CN201257161Y - 复方单硝酸异山梨酯双释胶囊 - Google Patents

复方单硝酸异山梨酯双释胶囊 Download PDF

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CN201257161Y
CN201257161Y CNU2007201904102U CN200720190410U CN201257161Y CN 201257161 Y CN201257161 Y CN 201257161Y CN U2007201904102 U CNU2007201904102 U CN U2007201904102U CN 200720190410 U CN200720190410 U CN 200720190410U CN 201257161 Y CN201257161 Y CN 201257161Y
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tablet
isosorbide mononitrate
capsule
release
medicaments
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张树祥
熊国裕
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Guangdong star Pharmaceutical Co., Ltd.
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BEIJING XINGHAO MEDICAL Co Ltd
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Abstract

复方单硝酸异山梨酯双释胶囊片属药品剂型结构技术领域，包括胶囊囊壳和装入胶囊囊壳内的药物，其中所述的药物的剂型形式为两种释放药物速度不同的片剂，分别为缓释片剂(a)和速释片剂(b)，所述的缓释片剂(a)为单硝酸异山梨酯片，所述的速释片剂(b)为阿司匹林片。

Description

复方单硝酸异山梨酯双释胶囊
技术领域
本实用新型涉及一种药品剂型结构，特别是一种复方单硝酸异山梨酯双释胶囊片。
背景技术
阿司匹林是一种使用了近百年的药物，人们一直作为解热镇痛药用于发热、头痛、神经痛、肌肉痛、牙痛、痛经、急性风湿性关节炎、类风湿性关节炎等的治疗。另一方面，阿司匹林在体内还具有抗血栓形成的特性，它可抑制环氧化酶，使血栓素和前列腺素生成减少。单硝酸异山梨酯是一种治疗冠心病和心绞痛的常用药物，经多年临床使用，疗效确切，其主要作用机理为扩张静脉容量和外周阻力血管，使心脏前后负荷下降，而减少心肌耗氧量，该药具有生物利用度高，个体差异性小，疗效显著的特点，对冠心病和心绞痛的预防优于消心痛和硝酸甘油。将两药科学配方，制备成复方制剂，具有明显的协同作用，以成为一种新型的心脑血管类治疗药物。
目前，市售的品种有复方单硝酸异山梨酯缓释片，为一种双层片，由单硝酸异山梨酯层1、隔离层2和阿司匹林层3构成。作为一种双层片，其制备工艺明显要较单层片复杂繁琐。
发明内容
本实用新型的目的是提供一种双释胶囊片。本发明胶囊囊壳中，所装入的片剂为单层片。
本实用新型包括胶囊囊壳和装入胶囊内部的药物组成，其中装入胶囊的药物为两种释放速度不同的片剂a和片剂b，所述的片剂a是由单硝酸异山梨酯和辅料构成的缓释片，所述的片剂b是由阿司匹林和药用辅料构成的速释片b。
本实用新型中，在缓释片中加有在胃内释放的缓释辅料，如羟丙基纤维素，羟丙基甲基纤维素，聚乙烯缩乙醛二乙胺基醋酸和甲基丙烯酸二甲氨基乙酯—中性甲基丙烯酸酯共聚物中的任一种。
速释片中，含有辅料崩解剂，如聚维酮、交联聚维酮、交联羧甲基纤维素钠、羧甲基淀粉钠等中的任一种或多种。
本实用新型中，每个胶囊中装有两个片剂，其中缓释片中每片含单硝酸异山梨酯60mg，速释片中每片含阿司匹林75mg。
附图说明
图1为本实用新型双释胶囊主视图
图2为现有技术缓释双层片的主视图。
具体实施方式
如图一所示，复方单硝酸异山梨酯，由胶囊囊壳和装入胶囊内部的药物组成，其中装入胶囊中的药物的形式为两种释放速度不同的药物片剂a和片剂b。片a是由单硝酸异山梨酯和药用辅料构成的缓释片，片b是由阿司匹林和药用辅料构成的速释片。具体地，缓释片由单硝酸异山梨酯、糊精、羟丙基甲基纤维素和硬脂酸镁、乙醇组成。速释片是由微晶纤维、交联聚维酮、聚维酮、硬脂酸镁、乙醇组成。
制作时：
(1)取处方量的单硝酸异山梨酯、糊精、部分羟丙基甲基纤维素混合均匀，以剩余部分的羟丙基甲基纤维素的乙醇溶液为粘合剂制粒，干燥、整粒，再与硬脂酸镁混匀，压片即得缓释片a；
(2)取处方量的阿司匹林、微晶纤维混合均匀，以聚维酮的乙醇溶液为粘合剂制粒，干燥，整粒后，再与交联聚维酮、硬脂酸镁混合均匀，压片，即得速释片b；
(3)将缓释片a和速释片b装入胶囊本体中，盖上胶囊囊冒，即得本实用新型双释胶囊片。

Claims (1)

1、一种复方单硝酸异山梨酯双释胶囊片，包括胶囊囊壳和装入胶囊内部的药物，其特征是所述的装入胶囊内部的药物为两种释放速度不同的片剂形式，分别为缓释片剂(a)和速释片剂(b)，所述的缓释片剂(a)为单硝酸异山梨酯片，所述的速释片剂(b)阿司匹林片。
CNU2007201904102U 2007-11-28 2007-11-28 复方单硝酸异山梨酯双释胶囊 Expired - Lifetime CN201257161Y (zh)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016063055A1 (en) * 2014-10-21 2016-04-28 Reckitt Benckiser Llc Pharmaceutical capsule containing at least two tablets
CN105902509A (zh) * 2015-09-28 2016-08-31 天方药业有限公司 一种复方单硝酸异山梨酯缓释片及其制备方法
US11278506B2 (en) 2015-10-09 2022-03-22 Rb Health (Us) Llc Pharmaceutical formulation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016063055A1 (en) * 2014-10-21 2016-04-28 Reckitt Benckiser Llc Pharmaceutical capsule containing at least two tablets
CN105902509A (zh) * 2015-09-28 2016-08-31 天方药业有限公司 一种复方单硝酸异山梨酯缓释片及其制备方法
CN105902509B (zh) * 2015-09-28 2018-08-17 天方药业有限公司 一种复方单硝酸异山梨酯缓释片及其制备方法
US11278506B2 (en) 2015-10-09 2022-03-22 Rb Health (Us) Llc Pharmaceutical formulation

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