CN201154086Y - Equipment for preparing drop pills by using cooling air - Google Patents

Equipment for preparing drop pills by using cooling air Download PDF

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Publication number
CN201154086Y
CN201154086Y CNU2007200994826U CN200720099482U CN201154086Y CN 201154086 Y CN201154086 Y CN 201154086Y CN U2007200994826 U CNU2007200994826 U CN U2007200994826U CN 200720099482 U CN200720099482 U CN 200720099482U CN 201154086 Y CN201154086 Y CN 201154086Y
Authority
CN
China
Prior art keywords
equipment
drop pill
cooling pipe
coolant
cooling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNU2007200994826U
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Chinese (zh)
Inventor
孙小兵
张文生
荣昌盛
王世庆
章顺楠
刘军
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tasly Pharmaceutical Group Co Ltd
Original Assignee
FATAI(TIANJIN) TECHNOLOGY Co Ltd
Tianjin Tasly Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by FATAI(TIANJIN) TECHNOLOGY Co Ltd, Tianjin Tasly Pharmaceutical Co Ltd filed Critical FATAI(TIANJIN) TECHNOLOGY Co Ltd
Priority to CNU2007200994826U priority Critical patent/CN201154086Y/en
Application granted granted Critical
Publication of CN201154086Y publication Critical patent/CN201154086Y/en
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Expired - Lifetime legal-status Critical Current

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Abstract

The utility model discloses equipment for producing dropping pills by adopting cooling air, which comprises a dropping pill device, a cooling pipeline hermetically communicated with the dropping pill device, and a gas refrigerating device communicated with the pipeline and used for feeding cooling air circularly into the cooling pipeline. The dropping pill device comprises a homogenizing tank communicated with the pipeline of a liquid conveying device, a dripper communicated with the homogenizing tank, a heat-preservation cavity arranged outside the dripper and used for performing heat preservation for the dripper. The dripper adopts a funnel-shaped structure which interpenetrates vertically, and has one to four layers with identical shape from the external part to the internal part. One to four homogenizing tanks are also arranged. An opening is formed at the lower outlet of the heat-preservation cavity corresponding to the dripper, and the opening is hermetically connected with the upper port of the cooling pipeline. The cooling pipeline adopts a straight barrel-shaped pipeline. The cooling device comprises a cold air refrigerating device and a cold trap refrigerating device. The equipment has the advantages that the working operation is simplified, the residual organic solvent is fully prevented, and the manufacture cost of the dropping pills is reduced. The equipment has no cleaning dead angle, and is convenient to be cleaned, therefore, the cross contamination during the production process is avoided, and the equipment is favorable for the stabilization of the product.

Description

Adopt the cooling air to prepare the equipment of drop pill
Technical field
This utility model relates to a kind of pharmaceutical equipment.It is simple particularly to relate to a kind of preparation section, does not have organic residue problem, no cross-contamination hidden danger, and the employing of being convenient to clean cooling air prepares the equipment of drop pill.
Background technology
The preparation of tradition drop pill is to adopt will to melt material and drip to the not miscible liquid lyase of material and obtain, and cools off lyase and can be water-soluble solvent and oil-dissolving solvent.Wherein water-soluble solvent mostly is water, glycerol etc.; Oil-dissolving solvent mostly is paraffin oil and silicone oil.The drop pill that adopts the oil-dissolving solvent cooling to make, liquid coolant is residual to be unavoidable problem.Follow-uply get rid of oil, the operation of polishing is indispensable, but can not solve organic residue problem; Simultaneously, because the adhesion of liquid coolant such as silicone oil makes equipment can't obtain to clean fully, becoming the hidden danger of cross-contamination, is the problem that faces of GMP enterprise now.
Summary of the invention
Technical problem to be solved in the utility model is, provides a kind of preparation section simple, do not have organic residue problem, no cross-contamination hidden danger, and the employing of being convenient to clean cooling air prepares the equipment of drop pill.
The technical scheme that this utility model adopted is: a kind of equipment that adopts the cooling air to prepare drop pill, include: drop pill device, the cooling pipe that is communicated with drop pill device sealing, and be connected with cooling pipe and the gas in the cooling pipe is carried out refrigerating refrigerating plant.
Described drop pill device includes: the change batch can that is connected with the pipeline of feed liquid conveyer device; The water dropper that is communicated with the change batch can; Be arranged on the incubation cavity that the water dropper outside is incubated water dropper.
Described water dropper is the funnel-shaped structure of upper and lower perforation, and has identical shaped 1~4 layer from outside to inside, every is fixedly connected by support between two-layer; Describedization batch can is corresponding with water dropper, also is provided with 1~4, and each changes the corresponding one deck that is communicated with water dropper of batch can.
Described incubation cavity skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity corresponding to the following exit of water dropper, the width size of described openings of sizes and water dropper is corresponding, and is tightly connected with the upper port of cooling pipe.
Described cooling pipe is straight barrel type or spiral type pipe, and the opening sealing of the upper port of cooling pipe and the incubation cavity lower end of drop pill device is communicated with cooling pipe) the lower end be and the corresponding hatch frame of drop pill collecting vessel.
Described refrigerating plant includes: cold wind refrigerating plant and cold-trap refrigerating plant.
Described cold wind refrigerating plant includes: inside is provided with the freezer of refrigeration machine, and the cold wind outlet of freezer is connected with the cold wind air inlet of cooling pipe by blast pipe, and the cold wind of freezer is answered back and is connected with the air outlet of cooling pipe by backwind tube.
The cold wind air inlet of described cooling pipe and horizontal plane angle a are 0-90 °.
Described cold-trap refrigerating plant includes: the coolant storage tank of coolant is equipped with in inside; Coolant in the coolant storage tank is carried out refrigerating refrigeration machine and heat exchanger; Be connected with the refrigerant exit of coolant storage tank and coolant inlet respectively, the chuck of the coolant of portion's circulation within it; Described chuck closely is enclosed within the outside of cooling pipe; The bottom of described chuck is provided with the coolant inlet that is connected by pump with the refrigerant exit of coolant storage tank, and the top of described chuck is provided with the refrigerant exit that is connected with the coolant inlet of coolant storage tank.
The outside of described chuck also is provided with heat-insulation layer.
Employing cooling air of the present utility model prepares the equipment of drop pill, be to adopt the cooling air mode drop pill, can avoid the follow-up residual solvent of condenses modes such as traditional employing liquid paraffin and silicone oil to handle formality, as follow-up removing oil treatment step, simplified operation sequence, organic solvent-free is residual fully, and has reduced the cost of drop pill preparation.Refrigeration plant particularly of the present utility model adopts two cover refrigerating plants, can reach effectively the air in the cooling pipe is carried out refrigerating purpose.And cooling pipe adopts straight bobbin road design, do not have the cleaning dead angle, and it is convenient to clean, and is convenient to clearing out a gathering place of GMP enterprise, avoids the cross-contamination in the production process, is beneficial to the stable of product.
Description of drawings
Fig. 1 is the structural representation of this utility model equipment;
Fig. 2 is the structural representation of the water dropper in this utility model equipment.
Wherein:
1: drop pill device 2: cooling pipe
3: cooling air unit 4: the cold-trap device
5: water dropper 6: incubation cavity
7: pipeline 8: vibrating device
9: change batch can 10: the coolant storage tank
11: pump 12: refrigeration machine
13: freezer 14: refrigeration machine
15: chuck 16: the cold wind air inlet
17: cold wind outlet 18: the coolant inlet
19: refrigerant exit 20: cold wind is answered back
21: cold wind outlet 22: heat exchanger
23: refrigerant exit 24: the coolant inlet
25: support 26: skin
27: internal layer
The specific embodiment
Below in conjunction with drawings and Examples the equipment that employing cooling air of the present utility model prepares drop pill is made a detailed description.
This utility model is to adopt Cryogenic air as cooling medium, and typical temperature is lower than 0 degree, contacts with fused drop pill adjuvant, it is cooled to below the freezing point, to guarantee the ball molding.Usually drop pill is according to the gravity free-falling, and this utility model utilizes cold-trap in conjunction with cold wind, finishes thermal energy exchange with the whereabouts drop pill in cooling pipe, guarantees that drop pill is shaped.Described cooling air adopts clean the filtration, reaches the requirement of medicine neatness standard fully, needn't worry that medicine is contaminated, and simultaneously, pipeline is more easy to clean, does not have the dead angle of cleaning.
As shown in Figure 1, employing cooling air of the present utility model prepares the equipment of drop pill, include: drop pill device 1, the cooling pipe 2 that is communicated with drop pill device 1 sealing, and be connected with cooling pipe 2 and cooling pipe 2 interior gases are carried out refrigerating refrigerating plant.
Described drop pill device 1 includes: the change batch can 9 that is connected with the pipeline 7 of feed liquid conveyer device; The water dropper 5 that is communicated with change batch can 9; Be arranged on the incubation cavity 6 that water dropper 5 outsides are incubated water dropper 5.Wherein, described feed liquid conveyer device can adopt the air pressurized mode to pressurize to changing batch can 4 by pipeline 7, finish material from changing the transfer of batch can, also can adopt air pump to pass through pipeline 7, finish material from changing the transfer of batch can 4 to water dropper 5 to changing batch can 4 pressurizations to water dropper.
As shown in Figure 2, described water dropper 5 is the funnel-shaped structure of upper and lower perforation, and has identical shaped 1~4 layer from outside to inside, every is fixedly connected by supporting 25 between two-layer.Shown in the figure is 2 layers of structure that adopt skin 26 and internal layer 27.
Describedization batch can 9 adopts the tank body of prior art, possesses dog-house, stirring, air pressurized, feed liquid conveyance conduit connection water dropper.Change batch can 9 and adopt the oil bath mode of heating, temperature is controlled at 40-180 ℃, and temperature is even, and the outside has heat-insulation layer.And it is corresponding with water dropper 5 to change batch can 9, also is provided with 1~4, and each changes batch can 9 corresponding one decks that are communicated with water dropper 5.
Described incubation cavity 6 skins are heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity 6 corresponding to the following exit of water dropper 5, the width size of described openings of sizes and water dropper 5 is corresponding, and is tightly connected with the upper port of cooling pipe 2.
For under identical water dropper diameter, the drop pill that acquisition varies in size, the top of described incubation cavity 6 also is provided with vibrating device 8, and the top that described vibrating device 8 passes incubation cavity 6 links to each other with water dropper 5, is used for water dropper 5 is produced vibration.At different material, adopt different mode of vibration vibration water droppers 5, by the adjusting of different frequency of vibration, can obtain the drop pill of required size.Its mode of vibration can adopt:
The mode of electric vibrating has the high 2-2000Hz of frequency of vibration, the characteristics that amplitude is little, the high speed drop pill mode of suitable low-viscosity material.
The mode of pneumatic vibration, frequency of vibration 2-90Hz, amplitude is big.When the material viscosity surpasses 800cp, electronic mode can't effectively be cut material, causes water dropper to stop up, and when influencing drop pill and preparing, can adopt the pneumatic vibration mode.
Described cooling pipe 2 is straight barrel type or spiral type pipe, and about long 6m, the upper port of cooling pipe 2 is communicated with the opening sealing of incubation cavity 6 lower ends of drop pill device 1, and the lower end of cooling pipe 2 is and the corresponding hatch frame of drop pill collecting vessel.
Described refrigerating plant includes: cold wind refrigerating plant 3 and cold-trap refrigerating plant 4.
Described cold wind refrigerating plant 3 includes: inside is provided with the freezer 13 of refrigeration machine 14, prepares 3 of cold units in the freezer 10, is equipped with mutually.The cold wind outlet 21 of freezer 13 is connected with the cold wind air inlet 16 of cooling pipe 2 by blast pipe, and the cold wind of freezer 13 is answered back and 20 is connected with the air outlet 17 of cooling pipe 2 by backwind tube.The cold wind air inlet 16 and the horizontal plane angle a of described cooling pipe 2 are 0-90 °.
Cold air after refrigeration tangentially enters cooling pipe 2 through the bottom of cooling pipe 2, and its top of rising twist by the air outlet inflow backwind tube 12 on cooling pipe 2 tops, flows in the freezers 10 through backwind tube 12 again and carries out kind of refrigeration cycle.Circulation reaches directly the gas in the cooling pipe is carried out refrigerating purpose so repeatedly.
Described cold-trap refrigerating plant 4 includes: the coolant storage tank 10 of coolant is equipped with in inside; Coolant in the coolant storage tank 10 is carried out refrigerating refrigeration machine 12 by heat exchanger 22; Be connected with the refrigerant exit 23 of coolant storage tank 10 and coolant inlet 24 respectively, the chuck 15 of the coolant of portion's circulation within it; Described chuck 15 closely is enclosed within the outside of cooling pipe 2; The bottom of described chuck 15 is provided with the coolant inlet 18 that is connected by pump 11 with the refrigerant exit 23 of coolant storage tank 10, and the top of described chuck 15 is provided with coolant inlet 24 refrigerant exits that are connected 19 with coolant storage tank 10.The outside of described chuck 15 also is provided with heat-insulation layer.
Be provided with refrigeration unit in the cold-trap refrigerating plant.Refrigeration machine passes through heat exchanger, and with the coolant cooling, the coolant after the cooling is by pump, and the coolant inlet bottom the cooling tube chuck enters chuck, is full of chuck, thereby makes the cooling pipe internal cooling, and coolant passes through pipeline again from the chuck top then, gets back to the coolant storage tank.Promptly, the coolant of coolant storage tank flows in the chuck by the coolant inlet of pump from the chuck bottom from refrigerant exit, gas in the cooling pipe is carried out heat exchange, the refrigerant exit that coolant top and coolant storage tank the inlet of coolant after the heat exchange by chuck is connected flows back to the coolant storage tank, in the coolant storage tank, by heat exchanger coolant is carried out cold and hot exchange again, make the coolant cooling in the coolant storage tank.Circulation reaches indirectly the gas in the cooling pipe is carried out refrigerating purpose so repeatedly.
In this utility model, more than two kinds of refrigerating plants can use simultaneously, also can use separately.When wherein a kind of refrigerating plant needs repairing, can not influence the work of integral device.
Employing cooling air of the present utility model prepares the equipment of drop pill, can adopt online water purging system, directly carry out the water spray Cleaning for High Capacity from the top, after cleaning end, pigging (pig's head cleaning) system utilizes Compressed Gas promotion pig's head that pipeline is carried out wiped clean from top to bottom, after finishing, pig's head is got back to the cleaning station.By clean hot gas cooling tube is carried out drying, thus reach cleaning purpose.

Claims (10)

1. one kind is adopted the equipment that air prepares drop pill that cools off, it is characterized in that, include: drop pill device (1), the cooling pipe (2) that is communicated with drop pill device (1) sealing, and be connected with cooling pipe (2) and the interior gas of cooling pipe (2) is carried out refrigerating refrigerating plant.
2. employing cooling air according to claim 1 prepares the equipment of drop pill, it is characterized in that described drop pill device (1) includes: the change batch can (9) that is connected with the pipeline (7) of feed liquid conveyer device; The water dropper (5) that is communicated with change batch can (9); Be arranged on the outside incubation cavity (6) that water dropper (5) is incubated of water dropper (5).
3. employing cooling air according to claim 2 prepares the equipment of drop pill, it is characterized in that described water dropper
(5) be the funnel-shaped structure of upper and lower perforation, and have identical shaped 1~4 layer from outside to inside, every be fixedly connected by support (25) between two-layer; Describedization batch can (9) is corresponding with water dropper (5), also is provided with 1~4, and each changes the corresponding one deck that is communicated with water dropper (5) of batch can (9).
4. employing cooling air according to claim 2 prepares the equipment of drop pill, it is characterized in that, described incubation cavity (6) skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity (6) corresponding to the following exit of water dropper (5), the width size of described openings of sizes and water dropper (5) is corresponding, and is tightly connected with the upper port of cooling pipe (2).
5. employing cooling air according to claim 1 prepares the equipment of drop pill, it is characterized in that, described cooling pipe (2) is straight barrel type or spiral type pipe, the upper port of cooling pipe (2) is communicated with the opening sealing of incubation cavity (6) lower end of drop pill device (1), and the lower end of cooling pipe (2) is and the corresponding hatch frame of drop pill collecting vessel.
6. employing cooling air according to claim 1 prepares the equipment of drop pill, it is characterized in that described refrigerating plant includes: cold wind refrigerating plant (3) and cold-trap refrigerating plant (4).
7. the equipment that utilizes preparing dropping pill with air cooled according to claim 6, it is characterized in that, described cold wind refrigerating plant (3) includes: inside is provided with the freezer (13) of refrigeration machine (14), the cold wind outlet (21) of freezer (13) is connected with the cold wind air inlet (16) of cooling pipe (2) by blast pipe, the cold wind of freezer (13) answer back (20) be connected with the air outlet (17) of cooling pipe (2) by backwind tube.
8. the equipment that utilizes preparing dropping pill with air cooled according to claim 7 is characterized in that, the cold wind air inlet (16) of described cooling pipe (2) is 0-90 ° with horizontal plane angle a.
9. employing cooling air according to claim 6 prepares the equipment of drop pill, and it is characterized in that described cold-trap refrigerating plant (4) includes: the coolant storage tank (10) of coolant is equipped with in inside; Coolant in the coolant storage tank (10) is carried out refrigerating refrigeration machine (12) and heat exchanger (22); Be connected with the refrigerant exit (23) of coolant storage tank (10) and coolant inlet (24) respectively, the chuck (15) of the coolant of portion's circulation within it; Described chuck (15) closely is enclosed within the outside of cooling pipe (2); The bottom of described chuck (15) is provided with the coolant inlet (18) that is connected by pump (11) with the refrigerant exit (23) of coolant storage tank (10), and the top of described chuck (15) is provided with the refrigerant exit (19) that is connected with the coolant inlet (24) of coolant storage tank (10).
10. employing cooling air according to claim 9 prepares the equipment of drop pill, it is characterized in that the outside of described chuck (15) also is provided with heat-insulation layer.
CNU2007200994826U 2007-12-28 2007-12-28 Equipment for preparing drop pills by using cooling air Expired - Lifetime CN201154086Y (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNU2007200994826U CN201154086Y (en) 2007-12-28 2007-12-28 Equipment for preparing drop pills by using cooling air

