CN201426856Y - Tilmicosin enteric coated granule - Google Patents
Tilmicosin enteric coated granule Download PDFInfo
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- CN201426856Y CN201426856Y CN2009200781744U CN200920078174U CN201426856Y CN 201426856 Y CN201426856 Y CN 201426856Y CN 2009200781744 U CN2009200781744 U CN 2009200781744U CN 200920078174 U CN200920078174 U CN 200920078174U CN 201426856 Y CN201426856 Y CN 201426856Y
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- tilmicosin
- enteric coated
- medicine
- coated granule
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Abstract
The utility model relates to a tilmicosin enteric coated granule comprising a base pill 1 as a center, a medicine layer 2 formed by mixing tilmicosin, microcrystalline cellulose, HPMC, starch and PVP,a polymer slowly-releasing coating layer 3 and a color-coat layer 4, wherein the medicine layer 2 is coated on the base pill 1, and the polymer slowly-releasing coating layer 3 and the color-coat layer 4 are used for orderly coating outward layer by layer. The tilmicosin enteric coated granule solves the problem that the tilmicosin is unstable in gastric acid, and makes up the disadvantages of the prior art.
Description
Technical field
This utility model relates to a kind of tilmicosin enteric coated particles.
Background technology
Tilmicosin is by the special-purpose antibiotic of the semisynthetic poultry of a kind of hydrolyzate of tylosin, medicinal its phosphate.Pharmacokinetics: for oral administration and subcutaneous injection absorbs fast, but not exclusively.Apparent volume of distribution is big, the drug level height in the lung tissue.Have the favorable tissue penetration power, can enter breast from blood rapidly and fully, the Ruzhong drug level is higher, the length of holding time, and the Ruzhong half-life reaches 1--2 days.Pharmacological action: gram positive bacteria, some gram negative bacteria, mycoplasma, spirillum etc. are all had inhibitory action; Pleuropneumonia actinomycetes, pasteurellosis bacillus had the antibacterial activity stronger than tylosin.Tilmicosin (Tilmicosin) is a kind of newer for the special-purpose antibiotic of the semisynthetic Macrolide poultry of tylosin, and the eighties is succeeded in developing by Britain Elanco Animal Health Care Products Corporation.Because its special antibacterial activity and characteristics of pharmacokinetics, the clinical control that is used for animal infectious diseases such as cattle, goat, sheep, milch cow, pig, chicken that gone through of this medicine, particularly livestock and birds respiratory disease reaches the treatment of lactogenic mammitis of animal as domestic animal Actinobacillus property pleuropneumonia, Bacillus pasteurii disease and gallisepticum chicken disease etc.Clinical practice: when on the veterinary clinic tilmicosin being used for disease such as prevention and treatment poultry pneumonia and mastitis, subcutaneous injection 10～20mg/kg once can obtain good efficacy.Can take the mode of 200～400mg/kg spice administration 15d when prevention and treatment swine mycoplasma pneumonia, poultry often by 100～200mg/l drinking-water logotype 5d, can prevent and treat mycoplasma, but be not used in laying hen.The definite curative effect of tilmicosin treatment mastitis is still to be tested, but it is generally acknowledged in milch cow does the breast phase in subcutaneous injection 10mg/kg or the breast perfusion 300mg/ time, and control action is played in growth, the breeding of mitigation symptoms and inhibition pathogenic bacterium preferably.But because tilmicosin is unstable in gastric acid, the curative effect of spice administration is not best usually.
Summary of the invention
The purpose of this utility model provides a kind of tilmicosin enteric coated particles, and this utility model has solved tilmicosin problem of unstable in gastric acid, has remedied the deficiencies in the prior art.
A kind of tilmicosin enteric coated particles of the present utility model, comprise basic ball as core, and the medicine layer that mixes of tilmicosin, microcrystalline Cellulose, HPMC, starch and PVP, with polymer sustained release coating layer and color clothing layer, medicine layer is coated on the basic ball, and polymer sustained release coating layer and color clothing layer outwards coat successively layer by layer.
A kind of tilmicosin enteric coated particles of the present utility model, at medicine layer outer wrapping polymer sustained release coating layer and color clothing layer, be absorbed after making medicine can have time enough to arrive intestinal, and medicine layer outer wrapping polymer sustained release coating layer can prevent tilmicosin destroyed inefficacy in gastric acid, can improve bioavailability greatly.
The beneficial effects of the utility model are:
A kind of tilmicosin enteric coated particles of the present utility model has realized that the protection tilmicosin is not subjected to the purpose of stomach acids destroy, has improved the bioavailability of tilmicosin greatly, has improved the product curative effect.
Description of drawings
Accompanying drawing is the structural representation of a kind of tilmicosin enteric coated particles of this utility model
Wherein 1 is that basic ball 2 is that medicine layer 3 is that polymer sustained release coating layer 4 is color clothing layers
The specific embodiment
Below in conjunction with the specific embodiment, further set forth the present invention.
As shown in the figure, it is a kind of tilmicosin enteric coated particles of the present utility model, comprise basic ball 1 as core, and the medicine layer 2 that mixes of tilmicosin, microcrystalline Cellulose, HPMC, starch and PVP, with polymer sustained release coating layer 3 and color clothing layer 4, medicine layer 2 is coated on the basic ball 1, and polymer sustained release coating layer 3 and color clothing layer 4 outwards coat successively layer by layer.
Prescription: tilmicosin 10g, microcrystalline Cellulose 45g, HPMC20g, starch 15g, PVP5g;
The coatings prescription: polyacrylic resin can adopt You Teqi
L30D-55 gets 53g, Pulvis Talci 8g, triethyl citrate 1.6g, water 37.4g; Solids content 25.5% in the coatings, and polymer content 15.9% in the coatings.
Behind the supplementary material mix homogeneously with amount of calculation, spray adds ready 5%PVP solution and makes suitable soft material.By the shot-blasting machine pill-rolling, fluid bed oven dry back screening 30-40 purpose micropill coating, weightening finish 5%.
Through evidence, a kind of tilmicosin enteric coated particles of the present utility model has solved tilmicosin problem of unstable in gastric acid really, has remedied the deficiencies in the prior art.
Claims (1)
1. tilmicosin enteric coated particles, it is characterized in that: comprise basic ball (1) as core, and the medicine layer (2) that mixes of tilmicosin, microcrystalline Cellulose, HPMC, starch and PVP, with polymer sustained release coating layer (3) and color clothing layer (4), medicine layer (2) is coated on the basic ball (1), and polymer sustained release coating layer (3) and color clothing layer (4) outwards coat successively layer by layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200781744U CN201426856Y (en) | 2009-07-13 | 2009-07-13 | Tilmicosin enteric coated granule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200781744U CN201426856Y (en) | 2009-07-13 | 2009-07-13 | Tilmicosin enteric coated granule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201426856Y true CN201426856Y (en) | 2010-03-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200781744U Expired - Fee Related CN201426856Y (en) | 2009-07-13 | 2009-07-13 | Tilmicosin enteric coated granule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201426856Y (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068412A (en) * | 2011-01-21 | 2011-05-25 | 黑龙江大学 | Enteric targeted tilmicosin particles and preparation method thereof |
| CN103622919A (en) * | 2013-11-14 | 2014-03-12 | 湖北龙翔药业有限公司 | Tilmicosin phosphate enteric granules and preparation method thereof |
| CN104586774A (en) * | 2015-01-26 | 2015-05-06 | 成都乾坤动物药业有限公司 | Process for preparing tilmicosin pellets |
| CN104586875A (en) * | 2014-12-30 | 2015-05-06 | 郑州都灵兽药科技有限公司 | Preparation method for compound tilmicosin enteric-coated granules |
| CN104606141A (en) * | 2013-11-01 | 2015-05-13 | 瑞普（天津）生物药业有限公司 | Tilmicosin enteric micro pellet |
| CN104983718A (en) * | 2015-07-17 | 2015-10-21 | 江西博莱大药厂有限公司 | Tilmicosin slow release pellet, and preparation method and application thereof |
| CN108478588A (en) * | 2018-04-26 | 2018-09-04 | 江西派尼生物药业有限公司 | A kind of Tilmicosin enteric-coated sustained release agent and preparation method thereof |
-
2009
- 2009-07-13 CN CN2009200781744U patent/CN201426856Y/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068412A (en) * | 2011-01-21 | 2011-05-25 | 黑龙江大学 | Enteric targeted tilmicosin particles and preparation method thereof |
| CN104606141A (en) * | 2013-11-01 | 2015-05-13 | 瑞普（天津）生物药业有限公司 | Tilmicosin enteric micro pellet |
| CN103622919A (en) * | 2013-11-14 | 2014-03-12 | 湖北龙翔药业有限公司 | Tilmicosin phosphate enteric granules and preparation method thereof |
| CN104586875A (en) * | 2014-12-30 | 2015-05-06 | 郑州都灵兽药科技有限公司 | Preparation method for compound tilmicosin enteric-coated granules |
| CN104586774A (en) * | 2015-01-26 | 2015-05-06 | 成都乾坤动物药业有限公司 | Process for preparing tilmicosin pellets |
| CN104586774B (en) * | 2015-01-26 | 2017-09-01 | 成都乾坤动物药业有限公司 | A kind of preparation technology of Tilmicosin micropill |
| CN104983718A (en) * | 2015-07-17 | 2015-10-21 | 江西博莱大药厂有限公司 | Tilmicosin slow release pellet, and preparation method and application thereof |
| CN108478588A (en) * | 2018-04-26 | 2018-09-04 | 江西派尼生物药业有限公司 | A kind of Tilmicosin enteric-coated sustained release agent and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100324 Termination date: 20140713 |
|
| EXPY | Termination of patent right or utility model |