CN201179196Y - Apparatus for preparing dropping pills with cooling gas - Google Patents
Apparatus for preparing dropping pills with cooling gas Download PDFInfo
- Publication number
- CN201179196Y CN201179196Y CNU2007200994845U CN200720099484U CN201179196Y CN 201179196 Y CN201179196 Y CN 201179196Y CN U2007200994845 U CNU2007200994845 U CN U2007200994845U CN 200720099484 U CN200720099484 U CN 200720099484U CN 201179196 Y CN201179196 Y CN 201179196Y
- Authority
- CN
- China
- Prior art keywords
- cooling pipe
- water dropper
- communicated
- equipment
- air cooled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006187 pill Substances 0.000 title claims abstract description 53
- 239000000112 cooling gas Substances 0.000 title abstract 2
- 238000001816 cooling Methods 0.000 claims abstract description 47
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 238000007789 sealing Methods 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 42
- 238000011534 incubation Methods 0.000 claims description 19
- 238000005057 refrigeration Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000004321 preservation Methods 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000011109 contamination Methods 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000011105 stabilization Methods 0.000 abstract 1
- 238000012864 cross contamination Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 102000004317 Lyases Human genes 0.000 description 2
- 108090000856 Lyases Proteins 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 239000003021 water soluble solvent Substances 0.000 description 2
- 239000005662 Paraffin oil Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000000289 melt material Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Images
Abstract
The utility model discloses an apparatus utilizing cooling gas to prepare dripping pills, which is provided with a dripping pill device, a cooling pipeline which is sealed and communicated with the dripping pill, and a gas cooling device which is communicated with the cooling pipeline and circularly conveys cold air into the cooling pipeline, wherein, the dripping pill device is provided with a chemical material can communicated with the pipeline of a material liquid conveyer, a dripper communicated with the chemical material can and a heat preservation cavity arranged outside the dripper to perform heat preservation for the dripper; the dripper is of a hopper-shaped structure with an upper part and a lower part which are mutually communicated, and 1 to 4 layers with identical shape are arranged from outside to inside; the chemical material can is provided with 1 to 4 layers; an opening is formed in the heat preservation cavity corresponding to the lower outlet of the dripper and is connected with the upper opening of the cooling pipeline in a sealing way; the cooling pipeline is a straight barrel type pipeline, and the cooling device is a cold wind cooling device. The apparatus simplifies the operation procedure, entirely has no residual organic solvent, reduces dripping pill preparation cost, has convenient cleaning and no clean dead corner, avoids crossed contamination in the production procedure, and is favorable for the production stabilization.
Description
Technical field
This utility model relates to a kind of pharmaceutical equipment.It is simple particularly to relate to a kind of preparation section, does not have organic residue problem, no cross-contamination hidden danger, the equipment of being convenient to clean that utilizes preparing dropping pill with air cooled.
Background technology
The preparation of tradition drop pill is to adopt will to melt material and drip to the not miscible liquid lyase of material and obtain, and cools off lyase and can be water-soluble solvent and oil-dissolving solvent.Wherein water-soluble solvent mostly is water, glycerol etc.; Oil-dissolving solvent mostly is paraffin oil and silicone oil.The drop pill that adopts the oil-dissolving solvent cooling to make, liquid coolant is residual to be unavoidable problem.Follow-uply get rid of oil, the operation of polishing is indispensable, but can not solve organic residue problem; Simultaneously, because the adhesion of liquid coolant such as silicone oil makes equipment can't obtain to clean fully, becoming the hidden danger of cross-contamination, is the problem that faces of GMP enterprise now.
Summary of the invention
Technical problem to be solved in the utility model is, provides a kind of preparation section simple, do not have organic residue problem, no cross-contamination hidden danger, the equipment of being convenient to clean that utilizes preparing dropping pill with air cooled.
The technical scheme that this utility model adopted is: a kind of equipment that utilizes preparing dropping pill with air cooled, include: drop pill device, the cooling pipe that is communicated with drop pill device sealing, and be communicated with cooling pipe and the gas refrigeration device of in the cooling pipe conveying cold air of circulating.
Described drop pill device includes: the change batch can that is connected with the pipeline of feed liquid conveyer device; The water dropper that is communicated with the change batch can; Be arranged on the incubation cavity that the water dropper outside is incubated water dropper.
Described water dropper is the funnel-shaped structure of upper and lower perforation, and has identical shaped 1～4 layer from outside to inside, every is fixedly connected by support between two-layer.
Describedization batch can is corresponding with water dropper, also is provided with 1～4, and each changes the corresponding one deck that is communicated with water dropper of batch can.
Described incubation cavity skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity corresponding to the following exit of water dropper, the width size of described openings of sizes and water dropper is corresponding, and is tightly connected with the upper port of cooling pipe.
The top of described incubation cavity also is provided with vibrating device, and the top that described vibrating device passes incubation cavity links to each other with water dropper, is used for water dropper is produced vibration.
Described cooling pipe is the straight barrel type pipeline, and the upper port of cooling pipe is communicated with the opening sealing of the incubation cavity lower end of drop pill device, and the lower end of cooling pipe is and the corresponding hatch frame of drop pill collecting vessel.The outside of described cooling pipe (2) also is provided with heat-insulation layer.
Described gas refrigeration device is the cold wind structure, include: inside is provided with the freezer of compressor, the cold gas exhausting outlet of freezer is connected with the upper and lower air inlet of cooling pipe by lateral line, blast pipe respectively, and the gas inflow entrance of freezer is connected with the air outlet of cooling pipe by backwind tube.
Described blast pipe and horizontal plane angle a are 0-90 °.
The equipment that utilizes preparing dropping pill with air cooled of the present utility model, adopt gas cooled mode drop pill, can avoid the follow-up residual solvent of condenses modes such as traditional employing liquid paraffin and silicone oil to handle formality, as follow-up removing oil treatment step, simplified operation sequence, organic solvent-free is residual fully, and has reduced the cost of drop pill preparation.Equipment adopts the design of straight bobbin road, does not have the cleaning dead angle, and it is convenient to clean, and is convenient to clearing out a gathering place of GMP enterprise, avoids the cross-contamination in the production process, is beneficial to the stable of product.
Description of drawings
Fig. 1 is the structural representation of this utility model equipment;
Fig. 2 is the structural representation of the water dropper in this utility model equipment.
Wherein:
1: drop pill device 2: cooling pipe
3: gas refrigeration device 4: change batch can
5: water dropper 6: incubation cavity
7: pipeline 8: vibrating device
9: compressor 10: freezer
11: blast pipe 12: backwind tube
13: lateral line 14: skin
15: nexine 16: support
The specific embodiment
Below in conjunction with drawings and Examples the equipment of preparing dropping pill with air cooled that utilizes of the present utility model is made a detailed description.
This utility model is to adopt cryogenic gas as cooling medium, and typical temperature is lower than 0 degree, contacts with fused drop pill adjuvant, it is cooled to below the freezing point, to guarantee the drop pill molding.Usually drop pill is according to the gravity free-falling, and cooling air is blown into by the bottom, finishes thermal energy exchange with the whereabouts drop pill.Described cooling air adopts clean the filtration, reaches the requirement of medicine neatness standard fully, needn't worry that medicine is contaminated, and simultaneously, pipeline is more easy to clean, does not have the dead angle of cleaning.
As shown in Figure 1, the equipment that utilizes preparing dropping pill with air cooled of the present utility model, include: drop pill device 1, the cooling pipe 2 that is communicated with drop pill device 1 sealing, and be communicated with cooling pipe 2 and the gas refrigeration device 3 of in the cooling pipe 2 conveying cold air of circulating.
Described drop pill device 1 includes: the change batch can 4 that is connected with the pipeline 7 of feed liquid conveyer device; The water dropper 5 that is communicated with change batch can 4; Be arranged on the incubation cavity 6 that water dropper 5 outsides are incubated water dropper 5.Wherein, described feed liquid conveyer device can adopt the gas pressurized mode to pressurize to changing batch can 4 by pipeline 7, finish material from changing the transfer of batch can, also can adopt air pump to pass through pipeline 7, finish material from changing the transfer of batch can 4 to water dropper 5 to changing batch can 4 pressurizations to water dropper.
Describedization batch can 4 adopts the tank body of prior art, possesses dog-house, stirring, gas pressurized, feed liquid conveyance conduit connection water dropper.Change batch can 4 and adopt the oil bath mode of heating, temperature is controlled at 40-180 ℃, and temperature is even, and the outside has heat-insulation layer.
Described incubation cavity 6 skins are heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity 6 corresponding to the following exit of water dropper 5, the width size of described openings of sizes and water dropper 5 is corresponding, and is tightly connected with the upper port of cooling pipe 2.
As shown in Figure 2, described water dropper 5 is the funnel-shaped structure of upper and lower perforation, and has identical shaped 1～4 layer from outside to inside, every is fixedly connected by supporting 16 between two-layer.Shown in the figure is 2 layers of structure that adopt skin 14 and nexine 15.
Describedization batch can 4 is corresponding with water dropper 5, also can be provided with 1～4, and each changes batch can 4 corresponding one decks that are communicated with water dropper 5.
For under identical water dropper diameter, the drop pill that acquisition varies in size, the top of described incubation cavity 6 also is provided with vibrating device 8, and the top that described vibrating device 8 passes incubation cavity 6 links to each other with water dropper 5, is used for water dropper 5 is produced vibration.At different material, adopt different mode of vibration vibration water droppers 5, by the adjusting of different frequency of vibration, can obtain the drop pill of required size.Its mode of vibration can adopt:
The mode of electric vibrating has the high 2-2000Hz of frequency of vibration, the characteristics that amplitude is little, the high speed drop pill mode of suitable low-viscosity material.
The mode of pneumatic vibration, frequency of vibration 2-90Hz, amplitude is big.When the material viscosity surpasses 800cp, electronic mode can't effectively be cut material, causes water dropper to stop up, and when influencing drop pill and preparing, can adopt the pneumatic vibration mode.
Described cooling pipe 2 is straight barrel type or spiral type pipe, and about long 6m, the upper port of cooling pipe 2 is communicated with the opening sealing of incubation cavity 6 lower ends of drop pill device 1, and the lower end of cooling pipe 2 is and the corresponding hatch frame of drop pill collecting vessel.The outside of described cooling pipe 2 can also be provided with heat-insulation layer.
Described gas refrigeration device 3 is the cold wind structure, includes: inside is provided with the freezer 10 of compressor 9, prepares 3 of cold units in the freezer 10, is equipped with mutually.The cold gas exhausting outlet of freezer 10 is connected with the upper and lower air inlet of cooling pipe 2 by lateral line 13, blast pipe 11 respectively, and the gas inflow entrance of freezer 10 is connected by the air outlet of backwind tube 12 with cooling pipe 2.Described blast pipe 11 is 0-90 ° with the angle of horizontal plane.
Cold air after refrigeration tangentially enters cooling pipe 2 through the bottom of cooling pipe 2, and its top of rising twist by the air outlet inflow backwind tube 12 on cooling pipe 2 tops, flows in the freezers 10 through backwind tube 12 again and carries out kind of refrigeration cycle.
The effect that lateral line 13 is set between the top of freezer 10 and cooling pipe 2 is, cold air through the refrigeration processing, directly rise to place through thinner lateral line 13 apart from water dropper outlet 10cm, directly be blown into refrigerating gas at an angle, make the medicine that oozes continuously drip the purging of the gas that obtains a small amount of lower temperature, maintain a certain distance, avoid drop pill even glutinous, influence follow-up molding in this zone.
The equipment that utilizes preparing dropping pill with air cooled of the present utility model, can adopt online water purging system, directly carry out the water spray Cleaning for High Capacity from the top, after cleaning end, pigging (pig's head cleaning) system utilizes Compressed Gas promotion pig's head that pipeline is carried out wiped clean from top to bottom, after finishing, pig's head is got back to the cleaning station.By clean hot gas cooling tube is carried out drying, thus reach cleaning purpose.
Claims (10)
1. equipment that utilizes preparing dropping pill with air cooled, it is characterized in that, include: drop pill device (1), the cooling pipe (2) that is communicated with drop pill device (1) sealing, and be communicated with cooling pipe (2) and the gas refrigeration device (3) of in cooling pipe (2) the conveying cold air of circulating.
2. the equipment that utilizes preparing dropping pill with air cooled according to claim 1 is characterized in that, described drop pill device (1) includes: the change batch can (4) that is connected with the pipeline (7) of feed liquid conveyer device; The water dropper (5) that is communicated with change batch can (4); Be arranged on the outside incubation cavity (6) that water dropper (5) is incubated of water dropper (5).
3. the equipment that utilizes preparing dropping pill with air cooled according to claim 2, it is characterized in that, described water dropper (5) is the funnel-shaped structure of upper and lower perforation, and has identical shaped 1～4 layer from outside to inside, every is fixedly connected by support (16) between two-layer.
