CN110523342A - Chinese medicinal granule production equipment and method - Google Patents
Chinese medicinal granule production equipment and method Download PDFInfo
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- CN110523342A CN110523342A CN201910940552.3A CN201910940552A CN110523342A CN 110523342 A CN110523342 A CN 110523342A CN 201910940552 A CN201910940552 A CN 201910940552A CN 110523342 A CN110523342 A CN 110523342A
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- storage tank
- clear cream
- extractor
- chinese medicinal
- medicinal granule
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 54
- 239000008187 granular material Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title abstract description 14
- 238000003860 storage Methods 0.000 claims abstract description 79
- 239000007788 liquid Substances 0.000 claims abstract description 75
- 239000006071 cream Substances 0.000 claims abstract description 73
- 238000001816 cooling Methods 0.000 claims abstract description 60
- 238000000605 extraction Methods 0.000 claims abstract description 44
- 239000000463 material Substances 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims description 43
- 238000010438 heat treatment Methods 0.000 claims description 14
- 239000012809 cooling fluid Substances 0.000 claims description 7
- 238000001694 spray drying Methods 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims 1
- 230000008542 thermal sensitivity Effects 0.000 abstract description 21
- 239000000126 substance Substances 0.000 abstract description 5
- 239000000498 cooling water Substances 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 239000002826 coolant Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 2
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 2
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 235000001368 chlorogenic acid Nutrition 0.000 description 2
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 2
- 229940074393 chlorogenic acid Drugs 0.000 description 2
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 2
- 239000000112 cooling gas Substances 0.000 description 2
- 235000001785 ferulic acid Nutrition 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 2
- 229940114124 ferulic acid Drugs 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0207—Control systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/028—Flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0292—Treatment of the solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Automation & Control Theory (AREA)
- Extraction Or Liquid Replacement (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of Chinese medicinal granule production equipment and methods, wherein, the Chinese medicinal granule production equipment includes the extractor being sequentially communicated, extracts liquid storage tank, inspissator and clear cream storage tank, the extractor and/or the extraction liquid storage tank are equipped with the first cooler, and first cooler is for cooling down the intracorporal material of corresponding tank.Chinese medicinal granule production equipment of the invention can be perfectly suitable for the production of the Chinese medicinal granule of the chemical component containing thermal sensitivity, and the effective component especially thermal sensitivity effective component that can be effectively reduced in production process is decomposed, to guarantee product quality.
Description
Technical field
The present invention relates to Chinese medicinal granule production technical fields, more particularly to a kind of Chinese medicinal granule production equipment
And method.
Background technique
In recent years, most of producers are usually carried out using multi-function extractor in Chinese medicinal granule production process
Heating extraction is put into extraction liquid storage tank and temporarily stores, then is concentrated by inspissator, the clear cream after concentration after extracting solution filtering
It is put into clear cream storage tank temporarily to store, then is spray-dried.Traditional Chinese medicinal granule production equipment can not be applicable in well
In the production of the Chinese medicinal granule of the chemical component containing thermal sensitivity, it is special that effective component in Chinese medicine extract is easily led in process of production
It is the content reduction of thermal sensitivity effective component (such as: chlorogenic acid, tanshin polyphenolic acid B, ferulic acid ingredient), and does not can guarantee product matter
Amount.
Summary of the invention
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of Chinese medicinal granule production equipment and method, the Chinese medicine are matched
Square particle manufacture equipment can be perfectly suitable for the production of the Chinese medicinal granule of the chemical component containing thermal sensitivity, and life can be effectively reduced
The loss of thermal sensitivity effective component during production, to guarantee product quality.
A kind of Chinese medicinal granule production equipment, including extractor, extraction liquid storage tank, inspissator and the clear cream being sequentially communicated
Storage tank, the extractor and/or the extraction liquid storage tank are equipped with the first cooler, and first cooler is used for corresponding tank
Intracorporal material cools down.
Above-mentioned Chinese medicinal granule production equipment is cooling by being provided with first on extractor and/or extraction liquid storage tank
Device can cool down the extracting solution in extractor and/or extraction liquid storage tank by the first cooler after the completion of heating extraction
Cooling, so avoidable extracting solution store always at relatively high temperatures, so as to effectively reduce the spy of the effective component in extracting solution
It is not that thermal sensitivity effective component is decomposed.Chinese medicinal granule production equipment of the invention can be perfectly suitable for containing thermal sensitivity chemistry
The loss of thermal sensitivity effective component in production process can be effectively reduced in the production of the Chinese medicinal granule of ingredient, to guarantee product
Quality.
First cooler also is provided on the clear cream storage tank in one of the embodiments,.
It is all provided on the extractor, the extraction liquid storage tank and the clear cream storage tank in one of the embodiments,
The first cooler is stated, first cooler is to be respectively coated by store up in the extractor, the extraction liquid storage tank and the clear cream
The cooling sandwith layer of tank periphery is respectively formed with the cooling channel for cooling fluid circulation in each cooling sandwith layer.
Pass through between the liquid outlet of the extractor and the inlet for extracting liquid storage tank in one of the embodiments,
The connection of extracting solution pipeline, is connected between the liquid outlet of the inspissator and the inlet of the clear cream storage tank by clear cream pipeline,
The extracting solution pipeline and/or the clear cream pipeline are equipped with the second cooler, and second cooler is used for corresponding pipe
Material in road cools down.
Second cooling is equipped on the extracting solution pipeline and the clear cream pipeline in one of the embodiments,
Device, second cooler are to be respectively coated by the cooling sandwith layer of the extracting solution pipeline and the clear cream pipeline periphery, each institute
State the cooling channel being respectively formed in cooling sandwith layer for cooling fluid circulation.
The Chinese medicinal granule production equipment further includes first for storing cold cut matchmaker in one of the embodiments,
Solvent tank, the first solvent tank are connected with the inlet of each cooling channel respectively by conveyance conduit, with to each institute
It states and conveys cold cut matchmaker in cooling channel.
The conveyance conduit includes the conveying being connected to the liquid outlet of the first solvent tank in one of the embodiments,
General pipeline and the multiple delivery branch pipes for being connected to the delivery main with the inlet of each cooling channel respectively, Mei Yisuo
It states and is equipped with flow control valve in delivery branch pipe.
The Chinese medicinal granule production equipment further includes the second solvent tank in one of the embodiments, each described cold
But the liquid outlet of access is connected with the second solvent tank, and the periphery of the second solvent tank is equipped with double-jacket, described to mention
The steam (vapor) outlet of tank and/or the inspissator and the inner cavity of the double-jacket is taken to be connected, the second solvent tank goes out liquid
Mouth is connected with the inlet of the extractor.
Pass through between the liquid outlet of the second solvent tank and the inlet of the extractor in one of the embodiments,
The connection of solvent pipeline, the solvent pipeline are equipped with flowmeter, and the flowmeter is used for being added to molten in the extractor
Matchmaker measures.
A kind of Chinese medicinal granule production method, comprising the following steps:
Heating extraction is carried out to raw material by extractor；
After the completion of extraction, the thermal extraction liquid in the extractor is cooled down；
Extracting solution in the extractor is delivered to extract in liquid storage tank and is kept in, and in the extractor storage tank
Extracting solution cool down；
Extracting solution in the extraction liquid storage tank is delivered in inspissator and carries out heating concentration；
The clear cream generated after concentration is delivered in clear cream storage tank and is kept in, and to the clear cream in the clear cream storage tank into
Row cools；
The clear cream extracted in the clear cream storage tank carries out spray drying treatment.
Detailed description of the invention
Fig. 1 is the schematic diagram of Chinese medicinal granule production equipment described in one embodiment of the invention；
Fig. 2 is the flow chart of Chinese medicinal granule production method described in one embodiment of the invention.
11, extractor, 12, extraction liquid storage tank, 13, inspissator, 14, clear cream storage tank, the 15, first cooler, 16, extracting solution
Pipeline, 17, clear cream pipeline, the 18, second cooler, the 19, first solvent tank, 20, delivery main, 21, delivery branch pipe, 22, flow
Control valve, the 23, second solvent tank, 24, double-jacket, 25, solvent pipeline, 26, flowmeter.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give better embodiment of the invention.But the present invention can be realized by different forms, however it is not limited to this paper institute
The embodiment of description.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure
It is thorough and comprehensive.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.On the contrary, when element is referred to as " directly existing " another element "upper",
There is no intermediary elements.Heretofore described " first ", " second " do not represent specific quantity and sequence, are only used for title
Differentiation.
Please refer to Fig. 1, a kind of Chinese medicinal granule production equipment, including extractor 11, the extraction liquid storage tank being sequentially communicated
12, inspissator 13 and clear cream storage tank 14, extractor 11 and/or extraction liquid storage tank 12 are equipped with the first cooler 15, and first is cooling
Device 15 is for cooling down the intracorporal material of corresponding tank.
When being produced using above-mentioned Chinese medicine preparation particle manufacture equipment, first passes through the progress of extractor 11 heating extraction and obtain
The extracting solution of heat, then extracting solution is delivered to extract in liquid storage tank 12 and is temporarily stored, then it will extract in liquid storage tank 12
Extracting solution is pumped to clear cream is concentrated to give in inspissator 13, and clear cream is delivered in clear cream storage tank 14 and is temporarily stored,
Clear cream can finally be carried out to spray drying treatment to obtain Chinese medicinal granule.By the first cooler 15 to extractor 11 and/
Or the extracting solution extracted in liquid storage tank 12 carries out cooling processing, can avoid because the reasons such as drawing liquid duration cannot be in time by extracting solution
It is concentrated, and leads to the loss of thermal sensitivity effective component in extracting solution.Wherein, the first cooler 15 specifically can be used liquid cooling,
Air-cooled or other types of cooling cool down the intracorporal extracting solution of corresponding tank, are not specifically limited herein.Preferably, it mentions
It takes tank 11 and extracts and be equipped with the first cooler 15 on liquid storage tank 12, it, can be cooling by first after completing heating extraction step
Device 15 tentatively cools down to the extracting solution in extractor 11, can be by the after extracting solution, which is delivered to, to be extracted in liquid storage tank 12
The extracting solution that one 15 pairs of cooler extracts in liquid storage tank 12 is cooled again, in this way, extracting solution can be greatly reduced
Temperature, be further reduced the loss of thermal sensitivity effective component (such as: chlorogenic acid, tanshin polyphenolic acid B, ferulic acid ingredient).
Above-mentioned Chinese medicinal granule production equipment is by being provided with first on extractor 11 and/or extraction liquid storage tank 12
Cooler 15 to extractor 11 and/or can extract mentioning in liquid storage tank 12 by the first cooler 15 after the completion of heating extraction
Liquid is taken to cool down, so avoidable extracting solution stores always at relatively high temperatures, so as to effectively reduce in extracting solution
Effective component especially thermal sensitivity effective component decompose.Chinese medicinal granule production equipment of the invention can be perfectly suitable for
The production of the Chinese medicinal granule of the chemical component containing thermal sensitivity, can be effectively reduced the damage of thermal sensitivity effective component in production process
It loses, to guarantee product quality.
In addition, in the actual operation process, due to waiting expecting etc. clear cream, thus cannot be by the clear cream in clear cream storage tank 14
It is spray-dried in time, in order to reduce the loss of the thermal sensitivity effective component in clear cream.Further, on clear cream storage tank 14
Equipped with the first cooler 15.By the first cooler 15 for being arranged on clear cream storage tank 14 can to the clear cream in clear cream storage tank 14 into
Row cools.
Preferably, as shown in Figure 1, being equipped with the first cooler on extractor 11, extraction liquid storage tank 12 and clear cream storage tank 14
15, the first cooler 15 is to be respectively coated by the cooling sandwith layer of 14 periphery of extractor 11, extraction liquid storage tank 12 and clear cream storage tank, respectively
The cooling channel for cooling fluid circulation is respectively formed in cooling sandwith layer.Specifically, the cooling fluid in cooling sandwith layer can be
The flowable medias such as coolant liquid or cooling gas, are preferably cooled down using cooling water as coolant liquid, are guaranteeing cooling effect
While can effectively reduce production cost.For example, cooling water can be passed through into each cooling sandwith layer, cooling water is during flowing
Heat exchange is carried out with the material in extractor 11, extraction liquid storage tank 12 and clear cream storage tank 14, so as to take away most of heat, is risen
To the effect of cooling.
Further, connected between the liquid outlet of extractor 11 and the inlet for extracting liquid storage tank 12 by extracting solution pipeline 16
It is logical, be connected between the liquid outlet and the inlet of clear cream storage tank 14 of inspissator 13 by clear cream pipeline 17, extracting solution pipeline 16 with/
Or clear cream pipeline 17 is equipped with the second cooler 18, the second cooler 18 is used to carry out the material in corresponding pipeline cooling drop
Temperature.The extracting solution in transmission process, clear cream are carried out continuing to cool by the second cooler 18, temperature-sensitive can be further decreased
The loss of property effective component.Liquid cooling specifically can be used in second cooler 18, air-cooled or other types of cooling cool down.
In one embodiment, the second cooler 18, the second cooler are equipped on extracting solution pipeline 16 and clear cream pipeline 17
18 be to be respectively coated by the cooling sandwith layer peripheral in extracting solution pipeline 16 and clear cream pipeline 17, and being respectively formed in each cooling sandwith layer can
For the cooling channel of cooling fluid circulation.Specifically, the cooling fluid in cooling sandwith layer can be that coolant liquid or cooling gas etc. can
Flow media is preferably cooled down using cooling water as coolant liquid, can effectively reduce production while guaranteeing cooling effect
Cost.For example, cooling water can be passed through into each cooling sandwith layer, cooling water during flowing with extracting solution pipeline 16 and clear cream
Material in pipeline 17 carries out heat exchange to be played the role of cooling so as to take away most of heat.
Further, Chinese medicinal granule production equipment further includes the first solvent tank 19 for storing cold cut matchmaker, and first
Solvent tank 19 is connected with the inlet of each cooling channel respectively by conveyance conduit, to convey cold cut into each cooling channel
Matchmaker.For example, as shown in Figure 1, outside extractor 11, extraction liquid storage tank 12, clear cream storage tank 14, extracting solution pipeline 16 and clear cream pipeline 17
It encloses and is respectively equipped with cooling sandwith layer, be stored in the first solvent tank 19 cold cut matchmaker (such as cooling water), when process to be extracted is completed, passed through
Cooling water is passed through in the cooling sandwith layer of extractor 11, extracting solution pipeline 16 and extraction liquid storage tank 12 by the first solvent tank 19, is passed through
Cooling water tentatively cools to the thermal extraction liquid in extractor 11, and extracting solution is extracted via extracting solution pipeline 16 to extraction
Continue to cool during liquid storage tank 12, cooling drop can be carried out again by being stored in the extracting solution extracted in liquid storage tank 12
Temperature improves product quality in this way, can farthest reduce the loss of thermal sensitivity effective component by multiple cooling effect.
Further, conveyance conduit includes the delivery main 20 being connected to the liquid outlet of the first solvent tank 19 and will be defeated
The multiple delivery branch pipes 21 for sending general pipeline 20 to be connected to respectively with the inlet of each cooling channel are equipped with stream in each delivery branch pipe 21
Control valve 22.The flow velocity of coolant liquid can be controlled by flow control valve 22, thus reach different cooling effects, with
Reduce the loss of thermal sensitivity effective component.
Please continue to refer to Fig. 1, further, Chinese medicinal granule production equipment further includes the second solvent tank 23, each cooling
The liquid outlet of access is connected with the second solvent tank 23, and the periphery of the second solvent tank 23 is equipped with double-jacket 24, extractor 11 and/
Or the steam (vapor) outlet of inspissator 13 is connected with the inner cavity of double-jacket 24, liquid outlet and the extractor 11 of the second solvent tank 23
Inlet is connected.
Specifically, as shown in Figure 1, extractor 11, extracting solution pipeline 16, extraction liquid storage tank 12, clear cream pipeline 17 and clear cream
Cooling sandwith layer is equipped on storage tank 14.After the completion of extraction, the cold cut matchmaker in the first solvent tank 19 is successively delivered to each cooling folder
To cool down processing in layer, the solvent in each cooling sandwith layer is collected in the second solvent tank 23 after completing heat exchange, so
The solvent in second solvent tank 23 is carried out into one by double-jacket 24 in the high-temperature steam for extracting, being generated in concentration process afterwards
Step heating, the thermosol matchmaker after heating be delivered to can be used as in extractor 11 the extraction solvent of the Chinese medicinal granule of next tank time into
Row utilizes again, to realize to the abundant effective of the solvent in the thermal energy and the first solvent tank 19 in extraction, concentration process
It utilizing, real-time is good, and it is with strong points, thermal sensitivity chemical composition of Chinese materia medica heating heated time in extractor 11 can be reduced, further
Reduce the loss of thermal sensitivity effective component.In the present embodiment, by carrying out one in turnover storing process to extracting solution, clear cream
The processing that cools of series, and the thermal energy for making full use of extraction, generating in concentration process, can farthest retain Chinese medicine
Thermal sensitivity effective component, guarantee product quality and economic indicator, improve extraction efficiency, reduce production cost and energy consumption, ensure
Each process equipment and pipeline meet the online site requirement of GMP.
In addition, be connected between the liquid outlet of the second solvent tank 23 and the inlet of extractor 11 by solvent pipeline 25, it is molten
Matchmaker's pipeline 25 is equipped with flowmeter 26, and flowmeter 26 is used to measure addition to the solvent in extractor 11.Optionally, it flows
Meter 26 uses electromagnetic flowmeter 26, measures more accurate.
Incorporated by reference to Fig. 1 and Fig. 2, the present invention also proposes a kind of Chinese medicinal granule production method, and the Chinese medicinal granule is raw
Production method the following steps are included:
S1: heating extraction is carried out to raw material by extractor 11；
S2: after the completion of extraction, the thermal extraction liquid in extractor 11 is cooled down；
S3: the extracting solution in extractor 11 is delivered to extract in liquid storage tank 12 and is kept in, and to 11 storage tank of extractor
Interior extracting solution cools down；
S4: the extracting solution extracted in liquid storage tank 12 is delivered in inspissator 13 and carries out heating concentration；
S5: the clear cream generated after concentration being delivered in clear cream storage tank 14 and is kept in, and to clear in clear cream storage tank 14
Cream cools down；
S6: the clear cream extracted in clear cream storage tank 14 carries out spray drying treatment.
When carrying out Chinese medicinal granule production using above-mentioned Chinese medicinal granule production method, by extractor 11 and
The extracting solution extracted in liquid storage tank 12 cools down, and cools down to the clear cream in clear cream storage tank 14, can avoid
Extracting solution and clear cream store always at relatively high temperatures, are especially so as to effectively reduce the effective component in extracting solution and clear cream
Thermal sensitivity effective component is decomposed, to guarantee product quality.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of Chinese medicinal granule production equipment, which is characterized in that including be sequentially communicated extractor, extract liquid storage tank, dense
Contracting device and clear cream storage tank, the extractor and/or the extraction liquid storage tank are equipped with the first cooler, and first cooler is used
It is cooled down in the intracorporal material of corresponding tank.
2. Chinese medicinal granule production equipment according to claim 1, which is characterized in that also be provided on the clear cream storage tank
First cooler.
3. Chinese medicinal granule production equipment according to claim 2, which is characterized in that the extractor, the extraction
First cooler is equipped on liquid storage tank and the clear cream storage tank, first cooler is to be respectively coated by the extraction
Tank, the cooling sandwith layer for extracting liquid storage tank and the clear cream storage tank periphery are respectively formed with cooling supply in each cooling sandwith layer
But the cooling channel of fluid circulation.
4. Chinese medicinal granule production equipment according to claim 1, which is characterized in that the liquid outlet of the extractor with
It is connected between the inlet for extracting liquid storage tank by extracting solution pipeline, the liquid outlet of the inspissator and the clear cream storage tank
Inlet between be connected to by clear cream pipeline, the extracting solution pipeline and/or the clear cream pipeline are equipped with the second cooler,
Second cooler is for cooling down the material in corresponding pipeline.
5. Chinese medicinal granule production equipment according to claim 4, which is characterized in that the extracting solution pipeline and described
It is equipped with second cooler on clear cream pipeline, second cooler is to be respectively coated by the extracting solution pipeline and described
The cooling sandwith layer of clear cream pipeline periphery is respectively formed with the cooling channel for cooling fluid circulation in each cooling sandwith layer.
6. the Chinese medicinal granule production equipment according to claim 3 or 5, which is characterized in that the Chinese medicinal granule
Production equipment further includes the first solvent tank for storing cold cut matchmaker, the first solvent tank by conveyance conduit respectively with each institute
The inlet for stating cooling channel is connected, to convey cold cut matchmaker into each cooling channel.
7. Chinese medicinal granule production equipment according to claim 6, which is characterized in that the conveyance conduit includes and institute
State the liquid outlet connection of the first solvent tank delivery main and by the delivery main respectively with each cooling channel into
Multiple delivery branch pipes of liquid mouth connection, are equipped with flow control valve in each delivery branch pipe.
8. Chinese medicinal granule production equipment according to claim 6, which is characterized in that the Chinese medicinal granule production
Equipment further includes the second solvent tank, and the liquid outlet of each cooling channel is connected with the second solvent tank, and described second is molten
The periphery of matchmaker's tank is equipped with double-jacket, and the steam (vapor) outlet of the extractor and/or the inspissator is interior with the double-jacket
Chamber is connected, and the liquid outlet of the second solvent tank is connected with the inlet of the extractor.
9. Chinese medicinal granule production equipment according to claim 8, which is characterized in that the second solvent tank goes out liquid
Mouth is connected to between the inlet of the extractor by solvent pipeline, and the solvent pipeline is equipped with flowmeter, the flow
Meter is for measuring addition to the solvent in the extractor.
10. a kind of Chinese medicinal granule production method, which comprises the following steps:
Heating extraction is carried out to raw material by extractor；
After the completion of extraction, the thermal extraction liquid in the extractor is cooled down；
Extracting solution in the extractor is delivered to extract in liquid storage tank and is kept in, and to mentioning in the extractor storage tank
Liquid is taken to cool down；
Extracting solution in the extraction liquid storage tank is delivered in inspissator and carries out heating concentration；
The clear cream generated after concentration is delivered in clear cream storage tank and is kept in, and the clear cream in the clear cream storage tank is carried out cold
But cool down；
The clear cream extracted in the clear cream storage tank carries out spray drying treatment.
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| CN114210090A (en) * | 2021-11-03 | 2022-03-22 | 重庆化工职业学院 | Traditional chinese medicine draws concentrated experiment teaching equipment |
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