CN1303717A - Transdermal medication apparatus - Google Patents
Transdermal medication apparatus Download PDFInfo
- Publication number
- CN1303717A CN1303717A CN 99126047 CN99126047A CN1303717A CN 1303717 A CN1303717 A CN 1303717A CN 99126047 CN99126047 CN 99126047 CN 99126047 A CN99126047 A CN 99126047A CN 1303717 A CN1303717 A CN 1303717A
- Authority
- CN
- China
- Prior art keywords
- face
- plaster
- space
- dish
- applying ointment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The present inventino discloses an endermosis apparatus, its core portion is a mounting disk consisting of top surface and outer and inner two annular side walls, between two side walls there is annular space communicated with negative pressure source. When it is used for therapy, the said mounting disk is tightly mounted on the skin so that the central concave space for applying drug can be completely sealed, and under the condition of heating with a heating element positioned in the top surface, the temp. of drug-applying space is raised, and the medicinal volatile components can be released, and the pressure in the space is raised so as to provide effective power to raise endermosis rate obviously and intensify therapeutic effect.
Description
The present invention relates to a kind of applying ointment or plaster makes drug transdermal enter in the body on human body skin and plays the transdermal medication apparatus of therapeutical effect.
The method transdermal of medicine by percutaneous dosing enters the human lesion position or the acupuncture point plays a role, can avoid the oral drugs medicine that especially toxicity is big that gastrointestinal is injured, avoid the decomposition destruction of the first pass effect of liver to effective ingredient, side effect is little, is a kind of effective method of treatment disease.But the skin of human body has very careful structure, and medicine sees through skin and is subjected to sizable resistance, is difficult to make medicine to reach needed therapeutic dose.Below two kinds of means can strengthen medicine percutaneous rate, increase the transdermal infiltration capacity of medicine: the first is heated, the temperature of drug of topical application position skin of can raising on the one hand of heating, accelerate local blood circulation, increase the permeability of skin, for entering, the transdermal of medicine provides physiological environment, can promote the release of drug volatilization composition on the other hand, strengthen the activity of medicine, active big drug microparticles transdermal enters intravital probability just greatly in the medicine because have only; It two is the local spaces (administration space) at sealing plaster medicine place, creates high as far as possible transdermal administration power.
General plastering therapy, as plaster and percutaneous dosing paster, all be medicine to be sticked on the skin, but because its administration space is not a complete closed, volatile ingredient easily leak by similar cover layer of applying ointment or plaster dish, the concentration that the active component of medicine is difficult to remain valid, can not form pressure differential between administration space and skin, and because the general means of heating that do not adopt, the permeability of skin is not high, the transdermal infiltration capacity of medicine was very little when this made treatment, affected the treatment.
Various hot-dressing therapeutic instruments on the market, as therapeutic instrument by patent ZL 91107121.0 mades, and another patent ZL 96205283.3 disclosed therapeutic instruments of the applicant, structure is had nothing in common with each other, but its basic skills all is to adopt heating to add the hot application dish, place the medicated cushion that is added with medicine under the dish of applying ointment or plaster, medicated cushion posts on skin, plays the effect of medication.This method posts on skin but the dish of applying ointment or plaster is the mode that adopts rope band bondage or sandbag to overlay by having added the permeability of skin heat gain, and the spatial closure of administration is still not tight, after the heating, the escape that scatters of drug volatilization active component, transdermal administration is short of power, and curative effect is not good enough.
Traditional cupping jar can form a tight-closed pressure field on the surface of skin.Patent ZL96218476.4 discloses a kind of vacuum tank medication scheme, rises on being adsorbed on skin in the vacuum tank of physiotherapy function, places a medicated cushion that is added with medicine, wishes to play the effect of medication.But this method, owing to do not heat, the permeability of skin is not high, and main is, and the administration space at medicated cushion place is a negative pressure field, and drug particle is difficult to reverse transdermal and enters human body and bring into play therapeutical effect.In addition,,, strengthen the transdermal infiltration capacity, should adopt large-area administration space as far as possible in order to improve therapeutic effect because the transdermal infiltration capacity of medicine is to be directly proportional with the contact area of skin with medicine.If adopt cupping jar or vacuum tank to come transdermal administration, just must adopt bigbore jar of type, but bigbore cupping jar, vacuum tank can only be adsorbed on the smooth part of health, and be difficult to be adsorbed on the uneven place or the cambered surface places such as neck, arm of health.
The purpose of this invention is to provide a kind of transdermal medication apparatus, can make the administration space tight-closed, and when heating, the administration space pressure is raise, become a malleation field of force,, improve the percutaneous rate of medicine for medicine provides transdermal administration power, increase the transdermal infiltration capacity of medicine, thereby strengthen therapeutic effect.
Transdermal medication apparatus of the present invention comprises the applying ointment or plaster dish and place medicated cushion under the dish of applying ointment or plaster that posts when using on the body local skin, and the dish of applying ointment or plaster is by heating heating placed on it and that join with power supply.The described dish of applying ointment or plaster is made of an end face and twice annular sidewall, is outer wall together wherein, is inwall together, and two walls are spaced a distance, and its upper end is all affixed with described end face, abuts on the skin of treatment place during the treatment of lower end.Described outer wall, inwall and end face have surrounded an annular space, constitute to have a passway on this spatial wall at least and communicate with a negative pressure source.Surrounded a concave shaped space by described inwall and end face, this space is the administration space, and described medicated cushion promptly places in this space.
The described dish of applying ointment or plaster is made by flexible material, is flat, and the height of described inside and outside wall is advisable with 2 to 8 millimeters.
Described passway can be opened on outer wall, also can open on inwall, but preferably open on end face or open angle of cut place at end face and inside and outside wall, the negative pressure in the time of can avoiding the position of or cutis laxa more at the fat of applying ointment or plaster like this in the annular space does not also reach desired numerical value and skin that the passway is just picked up is blocked.If open on end face the passway, preferably there are groove or duct that the angle of cut of passway and end face and inside and outside wall is linked up, then its probability that is blocked is just littler.
Adopt transdermal medication apparatus of the present invention, during use, its dish of applying ointment or plaster is applied ointment or plaster on the skin at human lesion position or place, acupuncture point, negative pressure source is taken the part air in the annular space away, form annular negative pressure cavity, suck skin, intermediary like this spill administration space is able to complete closed.Under the heating of heating, the temperature in the administration space of sealing raises, and the drug volatilization composition discharges in a large number, and active component increases, and the space internal pressure increases, and forms the malleation field of force of a sealing, helps drug transdermal and enters in the body.
The flat that adopts flexible material the to manufacture dish of applying ointment or plaster has whole and partial deformability, can apply ointment or plaster at the different parts of health, comprises cambered surface places such as neck, arm, and this provides possible for adopting large-sized medicated cushion to increase the drug transdermal infiltration capacity.
Transdermal medication apparatus of the present invention, owing to have unique sealing pressurizing mechanism of heating, sealing and have the injection tube of the administration space of pressure as syringe, medicine can obtain the propulsive power of transdermal, numerous ducts of the degree of opening of having improved under the effect of temperature are just as the syringe needle of pricking in the skin on the skin, thereby transdermal medication apparatus of the present invention compares with general percutaneous dosing method, can improve the percutaneous rate of medicine widely, makes medicine reach needed therapeutic dose at short notice.This point isolated skin permeability test of chamber has by experiment obtained confirmation.In addition,, use this instrument and cooperate the invigorating blood circulation of Chinese medicine, the kidney invigorating class medicine, hyperosteogeny, lumbago and skelalgia, cervical spondylosis, rheumatic and rheumatoid, the frequent micturition chronic diseases patient that suffers from a deficiency of the kidney has all been obtained significant curative effect through the clinical trial of 230 many cases.
Below in conjunction with accompanying drawing embodiment of the present invention is described in further detail.
Fig. 1 is the cross-sectional schematic of an embodiment of transdermal medication apparatus of the present invention.
Fig. 2 is the upward view of applying ointment or plaster among Fig. 1 and coiling.
Fig. 3 is the cutaway view of applying ointment or plaster and coiling of another embodiment of transdermal medication apparatus of the present invention.
Fig. 4 is the cutaway view of applying ointment or plaster and coiling of the another embodiment of transdermal medication apparatus of the present invention.
By Fig. 1, Fig. 2 as can be seen, in the end face 1 of the dish of applying ointment or plaster heating 4 is housed, connects power supply by lead 41, annular sidewall 2,3 upper ends and end face 1 join, and the lower end abuts on the skin 9 at human body therapy place.The annular space 6 that forms between outer wall 2 and the inwall 3 communicates with negative pressure source by passway 5.The concave shaped space 7 that forms between inwall 3 and the end face 1 is administration space, built-in medicated cushion 8.The dish of applying ointment or plaster is flat, is made by flexible material such as rubber or latex.The height of sidewall 2,3 is 2 to 8 millimeters, and 2 millimeters of the upper limits of this size are to guarantee that annular space 6 can be contained in the skin 9 that is lifted under the suction function and make the dish of applying ointment or plaster suck minimum dimension on skin; And the lower limit of this size is for 8 millimeters to make the dish of applying ointment or plaster have the full-size of good whole and local deformability, less than this size the dish of applying ointment or plaster during uneven or cambered surface position, can be out of shape with the fluctuating of health at the health of applying ointment or plaster, and it is tight to fit.In addition, the height of sidewall also can make the heat of heating 4 be transmitted to as soon as possible on the skin below 8 millimeters, shortens treatment time.In this embodiment, end face 1 is a plane, and passway 5 has only one, is positioned on the end face 1 of annular space 6.Have stria 51 at end face 1 lower surface, the angle of cut of this stria communication passage mouth 5 and end face 1 and inside and outside wall.Like this, when the position of the more or cutis laxa of fat of applying ointment or plaster, the skin that passway 5 is difficult for being lifted is blocked, and uses more reliable.Be understood that also have same effect if will open the duct that the stria 51 on end face 1 lower surface changes into open in end face 1.
In another embodiment that Fig. 3 provides, the end face 1 of the dish of applying ointment or plaster is a curved surface, the different parts of the health that is easier to like this to apply ointment or plaster, and the dish of applying ointment or plaster when applying ointment or plaster is difficult for perk; Passway 5 has two, lays respectively at the angle of cut place of outer wall 2 and inwall 3 and end face 1.
The embodiment that Fig. 4 provides is the modification of a last embodiment, and two passwaies 5 still are positioned at the angle of cut place of outer wall 2 and inwall 3 and end face 1, and different is that two passwaies 5 of a last embodiment are independently, the easy demoulding when mold pressing is produced; And two passwaies 5 among this embodiment merge into a place after passing end face 1, join with negative pressure source again, and are easy to use.
Claims (8)
1. transdermal medication apparatus, comprise posting when using and coil and place the medicated cushion (8) of applying ointment or plaster under coiling applying ointment or plaster on the body local skin, apply ointment or plaster dish by heating (4) heating placed on it and that join by lead 41 with power supply, it is characterized in that: the described dish of applying ointment or plaster is by an end face (1) and twice annular sidewall (2,3) constitute, be outer wall (2) together wherein, be inwall (3) together, two walls are spaced a distance, its upper end is all affixed with described end face (1), the lower end abuts on the skin (9) of treatment place when treating, described outer wall (2), inwall (3) and end face (1) have surrounded an annular space (6), constitute and have a passway (5) on this spatial wall at least and communicate with a negative pressure source, surrounded a concave shaped space (7) by described inwall (3) and end face (1), this space is administration space (7), and described medicated cushion (8) promptly places in this space.
2. transdermal medication apparatus according to claim 1 is characterized in that: the described dish of applying ointment or plaster is manufactured by flexible material, and is flat, and promptly the height of sidewall (2,3) is less than the size of end face (1) surface direction.
3. transdermal medication apparatus according to claim 1 and 2 is characterized in that: the height of described outer wall (2), inwall (3) is 2 to 8 millimeters.
4. transdermal medication apparatus according to claim 1 and 2 is characterized in that: described passway (5) are positioned on the end face (1) of described annular space (6).
5. transdermal medication apparatus according to claim 4 is characterized in that: the angle of cut of end face (1) in described passway (5) and the described annular space (6) and outer wall (2), inwall (3) has stria or duct (51) to communicate.
6. transdermal medication apparatus according to claim 1 and 2 is characterized in that: described passway (5) have two, lay respectively at the angle of cut place of interior end face (1) of described annular space (6) and outer wall (2), inwall (3).
7. transdermal medication apparatus according to claim 1 and 2 is characterized in that: described end face (1) of applying ointment or plaster dish is one successive, can be plane or curved surface.
8. transdermal medication apparatus according to claim 2 is characterized in that: the described flexible material of manufacturing the dish of applying ointment or plaster is rubber or latex.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99126047 CN1130237C (en) | 1999-12-14 | 1999-12-14 | Transdermal medication apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99126047 CN1130237C (en) | 1999-12-14 | 1999-12-14 | Transdermal medication apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1303717A true CN1303717A (en) | 2001-07-18 |
| CN1130237C CN1130237C (en) | 2003-12-10 |
Family
ID=5284294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99126047 Expired - Lifetime CN1130237C (en) | 1999-12-14 | 1999-12-14 | Transdermal medication apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1130237C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284157B (en) * | 2007-04-11 | 2012-05-02 | 北京神州汉方医药科技有限公司 | Transdermal drug delivery device |
| CN101584591B (en) * | 2008-05-20 | 2013-08-14 | 索尼株式会社 | Biological information acquisition method and instrument, and physiologically-active substance measurement method and instrument |
| WO2014146464A1 (en) * | 2013-03-22 | 2014-09-25 | 北京神州汉方医药科技有限公司 | Transdermal administration device |
| CN107019843A (en) * | 2017-06-07 | 2017-08-08 | 柴雪青 | negative pressure transdermal delivery device |
| CN108782198A (en) * | 2018-05-14 | 2018-11-13 | 佛山市瑞生通科技有限公司 | A kind of device of pouring root fertilising dispenser |
| CN109549777A (en) * | 2019-01-07 | 2019-04-02 | 蒋继芳 | Prevent and treat the dressing of pressure sore |
| CN114949576A (en) * | 2022-07-27 | 2022-08-30 | 北京神州汉方医药科技有限公司 | Drug delivery control method and device for dermal drug delivery |
| CN115487412B (en) * | 2022-11-01 | 2023-03-24 | 北京神州汉方医药科技有限公司 | Split transdermal drug delivery device and method of use |
-
1999
- 1999-12-14 CN CN 99126047 patent/CN1130237C/en not_active Expired - Lifetime
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101284157B (en) * | 2007-04-11 | 2012-05-02 | 北京神州汉方医药科技有限公司 | Transdermal drug delivery device |
| CN101584591B (en) * | 2008-05-20 | 2013-08-14 | 索尼株式会社 | Biological information acquisition method and instrument, and physiologically-active substance measurement method and instrument |
| WO2014146464A1 (en) * | 2013-03-22 | 2014-09-25 | 北京神州汉方医药科技有限公司 | Transdermal administration device |
| US10052466B2 (en) | 2013-03-22 | 2018-08-21 | Beijing Sinohanfang Pharmaceutical Sci. & Tech Co., Ltd. | Transdermal drug delivering device |
| CN107019843A (en) * | 2017-06-07 | 2017-08-08 | 柴雪青 | negative pressure transdermal delivery device |
| CN107019843B (en) * | 2017-06-07 | 2024-02-06 | 柴雪青 | Negative pressure transdermal drug delivery device |
| CN108782198A (en) * | 2018-05-14 | 2018-11-13 | 佛山市瑞生通科技有限公司 | A kind of device of pouring root fertilising dispenser |
| CN109549777A (en) * | 2019-01-07 | 2019-04-02 | 蒋继芳 | Prevent and treat the dressing of pressure sore |
| CN114949576A (en) * | 2022-07-27 | 2022-08-30 | 北京神州汉方医药科技有限公司 | Drug delivery control method and device for dermal drug delivery |
| CN115487412B (en) * | 2022-11-01 | 2023-03-24 | 北京神州汉方医药科技有限公司 | Split transdermal drug delivery device and method of use |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1130237C (en) | 2003-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220072288A1 (en) | Medical treatment system and method of use | |
| CN102036710B (en) | Magnetic breather pump and method for treating brain tumor using the same | |
| US8353882B1 (en) | Wound treatment system and method of use | |
| US8663179B2 (en) | Wound treatment system and method of use | |
| CN1130237C (en) | Transdermal medication apparatus | |
| KR20100087369A (en) | Ultrasonic medicine paste | |
| CN2414777Y (en) | Transcutaneous medicine osmosis instrument | |
| CN106725687A (en) | A kind of Novel anal-intestinal surgical postoperative pain easing and hemostasis device | |
| CN213407458U (en) | Transdermal drug delivery device | |
| CN104720131B (en) | A kind of medicated bra with health plumping out breast and preventing and treating mastopathy function | |
| CN2875410Y (en) | Mobile multi-functional medicated boathing set equipment having 03 ozone anion and traditional Chinese herb medicines | |
| CN2933393Y (en) | Fumigating therapeutical instrument | |
| CN2209983Y (en) | Medicinal prepn. easily for suction | |
| CN2294742Y (en) | Navel application band for curing stomach troubles | |
| CN201094729Y (en) | Medicaments fumigation health-care bed | |
| KR100627249B1 (en) | Drug Transfer Device by Negative Pressure | |
| CN201752537U (en) | Insole used for nursing in endocrinology department | |
| CN2215320Y (en) | Waistcoat with medicine for children asthmatic bronchitis | |
| CN2301216Y (en) | Miniature inhalation gas medicine therapy device | |
| CN2647343Y (en) | Multifunction drainage device for nose cavity | |
| CN2481296Y (en) | Cervical vertebra disease physiotherapy pillow | |
| CN2664693Y (en) | Medical liquid aerosol mask for inhalation | |
| CN2105957U (en) | Steam bath therapeutic device | |
| KR200179540Y1 (en) | Medical device with acupuncture | |
| JPH0541707Y2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BEIJING FULI ANKANG TECHNOLOGY DEVELOPMENT CO., L Free format text: FORMER OWNER: CHEN GANG Effective date: 20060331 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060331 Address after: 100085 2, building 1, building four, 201, east east, Beijing, Haidian District Patentee after: Beijing Fu Fu Ankang science and Technology Development Co., Ltd. Address before: 100094 College of animal science and technology, China Agricultural University, Beijing Patentee before: Chen Gang |
|
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Chen Gang Document name: Notice of conformity |
|
| ASS | Succession or assignment of patent right |
Owner name: BEIJING SHENZHOU KAMPO MEDICINE TECHNOLOGY LTD. Free format text: FORMER OWNER: BEIJING FULI ANKANG TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20070427 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20070427 Address after: 100101, room 1602, Zhong Sheng building, 168 Beiyuan Road, Chaoyang, Beijing Patentee after: Beijing Sino Hanfang Pharmaceutical Sci. & Tech. Co., Ltd. Address before: 100085 2, building 1, building four, 201, east east, Beijing, Haidian District Patentee before: Beijing Fu Fu Ankang science and Technology Development Co., Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20031210 |