4. according to claim 2 or the 3 described equipment that utilize preparing dropping pill with air cooled, it is characterized in that describedization batch can (4) is corresponding with water dropper (5), also be provided with 1～4, each changes the corresponding one deck that is communicated with water dropper (5) of batch can (4).
5. the equipment that utilizes preparing dropping pill with air cooled according to claim 2, it is characterized in that, described incubation cavity (6) skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity (6) corresponding to the following exit of water dropper (5), the width size of described openings of sizes and water dropper (5) is corresponding, and is tightly connected with the upper port of cooling pipe (2).
6. the equipment that utilizes preparing dropping pill with air cooled according to claim 1, it is characterized in that, the top of described incubation cavity (6) also is provided with vibrating device (8), and the top that described vibrating device (8) passes incubation cavity (6) links to each other with water dropper (5), is used for water dropper (5) is produced vibration.
7. the equipment that utilizes preparing dropping pill with air cooled according to claim 1, it is characterized in that, described cooling pipe (2) is the straight barrel type pipeline, the upper port of cooling pipe (2) is communicated with the opening sealing of incubation cavity (6) lower end of drop pill device (1), and the lower end of cooling pipe (2) is and the corresponding hatch frame of drop pill collecting vessel.
8. the equipment that utilizes preparing dropping pill with air cooled according to claim 1 is characterized in that, the outside of described cooling pipe (2) also is provided with heat-insulation layer.
9. the equipment that utilizes preparing dropping pill with air cooled according to claim 1, it is characterized in that, described gas refrigeration device (3) is the cold wind structure, include: inside is provided with the freezer (10) of compressor (9), the cold gas exhausting outlet of freezer (10) is connected with the upper and lower air inlet of cooling pipe (2) by lateral line (13), blast pipe (11) respectively, and the gas inflow entrance of freezer (10) is connected by the air outlet of backwind tube (12) with cooling pipe (2).
10. the equipment that utilizes preparing dropping pill with air cooled according to claim 9 is characterized in that, described blast pipe (11) is 0-90 ° with horizontal plane angle a.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200994845U CN201179196Y (en) | 2007-12-28 | 2007-12-28 | Apparatus for preparing dropping pills with cooling gas |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200994845U CN201179196Y (en) | 2007-12-28 | 2007-12-28 | Apparatus for preparing dropping pills with cooling gas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201179196Y true CN201179196Y (en) | 2009-01-14 |
Family
ID=40248698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007200994845U Expired - Lifetime CN201179196Y (en) | 2007-12-28 | 2007-12-28 | Apparatus for preparing dropping pills with cooling gas |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201179196Y (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279220B (en) * | 2007-12-28 | 2011-06-08 | 天津天士力制药股份有限公司 | Method for preparing dropping pill using cool air and equipment using the method |
-
2007
- 2007-12-28 CN CNU2007200994845U patent/CN201179196Y/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279220B (en) * | 2007-12-28 | 2011-06-08 | 天津天士力制药股份有限公司 | Method for preparing dropping pill using cool air and equipment using the method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yan Xijun Inventor after: Sun Xiaobing Inventor after: Zhang Wensheng Inventor after: rongchangsheng Inventor after: Wang Shiqing Inventor after: Zhang Shunnan Inventor after: Liu Jun Inventor before: Sun Xiaobing Inventor before: Zhang Wensheng Inventor before: rongchangsheng Inventor before: Wang Shiqing Inventor before: Zhang Shunnan Inventor before: Liu Jun |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20090109 Address after: Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 the modern Chinese medicine city, zip code: 300402 Patentee after: Tianjin Tianshili Pharmaceutical Co., Ltd. Address before: Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 the modern Chinese medicine city, zip code: 300402 Co-patentee before: Fatai(Tianjin) Technology Co., Ltd. Patentee before: Tianjin Tian Shi Li pharmaceutical Limited by Share Ltd |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SUN XIAOBING; ZHANG WENSHENG; RONG CHANGSHENG; WANG SHIQING; ZHANG SHUNNAN; LIU JUN TO: YAN XIJUN; SUN XIAOBING; ZHANG WENSHENG; RONG CHANGSHENG; WANG SHIQING; ZHANG SHUNNAN; LIU JUN |
|
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 city of the modern Chinese Medicine Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 city of the modern Chinese Medicine Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20090114 |
|
| CX01 | Expiry of patent term |