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNU2007200994826U CN201154086Y (en) 2007-12-28 2007-12-28 Equipment for preparing drop pills by using cooling air

Publications (1)

Publication Number Publication Date
CN201154086Y true CN201154086Y (en) 2008-11-26

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101229099B (en) * 2007-12-28 2011-06-08 天津天士力制药股份有限公司 Equipment for preparing pill using cold wind and trap cooling gas
CN101491483B (en) * 2008-12-24 2011-12-28 烟台开发区博森制药机械有限公司 Step-by-step pressurization air-blasting fine drop-pills dripper
CN101518495B (en) * 2009-03-26 2011-12-28 天津大学 Vibration crushing type pill dropping machine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101229099B (en) * 2007-12-28 2011-06-08 天津天士力制药股份有限公司 Equipment for preparing pill using cold wind and trap cooling gas
CN101491483B (en) * 2008-12-24 2011-12-28 烟台开发区博森制药机械有限公司 Step-by-step pressurization air-blasting fine drop-pills dripper
CN101518495B (en) * 2009-03-26 2011-12-28 天津大学 Vibration crushing type pill dropping machine

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Legal Events

Date Code Title Description
C14 Grant of patent or utility model
GR01 Patent grant
C41 Transfer of patent application or patent right or utility model
C53 Correction of patent for invention or patent application
CB03 Change of inventor or designer information

Inventor after: Yan Xijun

Inventor after: Sun Xiaobing

Inventor after: Zhang Wensheng

Inventor after: rongchangsheng

Inventor after: Wang Shiqing

Inventor after: Zhang Shunnan

Inventor after: Liu Jun

Inventor before: Sun Xiaobing

Inventor before: Zhang Wensheng

Inventor before: rongchangsheng

Inventor before: Wang Shiqing

Inventor before: Zhang Shunnan

Inventor before: Liu Jun

TR01 Transfer of patent right

Effective date of registration: 20090116

Address after: Hedong District of Beichen Puji road in Tianjin No. 2 the modern Chinese medicine city, zip code: 300410

Patentee after: Tianjin Tianshili Pharmaceutical Co., Ltd.

Address before: Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 the modern Chinese medicine city, zip code: 300402

Co-patentee before: Fatai(Tianjin) Technology Co., Ltd.

Patentee before: Tianjin Tian Shi Li pharmaceutical Limited by Share Ltd

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: SUN XIAOBING; ZHANG WENSHENG; RONG CHANGSHENG; WANG SHIQING; ZHANG SHUNNAN; LIU JUN TO: YAN XIJUN; SUN XIAOBING; ZHANG WENSHENG; RONG CHANGSHENG; WANG SHIQING; ZHANG SHUNNAN; LIU JUN

C56 Change in the name or address of the patentee

Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD.

Free format text: FORMER NAME: TIANJIN TASLY PHARMACEUTICAL CO., LTD.

CP01 Change in the name or title of a patent holder

Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine

Patentee after: Tasly Pharmaceutical Group Co., Ltd.

Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine

Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd.

CX01 Expiry of patent term

Granted publication date: 20081126

CX01 Expiry of patent term