CN100574856C - Utilize the equipment of cold-trap preparing dropping pill with air cooled - Google Patents
Utilize the equipment of cold-trap preparing dropping pill with air cooled Download PDFInfo
- Publication number
- CN100574856C CN100574856C CN200710060642A CN200710060642A CN100574856C CN 100574856 C CN100574856 C CN 100574856C CN 200710060642 A CN200710060642 A CN 200710060642A CN 200710060642 A CN200710060642 A CN 200710060642A CN 100574856 C CN100574856 C CN 100574856C
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- Prior art keywords
- refrigerant
- cooling pipe
- water dropper
- trap
- cold
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- 239000006187 pill Substances 0.000 title claims abstract description 52
- 239000003507 refrigerant Substances 0.000 claims abstract description 74
- 238000001816 cooling Methods 0.000 claims abstract description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 238000003860 storage Methods 0.000 claims abstract description 24
- 238000011534 incubation Methods 0.000 claims abstract description 21
- 238000007789 sealing Methods 0.000 claims abstract description 8
- 238000005057 refrigeration Methods 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 abstract description 8
- 238000002360 preparation method Methods 0.000 abstract description 5
- 229920002545 silicone oil Polymers 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000013557 residual solvent Substances 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000012809 cooling fluid Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000003021 water soluble solvent Substances 0.000 description 2
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000000289 melt material Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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Abstract
Utilize the equipment of cold-trap preparing dropping pill with air cooled, include: dripping pill device, the cooling pipe that is communicated with dripping pill device sealing, and be connected with cooling pipe and circulate to the refrigerating plant of the outside of cooling pipe conveying refrigerant.The dripping pill device has interconnectiveization batch can, water dropper, and the incubation cavity of water dropper outside; The upper port of cooling pipe is communicated with the sealing of incubation cavity lower ending opening, and the lower end is corresponding with the dripping pill collecting vessel.Refrigerating plant has refrigerant storage tank and coupled refrigeration machine, and be connected with the refrigerant storage tank, the refrigerant of portion's circulation within it and closely be enclosed within the chuck in the cooling pipe outside.The present invention's cooling air mode dripping pill can avoid the follow-up residual solvent of condenses modes such as traditional employing atoleine and silicone oil to handle formality, has simplified operational sequence, and organic solvent-free is residual fully, and has reduced the cost of dripping pill preparation.Equipment adopts the design of straight bobbin road, does not have the cleaning dead angle, and it is convenient to clean, and avoids the cross pollution in the production process, is beneficial to the stable of product.
Description
Technical field
The present invention relates to a kind of pharmaceutical equipment.It is simple particularly to relate to a kind of preparation section, does not have organic residue problem, no cross pollution hidden danger, the equipment of being convenient to clean that utilizes the cold-trap preparing dropping pill with air cooled.
Background technology
The preparation of tradition dripping pill is to adopt will to melt material and drip to the not miscible liquid lyase of material and obtain, and refrigerant can be water-soluble solvent and oil-dissolving solvent.Wherein water-soluble solvent mostly is water, glycerine etc.; Oil-dissolving solvent mostly is paraffin oil and silicone oil.The dripping pill that adopts the oil-dissolving solvent cooling to make, cooling fluid is residual to be unavoidable problem.Follow-uply get rid of oil, the operation of polishing is indispensable, but can not solve organic residue problem; Simultaneously, because the adhesion of cooling fluid such as silicone oil makes equipment can't obtain to clean fully, becoming the hidden danger of cross pollution, is the problem that faces of GMP enterprise now.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of preparation section simple, do not have organic residue problem, no cross pollution hidden danger, the equipment of being convenient to clean that utilizes the cold-trap preparing dropping pill with air cooled.
The technical solution adopted in the present invention is: the equipment that utilizes the cold-trap preparing dropping pill with air cooled, it is characterized in that, include: dripping pill device, the cooling pipe that is communicated with dripping pill device sealing, and be connected with cooling pipe and circulate to the refrigerating plant of the outside of cooling pipe conveying refrigerant; Described dripping pill device includes: the change batch can that is connected with the pipeline of feed liquid conveying device; The water dropper that is communicated with the change batch can; Be arranged on the incubation cavity that the water dropper outside is incubated water dropper; Described water dropper is the funnel-shaped structure of upper and lower perforation, and has identical shaped 2～4 layers from outside to inside, every is fixedly connected by support between two-layer.
Describedization batch can and the interior corresponding setting of the number of plies of water dropper also are provided with 2～4, and each changes the corresponding one deck that is communicated with water dropper of batch can.
Described incubation cavity skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity corresponding to the following exit of water dropper, the width size of described openings of sizes and water dropper is corresponding, and is tightly connected with the upper port of cooling pipe.
The top of described incubation cavity also is provided with vibrating device, and the top that described vibrating device passes incubation cavity links to each other with water dropper, is used for water dropper is produced vibration.
Described cooling pipe is straight barrel type or spiral type pipe, and the upper port of cooling pipe is communicated with the opening sealing of the incubation cavity lower end of dripping pill device, and the lower end of cooling pipe is and the corresponding hatch frame of dripping pill collecting vessel.
Described refrigerating plant is the cold-trap structure, includes: the refrigerant storage tank of refrigerant is equipped with in inside; The refrigeration machine that refrigerant in the refrigerant storage tank is freezed; Be connected with the refrigerant exit of refrigerant storage tank and refrigerant inlet respectively, the chuck of the refrigerant of portion's circulation within it; Described chuck closely is enclosed within the outside of cooling pipe.
The bottom of described chuck is provided with the refrigerant inlet that is connected by pump with the refrigerant exit of refrigerant storage tank, and the top of described chuck is provided with the refrigerant exit that is connected with the refrigerant inlet of refrigerant storage tank.
The outside of described chuck also is provided with heat-insulation layer.
A kind of equipment that utilizes the cooling air to prepare dripping pill of the present invention, adopt the cooling air mode dripping pill, can avoid the follow-up residual solvent of condenses modes such as traditional employing atoleine and silicone oil to handle formality, as follow-up de-oiling treatment step, simplified operational sequence, organic solvent-free is residual fully, and has reduced the cost of dripping pill preparation.Equipment adopts the design of straight bobbin road, does not have the cleaning dead angle, and it is convenient to clean, and is convenient to clearing out a gathering place of GMP enterprise, avoids the cross pollution in the production process, is beneficial to the stable of product.
Description of drawings
Fig. 1 is the structural representation of present device;
Fig. 2 is the structural representation of the water dropper in the present device.
Wherein:
1: dripping pill device 2: cooling pipe
3: air cooling device 4: change batch can
5: water dropper 6: incubation cavity
7: pipeline 8: vibrating device
9: refrigeration machine 10: the refrigerant storage tank
11: pump 12: chuck
13: lateral line 14: skin
15: nexine 16: support
17: refrigerant exit 18: the refrigerant inlet
19: refrigerant inlet 20: refrigerant exit
21: heat exchanger
The specific embodiment
Below in conjunction with drawings and Examples the equipment of cold-trap preparing dropping pill with air cooled that utilizes of the present invention is made a detailed description.
Structure of the present invention is to adopt Cryogenic air as cooling medium, and typical temperature is lower than 0 degree, contacts with the dripping pill auxiliary material of fusion, it is cooled to below the freezing point, to guarantee the dripping pill moulding.
As shown in Figure 1, the equipment that utilizes the cold-trap preparing dropping pill with air cooled of the present invention, include: dripping pill device 1, the cooling pipe 2 that is communicated with dripping pill device 1 sealing, and be connected with cooling pipe 2 and circulate to the refrigerating plant 3 of the outside of cooling pipe 2 conveying refrigerant.
Described dripping pill device 1 includes: the change batch can 4 that is connected with the pipeline 7 of feed liquid conveying device; The water dropper 5 that is communicated with change batch can 4; Be arranged on the incubation cavity 6 that water dropper 5 outsides are incubated water dropper 5.Wherein, described feed liquid conveying device can adopt the air pressurized mode to pressurize to changing batch can 4 by pipeline 7, finish material from changing the transfer of batch can, also can adopt air pump to finish material from changing the transfer of batch can 4 to changing batch can 4 pressurizations to water dropper 5 by pipeline 7 to water dropper.
As shown in Figure 2, described water dropper 5 is the funnel-shaped structure of upper and lower perforation, and has identical shaped 1～4 layer from outside to inside, every is fixedly connected by supporting 16 between two-layer.Shown in the figure is 2 layers of structure that adopt skin 14 and nexine 15.
Describedization batch can 4 adopts the tank body of prior art, possesses dog-house, stirring, air pressurized, feed liquid conveyance conduit connection water dropper.Change batch can 4 and adopt the oil bath mode of heating, temperature is controlled at 40-180 ℃, and temperature is even, and the outside has heat-insulation layer.And it is corresponding with water dropper 5 to change batch can 4, also is provided with 1～4, and each changes batch can 4 corresponding one decks that are communicated with water dropper 5.
Described incubation cavity 6 skins are heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity 6 corresponding to the following exit of water dropper 5, the width size of described openings of sizes and water dropper 5 is corresponding, and is tightly connected with the upper port of cooling pipe 2.
For under identical water dropper diameter, the dripping pill that acquisition varies in size, the top of described incubation cavity 6 also is provided with vibrating device 8, and the top that described vibrating device 8 passes incubation cavity 6 links to each other with water dropper 5, is used for water dropper 5 is produced vibration.At different material, adopt different mode of vibration vibration water droppers 5, by the adjusting of different vibration frequencies, can obtain the dripping pill of required size.Its mode of vibration can adopt:
The mode of electric vibrating has the high 2-2000Hz of vibration frequency, the characteristics that amplitude is little, the high speed dripping pill mode of suitable low-viscosity material.
The mode of pneumatic vibration, vibration frequency 2-90Hz, amplitude is big.When the material viscosity surpasses 800cp, electronic mode can't effectively be cut material, causes water dropper to stop up, and when influencing dripping pill and preparing, can adopt the pneumatic vibration mode.
Described cooling pipe 2 is straight barrel type or spiral type pipe, and about long 6m, the upper port of cooling pipe 2 is communicated with the opening sealing of incubation cavity 6 lower ends of dripping pill device 1, and the lower end of cooling pipe 2 is and the corresponding hatch frame of dripping pill collecting vessel.
Described refrigerating plant 3 is the cold-trap structure, includes: the refrigerant storage tank 10 of refrigerant is equipped with in inside; The refrigeration machine 9 that refrigerants in the refrigerant storage tank 10 are freezed by heat exchanger 21; Be connected with the refrigerant exit 17 of refrigerant storage tank 10 and refrigerant inlet 18 respectively, the chuck 12 of the refrigerant of portion's circulation within it; Described chuck 12 closely is enclosed within the outside of cooling pipe 2.
The bottom of described chuck 12 is provided with the refrigerant inlet 19 that is connected by pump 11 with the refrigerant exit 17 of refrigerant storage tank 10, and the top of described chuck 12 is provided with refrigerant inlet 18 refrigerant exits that are connected 20 with refrigerant storage tank 10.The outside of described chuck 12 can also be provided with heat-insulation layer.
Be provided with 3 of refrigeration unit in the refrigerating plant 3, be equipped with mutually.Refrigeration machine is by heat exchanger, and with the refrigerant cooling, the refrigerant after the cooling is by pump 11, enter chuck from the refrigerant inlet of cooling tube chuck 12 bottoms, be full of chuck, thereby make the cooling pipe internal cooling, refrigerant passes through pipeline again from the chuck top then, gets back to the refrigerant storage tank.Promptly, the refrigerant of refrigerant storage tank 10 flows in the chuck 12 by the refrigerant inlet 19 of pump 11 from chuck 12 bottoms from refrigerant exit 17, gas in the cooling pipe 2 is carried out heat exchange, refrigerant after the heat exchange flows back to refrigerant storage tank 10 by refrigerant inlet 18 refrigerant exits that are connected 20 top and refrigerant storage tank 10 of chuck 12, in refrigerant storage tank 10, carry out cold and hot exchange by 21 pairs of refrigerants of heat exchanger again, make the refrigerant cooling in the refrigerant storage tank 10.Circulation so repeatedly reaches the purpose that the gas in the cooling pipe 2 is freezed.
Dripping pill is according to the gravity free-falling, and cold-trap carries out heat exchange by refrigerant in the chuck and the air in the cooling pipe, and the air in the cooling pipe is finished heat exchange with the whereabouts dripping pill again.Cooling air of the present invention adopts clean the filtration, reaches the requirement of medicine neatness standard fully, needn't worry that medicine is contaminated, and simultaneously, pipeline is more easy to clean, does not have the dead angle of cleaning.
The equipment that utilizes the cold-trap preparing dropping pill with air cooled of the present invention, can adopt online water purging system, directly carry out the water spray Cleaning for High Capacity from the top, after cleaning end, pigging (pig's head cleaning) system utilizes Compressed Gas promotion pig's head that pipeline is carried out wiped clean from top to bottom, after finishing, pig's head is got back to the cleaning station.By clean hot gas cooling tube is carried out drying, thus reach cleaning purpose.
Claims (8)
1. utilize the equipment of cold-trap preparing dropping pill with air cooled, it is characterized in that, include: dripping pill device (1), the cooling pipe (2) that is communicated with dripping pill device (1) sealing, and be connected with cooling pipe (2) and circulate to the refrigerating plant (3) of the outside of cooling pipe (2) conveying refrigerant;
Described dripping pill device (1) includes: the change batch can (4) that is connected with the pipeline (7) of feed liquid conveying device; The water dropper (5) that is communicated with change batch can (4); Be arranged on the outside incubation cavity (6) that water dropper (5) is incubated of water dropper (5);
Described water dropper (5) is the funnel-shaped structure of upper and lower perforation, and has identical shaped 2～4 layers from outside to inside, every is fixedly connected by support (16) between two-layer.
2. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 1 is characterized in that, describedization batch can (4) and the interior corresponding setting of the number of plies of water dropper (5) also are provided with 2～4, and each changes the corresponding one deck that is communicated with water dropper (5) of batch can (4).
3. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 1, it is characterized in that, described incubation cavity (6) skin is a heat-barrier material, internal layer is a kind of in steam heater or electric heater unit or the infrared heating device, be formed with opening at incubation cavity (6) corresponding to the following exit of water dropper (5), the width size of described openings of sizes and water dropper (5) is corresponding, and is tightly connected with the upper port of cooling pipe (2).
4. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 1, it is characterized in that, the top of described incubation cavity (6) also is provided with vibrating device (8), the top that described vibrating device (8) passes incubation cavity (6) links to each other with water dropper (5), is used for water dropper (5) is produced vibration.
5. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 1, it is characterized in that, described cooling pipe (2) is straight barrel type or spiral type pipe, the upper port of cooling pipe (2) is communicated with the opening sealing of incubation cavity (6) lower end of dripping pill device (1), and the lower end of cooling pipe (2) is and the corresponding hatch frame of dripping pill collecting vessel.
6. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 1 is characterized in that, described refrigerating plant (3) is the cold-trap structure, includes: the refrigerant storage tank (10) of refrigerant is equipped with in inside; The refrigeration machine (9) that refrigerant in the refrigerant storage tank (10) is freezed; Be connected with the refrigerant exit (17) of refrigerant storage tank (10) and refrigerant inlet (18) respectively, the chuck (12) of the refrigerant of portion's circulation within it; Described chuck (12) closely is enclosed within the outside of cooling pipe (2).
7. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 6, it is characterized in that, the bottom of described chuck (12) is provided with the refrigerant inlet (19) that is connected by pump (11) with the refrigerant exit (17) of refrigerant storage tank (10), and the top of described chuck (12) is provided with the refrigerant exit (20) that is connected with the refrigerant inlet (18) of refrigerant storage tank (10).
8. the equipment that utilizes the cold-trap preparing dropping pill with air cooled according to claim 6 is characterized in that, the outside of described chuck (12) also is provided with heat-insulation layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710060642A CN100574856C (en) | 2007-12-28 | 2007-12-28 | Utilize the equipment of cold-trap preparing dropping pill with air cooled |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710060642A CN100574856C (en) | 2007-12-28 | 2007-12-28 | Utilize the equipment of cold-trap preparing dropping pill with air cooled |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101279221A CN101279221A (en) | 2008-10-08 |
| CN100574856C true CN100574856C (en) | 2009-12-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710060642A Active CN100574856C (en) | 2007-12-28 | 2007-12-28 | Utilize the equipment of cold-trap preparing dropping pill with air cooled |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100574856C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574305B (en) * | 2009-06-12 | 2013-05-08 | 天津大学 | Vibration-crushing micro-pill machine |
| CN104274323B (en) * | 2013-07-11 | 2019-05-17 | 天士力医药集团股份有限公司 | Liquid cooling dripping pill production line |
| CN104274324B (en) * | 2013-07-11 | 2019-08-27 | 天士力医药集团股份有限公司 | Dripping pill air cooling production line |
| CN105268370A (en) * | 2015-11-27 | 2016-01-27 | 清远先导材料有限公司 | Fluidization device and fluidization technology |
| CN111545141A (en) * | 2020-05-08 | 2020-08-18 | 云南巴菰生物科技有限公司 | Hollow crystal ball particle microcapsule processing equipment |
-
2007
- 2007-12-28 CN CN200710060642A patent/CN100574856C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101279221A (en) | 2008-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20090109 Address after: Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 the modern Chinese medicine city post encoding: 300402 Applicant after: Tianjin Tianshili Pharmaceutical Co., Ltd. Address before: Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 the modern Chinese medicine city post encoding: 300402 Applicant before: Tianjin Tian Shi Li pharmaceutical Limited by Share Ltd Co-applicant before: Fatai(Tianjin) Technology Co., Ltd. |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TIANSHILI PHARMACEUTICAL CO., LTD. |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 city of the modern Chinese Medicine Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 city of the modern Chinese Medicine Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
| CP03 | Change of name, title or address |
Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin City, Beichen science and Technology Park Puji Hedong Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |