwards under the promotion of the pressure in the sampling through pipe 12, the sealing slide block 27 pushes the cover plate 22 through the connecting rod 26, the cover plate 22, the push block 23 and the sampler move outwards together, at the moment, the sampler samples the medicine intermediate, then the cover plate 22, the push block 23 and the sampler reset inwards under the promotion of the pressure in the sampling through pipe 12, after the reset of the push block 23 is completed, the torsion spring 29 drives the Z-shaped fixture block 28 to lock the sampler immediately, so as to avoid that when the sampler completes the reset inwards movement, the cover plate 22 moves outwards due to the high pressure state in the sampling through pipe 12, and in the outwards moving and resetting processes of the sealing cover component, the piston ring 25 plays a role in sealing during movement, the U-shaped rubber sealing ring 24 deforms under a pressure environment, and a better liquid sealing effect is formed between the U-shaped rubber sealing ring 24 and the inner wall of the outer end of the sampling through pipe 12.
As shown in fig. 7, the sampler includes a sampling outer shell 30, a second communicating port 31, a sampling inner shell 32 and a first spring 33, the sampling outer shell 30 slides and sets up in the sampling through pipe 12, the rear portion is the echelonment setting between the front portion in the sampling outer shell 30, four second communicating ports 31 have been seted up to the outside end circumference of the sampling outer shell 30, the through-hole has been opened to the front side end of the sampling outer shell 30, the inside sample inner shell 32 that slides that is provided with of the sampling outer shell 30, the circumference of the outside end of the sample inner shell 32 is opened and is had a plurality of feed liquor hole, be provided with the first spring 33 in the cavity that leaves between the sampling outer shell 30 and the sampling inner shell 32, the first spring 33 is in the compression state and closely contacts with the sampling outer shell 30 and the sampling inner shell 32.
The sampler is used for collecting the sample of medicine midbody, second intercommunication mouth 31 on the sample shell 30 is at sample siphunculus 12 slip in-process, gaseous exchange can not take place with the contact of sample siphunculus 12 inner wall, when arriving sample siphunculus 12 outside end, first intercommunication mouth 17 and second intercommunication mouth 31 intercommunication, the gas in the cavity is taken out between sample shell 30 and the sample inner shell 32, sample inner shell 32 slides to the outside, the through-hole of sample shell 30 is used for balanced atmospheric pressure, sample inner shell 32 outwards moves to the feed liquor hole and arranges the medicine midbody in, the gaseous outwards spills over in the sample inner shell 32, the medicine midbody inwards pours into in the sample inner shell 32, at the in-process that resets of sample inner shell 32, sample siphunculus 12 clears away the unnecessary liquid of adhesion on sample inner shell 32, first spring 33 plays the effect of supplementary reseing.
As shown in fig. 3 and 8, the sampling and storing mechanism includes two fixed sliders 34, a platform base 35, a circular baffle 36, a fixed mount 37, a second motor 38, a gear set 39, a limiting ring 40, a rotating platform 41, a supporting frame 42, an electric push rod 43, a first fixed block 44 and a sampler fixing component, the two fixed sliders 34 are respectively slidably disposed on the screw rod 11, the platform base 35 is fixedly connected between the two fixed sliders 34, the circular baffle 36 is fixedly connected to the periphery of the platform base 35, the fixed mount 37 is fixedly connected to the upper surface of the front portion of the platform base 35, the second motor 38 is fixedly connected to the fixed mount 37, the gear set 39 is disposed at the front portion of the platform base 35, the output shaft of the second motor 38 is connected to the gear set 39, the limiting ring 40 and the rotating platform 41 are rotatably disposed on the platform base 35, the limiting ring 40 is provided with a limiting block, the inner side surface of the limiting ring 40 is provided with a gear ring, the limit block on the limit ring 40 is used for lifting the sampler fixing component to the horizontal direction, the outer side surface of the rotating platform 41 is provided with a toothed ring, the toothed rings of the limit ring 40 and the rotating platform 41 are respectively meshed with the gear set 39, the rotating angular speeds of the limit ring 40 and the rotating platform 41 are the same through the setting of the transmission ratio of the gear set 39, the rotating platform 41 is fixedly connected with a support frame 42, the support frame 42 is fixedly connected with an electric push rod 43, the electric push rod 43 is used for pushing the sampler fixing component to enable the sampler to enter a communicated sampling mechanism, the directions of the communicated sampling mechanism are different, when the sampler is pushed, the electric push rod 43, the sampler fixing component and the communicated sampling mechanism need to be in a line of three points, therefore, the rotating angular speeds of the rotating platform 41 and the limit ring 40 which need to carry the electric push rod 43 are the same, the limit block of the limit ring 40 and the electric push rod 43 are in the same direction, the inner side of the upper end of the circular baffle plate 36 is fixedly connected with a plurality of first fixing blocks 44 in the circumferential direction, each first fixing block 44 is hinged with a sampler fixing assembly.
The sampling storage mechanism is used for conveying the sampler to a specified height and sending the sampler into the communicating sampling mechanism, the fixed slide block 34 slides up and down along the screw rod 11, the fixed slide block 34 drives the platform base 35 to move, when the upper end of the circular baffle plate 36 is flush with the lower end of the specified sampling through pipe 12, the sampling storage mechanism reaches the specified height, at the moment, the sampler fixing component aligned with the sampling through pipe 12 is lifted up, the induction control module 3 controls the second motor 38 to start, the second motor 38 drives the gear set 39 to transmit power to the limiting ring 40 and the rotating platform 41, the sampler fixing component swings around the first fixing block 44 to the horizontal direction through the limiting block of the limiting ring 40, the induction control module 3 controls the second motor 38 to close, then the induction control module 3 controls the electric push rod 43 to push the sampler fixing component, the sampler is sent into the communicating sampling mechanism, and the electric push rod 43 is reset immediately after pushing, after the sampler returns to the sampler fixing component, the induction control module 3 controls the second motor 38 to be started, so that the sampler fixing component is reset.
As shown in fig. 8 and 9, the sampler fixing assembly includes a fixing baffle 45, two electromagnetic fixing seats 46, two supporting sliding tables 47, two fixing blocks 48, two springs 49, two third fixing blocks 50, and a sliding rod 51, the fixing baffle 45 is provided with two fixing blocks 45, the fixing baffle 45 is used for limiting the sampler and limiting the supporting sliding tables 47, the lower ends of the two fixing baffles 45 are fixedly connected with the electromagnetic fixing seats 46, the middle of the electromagnetic fixing seats 46 is provided with a through hole, the electromagnetic fixing seats 46 are electrically connected with the induction control module 3, the supporting sliding tables 47 are slidably arranged between the two fixing baffles 45, the two fixing baffles 45 are symmetrically and fixedly connected with the two second fixing blocks 48 in the front-back direction, the two second fixing blocks 48 and the supporting sliding tables 47 are respectively provided with the second springs 49, when the supporting sliding tables 47 and the electromagnetic fixing seats 46 are locked, the second springs 49 are in a stretching state, the fixing baffles 45 adjacent to the circular baffle 36 are fixedly connected with the third fixing blocks 50, the third fixing block 50 is hinged with a slide rod 51, and the lower end of the slide rod 51 is positioned on the upper surface of the limiting ring 40.
The sampler fixing component is used for fixing and buffering and receiving when a sampler at a specified position is required to be sampled, the electromagnetic fixing seat 46 is controlled to close through the induction control module 3, the electromagnetic fixing seat 46 loses locking on the supporting sliding table 47, the second spring 49 drives the supporting sliding table 47 to slide upwards for a certain distance, when the limiting block of the limiting ring 40 rotates to be in contact with the sliding rod 51, the limiting block of the limiting ring 40 pushes the sliding rod 51 to move upwards, the sliding rod 51 pushes the third fixing block 50 and the fixing baffle 45 to rotate upwards around the first fixing block 44 to the horizontal direction, the electric push rod 43 pushes the supporting sliding table 47 outwards, the supporting sliding table 47 pushes the sampler to enter the sampling through pipe 12, when the sampler is ejected out of the sampling through pipe 12, the electromagnetic fixing seat 46 is controlled to start through the induction control module 3, and the speed is increased when the sampler enters the fixing baffle 45, when the sampler contacts the supporting sliding table 47, the sampler is gradually decelerated under the buffering of the second spring 49, the supporting sliding table 47 stops and is locked when moving to contact with the electromagnetic fixing seat 46, and then the sampler fixing group is restored to the vertical state again through the rotation of the limiting ring 40.
It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.
Claims (10)
1. A medicine intermediate level detection system is characterized by comprising a storage tank (1), a liquid passing pipe (2), a sensing control module (3), a first separation pipe (4), a second separation pipe (5), a sampling driving mechanism, a communicated sampling mechanism, a sampler and a sampling storage mechanism, wherein the storage tank (1) is internally filled with a liquid medicine intermediate, the upper surface of the storage tank (1) is provided with a through hole, the upper end and the lower end of the storage tank (1) are respectively provided with the liquid passing pipe (2), the sensing control module (3) is arranged on the upper surface of the storage tank (1), the upper end of the first separation pipe (4) is fixedly connected in the through hole of the storage tank (1), the second separation pipe (5) is arranged inside the first separation pipe (4), sliding grooves are symmetrically formed in the front and the back of the second separation pipe (5), the sampling driving mechanism is arranged in the storage tank (1), and the sampling driving mechanism is electrically connected with the sensing control module (3), the communicating and sampling mechanism runs through and is arranged on the first separation pipe (4) and the second separation pipe (5), the sampler is provided with a plurality of, the sampler is connected with the communicating and sampling mechanism in a sliding manner, the sampling and storing mechanism slides up and down and is arranged in the second separation pipe (5), the sampler is connected with the sampling and storing mechanism in a sliding manner, and the sampling and storing mechanism is electrically connected with the induction control module (3).
2. The system for detecting each level of the drug intermediate according to claim 1, wherein the sampling driving mechanism comprises a bidirectional air pump (6), a gas storage housing (7), a vent pipe (8), an electromagnetic valve (9), a first motor (10) and a lead screw (11), the bidirectional air pump (6) is arranged on the upper surface of the storage tank (1), the bidirectional air pump (6) is electrically connected with the induction control module (3), the gas storage housing (7) is arranged between the upper ends of the first separation pipe (4) and the second separation pipe (5), the bidirectional air pump (6) is communicated with the gas storage housing (7), the vent pipe (8) is fixedly connected to the lower surface of the gas storage housing (7), the vent pipe (8) is arranged between the first separation pipe (4) and the second separation pipe (5), the electromagnetic valve (9) is arranged on the vent pipe (8), and the electromagnetic valve (9) is electrically connected with the induction control module (3), the first motor (10) is arranged on the upper surface of the storage tank (1), the first motor (10) is electrically connected with the induction control module (3), the two screw rods (11) are symmetrically arranged front and back, the two screw rods (11) are respectively connected into the sliding grooves of the second separation pipe (5) in an up-and-down rotating mode, and the first motor (10) and the screw rods (11) are used for up-and-down sliding of the sampling and storing mechanism.
3. The system for detecting each level of the drug intermediate as claimed in claim 1, wherein the communicating and sampling mechanism comprises a sampling through pipe (12), an air inlet (13), a ventilation cavity (14), a first sliding cavity (15), a supporting block (16), a first communicating port (17), a second sliding cavity (18), a stop block (21) and a sealing cover component, the sampling through pipe (12) is provided with a plurality of sampling through pipes (12), the sampling through pipes (12) are respectively fixedly connected to the first separating pipe (4) and the second separating pipe (5) in a penetrating manner, the wall thickness of the outer side end pipe wall of each sampling through pipe (12) is larger than that of the rest part of pipe wall, the inner surface of the outer side end pipe wall of each sampling through pipe (12) is provided with four mounting grooves, the inner side end of each sampling through pipe (12) is provided with the air inlet (13), the air inlet (13) is positioned between the first separating pipe (4) and the second separating pipe (5), and the air inlet (13) is communicated with the ventilation pipe (8), open in the pipe wall of sample siphunculus (12) and have ventilate chamber (14), be first slip chamber (15) in the middle of sample siphunculus (12), outside end at ventilate chamber (14) is provided with supporting shoe (16), ventilate chamber (14) and first slip chamber (15) through being located the outside portion first intercommunication mouth (17) intercommunication, it slides chamber (18) to have four seconds in the outside of sample siphunculus (12) pipe wall internal division, four second slide chamber (18) are respectively through first through-hole (19) and second through-hole (20) and first intercommunication mouth (17) intercommunication, dog (21) are provided with four, dog (21) rigid coupling respectively in the outside end in second slip chamber (18), the outside end of sample siphunculus (12) is provided with sealed lid subassembly.
4. The system for detecting each level of a pharmaceutical intermediate as claimed in claim 3, wherein the sampling through pipes (12) are uniformly arranged up and down on the first separating pipe (4) and the second separating pipe (5), and an included angle between two adjacent sampling through pipes (12) is 45 ° or 90 °.
5. A pharmaceutical intermediate level detection system according to claim 3, wherein the diameter of the first through hole (19) is substantially larger than the diameter of the second through hole (20), the first through hole (19) communicating with the outer end of the second sliding chamber (18), and the second through hole (20) communicating with the inner end of the second sliding chamber (18).
6. The system for detecting each level of a drug intermediate according to claim 3, wherein the sealing cover assembly comprises a cover plate (22), a push block (23), a U-shaped rubber sealing ring (24), a piston ring (25), a connecting rod (26), a sealing slider (27), a Z-shaped fixture block (28) and a torsion spring (29), the cover plate (22) is arranged at the outer side end of the sampling through pipe (12), the push block (23) is fixedly connected to the inner side surface of the cover plate (22), the U-shaped rubber sealing ring (24) and the piston ring (25) are arranged at the outer side end of the push block (23), the U-shaped rubber sealing ring (24) is arranged at the outer side of the piston ring (25), the inner side surface of the cover plate (22) is fixedly connected with the four connecting rods (26), the inner side ends of the four connecting rods (26) are respectively and fixedly connected with the sealing slider (27), and the Z-shaped fixture block (28) is rotatably connected to the mounting groove of the sampling through pipe (12), trapezoidal bulges are arranged on the inner side surfaces of the Z-shaped clamping blocks (28) close to the push block (23), and two torsion springs (29) are respectively arranged between each Z-shaped clamping block (28) and the mounting groove of the sampling through pipe (12).
7. The system for detecting each level of pharmaceutical intermediates according to claim 1, wherein the sampler comprises a sampling housing (30) and a second communication port (31), sample inner shell (32) and first spring (33), sample shell (30) slide to set up in sample siphunculus (12), rear portion sets up for the echelonment between the front portion in sample shell (30), four second intercommunication mouth (31) have been seted up to sample shell (30) outside end circumference, the side is opened before sample shell (30) has the through-hole, sample shell (30) inside slide is provided with sample inner shell (32), open sample inner shell (32) outside end circumference has a plurality of feed liquor hole, be provided with first spring (33) in the cavity that leaves between sample shell (30) and sample inner shell (32), first spring (33) are in compression state and with sample shell (30) and sample inner shell (32) in close contact with.
8. The system for detecting each level of a drug intermediate as claimed in claim 1, wherein the sampling and storing mechanism comprises two fixed sliding blocks (34), a platform base (35), a circular baffle (36), a fixed frame (37), a second motor (38), a gear set (39), a limiting ring (40), a rotating platform (41), a support frame (42), an electric push rod (43), a first fixed block (44) and a sampler fixing component, the two fixed sliding blocks (34) are respectively arranged on a lead screw (11) in a sliding manner, the platform base (35) is fixedly connected between the two fixed sliding blocks (34), the circular baffle (36) is fixedly connected to the periphery of the platform base (35), the fixed frame (37) is fixedly connected to the upper surface of the front portion of the platform base (35), the second motor (38) is fixedly connected to the fixed frame (37), the gear set (39) is arranged on the front portion of the platform base (35), second motor (38) output shaft is connected with gear train (39), spacing ring (40) and rotation platform (41) rotate and set up on platform base (35), be provided with the stopper on spacing ring (40), spacing ring (40) inboard surface is provided with the ring gear, rotation platform (41) lateral surface is provided with the ring gear, the ring gear of spacing ring (40) and rotation platform (41) meshes with gear train (39) respectively, the rigid coupling has support frame (42) on rotation platform (41), the rigid coupling has electric putter (43) on support frame (42), the inboard circumference rigid coupling in circular baffle (36) upper end has a plurality of first fixed block (44), it has a sampler fixed component to articulate on every first fixed block (44).
9. The system for detecting each level of a pharmaceutical intermediate as claimed in claim 8, wherein the rotational angular velocity of the limiting ring (40) and the rotational platform (41) is the same, and the limiting block of the limiting ring (40) and the electric push rod (43) are in the same direction by setting the transmission ratio of the gear set (39).
10. The system for detecting each level of a drug intermediate according to claim 1, wherein the sampler fixing assembly comprises two fixing baffles (45), two electromagnetic fixing seats (46), two supporting sliding tables (47), two second fixing blocks (48), two second springs (49), a third fixing block (50) and a sliding rod (51), the two fixing baffles (45) are fixedly connected with the electromagnetic fixing seats (46) at the lower ends of the two fixing baffles (45), the middle of each electromagnetic fixing seat (46) is provided with a through hole, the electromagnetic fixing seats (46) are electrically connected with the induction control module (3), the supporting sliding tables (47) are slidably arranged between the two fixing baffles (45), the two second fixing blocks (48) are symmetrically fixedly connected with each other in the front-back direction between the two fixing baffles (45), the second springs (49) are respectively arranged between the two second fixing blocks (48) and the supporting sliding tables (47), when the supporting sliding table (47) is locked with the electromagnetic fixing seat (46), the second spring (49) is in a stretching state, a third fixing block (50) is fixedly connected to the fixing baffle (45) adjacent to the circular baffle (36), the third fixing block (50) is hinged to a sliding rod (51), and the lower end of the sliding rod (51) is located on the upper surface of the limiting ring (40).
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| CN117664656A (en) * | 2024-02-01 | 2024-03-08 | 诸城兴贸玉米开发有限公司 | Semi-manufactured goods inspection sampling device is used in maize starch production |
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| CN117664656B (en) * | 2024-02-01 | 2024-04-30 | 诸城兴贸玉米开发有限公司 | Semi-manufactured goods inspection sampling device is used in maize starch production |
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