CN2418890Y - Medicine supplier by negative pressure on skin - Google Patents
Medicine supplier by negative pressure on skin Download PDFInfo
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- CN2418890Y CN2418890Y CN 00206314 CN00206314U CN2418890Y CN 2418890 Y CN2418890 Y CN 2418890Y CN 00206314 CN00206314 CN 00206314 CN 00206314 U CN00206314 U CN 00206314U CN 2418890 Y CN2418890 Y CN 2418890Y
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Abstract
The utility model relates to a medicine-supplying therapeutic device by negative pressure on skin, which is composed of a tank body, a circular negative-pressure device, an annular negative-pressure device, a rubber valve, a sealed mobile medicine applying piston, a top cover, etc. which are connected with an air pumping device. The utility model has the action of implementing negative pressure for partial medicine giving skin so that medicament arranged between the skin and the sealed mobile medicine applying piston has accelerated medicine permeating rate on the skin under the action of the annular negative-pressure device, overcomes the problem that most of medicine is not easy to penetrate skin barrier and generate intracutaneous medicine retention, and is a new method for supplying medicine on the skin. The utility model can also be combined with oxygen for use to realize a partial 'negative-pressure oxygen-rich therapy' and can also be combined with laser for use to carry out 'negative-pressure laser irradiating therapy', and can treat various clinical difficult diseases.
Description
A kind ofly connect to form the percutaneous negative pressure drug treatment device that can produce suction function, belong to technical field of medical instruments by tank body, valve, mobile drug of topical application piston, top cover and the utensil of bleeding.
The application of negative pressure energy on health care in the past, the earliest be China (Chinese) cupping therapy.Occurred local decompression's therapy apparatus, vacuum-therapy machine etc. subsequently, though than (Chinese) cupping therapy safety, easy, range of application is identical with (Chinese) cupping therapy with the treatment principle.The inventor in 1985 combines negtive-pressure implement first and carries out local irradiation and acupoint therapy and applied for that " a kind of radiation exposure device " is awarded patent for invention, the patent No. 85109066.1 with laser, ray.Afterwards, occurred the device that magnetic therapy acupuncture etc. utilizes negative pressure therapy in succession, but to sum up a bit be a kind of physiotherapy to these devices, all do not utilize negative pressure principle, by the function of percutaneous drug delivery.
As everyone knows, the market sales revenue increases considerably since U.S.'s initiative transdermal delivery system (TDS) launch in 1981, and the development of percutaneous dosing kind is very rapid, occupies first of the various medicaments growths.But, because reaching through medicine behind the skin, the skin barrier performance is detained formation storage storehouse, still there is certain limitation, and it only is suitable for reaching by certain area absorption the medicine of effective blood concentration.This is carried out a large amount of research and experiment both at home and abroad, still do not had a kind of device and equipment of clinical practiceization.Percutaneous negative pressure drug treatment device of the present invention, after principle of negative pressure is furtherd investigate comprehensively, correct and replenished traditional negative pressure theory and reformed negative pressure administration strategy, solved the emphasis and the difficult point of percutaneous dosing effectively, for percutaneous negative pressure medication has been established theoretical basis.
The purpose of percutaneous negative pressure drug treatment device of the present invention is, the negative pressure therapy device that overcomes in the past is difficult to reach the defective of disease preventing and treating by percutaneous drug delivery, and emphasis solves the key technology of keratodermatitis barrier action of percutaneous dosing and the difficult point that the delay behind the drug transdermal forms the storage storehouse.Percutaneous negative pressure drug treatment device utilizes principle of negative pressure, make a series of variations that help drug osmotic such as increase of skin keratin lamellar spacing or fracture, the loose gap of cutin granular layer become greatly, telangiectasis earlier, medicine is placed on the piston medicator directly to be contacted with skin, under annular negtive-pressure implement effect, make medicine quicken Transdermal absorption and enter body and circulate, reaching the effect of treatment disease, is a kind of safe, effective, technological innovation method that practicality is good, economic.
Percutaneous negative pressure drug treatment device of the present invention is achieved in that
Percutaneous negative pressure drug treatment device is by two negative pressure tank bodies of the Chinese old bell of likeness in form, the garden shape negative pressure tank body that inside is hollow, the annular negative pressure tank body that its outside is hollow, upper end opening part rubber valve at garden shape negative-pressure cup is contained in the shape breather of garden, and breather links to each other with mobile tubing string; The upper end of annular negtive-pressure implement tank body is equipped with rubber valve too.Can be with the utensil of bleeding during use, as vacuum pump, the rifle of bleeding (pump), pinch ball etc. and all can.
Below in conjunction with accompanying drawing percutaneous negative pressure drug treatment device of the present invention being done one describes in detail.
Accompanying drawing is a structural representation of the present invention, (1) negtive-pressure implement tank body among the figure, (2) garden shape negtive-pressure implement tank body, (3) annular negtive-pressure implement tank body, (4) breather, (5) rubber valve, (6) mobile tubing string, (7) head tube handle, the mobile drug of topical application piston of (8) sealing, (9) garden shape negtive-pressure implement tank body end opening, (10) annular negtive-pressure implement tank body end opening, (11) reverse valve seat, (12) reverse formula ventilation flap, (13) valve seat passage, (14) annular embeds mouth, (15) ring-shaped groove, (16) tops (medicated cap) lid.
At first adopt the inside of negative pressure tank body (1) of the percutaneous negative pressure drug treatment device of the outer likeness in form old bell shape that transparent medical engineering plastics or lucite make to be shaped to garden shape hollow negative pressure tank body (2), periphery at garden shape negative pressure tank body (2) is shaped to annular negative pressure tank body (3), top inner tubal wall at garden shape negative pressure tank body (2) is the garden tubulose, in the hollow garden column that links to each other with head tube handle (7) is housed push-and-pull move tubing string (6), in head tube handle (7), rubber valve (5) is housed in the breather (4), the lower end of mobile tubing string (6) is ring-shaped groove (15), and its groove place links to each other with the annular embedding mouthful (14) of the upper end of the mobile drug of topical application piston of sealing (8).The reverse valve seat (11) of rubber valve (5) embeds in the breather (4), the upper end of reverse valve seat (11) is a reverse ventilation flap (12), there is valve seat passage (13) in the central authorities of reverse ventilation flap (12), tank body (1) bottom is flat opening shape, be provided with rubber valve (5) equally at sealing mobile drug of topical application piston (8) and annular negtive-pressure implement tank body upper end, top (medicated cap) lid (16) is housed on the top of rubber valve, and this is percutaneous negative pressure drug treatment device; Also the negtive-pressure implement tank body can be designed to the percutaneous negative pressure drug treatment device of square or polygonal conjuncted structure.
One, percutaneous negative pressure medication
The administration of percutaneous negative pressure is different from administration and existing percutaneous dosing method in the common negative pressure cup.
1. negative pressure tank body: by the one negtive-pressure implement that annular negtive-pressure implement tank body and circular syringe type administration negative pressure tank body are formed, annular negtive-pressure implement is a negative pressuren zone, and circular negtive-pressure implement is the administration district, and negative pressuren zone and administration district are interchangeable.
2. medication: after starting circular negtive-pressure implement before the administration earlier local skin being imposed suction function, with the local skin externally-applied powder, semisolid or liquid preparation are urged to the skin behind the medicament process suction function and the negative-pressure adsorption effect of annular negtive-pressure implement with the tube core of the syringe type of administration negtive-pressure implement, help the transdermal change of medicine.
3. transdermal approach of medicine and mode:
Percutaneous dosing is under suction function, the transdermal approach of medicine, promptly see through the cuticular process of main barrier two kinds of main diffusion paths are arranged, the one, the horny layer that passes fracture spreads, the 2nd, by the interstitial diffusion that the broken ring in the interval of horn cell increases, part is to permeate through the local skin appendages.
(1) passes the horny layer of suction function: under the effect of percutaneous negative pressure drug treatment device, impaired even the fracture of the horny layer of epiderm skin, overcome the main resistance that medicine absorbs by epidermis, for medicine has been opened passage by skin, particularly organic chemistry medicine and the biological preparation percutaneous dosing to macromolecule provides new method, as the target administration of insulin for reducing blood sugar and cancer therapy drug, other percutaneous dosings accelerated percutaneous rate, make it to become a kind of medication safely and efficiently.
(2) destroy the gap that increases by the interval of horn cell: the effect of negative pressure draw tension, part horny layer of epidermis cell compartment is destroyed, gap enlargement, making medicine see through horny layer diffusion path length increases, and the organic compound transmission rates of macromolecule improves.
(3) the skin appendages transmitance is quickened: negative pressure is quickened local skin appendages hair follicle, sebaceous gland and sweat gland expansion, secretion, promotes the infiltration of medicine.
4. quicken the diffusion of medicine in skin: suction function has not only overcome the barrier action function of horny layer to medicine, and after the negative pressure gravitational solution is removed, local skin and corresponding hypodermic blood flow acceleration cycle, phagocytosis strengthen, and enter corium after having promoted medicine by active epidermis.The administration of percutaneous negative pressure can prevent delay and the formation storage storehouse of medicine in skin, has solved another difficult problem of percutaneous dosing.
Two, clinical practice and using method
(1) percutaneous negative pressure administration
1. using method: earlier negative pressuren zone in circular is placed local skin position during treatment through selecting, by following procedure operation:
(1) negtive-pressure implement in startup percutaneous negative pressure drug treatment device administration district, the head tube handle is lifted to certain altitude, join with the breather on bleed utensil and the head tube handle, continuous air extraction is to certain negative pressure intensity, for the enhanced leaktightness performance, the cap of sealing ring is arranged in the ventilation mouth of pipe is added a cover, make local decompression's continuous action remove negative pressure state after 10 to 15 minutes.Local skin behind the suction function is the administration district.
(2) negative pressure administration: with the local skin external preparation can be powder, and semisolid and liquid place administration district local skin, and the head tube handle is pushed, and the mobile drug of topical application piston disc of sealing is pressed in above the skin.
(3) start annular negtive-pressure implement: will bleed utensil suction nozzle mouth and annular negtive-pressure implement breather muzzle connect, the extremely certain negative pressure intensity of continuous air extraction, and reverse flap closure, skin places under the annular suction function.Because the effect of annular negtive-pressure implement, make administration district skin be in the state of straining to all around, local skin drug osmotic rate behind the suction function is accelerated, the edge negative pressure draw tension of annular negtive-pressure implement contact skin makes the medicine in administration district quicken to enter annular negative pressuren zone skin, becomes a passage of negative pressure administration.Act on 10 minutes and remove negative pressure later on, can continue to keep the medicament and the contact skin effect in negative pressure administration district.Stop administration after 10 minutes.
The administration of percutaneous negative pressure also can be used for long-time transdermal topical administration.Local skin behind the suction function changes into mainly that epidermis side is loose, density reductions, Intradermal hyperemia, capillary rupture, horny layer of epidermis fracture, the increase of horn cell gap, hair follicle, sweat gland and the increase of sebaceous gland permeability, skin resistance obviously reduces, and the change of local skin is sustainable more than 3 days.Therefore, the local skin behind suction function can be used as the long-time administration district of percutaneous negative pressure drug treatment.The epidermal barrier performance is after suction function destroys, and it is repaired and metabolism time horny layer needs 7 to 21 days, therefore, is feasible as 7 days districts that continue medication.
2. clinical practice:
(1) is used for the patch that the percutaneous that gone on the market absorbs: can quicken percutaneous rate, eliminate the storage storehouse side effect of medicine in skin, be applicable to the patch of treatment systemic disease and topical application.
(2) insulin percutaneous negative pressure drug treatment diabetes: the local skin of suction function can make most of insulin see through skin, particularly insulin is made the carrier of suspension, can make 85% insulin see through skin and enter systemic circulation.Adopt long-lasting insulin human carrier to treat 1 type and type 2 diabetes mellitus.
(3) percutaneous dosing treatment cancer: the Drug therapy of tumor does not still have breakthrough at present, and effective chemical medicine, biological preparation are owing to be subjected to the restriction and the toxic and side effects of route of administration and method, and drug effect is not good on clinical treatment.The administration of percutaneous negative pressure can strengthen drug effect, alleviate toxic and side effects, as 5-fluorouracil percutaneous dosing treatment tumor; Especially the administration of hemoporphyrin percutaneous target administration or biological gene cancer therapy drug selection percutaneous negative pressure is best Therapeutic Method.
(4) accurate targeting administration: the administration of percutaneous negative pressure is owing to avoided the interference and the degraded of the first-pass effect factor of gastrointestinal tract and liver, percutaneous dosing more stably directly enters local skin tissue and corresponding subcutaneous organ than oral administration, reach accurate targeting administration, reduce the individual variation of medication.
(5) the percutaneous negative pressure administration of gene therapy: because the rise of gene therapy, the administration of genomic medicine becomes a valued problem, and it may be best selection that the percutaneous negative pressure gives gene therapy.The special biological requirement of gene therapy selects for use liposome to make the administration of gene carrier percutaneous negative pressure.
(6) local skin negative pressure administration: the oral and injecting method of skin difficult disease commonly encountered diseases treatment administration is difficult to give full play to drug effect, the particularly administration of leukoderma, stubborn dermatitis etc., the curative effect that adopts negative pressure transdermal administration melanogen, antipsoric to obtain getting twice the result with half the effort can also be used for the treatment of Dermatology.
The administration of local skin negative pressure has special therapeutical effect to the local skin administration of thromboangiitis obliterans, varicosis and veins beneath the skin spasm and diabetic foot etc.
(2) negative pressure oxygen enrichment therapy
1. using method:
Earlier percutaneous negative pressure treatment administrator is placed local skin when (1) treating, with the air in the oxygen flushing negative-pressure cup of the medical plastic bag that is provided with reverse air valve that the medical pure oxygen of 500-1000 milliliter is arranged in special, oxygen concentration in the negtive-pressure implement is reached more than 90%, bleed and cause the negative pressure oxygen enriched environment;
(2) the negative pressure ring set made from rubber at the opening of circular negtive-pressure implement is on circular tube chamber, negative pressure ring adapter ring borehole jack is being difficult to use the acral of negtive-pressure implement, carry out the treatment of negative pressure oxygen enrichment as hands fat, toe and local outstanding vegetation etc., make the part obtain " hyperbaric oxygen " effect.
2. clinical practice: the inventor clearly proposes the neodoxy to negative pressure treatment mechanism, be to be under the low oxygen partial pressure effect in the tank body of the special (Chinese) cupping therapy of negative-pressure therapeutic apparatus to cause anoxia, to local skin is deleterious, therefore, negative pressure treatment replaces the gas of low oxygen partial pressure can increase the clinical effectiveness of negative pressure treatment with oxygen enrichment, and the inventor is called this therapy " low pressure oxygen enrichment therapy ".Being used for general negative pressure treatment, reducing the ill effect of low oxygen partial pressure to local skin, be particularly useful for local anoxia treatment, is to the replenishing of hyperbaric oxygen therapy, and is a kind of " partial high pressure oxygen therapy ".
(1) thromboangiitis obliterans negative pressure oxygen enrichment treatment: eliminate thromboembolism, improve local microcirculation and oxygen supply deficiency, share thrombolytic and blood circulation promoting medicine will speed up healing.
(2) osteomyelitis, osteonecrosis: improve the hypoxic-ischemic situation, help improving symptom, stop course of disease progress.
(3) malignant pustule, skin-grafting, burn can suppress and kill anthrax bacillus, improve medication effect; Skin-grafting, skin burn under the effect of negative pressure oxygen enrichment, the disperse that improves local partial pressure of oxygen and oxygen, skin-grafting survived with burn-healing remarkable effect.
(3) negtive-pressure implement share laser therapy
1. laser irradiating method:
(1) directly throw according to method: the tube core cylinder of percutaneous negative pressure drug treatment device is pulled out, and the laser direct irradiation is at the local skin of negative pressuren zone.
(2) optical fibers method: be not easy to the position of laser direct irradiation, can laser be caused irradiated region, can enlarge facular area and cover negative pressuren zone, to skin under the local decompression or acupuncture point irradiation by optical fibers.
2. clinical practice:
(1) photodynamic therapy diagnosis and treatment tumor: earlier with the administration of photosensitizer hemoporphyrin percutaneous negative pressure, carry out local lesion's laser irradiation in the certain hour, be applicable to the treatment of skin carcinoma, hemangioma, nevus and skin vegetations.
(2) laser point irradiation treatment: the negative pressure local action again through laser irradiation, is played the excitor nerve reflection to the stimulation of acupuncture points on the human body, and regulating menstruation and activating blood reaches the acupuncture treatment purpose.
Advantage of the present invention is:
1. make the traditional (Chinese) cupping therapy of China become a kind of through skin negative pressure drug treatment device through innovation and development, A kind of effectively through skin negative pressure medication.
2. become the negtive-pressure implement of conjuncted multiple tank of the present invention by previously single cup innovation, and first design Go out annular negtive-pressure implement and circular negtive-pressure implement is combined into the negative-pressure therapeutic apparatus with administration specific function.
3. enlarge the application of negative pressure therapy, make it be used for control inside and outside, dept. of dermatology's difficult disease, also make Inventor's invention " hyperbaric oxygen chamber inner laser irradiation unit " formerly (CM85103131.1) and " a kind of putting Beam exposure apparatus " (CN85109066.1) " radiation apparatus producing local negative pressure and laser or redioactive ray " use through skin Negative pressure drug treatment device share oxygen " negative pressure oxygen enrichment therapy " and share " the vacuum laser photograph of Ear Mucosa Treated by He Ne Laser Irradiation Penetrate therapy " replace.
4. moulding of the present invention is succinctly bright, safe and convenient to use, becomes effective therapeutic apparatus of transdermal administration new method.
