CN201061675Y - Percutaneous drug administration device - Google Patents
Percutaneous drug administration device Download PDFInfo
- Publication number
- CN201061675Y CN201061675Y CNU2007201435735U CN200720143573U CN201061675Y CN 201061675 Y CN201061675 Y CN 201061675Y CN U2007201435735 U CNU2007201435735 U CN U2007201435735U CN 200720143573 U CN200720143573 U CN 200720143573U CN 201061675 Y CN201061675 Y CN 201061675Y
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- cavity
- central chamber
- face
- negative pressure
- dividing plate
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Abstract
The utility model discloses a percutaneous drug delivery device, comprising an application tray (1) which is pasted on the skin, and a wad (2) which is arranged on the lower portion of the application tray (1). The upper portion of the application tray (1) is a top surface (3), an external loop cavity (4) and a central cavity (5) which are provided with downward openings are arranged below the top surface (3), a ring-shaped sidewall (6) is arranged between the external loop cavity (4) and the central cavity (5), the external loop cavity (4) is communicated with a negative pressure source by a negative pressure passage (7) which is arranged on the top surface (3), the wad (2) is arranged inside the central cavity (5), the external loop cavity (4) is divided into upper and lower cavities by an aeration barricade (8), the upper cavity is communicated with the negative pressure source by the negative pressure passage (7), and the lower cavity is provided with a downward opening. At the time of treating with medications, the utility model enlarges the motivation of percutaneous drug-ingress, and the human skin surface forms a tight seal.
Description
Technical field:
This utility model relates to a kind of medical apparatus and instruments, particularly a kind of transdermal delivery device.
Background technology:
Percutaneous has only function fixing, that cover medicine and promote drug osmotic to device.On March 20th, 1994, the Chinese utility model patent CN2159790Y of bulletin disclosed a kind of " the medical medicinal cupping that puts a chimney on the stove and make the fire draw ".In the conventional cylinder cupping jar, set up a concentric cylinder tank body.During use between two cylinders annular chamber form negative pressure by common method, the skin at adsorbing therapy position is located the medicine that is built in the middle calamity chamber that inner cylinder encloses, simultaneously, medicine under the attraction of annular chamber negative pressure, has increased the power of infiltration around.Annular chamber is raised skin under the effect of negative pressure, the time slightly length the blood capillary of skin is ruptured.That skin takes place is congested, break, even gets blister, and traditional cupping therapy is to reach therapeutical effect to the destruction of skin like this.So the treatment time of traditional cupping therapy generally was controlled in 8-10 minute, and two treatments takes between the time at interval more than 1 day at least, can not treat continuously every day.So the adsorption method of above-mentioned cupping jar-type can produce bigger negative pressure, and sealing is tight, but causes the infringement to skin easily, is not suitable for the long-time percutaneous dosing mode of using on skin that needs.It applies ointment or plaster the Chinese utility model patent CN1130237C institute public outer " transdermal medication apparatus " of December in 2003 bulletin on the 14th and coils by end face and inner ring, fixed the forming of outer ring twice annular sidewall.The annular chamber that multiplies each other between Internal and external cycle and the end face communicates with negative pressure source by the passway.During use, annular chamber adsorbs skin under the effect of negative pressure and raises, because the height of annular sidewall is low, skin is lifted to a certain degree and will contacts with end face, and when negative pressure continued to raise, skin can not continue to raise, and has stoped skin damage thus.But the skin of raising also can the passage mouth, make that the suffered negative pressure of skin is not high, that is the suffered negative pressure of skin is lower than the pressure of negative pressure source.Annular chamber is raised skin under the effect of negative pressure, the feasible medicine that is positioned at the central chamber of inner ring and end face formation is sealed, central chamber temperature under the heating of heating raises, and pressure increases, and medicine is under the attraction of the promotion of central chamber normal pressure and annular chamber negative pressure on every side.Can quicken transdermal and enter performance therapeutical effect in the skin.When central chamber produces normal pressure.The end face of intracavity can be subjected to outside thrust, and annular chamber is subjected to being affixed to the suction of skin at its end face of effect of negative pressure.The sealing of annular chamber imposes on the thrust of inner ring and outer ring twice annular sidewall and realizes that thrust is big more by end face, seals tight more.But because the thrust that makes progress that the central chamber normal pressure produces has been offset the part suction that is produced by annular chamber, make the thrust that acts on the annular sidewall reduce to skin, and when annular chamber actual negative pressure is less, will reduce the sealing of the dish of applying ointment or plaster, the dish that causes easily applying ointment or plaster comes off, and influences normally carrying out of operating process.
The utility model content:
The purpose of this utility model provides a kind of transdermal delivery device, make it when cooperating Drug therapy, when increasing transdermal administration power, not only can form tight sealing at skin surface, and the infringement that can effectively avoid long negative-pressure adsorption that skin is caused, outer ring cavity is separated into two cavitys up and down by a ventilative dividing plate; Solved the long negative-pressure adsorption of existing transdermal delivery device to the hurtful technical deficiency of skin;
Also provide and establish one on a kind of end face above central chamber from the transdermal delivery device of atmospheric environment through the air supply passage mouth of the inside QI invigorating of check valve; A kind of transdermal delivery device of establishing a malleation passway that communicates with positive pressure source also is provided; Solve existing central chamber and in therapeutic process, can not keep needed certain normal pressure, the technical deficiency of percutaneous dosing poor effect;
A kind of transdermal delivery device that is provided with a secondary cavity that communicates with it between central chamber and end face also is provided; The medicinal liquid that has solved in the existing medicated cushion is adsorbed to passway and the interior technical deficiency of pressure source.
For realizing that the technical scheme that this utility model purpose is taked is:
A kind of transdermal delivery device, comprise the dish of applying ointment or plaster that posts on skin, with the medicated cushion of being located at the dish bottom of applying ointment or plaster, apply ointment or plaster the dish top be end face, below end face, be provided with outer ring cavity and the central chamber that Open Side Down, it between outer ring cavity and the central chamber annular sidewall, outer ring cavity communicates with negative pressure source by the negative pressure channel mouth in the end face, medicated cushion places in the central chamber, it is characterized in that: described outer ring cavity is separated into two cavitys up and down by a ventilative dividing plate, wherein epicoele communicates with negative pressure source through described negative pressure channel mouth, and cavity of resorption is under shed.
Described ventilative dividing plate is made of gas permeable material, and ringwise, ventilative dividing plate sealing is located between the annular sidewall of outer ring cavity both sides.
The end of the annular sidewall of ring cavity both sides is provided with annular groove in annular sidewall outside described, is provided with annular notches on annular sidewall two medial extremitys; Described breathing freely constitutes every pulling by gas permeable material, and ringwise, the longitudinal section is the bow font; Two side ends at ventilative dividing plate is provided with the spill endless belt, and the outboard end of two matrix endless belt is embedded in the annular groove, being embedded in the annular notches bottom of ventilative dividing plate, and be lower than the outboard end of annular sidewall.
Described ventilative dividing plate is composited by sieve plate with some through holes and gas permeable material; Described sieve is pulled on the annular sidewall that is cemented in described outer shroud intracavity both sides, and described gas permeable material posts on the lower surface of sieve plate.
Described gas permeable material is at least a kind of in cloth, breathable rubber, the permeable-gas ceramics.
Be provided with heating in described end face, connector and power line by end face top join.
Be provided with an air supply passage mouth on the end face above the described central chamber, the air supply passage mouth communicates with atmospheric environment by a check valve, and gas flow direction is for to flow to central chamber from atmospheric environment.
On the end face above the described central chamber, be provided with a malleation passway that communicates with positive pressure source.
Also be provided with a secondary cavity that communicates with it between described central chamber and end face, secondary cavity communicates with the variable pressure source through a variable pressure passway.
Describedly be provided with several be communicated with both through holes on the dividing plate between secondary cavity and the central chamber, through hole is evenly distributed in the center and the outer edge inboard of dividing plate.
The beneficial effects of the utility model are: when cooperating Drug therapy, increase transdermal administration power, also can form tight sealing on the human body skin surface; When carrying out the percutaneous dosing treatment, the negative pressure channel mouth of outer ring cavity is with after negative pressure source is communicated with, pressure descends, pairing skin can progressively stretch and raise, because the outer shroud intracavity has increased a ventilative dividing plate, contact skin can not continue to raise behind ventilative dividing plate lower surface, thereby protection skin is not subjected to excessively to stretch to cause damage, and guarantees that percutaneous dosing can normally carry out for a long time; And this moment, outer ring cavity cavity pressure also can continue to descend, up to equating with negative pressure source pressure; Because outer ring cavity negative pressure is big, under same outer shroud cavity area, the absorption affinity that acts on the dish of applying ointment or plaster is big, on skin absorption firm, can effectively offset the outside thrust that the central chamber normal pressure produces, the dish that prevents to apply ointment or plaster comes off and the treatment interruption that causes; Simultaneously, increase, can improve sealing for the thrust that acts on annular sidewall, make the leakage of central chamber reduce, guarantee that more effectively central chamber keeps higher normal pressure, add the negative pressure increase of outer ring cavity, can make the power of percutaneous dosing increase, improve the percutaneous dosing effect; Medicinal liquid in the central chamber medicated cushion can not be adsorbed in passway and the pressure source.
Description of drawings:
Fig. 1 is the cross-sectional schematic under user mode of this utility model embodiment;
Fig. 2 is the upward view of this utility model embodiment;
Fig. 3 is the partial sectional view of this utility model embodiment 1;
Fig. 4 is the partial sectional view of this utility model embodiment 2;
Fig. 5 is the partial sectional view of this utility model embodiment 3;
Fig. 6 is the cutaway view of this utility model embodiment 4;
Fig. 7 is the cutaway view of this utility model embodiment 5;
Fig. 8 is the cutaway view of this utility model embodiment 6;
Fig. 9 is the upward view of this utility model embodiment 6.
1, apply ointment or plaster dish 2, medicated cushion 3, end face 4, outer ring cavity 5, central chamber 6, annular sidewall 7, negative pressure channel mouth 8, ventilative dividing plate 9, annular groove 10, annular notches 11, spill endless belt 12, connector 13, sieve plate 14, gas permeable material 15, heating 16, malleation passway 17, secondary cavity 18, variable pressure passway 19, through hole
The specific embodiment:
Below in conjunction with drawings and Examples this utility model is described in further detail.
As shown in Figure 1 and Figure 2, Fig. 1 is the structure chart under user mode of this utility model embodiment.This utility model comprise post on skin applying ointment or plaster the dish 1 and be located at apply ointment or plaster the dish 1 bottom medicated cushion 2.Dish 1 the top of applying ointment or plaster is end face 3, is provided with outer ring cavity 4 and the central chamber 5 that Open Side Down below end face 3, is an annular sidewall 6 between outer ring cavity 4 and the central chamber 5.Described outer ring cavity 4 is separated into two cavitys up and down by a ventilative dividing plate 8, and wherein epicoele communicates with negative pressure source through described negative pressure channel mouth 7, and cavity of resorption is under shed.Cavity of resorption can hold the skin that is lifted by negative-pressure adsorption in use.Outer ring cavity 4 communicates with negative pressure source by the negative pressure channel mouth 7 in the end face 3, and medicated cushion 2 places in the central chamber 5.
In embodiment 1 as shown in Figure 3, described ventilative dividing plate 8 is made of gas permeable material 14, and ringwise, ventilative dividing plate 8 sealings are located between the annular sidewall 6 of outer ring cavity 4 both sides, and are parallel with end face 3.
In embodiment 2 as shown in Figure 4, the end of the annular sidewall 6 of ring cavity 4 both sides is provided with annular groove 9 in annular sidewall 6 outside described.And on 6 liang of medial extremitys of annular sidewall, be provided with annular notches 10.Described breathing freely constitutes every pulling by gas permeable material, and ringwise, the longitudinal section is the bow font.Two side ends at ventilative dividing plate 8 is provided with spill endless belt 11, and the outboard end of matrix endless belt 11 is embedded in the annular groove 9, and promptly both adopt plug to connect mode.Being embedded in bottom in the annular notches 10 of ventilative dividing plate 8, and be lower than the outboard end of annular sidewall 6.Back spill endless belt 11 skin under the central chamber 5 when treatment is used is installed is raised under suction function, contact with ventilative dividing plate 8, spill endless belt 11 is close to skin, and sealing function can be played in its adjacent annular sidewall 6 ends.
In embodiment 3 as shown in Figure 5, described ventilative dividing plate 8 is composited by sieve plate 13 with some through holes and gas permeable material 14.Described sieve is pulled 13 and is cemented on the annular sidewall 6 of both sides in the described outer ring cavity 4, and described gas permeable material 14 posts on the lower surface of sieve plate 13, when promptly treating towards skin surface.Sieve is pulled 13 material, also different materials.If sieve is pulled 13 and adopted pottery, outer ring cavity 4 can adopt the imitative method molding of dewax pattern to fire; If sieve plate 13 adopts elastomeric materials, can adopt Di-cure method, enter the second operation work sulfuration behind the sieve plate semi-finished product that first procedure divided mold forming and the disc main body location of applying ointment or plaster, obtain end product.Aperture on the sieve plate 13 can directly be made in patternmaking process.Also can make the back at finished product processes by bore mode.
Among the embodiment 1～3, provided the fixed form of ventilative dividing plate 8 and annular sidewall 6, described gas permeable material 14 is at least a kind of in cloth, breathable rubber, the permeable-gas ceramics.Embodiment 1, for inflexible permeable-gas ceramics, can adopt friction tight consolidation style.The dish 1 of will applying ointment or plaster when using like this posts on human body skin, and the negative pressure channel mouth 7 that is positioned on outer ring cavity 4 end faces 3 communicates with negative pressure source, the pressure reduction that outer ring cavity 4 is interior, pairing skin is lifted gradually, up to be full of whole outside during ring cavity 4.Like this,, do not have the slit, stopped that skin is snapped into the slit and the danger that damages in conjunction with closely.Softish cloth or breathable rubber are adopted agglutinating consolidation style.
In embodiment 4 as shown in Figure 6, in described end face 3, be provided with heating 15, the connector 12 by end face 3 tops joins with power line.In therapeutic process, along with 15 pairs of central chambers 5 of heating are heated, the intracavity gas temperature of central chamber 5 raises, the volatile ingredient of medicine progressively discharges, and cavity pressure raises.Simultaneously, treatment place skin temperature also can raise, and can accelerate the movement velocity of subcutaneous blood capillary inner blood, increases the permeability of skin, promotes the infiltration of medicine.Applying ointment or plaster the end face 3 of dish 1 central chamber 5 can be the same with the end face 3 of outer ring cavity 4, is in the same plane, and with shown in Figure 1 similar, medicated cushion is by convection current and radiating mode and end face generation heat exchange, the absorption heat.Also can be as shown in Figure 5, central chamber 5 end faces 3 are provided with lowlyer, the height of the height of central chamber 5 and medicated cushion 2 is suitable, the mode that the heat of end face 3 can directly conduct with contact adds Hot medicine pad, little in heater element power, under the not high situation of table top surface surface temperature, such heat transfer type is more direct effectively.
In embodiment 5 as shown in Figure 7, on the end face above the described central chamber 5, be provided with an air supply passage mouth, the air supply passage mouth communicates with atmospheric environment by a check valve, and gas flow direction is for to flow to central chamber 5 from atmospheric environment.Can stop outer ring cavity 4 like this when bleeding with the negative pressure source connection, under the poorly sealed situation of annular sidewall 6 and skin and make the gas in the central chamber 5 leak in the adjacent outer ring cavity 4, cause the initial pressure of central chamber 5 low, even be negative pressure, and making central chamber 5 under the situation that the heating nature heats up, final elevated pressure is low.After adopting this check valve, relatively promote the power of percutaneous dosing, can promote the osmotic effect of medicine.On the end face above the described central chamber 5, be provided with a malleation passway 16 that communicates with positive pressure source.Can make central chamber 5 keep needed normal pressure so always, improve the effect of percutaneous dosing.
In embodiment 6 as shown in Figure 8, on the basis of embodiment 5, between described central chamber 5 and end face 3, also be provided with a secondary cavity that communicates with it 17, secondary cavity 17 communicates with the variable pressure source through a variable pressure passway 18.During the treatment beginning, connect negative pressure source earlier, secondary cavity 17 all is a negative pressure with central chamber 5, and the skin under the central chamber 5 is subjected to vacuum suction and increases permeability.Connect positive pressure source again, secondary cavity 17 and central chamber 5 have all become malleation, can make in medicine penetrates to the skin better.Secondary cavity 17 is set, when in the negative pressure in cut-in pressure source during the stage, because 2 of the medicated cushion of variable pressure passway 18 and central chamber 5 are across secondary cavity 17, can avoid placing the medicinal liquid in the medicated cushion 2 in the central chamber 5 to be adsorbed in variable pressure passway 18 and the pressure source, and cause the pollution of variable pressure passway 18 and the fault of pressure source, also avoided the loss of medicinal liquid simultaneously.Be provided with several through holes that is communicated with both 19 on the dividing plate between secondary cavity 17 and the central chamber 5, through hole 19 is evenly distributed in dividing plate center and outer edge inboard.When secondary cavity 17 was connected negative pressure source, medicinal liquid was drawn onto in the secondary cavity 17 from central chamber 5; When secondary cavity 17 was connected positive pressure source, medicinal liquid via through holes 19 was again got back to central chamber 5.
In sum, embodiment 1～3rd, to the explanation of several different structures of the ventilative dividing plate 8 of this utility model.And embodiment 4～6th, the structure optimization of carrying out on the basis of embodiment 1～3 can be selected a kind of or combinative structure wherein for use.And can make up with three kinds that are showed ventilative dividing plates 8.In addition, ventilative dividing plate 8 structures also are not limited to above three kinds of structures.For the cross section of described utility model is as shown in Figure 2 racetrack, or circle shown in Figure 9, or special-shaped formula.
Claims (10)
1. transdermal delivery device, comprise the dish (1) of applying ointment or plaster that posts on skin, with the medicated cushion (2) of being located at dish (1) bottom of applying ointment or plaster, the apply ointment or plaster top of dish (1) is end face (3), be provided with outer ring cavity (4) and the central chamber (5) that Open Side Down in end face (3) below, be an annular sidewall (6) between outer ring cavity (4) and the central chamber (5), outer ring cavity (4) communicates with negative pressure source by the negative pressure channel mouth (7) in the end face (3), medicated cushion (2) places in the central chamber (5), it is characterized in that: described outer ring cavity (4) is separated into two cavitys up and down by a ventilative dividing plate (8), wherein epicoele communicates with negative pressure source through described negative pressure channel mouth (7), and cavity of resorption is under shed.
2. a kind of transdermal delivery device according to claim 1 is characterized by: described ventilative dividing plate (8) is made of gas permeable material (14), and ringwise, ventilative dividing plate (8) sealing is located between the annular sidewall (6) of outer ring cavity (4) both sides.
3. a kind of transdermal delivery device according to claim 1, it is characterized by: the end of the annular sidewall (6) of ring cavity outside described (4) both sides is provided with annular groove (9) in annular sidewall (6), is provided with annular notches (10) on annular sidewall (6) two medial extremitys; Described breathing freely is made of gas permeable material every pulling (8), and ringwise, the longitudinal section is the bow font; Two side ends at ventilative dividing plate (8) is provided with spill endless belt (11), and the outboard end of two matrix endless belt is embedded in the annular groove (9), being embedded in bottom in the annular notches (10) of ventilative dividing plate (8), and be lower than the outboard end of annular sidewall (6).
4. a kind of transdermal delivery device according to claim 1 is characterized by: described ventilative dividing plate (8) is composited by sieve plate with some through holes (13) and gas permeable material (14); Described sieve is pulled on the annular sidewall (6) that is cemented in the interior both sides of described outer ring cavity (4), and described gas permeable material (14) posts on the lower surface of sieve plate (13).
5. according to claim 2 or 3 or 4 described a kind of transdermal delivery devices, it is characterized by: described gas permeable material (14) is at least a kind of in cloth, breathable rubber, the permeable-gas ceramics.
6. a kind of transdermal delivery device according to claim 1 is characterized by: be provided with heating (15) in described end face (3), the connector (12) by end face (3) top joins with power line.
7. a kind of transdermal delivery device according to claim 1, it is characterized by: on the end face of described central chamber (5) top, be provided with an air supply passage mouth, the air supply passage mouth communicates with atmospheric environment by a check valve, and gas flow direction is for to flow to central chamber (5) from atmospheric environment.
8. a kind of transdermal delivery device according to claim 7 is characterized by: be provided with a malleation passway (16) that communicates with positive pressure source on the end face of described central chamber (5) top.
9. according to claim 1 or 6 described a kind of transdermal delivery devices, it is characterized by: also be provided with a secondary cavity that communicates with it (17) between described central chamber (5) and end face (3), secondary cavity (17) communicates with the variable pressure source through a variable pressure passway (18).
10. a kind of transdermal delivery device according to claim 9, it is characterized by: be provided with several through holes that is communicated with both (19) on the dividing plate between secondary cavity (17) and the central chamber (5), through hole (19) is evenly distributed in the center and the outer edge inboard of dividing plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201435735U CN201061675Y (en) | 2007-04-11 | 2007-04-11 | Percutaneous drug administration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007201435735U CN201061675Y (en) | 2007-04-11 | 2007-04-11 | Percutaneous drug administration device |
Publications (1)
| Publication Number | Publication Date |
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| CN201061675Y true CN201061675Y (en) | 2008-05-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CNU2007201435735U Expired - Lifetime CN201061675Y (en) | 2007-04-11 | 2007-04-11 | Percutaneous drug administration device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014146464A1 (en) * | 2013-03-22 | 2014-09-25 | 北京神州汉方医药科技有限公司 | Transdermal administration device |
| CN111870432A (en) * | 2020-08-03 | 2020-11-03 | 曹雷磊 | Plaster for treating poisonous insect bite |
| CN115400342A (en) * | 2022-11-01 | 2022-11-29 | 北京神州汉方医药科技有限公司 | Plug-in transdermal drug delivery device and method of use |
| CN115487412B (en) * | 2022-11-01 | 2023-03-24 | 北京神州汉方医药科技有限公司 | Split transdermal drug delivery device and method of use |
-
2007
- 2007-04-11 CN CNU2007201435735U patent/CN201061675Y/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014146464A1 (en) * | 2013-03-22 | 2014-09-25 | 北京神州汉方医药科技有限公司 | Transdermal administration device |
| JP2016507310A (en) * | 2013-03-22 | 2016-03-10 | ベイジン サイノハンファン ファーマシューティカル エスシーアイ アンド テック シーオー エルティーディー | Transdermal drug delivery device |
| US10052466B2 (en) | 2013-03-22 | 2018-08-21 | Beijing Sinohanfang Pharmaceutical Sci. & Tech Co., Ltd. | Transdermal drug delivering device |
| CN111870432A (en) * | 2020-08-03 | 2020-11-03 | 曹雷磊 | Plaster for treating poisonous insect bite |
| CN115400342A (en) * | 2022-11-01 | 2022-11-29 | 北京神州汉方医药科技有限公司 | Plug-in transdermal drug delivery device and method of use |
| CN115400342B (en) * | 2022-11-01 | 2023-02-10 | 北京神州汉方医药科技有限公司 | Plug-in transdermal drug delivery device and method of use |
| CN115487412B (en) * | 2022-11-01 | 2023-03-24 | 北京神州汉方医药科技有限公司 | Split transdermal drug delivery device and method of use |
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