Claims (4)
1. one kind by tank body, valve, mobile drug of topical application piston, top covers etc. connect to form the percutaneous negative pressure drug treatment device that can produce suction function with the utensil of bleeding, the inside that it is characterized in that the negtive-pressure implement tank body (1) of percutaneous negative pressure drug treatment device is the garden shape negtive-pressure implement tank body (2) of garden shape hollow, periphery at garden shape negtive-pressure implement tank body (2) is the annular negtive-pressure implement tank body (3) of hollow, vertical inner tubal wall at garden shape negtive-pressure implement tank body (2) is the garden tubulose, in the hollow garden cylindricality that links to each other with head tube handle (7) is housed push-and-pull move tubing string (6), in head tube handle (7) breather (4), in the inside of breather (4) rubber valve (5) is housed, the lower end of mobile tubing string (6) is ring-shaped groove (15), its groove place links to each other with the annular embedding mouthful (14) of the mobile drug of topical application piston of sealing (8) upper end, the bottom of tank body (1) is flat opening, in the middle of the mobile drug of topical application piston of sealing (8) and on the annular negtive-pressure implement tank body (3) rubber valve (5) is being housed respectively, top (medicated cap) lid (16) is being housed on the top of rubber valve.
2. percutaneous negative pressure drug treatment device according to claim 1, the reverse valve seat (11) that it is characterized in that described rubber valve (5) embeds in the breather (4), its upper end is a reverse ventilation flap (12), and there is valve seat passage (13) in the central authorities of reverse ventilation flap (12).
3. percutaneous negative pressure drug treatment device according to claim 1 and 2 is characterized in that in the middle of the mobile drug of topical application piston of described sealing (8) rubber valve (5) being housed.
4. percutaneous negative pressure drug treatment device according to claim 1 is characterized in that rubber valve (5) is equipped with in the upper end of described annular negtive-pressure implement.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00206314 CN2418890Y (en) | 2000-03-16 | 2000-03-16 | Medicine supplier by negative pressure on skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00206314 CN2418890Y (en) | 2000-03-16 | 2000-03-16 | Medicine supplier by negative pressure on skin |
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| Publication Number | Publication Date |
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| CN2418890Y true CN2418890Y (en) | 2001-02-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00206314 Expired - Fee Related CN2418890Y (en) | 2000-03-16 | 2000-03-16 | Medicine supplier by negative pressure on skin |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446674A (en) * | 2012-05-30 | 2013-12-18 | 江门市江海区新力医疗器械有限公司 | Laser cupping glass |
| CN105055149A (en) * | 2015-08-19 | 2015-11-18 | 崇州市地龙海龙生物制品开发研究所 | Making method for human body acupuncture point new-therapy device |
| CN105983145A (en) * | 2015-03-03 | 2016-10-05 | 王科 | Device capable of moxibustion, medicine permeation and acupuncture while cupping |
| CN107019843A (en) * | 2017-06-07 | 2017-08-08 | 柴雪青 | negative pressure transdermal delivery device |
| CN111212675A (en) * | 2017-10-17 | 2020-05-29 | 3M创新有限公司 | Applicator for applying microneedle arrays to skin |
-
2000
- 2000-03-16 CN CN 00206314 patent/CN2418890Y/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446674A (en) * | 2012-05-30 | 2013-12-18 | 江门市江海区新力医疗器械有限公司 | Laser cupping glass |
| CN105983145A (en) * | 2015-03-03 | 2016-10-05 | 王科 | Device capable of moxibustion, medicine permeation and acupuncture while cupping |
| CN105983145B (en) * | 2015-03-03 | 2019-02-19 | 王科 | It is a kind of can be carried out while cupping moxa-moxibustion, Medicated Permeation, needle thorn device |
| CN105055149A (en) * | 2015-08-19 | 2015-11-18 | 崇州市地龙海龙生物制品开发研究所 | Making method for human body acupuncture point new-therapy device |
| CN107019843A (en) * | 2017-06-07 | 2017-08-08 | 柴雪青 | negative pressure transdermal delivery device |
| CN107019843B (en) * | 2017-06-07 | 2024-02-06 | 柴雪青 | Negative pressure transdermal drug delivery device |
| CN111212675A (en) * | 2017-10-17 | 2020-05-29 | 3M创新有限公司 | Applicator for applying microneedle arrays to skin |
| CN111212675B (en) * | 2017-10-17 | 2022-01-25 | 3M创新有限公司 | Applicator for applying microneedle arrays to skin |
| US11458289B2 (en) | 2017-10-17 | 2022-10-04 | Kindeva Drug Delivery L.P. | Applicator for applying a microneedle array to skin |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |