CN115487412B

CN115487412B - Split transdermal drug delivery device and method of use

Info

Publication number: CN115487412B
Application number: CN202211354652.6A
Authority: CN
Inventors: 请求不公布姓名; 王梅林
Original assignee: Beijing Sinohanfang Pharmaceutical Sci& Tech Co ltd
Current assignee: Beijing Sinohanfang Pharmaceutical Sci& Tech Co ltd
Priority date: 2022-11-01
Filing date: 2022-11-01
Publication date: 2023-03-24
Anticipated expiration: 2042-11-01
Also published as: CN115487412A

Abstract

The present application relates to the field of introducing drugs into the body transdermally, i.e., by skin permeation, and more particularly, to a split transdermal drug delivery device and method of use. In some embodiments of the application, the combination of the locking strip, the buckle part and the elastic part achieves the effect of detachably connecting the disc body assembly and the disc cover assembly, after the locking head and the buckle head are separated from each other, the first electric connecting part and the second electric connecting part are disconnected, the disc body assembly and the disc cover assembly are separated from each other, the disc body assembly in contact with the skin can be disinfected independently after the treatment is finished, and the biological safety in the next use is ensured. In some embodiments of the present application, the second electrical connector is a pogo pin, the first electrical connector is an electrical socket, and a needle of the pogo pin can maintain electrical connection with the first electrical connector under the action of an internal spring, thereby improving the reliability of electrical connection of the split type transdermal drug delivery device.

Description

Split transdermal drug delivery device and method of use

Technical Field

The present application relates to the field of introducing drugs into the body transdermally, i.e., by skin permeation, and more particularly, to a split transdermal drug delivery device and method of use.

Background

Transdermal drug delivery is a method for introducing drugs into the body through skin penetration, and the drugs in the using process enter the pathological change part or acupuncture points of the human body through the skin to play a role, so that the damage of oral drugs to the gastrointestinal tract can be avoided, and the method is an effective method for treating diseases. However, the skin of the human body has a very meticulous structure, and the drug is subjected to considerable resistance through the skin, so that the drug is difficult to achieve the required treatment dosage. The transdermal speed of the medicine can be increased, and the transdermal penetration of the medicine can be increased by the following two means: firstly, the heating can raise the temperature of the skin at the medicine application part, accelerate the local blood circulation, increase the permeability of the skin and provide a physiological environment for the transdermal entry of the medicine on the one hand, and can promote the release of volatile components of the medicine on the other hand; the other is to close the local space (administration space) where the drug is located to create as high transdermal administration kinetics as possible.

After the existing transdermal drug delivery device is used, in order to avoid the damage of electronic elements, alcohol cotton balls are generally used for wiping and disinfecting. With the increase of the disinfection mode, products with richer disinfection modes are needed.

Disclosure of Invention

In view of the above, the present application provides a split-type transdermal drug delivery device and a method of using the same to solve one or more technical problems of the prior art, and the present application is implemented as follows:

in a first aspect, embodiments of the present application provide a split transdermal drug delivery device comprising:

a tray body assembly, the tray body assembly includes:

the tray body is provided with a central cavity, a central convex column positioned in the central cavity and an annular negative pressure annular cavity;

the electronic element comprises an electric heating element and a temperature sensing element, the electric heating element is positioned on the tray body and positioned above the central cavity to indirectly heat the central cavity, and the temperature sensing element is connected with the electric heating element to detect the temperature of the electric heating element;

the tray seat is arranged above the electronic element and is in sealed connection with the tray body, and a vertical first support seat and a vertical seat wall are formed on the tray seat;

the first plug board is connected to the first support in a sealing mode;

the first electrical connector is connected with the first plug board in a sealing mode, the top of the first electrical connector extends upwards out of the first plug board, and the bottom of the first electrical connector is electrically connected with the electronic element;

the dish lid subassembly is arranged in on the disk body subassembly, the dish lid subassembly includes:

the cover body is provided with a vertical second support and a vertical cover wall;

the second inserting plate is arranged in the cover body and is detachably connected to the second support;

the bottom of the second connecting piece extends downwards out of the second plug board, and the top of the second connecting piece is used for being electrically connected with an external power supply through a lead;

wherein, the disk body subassembly with be formed with buckle mechanism between the cover subassembly, buckle mechanism includes hasp strip, buckle spare, elastic component:

the lock catch strip extends vertically, the bottom of the lock catch strip is connected with the disk seat, the top of the lock catch strip is provided with a lock catch head, and the lock catch head extends towards the inner side of the disk seat;

the clamping piece extends vertically, a clamping head is arranged at the bottom of the clamping piece, and the clamping head extends towards the outer side direction of the disc seat;

the elastic piece is connected with the buckle piece, and drives the locking head to move towards the buckle head and keeps the locking head and the buckle head locked with each other; after the locking head and the buckling head are locked with each other, the first electric connecting piece is electrically connected with the second electric connecting piece; the elastic piece drives the locking head to move away from the buckling head, and after the locking head and the buckling head are separated from each other, the first electric connecting piece is disconnected with the second electric connecting piece;

the first support is provided with a first edge extending upwards, the top of the first edge is higher than the first plug board, the second support is provided with a second edge extending downwards, the bottom of the second edge is lower than the second plug board, and the first edge and the second edge are used for preventing the buckle part from colliding with the first electric connecting piece or/and the second electric connecting piece in the process of mutually locking and separating the buckle head and the buckle head.

In some embodiments, the fastening member is rotatably connected to a first pin shaft, the first pin shaft is connected to a vertical cover wall of the cover body, and a first pin hole matched with the first pin shaft is formed in the cover wall;

the elastic piece is an arc-shaped elastic lath, and two ends of the elastic lath are rotatably connected with the top of the buckling piece through a second pin shaft;

after the locking head and the buckling head are locked with each other, the top of the elastic strip is pressed to move downwards, so that two ends of the elastic strip extend towards the outer side direction of the cover body, the second pin shaft connected to the elastic strip and the top of the buckling piece are driven to move towards the outer side direction of the cover body, the buckling head located at the bottom of the buckling piece is driven to move towards the inner side direction of the cover body around the first pin shaft, and the buckling head and the locking head are separated from each other.

In some embodiments, the first pin hole is circular.

In some embodiments, the first pin hole has a vertical dimension greater than a lateral dimension;

the top of the elastic lath is pressed to move downwards, the elastic lath is compressed downwards to drive the second pin shaft connected to the elastic lath and the top of the buckling piece to move downwards, and then the first pin shaft is driven to slide downwards in the first pin hole, so that the buckling head is far away from the buckling head downwards; the top of the elastic lath is pressed to move downwards, so that two ends of the elastic lath extend towards the outer side direction of the cover body, the second pin shaft connected to the elastic lath and the top of the buckling piece are driven to move towards the outer side direction of the cover body, and the buckling head at the bottom of the buckling piece is driven to move towards the inner side direction of the cover body around the first pin shaft;

when the top of the elastic lath is loosened, the elastic lath provides restoring force to drive the top of the elastic lath, the second pin shaft and the top of the buckling piece to move upwards and drive the first pin shaft to slide upwards in the first pin hole; the elastic strip provides restoring force to drive the two ends of the elastic strip to retract towards the inner side direction of the cover body, the second pin shaft connected to the elastic strip and the top of the buckling piece are driven to move towards the inner side direction of the cover body, and then the buckling head located at the bottom of the buckling piece is driven to move around the first pin shaft towards the outer side direction of the cover body until the buckling head is upwards locked with the buckling head;

In some embodiments, the elastic member is a cylindrical compression spring, the cylindrical compression spring is transversely arranged, and two ends of the cylindrical compression spring are respectively connected with the buckle member and the second support;

after the locking head and the buckling head are locked with each other, the cylindrical compression spring is transversely compressed, and the resilience force provided by the cylindrical compression spring maintains the locking head and the buckling head to be locked with each other; the buckling piece is pressed to move towards the inner side direction of the cover body, so that the cylindrical compression spring is further transversely compressed, and the buckling head is separated from the buckling head.

In some embodiments, the elastic member is a conical compression spring including a cylindrical portion and a conical portion, the conical compression spring is transversely arranged, and two ends of the conical compression spring are respectively connected with the buckle member and the second support;

after the locking head and the buckling head are locked with each other, the conical column compression spring is transversely compressed, and the resilience force provided by the conical column compression spring maintains the locking head and the buckling head to be locked with each other;

after the locking head and the buckling head are locked with each other, the edge of the buckling piece moves towards the inner side direction of the cover body by taking the conical part as the center when being pressed, so that the buckling piece is positioned to further press the buckling piece; when the buckling piece is further pressed, the buckling piece moves towards the inner side direction of the cover body, so that the conical column compression spring is further transversely compressed, and the buckling head is separated from the buckling head.

In some embodiments, the split transdermal delivery device further comprises:

the guide bar, at least a part cover of elastic component is located stretch out and draw back on the guide bar to improve the elastic component carries out flexible stability.

In some embodiments, a disk body air passage is arranged between the first support and the base wall, a disk cover air passage is arranged between the second support and the cover wall, and an annular sealing gasket is arranged between the disk body air passage and the disk cover air passage and seals the disk body air passage and the disk cover air passage;

the air guide device is characterized in that an air guide elbow joint communicated with the air passage of the tray body is arranged on the wall of the seat, the air guide elbow joint is used for communicating with the negative pressure annular cavity through an air guide elbow, the air passage of the tray cover is communicated with an air guide pipe arranged on the tray cover, and the air guide pipe is communicated with an external air extractor.

In some embodiments, the top of the first electrical connector is flush with the top of the first patch panel to facilitate cleaning of residual liquid on the top of the first electrical connector and the top of the first patch panel after the tray assembly is retort sterilized.

In some embodiments, the second connector is a pogo pin, a needle head of the pogo pin faces downward toward the first connector, and a housing of the pogo pin is connected with the second socket plate; after the locking head and the buckling head are locked with each other, the top of the first connecting piece is abutted against the needle head of the spring needle to form electric connection; and after the locking head and the buckling head are separated from each other, the top of the first electric connector is disconnected with the second electric connector.

In a second aspect, embodiments of the present application provide a method of using a split transdermal drug delivery device, comprising:

the medicine pad is sleeved on the central convex column in the central cavity;

combining the tray cover assembly with the tray body assembly; a buckle mechanism is formed between the disc body assembly and the disc cover assembly and comprises a lock catch strip, a buckle piece and an elastic piece, wherein the lock catch strip extends vertically, the bottom of the lock catch strip is connected with the disc seat, the top of the lock catch strip is provided with a lock catch head, and the lock catch head extends towards the inner side direction of the disc seat; the clamping piece extends vertically, a clamping head is arranged at the bottom of the clamping piece, and the clamping head extends towards the outer side direction of the disc seat; the locking head and the buckling head are locked with each other, and the first electric connecting piece is electrically connected with the second electric connecting piece;

air is extracted through an air guide duct on the disk cover assembly, so that negative pressure is formed in the negative pressure annular cavity;

adsorbing the negative pressure ring cavity on the skin;

indirectly heating the central cavity by an electrical heating element, causing the temperature of the central cavity to increase to facilitate passage of drug molecules of the drug pad through the skin;

the temperature sensing element is connected with the electric heating element to detect the temperature of the electric heating element;

after treatment is finished, separating the tray cover assembly from the tray body assembly; the elastic piece drives the locking head to move away from the buckling head, and after the locking head and the buckling head are separated from each other, the first electric connecting piece is disconnected with the second electric connecting piece;

the tray body assembly is steam sterilized for the next use.

The beneficial effects brought by some embodiments of the application are: the combination of the locking strip, the buckle piece and the elastic piece achieves the effect of detachably connecting the disc body assembly and the disc cover assembly, the disc body assembly and the disc cover assembly are combined together when the locking head and the buckle head are mutually interlocked, and the first electric connecting piece and the second electric connecting piece are electrically connected and can be used for indirectly heating the central cavity by the electric heating element. After the locking head and the buckle head are separated from each other, the first electric connector and the second electric connector are disconnected, the tray body assembly and the tray cover assembly are separated from each other, the tray body assembly in contact with skin can be sterilized independently after treatment is finished, for example, high-temperature water boiling sterilization is performed, and biological safety during next use is guaranteed.

In some embodiments of the present application, the first support has a first rim extending upward, a top of the first rim is higher than the first plugboard, the second support has a second rim extending downward, a bottom of the second rim is lower than the second plugboard, and the first rim and the second rim perform an anti-collision function on the first electrical connector 15 or/and the second electrical connector 24.

In some embodiments of the present application, the fastening member is rotatably connected to the first pin, the cover wall is provided with a first pin hole matched with the first pin, the first pin hole is a long pin hole, and because the vertical dimension of the long pin hole is greater than the horizontal dimension, in the locking and unlocking processes of the locking head and the fastening head, the fastening head moves downward while being close to or away from the locking head, so that the fastening head is prevented from being clamped by the locking head in the moving process, the smoothness in use of the split type transdermal drug delivery device is improved, and the failure rate is reduced.

It should be understood that the statements in this section are not intended to identify key or critical features of the embodiments of the present application, nor are they intended to limit the scope of the present application. Other features of the present application will become apparent from the following description. The above and other objects, advantages and features of the present application will become more apparent to those skilled in the art from the following detailed description of specific embodiments thereof, taken in conjunction with the accompanying drawings.

Drawings

Some specific embodiments of the present application will be described in detail hereinafter, by way of example and not by way of limitation, with reference to the accompanying drawings, which are included to provide a better understanding of the present application and are not to be construed as limiting the present application. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the drawings:

FIG. 1 is a schematic top view of a split-type transdermal drug delivery device according to some embodiments of the present application;

FIG. 2 isbase:Sub>A cross-sectional view A-A of FIG. 1 according to some embodiments of the present application;

FIG. 3 is a cross-sectional view B-B of FIG. 1 illustrating the locking head and the buckle head interlocked with each other according to some embodiments of the present disclosure;

FIG. 4 is a cross-sectional view B-B of FIG. 1 illustrating the locking head and the snapper head separated from each other in accordance with some embodiments of the present disclosure;

FIG. 5 is an isometric view of a cover illustrating a first pin hole as a circular pin hole according to some embodiments of the present disclosure;

FIG. 6 is a schematic view of a tray assembly according to some embodiments of the present application;

FIG. 7 is a cross-sectional view B-B of FIG. 1 illustrating the locking head and the buckle head interlocked with each other in accordance with further embodiments of the present application;

FIG. 8 is a cross-sectional view B-B of FIG. 1 illustrating the locking head and the snapper head separated from each other in accordance with other embodiments of the present application;

FIG. 9 is an isometric view of a cover according to other embodiments of the present application, showing the first pin hole as an elongated pin hole;

FIG. 10 is a schematic top view of a split-type transdermal delivery device according to still further embodiments of the present application;

FIG. 11 is a cross-sectional view C-C of FIG. 10 in accordance with still other embodiments of the present application;

FIG. 12 is a cross-sectional view D-D of FIG. 10 in accordance with still other embodiments of the present application; wherein, the elastic element is shown to be a cylindrical compression spring, and the locking head and the buckle head are locked with each other;

FIG. 13 is a schematic bottom view of a cover assembly according to still other embodiments of the present application;

FIG. 14 is a cross-sectional view D-D of FIG. 10 in accordance with still other embodiments of the present application; wherein the locking head and the snap head are shown separated from each other;

FIG. 15 is a cross-sectional view D-D of FIG. 10 in accordance with still further embodiments of the present application; wherein the elastic element is shown as a conical compression spring comprising a cylindrical part and a conical part, and the locking head and the buckling head are locked with each other;

FIG. 16 is a schematic flow chart illustrating a method of using a split transdermal delivery device according to some embodiments of the present application.

Description of the main element symbols:

10-a tray assembly;

11-a disk body, 111-a negative pressure ring cavity, 112-a central cavity, 113-a central convex column, 114-an air guide bent pipe interface and 115-the upper edge of the disk body;

12-disk seat, 121-seat wall, 122-first support, 122 a-first edge, 123-disk air passage, 124-locking strip, 124 a-locking head and 125-air guide elbow joint;

13-electronic element, 131-temperature sensing element, 132-electric heating element, 133-inner lead;

14-a first patch panel;

15-first electrical connection, 151-electrical connection;

20-a tray cover assembly;

21-cover body, 211-cover wall, 212-second support, 212 a-second edge, 213-cover top, 214-disk cover air channel, 215-guide groove, 216-stop block, 217-first pin hole, 217 a-round pin hole and 217 b-long pin hole;

22-conduit, 221-gas conduit, 222-conductive conduit;

23-a second patch panel;

24-second electrical connection, 241-pogo pin;

25-snap mechanism, 251-snap, 251 a-snap, 251 b-snap, 251 c-limit plate, 251 d-guide, 251 e-guide; 252-elastomer, 252 a-cylindrical compression spring, 252 b-conical compression spring, 252 c-elastic strip; 253-pin, 253 a-first pin, 253 b-second pin; 254-pressing the cap;

26-an air guide bent pipe;

27-a gasket.

Detailed Description

The technical solution in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application, wherein: numerous details of the embodiments of the present application are set forth to provide an understanding that the described embodiments are merely possible technical implementations of the present application and should be considered merely exemplary and not all possible implementations. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.

The use of ordinal numbers such as "first," "second," etc., in the specification and claims to modify a corresponding element does not by itself connote any ordinal number of the element or the order in which it is associated with one element or another or the order in which it is manufactured, and is used merely to clearly distinguish one element having a certain name from another element having a same name. In this application "or/and", "and/or" means that the object is at least one of the objects, or "means that the object is one of the objects.

The terms "upper," "lower," "vertical," "high," and "low" in this application are used with reference to the orientation shown in fig. 3, and are used primarily for the purpose of better describing the application and its embodiments, and are not intended to limit the indicated devices, elements, or components to a particular orientation or to be constructed and operated in a particular orientation. The term "plurality" shall mean two as well as more than two. The terms "inner", "outer", and the like, indicate an orientation or positional relationship based on that shown in the drawings, merely for convenience in describing the present application and for simplicity of description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present application.

According to a first aspect of the present application, there is provided a split transdermal drug delivery device comprising:

tray assembly 10, tray assembly 10 includes:

the disk body 11 is formed with a central cavity 112 and an annular negative pressure annular cavity 111.

The electronic component 13 includes an electrical heating element 132, and the electrical heating element 132 is located on the tray body 11 and above the central cavity 112 to indirectly heat the central cavity 112.

And a tray 12 disposed above the electronic component 13 and hermetically connected to the tray body 11, wherein the tray 12 is formed with a vertical first seat 122 and a vertical seat wall 121.

The first socket plate 14 is sealingly connected to the first support 122.

And the first connecting piece 15 is connected with the first plug board 14 in a sealing mode, the top of the first connecting piece 15 extends upwards out of the first plug board 14, and the bottom of the first connecting piece 15 is electrically connected with the electronic element 13.

The tray cover assembly 20 is arranged on the tray body assembly 10, and the tray cover assembly 20 comprises:

the cover 21 is formed with a vertical second support 212 and a vertical cover wall 211.

And a second socket plate 23 disposed inside the cover body 21 and detachably coupled to the second holder 212.

And the second connecting piece 24 is connected with the second plug board 23, the bottom of the second connecting piece 24 extends downwards out of the second plug board 23, and the top of the second connecting piece 24 is used for being electrically connected with an external power supply through a lead.

Wherein, a fastening mechanism 25 is formed between the tray body assembly 10 and the tray cover assembly 20, and the fastening mechanism 25 includes a locking strip 124, a fastener 251, and an elastic element 252:

the locking strip 124 extends vertically, the bottom of the locking strip 124 is connected to the tray 12, and the top of the locking strip 124 has a locking head 124a, and the locking head 124a extends toward the inner side of the tray 12.

The locking member 251 extends vertically, and the bottom of the locking member 251 has a locking head 251b, and the locking head 251b extends towards the outer side of the tray 12.

The elastic member 252 is connected to the locking member 251, and the elastic member 252 drives the locking head 124a to move towards the locking head 251b and keeps the locking head 124a and the locking head 251b locked with each other; after the locking head 124a and the locking head 251b are locked with each other, the first electrical connector 15 is electrically connected with the second electrical connector 24; the elastic member 252 drives the locking head 124a to move away from the locking head 251b, and after the locking head 124a and the locking head 251b are separated from each other, the first electrical connector 15 is disconnected from the second electrical connector 24.

In the present application, the combination of the locking strip 124, the fastener 251 and the elastic element 252 achieves the effect of detachably connecting the disc assembly 10 and the cover assembly 20, when the locking head 124a is interlocked with the fastener 251b, the disc assembly 10 is combined with the cover assembly 20, and the electrical connection between the first electrical connector 15 and the second electrical connector 24 can be used for indirectly heating the central cavity 112 by the electrical heating element 132; after the locking head 124a and the locking head 251b are separated from each other, the first electrical connector 15 and the second electrical connector 24 are disconnected, the tray body assembly 10 and the tray cover assembly 20 are separated from each other, and the tray body assembly 10 in contact with the skin can be sterilized independently after treatment is finished, for example, high-temperature water boiling sterilization is performed, so that the biological safety in the next use is ensured.

In the application, the tray 12 is arranged above the electronic element 13 and is connected with the tray body 11 in a sealing manner, the first plug board 14 is connected with the first support 122 of the tray 12 in a sealing manner, the first electrical connector 15 is connected with the first plug board 14 in a sealing manner, a sealing space formed by the tray body 11, the tray 12 and the first plug board 14 is formed through the arrangement, so that the electric heating element 132 is sealed to be waterproof, the electronic element 13 is always isolated from disinfection liquid such as water and alcohol when being disinfected by boiling high-temperature water, and the electronic element 13 is prevented from being damaged by short circuit when being soaked with water in next use. In some embodiments, the electronic element 13 further includes a temperature sensing element 131, the temperature sensing element 131 is connected to the electric heating element 132 to detect the temperature of the electric heating element 132, and the temperature sensing element 131 is disposed in the central cavity 112, so that the temperature sensing element 131 is sealed to achieve a waterproof effect. Specifically, the first socket plate 14 is hermetically connected to the first support 122 on the tray 12, the first electrical connector 15 is hermetically connected to the first socket plate 14, and the first electrical connector 15 is electrically connected to the electric heating element 132 and the temperature sensing element 131 through the inner lead 133.

In the embodiments shown in fig. 2-4, 6-8, 11-12, and 14-15, the seat 12 and the tray 11 are of a split structure, so that during manufacture, the electric heating element 132 is conveniently placed between the seat 12 and the tray 11, and the seat 12 and the tray 11 are sealed at the upper edge 115 of the tray. In other embodiments, the seat 12 and the tray 11 may be fixed together to form an integral structure.

In the embodiment shown in fig. 3, 4, 7, 8, 12, 14, and 15, the first support 122 has a first edge 122a extending upward, the top of the first edge 122a is higher than the first plugboard 14, the second support 212 has a second edge 212a extending downward, the bottom of the second edge 212a is lower than the second plugboard 23, and the first edge 122a and the second edge 212a are used to prevent the latch 251 from colliding with the first electrical connector 15 or/and the second electrical connector 24 during the process of locking and separating the locking head 124a and the locking head 251 b. In this design, first and

second edges

122a and 212a serve as anti-collision features for first and/or second electrical connectors 15 and 24.

The latch mechanism 25 of the present application is described in detail below.

In the embodiment shown in fig. 3, 4, 7, and 8, the locking member 251 is rotatably connected to a first pin 253a, the first pin 253a is connected to a vertical cover wall 211 of the cover 21, and the cover wall 211 is provided with a first pin hole 217 matching with the first pin 253 a; the elastic member 252 is an arc-shaped elastic strip 252c, and two ends of the elastic strip 252c are rotatably connected to the top of the locking member 251 through a second pin 253 b. After the locking head 124a and the locking head 251b are locked with each other, the top of the elastic strip 252c is pressed to move downward so that two ends of the elastic strip 252c extend toward the outer side of the cover 21, the second pin shaft 253b connected to the elastic strip 252c and the top of the locking element 251 move toward the outer side of the cover 21, and the locking head 251b at the bottom of the locking element 251 is further driven to move toward the inner side of the cover 21 around the first pin shaft 253a, so that the locking head 251b and the locking head 124a are separated from each other.

In the embodiment shown in fig. 3, 4, 7 and 8, a protrusion is disposed on the top of the elastic strip 252c, a pressing cap 254 is sleeved on the protrusion, and the pressing cap 254 extends out of the top 213 of the cover body 21 so as to press the top of the elastic strip 252 c. The elastic strip 252c is integrally arched, so that when the top of the elastic strip 252c is pressed, a larger deformation can be provided, the length of the two ends of the elastic strip 252c extending towards the outer side of the cover 21 is increased, the distance of the second pin 253b connected to the elastic strip 252c and the top of the locking element 251 moving towards the outer side of the cover 21 is increased, the distance of the locking head 251b moving towards the inner side of the cover 21 around the first pin 253a is further increased, and the locking head 251b and the locking head 124a are more easily separated from each other.

Fig. 5 shows the structure of the cover 21 in some embodiments, the cover 21 includes a cover top 213 extending in a transverse direction and a cover wall 211 extending in a vertical direction, the cover wall 211 is provided with a first pin hole 217, the first pin hole 217 is a circular pin hole 217a, and the circular pin hole 217a defines the first pin 253a to rotate in the circular pin hole 217a, so that the movement of the first pin 253a is simple and reliable, the first pin 253a has no movement in other directions, the error rate during the movement of the first pin 253a is reduced, and the reliability of the split transdermal drug delivery device is improved.

Fig. 9 shows the structure of the cover body 21 in some embodiments, which is different from fig. 5 in that the first pin hole 217 is a long pin hole 217b, and the long pin hole 217b defines the first pin shaft 253a to rotate in the long pin hole 217b and move up and down in the long pin hole 217b. Specifically, the locking head 124a and the locking head 251b are locked with each other as follows: the vertical dimension of the first pin hole 217 is greater than the lateral dimension; the top of the elastic strip 252c is pressed to move downward, the elastic strip 252c is compressed downward to drive the second pin 253b connected to the elastic strip 252c and the top of the locking member 251 to move downward, and further drive the first pin 253a to slide downward in the first pin hole 217, so that the locking head 251b moves downward away from the locking head 124a of the locking strip 124. Moreover, the top of the elastic strip 252c is pressed to move downward, so that both ends of the elastic strip 252c extend toward the outer side of the cover 21, and the second pin 253b connected to the elastic strip 252c and the top of the locking element 251 are driven to move toward the outer side of the cover 21, and the locking head 251b located at the bottom of the locking element 251 is driven to move toward the inner side of the cover 21 around the first pin 253 a. When the top of the elastic strip 252c is released, the elastic strip 252c provides restoring force to drive the top of the elastic strip 252c, the second pin shaft 253b and the top of the fastener 251 to move upwards, and drive the first pin shaft 253a to slide upwards in the first pin hole 217; moreover, the elastic strip 252c provides a restoring force to drive the two ends of the elastic strip 252c to retract toward the inner side of the cover 21, and drive the second pin 253b connected to the elastic strip 252c and the top of the locking element 251 to move toward the inner side of the cover 21, so as to drive the locking head 251b located at the bottom of the locking element 251 to move toward the outer side of the cover 21 around the first pin 253a until the locking head 251b is locked with the locking head 124a upward.

The process of unlocking or separating the locking head 124a from the locking head 251b is as follows: after the locking head 124a and the locking head 251b are locked with each other, the top of the elastic strip 252c is pressed to move downward, so that both ends of the elastic strip 252c extend toward the outer side of the cover 21, the second pin 253b connected to the elastic strip 252c and the top of the locking member 251 are driven to move toward the outer side of the cover 21, and the locking head 251b at the bottom of the locking member 251 is driven to move toward the inner side of the cover 21 around the first pin 253a, so that the locking head 251b and the locking head 124a are separated from each other.

In the design, because the vertical dimension of the long pin hole 217b is larger than the transverse dimension, in the locking and unlocking processes of the locking head 124a and the buckling head 251b, the buckling head 251b moves downwards while approaching or departing from the locking head 124a, so that the buckling head 251b is prevented from being clamped by the locking head 124a in the moving process, the use fluency of the split type transdermal drug delivery device is improved, and the failure rate is reduced.

In the embodiment shown in fig. 12 and 14, the elastic member 252 is a cylindrical compression spring 252a, the cylindrical compression spring 252a is transversely disposed, and two ends of the cylindrical compression spring 252a are respectively connected with the latch 251 and the second support 212. After the locking head 124a and the locking head 251b are locked with each other, the cylindrical compression spring 252a is compressed transversely, and the resilience provided by the cylindrical compression spring 252a maintains the locking head 251b and the locking head 124a locked with each other; the latch 251 is pressed to move toward the inner side of the cover 21, so that the cylindrical compression spring 252a is further compressed laterally, and the latch head 251b and the latch head 124a are separated from each other. In the design, the cylindrical compression spring 252a basically extends and retracts in the direction of the central line thereof, the connection surfaces of the two ends of the cylindrical compression spring 252a, the fastener 251 and the second support 212 are large, the cylindrical compression spring 252a can provide stable support for the fastener 251, and the fastener 251b cannot move to be separated from the fastener 124a when the fastener 251 is accidentally touched, so that the disc cover assembly 20 is prevented from accidentally falling off from the disc assembly 10 in the use process, and the reliability of the split type transdermal drug delivery device is improved.

In the embodiment shown in fig. 15, the elastic member 252 is a conical compression spring 252b including a cylindrical portion and a tapered portion, the conical compression spring 252b is transversely disposed, and two ends of the conical compression spring 252b are respectively connected to the latch 251 and the second support 212. After the locking head 124a and the locking head 251b are locked with each other, the conical column compression spring 252b is transversely compressed, and the resilience provided by the conical column compression spring 252b maintains the locking head 251b and the locking head 124a to be locked with each other; after the locking head 124a and the locking head 251b are locked with each other, the edge of the locking member 251 moves toward the inner side of the cover 21 with the tapered portion as the center when being pressed, so as to position the locking member 251 to further press the locking member 251; when the latch 251 is further pressed, the latch 251 moves toward the inner side of the cover 21, so that the conical compression spring 252b is further compressed laterally, and the latch head 251b and the latch head 124a are separated from each other.

In this design, the conical compression spring 252b provides support for the fastening member 251, and when the fastening member 251 is accidentally touched, the fastening head 251b will not be moved to separate from the fastening head 124a, so as to prevent the disc cover assembly 20 from accidentally falling off from the disc assembly 10 during use, thereby improving the reliability of the split transdermal drug delivery device. In order to maintain the locking of the locking head 124a and the locking head 251b, and prevent the tray cover assembly 20 from falling off the tray assembly 10 during the treatment, the elastic member 252 should provide a large resilient force. Thus, the latch 251 does not move when a small pressing force is applied only by hand, and it is not easy to position the latch 251 only by hand. In the embodiment shown in fig. 15, the cylindrical portion of the conical compression spring 252b is connected to the latch 251 with a larger area, and the conical portion is connected to the second support 212 with a smaller area, so that pressing the edge of the latch 251 with a smaller force can easily move the latch 251 toward the inner side of the cover 21 with the conical portion as the center, thereby quickly positioning the latch 251 so as to further press the latch 251 to separate the tray assembly 10 and the tray cover assembly 20 from each other. In other embodiments, a cylindrical portion of the conical compression spring 252b may be connected to the second seat 212, and a conical portion may be connected to the latch 251.

In the embodiment shown in fig. 12, 14 and 15, the latch 251 is provided with a guide rod 251e, and the guide rod 251e extends toward the second support 212. At least a portion of the elastic member 252 is sleeved on the guide rod 251e for extending and contracting, so as to improve the stability of the elastic member 252 for extending and contracting. A portion of the cylindrical compression spring 252a is fitted over the guide rod 251e in the embodiment shown in fig. 12 and 14, and a cylindrical portion of the conical compression spring 252b is fitted over the guide rod 251e in the embodiment shown in fig. 15. In other embodiments, a guide rod 251e may be further disposed on the second support 212, and the guide rod 251e extends toward the locking member 251.

In the embodiment shown in fig. 2 and 11, a tray body air passage 123 is arranged between the first support 122 and the base wall 121, a tray cover air passage 214 is arranged between the second support 212 and the cover wall 211, and the annular sealing gasket 27 is arranged between the tray body air passage 123 and the tray cover air passage 214 and seals the tray body air passage 123 and the tray cover air passage 214. An air guide elbow joint 125 communicated with the air passage 123 of the tray body is arranged on the seat wall 121, the air guide elbow joint 125 is used for being communicated with the negative pressure annular cavity 111 through an air guide elbow 26, the air passage 214 of the tray cover is communicated with an air guide conduit 221 arranged on the tray cover, and the air guide conduit 221 is communicated with an external air extraction device. Through the arrangement, the air suction paths of the negative pressure annular cavity 111, the air guide bent pipe 26, the disk body air passage 123 and the disk cover air passage 214 are formed, the sealing between the disk cover assembly 20 and the disk body assembly 10 is not depended on, and the sealing requirements between the disk cover assembly 20 and the disk body assembly 10 are reduced. In the embodiment shown in fig. 2 and 11, the air guide duct 221 and the air guide elbow 26 are disposed on opposite sides of the cover wall 211, and the tray cover air duct 214 is connected to the air guide duct 221 through the air passage between the cover body 21 and the second support 212. It is understood that the air guide duct 221 and the air guide elbow 26 may be disposed on the same side of the cover wall 211, and the cover plate air duct 214 may be directly connected to the air guide duct 221 disposed on the cover plate.

In the embodiment shown in fig. 2-4, 6-8, 11-12, 14-15, the top of the first electrical connector 15 is flush with the top of the first patch panel 14 to facilitate cleaning of residual liquid on the top of the first electrical connector 15 and the top of the first patch panel 14 after the tray assembly 10 is retort sterilized. In this design, the top of the first connector 15 can be a flat surface, and the second connector 24 can be electrically connected to the top of the first connector 15.

In the embodiments shown in fig. 2-4, 7-8, 11-12, 14-15, the second patch panel 23 is removably coupled to a second mount 212 formed on the interior of the cover 21 to facilitate mounting of the second patch panel 23. For example, the second connector 24 is first inserted into the corresponding mounting hole of the second insertion plate 23, the second connector 24 is electrically connected to the conductive wire in the conductive conduit 222 by a conductive wire, and then the second insertion plate 23 is mounted on the second support 212.

In order to improve the electrical connection stability of the second electrical connector 24 capable of making electrical connection with the top of the first electrical connector 15, in the embodiments shown in fig. 2-4, 6-8, 11-12, and 14-15, the second electrical connector 24 is a pogo pin 241, and the first electrical connector 15 is an electrical socket 151. The needle head of the pogo pin 241 faces downward toward the first electrical connector 15, and the housing of the pogo pin 241 is connected to the second socket plate 23; after the locking head 124a and the locking head 251b are locked with each other, the top of the first electrical connector 15 is abutted against the needle head of the pogo pin 241 to form electrical connection; after the locking head 124a and the locking head 251b are separated from each other, the top of the first connector 15 is disconnected from the second connector 24. In this design, if the tray cover assembly 20 and the tray assembly 10 are relatively displaced during the treatment process, which results in the displacement of the second connector 24 and the first connector 15, the needle of the pogo pin 241 can maintain the electrical connection with the first connector 15 under the action of the internal spring, thereby improving the reliability of the electrical connection of the split type transdermal drug delivery device. In these embodiments, the top surface of the electrical receptacle 151 is flat. In other embodiments, the first electrical connector 15 may be a pogo pin 241, and the second electrical connector 24 may be an electrical socket 151.

In the embodiment shown in fig. 2-4, 6-8, 11-12, 14-15, the tray upper edge 115 is formed with an annular groove opening toward the center of the tray 12, and the bottom of the tray 12 is inserted into the annular groove and adhesively attached thereto to seal the tray 12 with the tray 11 at the tray upper edge 115. By arranging the annular groove, the upper edge 115 of the disc body forms mechanical limit on the disc seat 12, so that the disc seat 12 can be effectively prevented from shaking and loosening, and the long-term sealing effect of the disc seat 12 and the disc body 11 at the upper edge 115 of the disc body is improved. In other embodiments, the following steps can be further provided: the bottom of the tray 12 forms an annular groove opening toward the upper edge 115 of the tray body, and the upper edge 115 of the tray body is inserted into the annular groove and sealed with the annular groove by bonding.

It should be noted that, in the present application, the technical features in the embodiments and the embodiments may be combined with each other without conflict, and some combined embodiments are schematically presented in the present application to illustrate possible combinations:

example 1:

fig. 1 is a schematic top view of a split-type transdermal drug delivery device according to some embodiments of the present application, showing a tray cover assembly 20, a tray body assembly 10, an air guide elbow 26, and a conduit 22 disposed on opposite sides of the tray cover assembly 20, and a push cap 254 disposed on the tray cover assembly 20. FIG. 2 isbase:Sub>A cross-sectional view A-A of FIG. 1 showing the second electrical connector 24 asbase:Sub>A pogo pin 241,base:Sub>A cap 254 withbase:Sub>A resilient strip 252c attached thereto, an air guide tube 221 for communicating with an external suction device, and an electrically conductive tube 222 for connecting to an external power source via internal wiring, according to some embodiments of the present application; the first socket plate 14 is sealingly connected to the first support 122, and the second socket plate 23 is disposed inside the cover 21 and detachably connected to the second support 212. Fig. 3 is a cross-sectional view B-B of fig. 1 illustrating the latch 251 being pivotally connected to the first pin 253a, the two ends of the elastic strip 252c being pivotally connected to the top of the latch 251 through the second pin 253B, and the locking head 124a being interlocked with the locking head 251B according to some embodiments of the present application. Fig. 4 is a cross-sectional view B-B of fig. 1 showing the resilient strip 252c in an extended state, with the resilient strip 252c spreading the top of the latch 251 outward and the locking head 124a and the locking head 251B separated from each other, according to some embodiments of the present application, and it can be seen from a comparison of fig. 3 and 4 that the locking strip 124 is part of the housing wall 121. Fig. 5 is an axial view of the cover 21 according to some embodiments of the present disclosure, wherein the first pin hole 217 is a circular pin hole 217a. FIG. 6 is a schematic view of the tray assembly 10 illustrating the top of the first electrical connector 15 flush with the top of the first docking plate 14 and the top of the first electrical connector 15 flush with the top of the first docking plate 14 to facilitate cleaning of residual liquid on the top of the first electrical connector 15 and the top of the first docking plate 14 after the tray assembly 10 is retort sterilized. The embodiment of the combination is a combination of the structures shown in fig. 1-6, and has technical effects brought by corresponding structures.

Example 2: fig. 7 is a cross-sectional view B-B of fig. 1 illustrating the locking head 124a and the locking head 251B locked to each other according to other embodiments of the present disclosure. Fig. 8 is a cross-sectional view B-B of fig. 1 illustrating the locking head 124a and the snap head 251B separated from each other according to other embodiments of the present disclosure. Fig. 9 is an axial view of cover 21 according to other embodiments of the present application, wherein first pin hole 217 is shown as long pin hole 217b. The embodiment of the combination is a combination of the structures shown in fig. 7, 8 and 9, and has technical effects brought by corresponding structures.

Example 3: fig. 10 is a schematic top view of a split-type transdermal delivery device according to further embodiments of the present application, without the push cap 254 on top of the cap 213. FIG. 11 is a cross-sectional view C-C of FIG. 10 according to still further embodiments of the present application. Fig. 12 is a cross-sectional view taken along line D-D of fig. 10 illustrating the resilient member 252 being a cylindrical compression spring 252a, the locking head 124a and the locking head 251b being interlocked with each other according to yet another embodiment of the present application. FIG. 13 is a bottom view of the cover assembly 20 showing the retainer plate 251c, the guide plate 251d and the stopper 216, wherein the retainer plate 251c and the stopper 216 cooperate to define the maximum extension distance of the cylindrical compression spring 252a, maintaining the latch 251 on the cover wall 211 to improve the integrity of the split transdermal drug delivery device; the guide plate 251d is matched with the guide rod 251e for use, so that the telescopic direction of the cylindrical compression spring 252a is ensured; in fig. 13, the stopper 216 is provided on the tray body 11, the stopper plate 251c and the guide plate 251d are provided on the latch 251, and the latch surface 251a is a surface which is contacted when the latch 251 is operated by hand. Fig. 14 is a cross-sectional view D-D of fig. 10 illustrating the locking head 124a and the snap head 251b separated from each other according to still other embodiments of the present application. The embodiment of the combination is a combination of the structures shown in fig. 10-14, and has technical effects brought by corresponding structures.

Example 4: fig. 10 is a schematic top view of a split-type transdermal delivery device according to further embodiments of the present application, without the push cap 254 on top of the cap 213. Fig. 15 is a cross-sectional view taken along line D-D of fig. 10 illustrating the resilient member 252 as a conical compression spring 252b including a cylindrical portion and a tapered portion, with the locking head 124a interlocking with the locking head 251b according to yet other embodiments of the present application. The embodiment of the combination is a combination of the structures shown in fig. 10 and 15, and has technical effects brought by corresponding structures.

Based on the same concept, embodiments of the second aspect of the present application also provide a method of using a split transdermal drug delivery device, the method of using comprising:

s101, the medicine pad is sleeved on the central convex column 113 in the central cavity 112.

And S102, combining the tray cover assembly 20 with the tray body assembly 10. Wherein, a buckle mechanism 25 is formed between the tray body assembly 10 and the tray cover assembly 20, the buckle mechanism 25 comprises a locking strip 124, a buckle 251 and an elastic element 252, the locking strip 124 extends vertically, the bottom of the locking strip 124 is connected with the tray 12, the top of the locking strip 124 is provided with a locking head 124a, and the locking head 124a extends towards the inner side of the tray 12; the fastener 251 extends vertically, a fastener head 251b is arranged at the bottom of the fastener 251, and the fastener head 251b extends towards the outer side direction of the disc seat 12; the locking head 124a and the locking head 251b are locked with each other, and the first electrical connector 15 is electrically connected with the second electrical connector 24.

S103, air is extracted through the air guide duct 221 on the disk cover assembly 20, so that the negative pressure annular cavity 111 forms negative pressure.

S104, adsorbing the negative pressure ring cavity 111 on the skin.

S105, the electric heating element 132 indirectly heats the central cavity 112, and the temperature of the central cavity 112 is increased to promote the drug molecules of the drug pad to pass through the skin.

S106, the temperature sensing element 131 is connected with the electric heating element 132 to detect the temperature of the electric heating element 132.

And S107, after the treatment is finished, separating the tray cover assembly 20 from the tray body assembly 10. The elastic element 252 drives the locking head 124a to move away from the locking head 251b, and after the locking head 124a and the locking head 251b are separated from each other, the first electrical connector 15 is disconnected from the second electrical connector 24.

S108, the tray assembly 10 is steamed and sterilized for the next use.

In the present application, a central convex column 113 protruding downwards is formed in the central cavity 112, and the medicine pad can be sleeved on the central convex column 113 for positioning. The central lumen 112 is connected to the negative pressure annulus 111 by an upwardly opening annular channel to provide skin compliance. In fig. 2, the electric heating element 132 is located between the plate 11 and the plate holder 12, and the temperature sensing element 131 connected to the electric heating element 132 is located in the central pillar 113, so that the bottom surface of the central pillar 113 can support and fix the temperature sensing element 131. The temperature sensing element 131 can detect the temperature of the electric heating element 132, thereby indirectly detecting the temperature in the central cavity 112, on one hand, the release speed of the drug molecules in the drug pad can be controlled, and on the other hand, the temperature of the skin can be controlled, thereby preventing the skin from being scalded or controlling the local blood circulation speed of the skin and further controlling the permeability of the skin.

In this application, the combination of the locking strip 124, the fastener 251 and the elastic element 252 achieves the effect of detachably connecting the disc assembly 10 and the cover assembly 20, when the locking head 124a is interlocked with the fastening head 251b, the disc assembly 10 is combined with the cover assembly 20, and the electrical connection between the first electrical connector 15 and the second electrical connector 24 can be used for indirectly heating the central cavity 112 by the electrical heating element 132. After the locking head 124a and the locking head 251b are separated from each other, the first electrical connector 15 and the second electrical connector 24 are disconnected, the tray body assembly 10 and the tray cover assembly 20 are separated from each other, and the tray body assembly 10 in contact with the skin can be sterilized independently after treatment is finished, for example, high-temperature water boiling sterilization is performed, so that the biological safety in the next use is ensured.

So far, the embodiments of the present application have been described in detail with reference to the accompanying drawings. It is to be noted that, in the attached drawings or in the description, the implementation modes not shown or described are all the modes known by the ordinary skilled person in the field of technology, and are not described in detail.

The above embodiments are only examples of the present application and should not be construed as limiting the present application, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present application should be included in the protection scope of the present application.

Claims

1. A split transdermal drug delivery device, comprising:

a tray body assembly, the tray body assembly includes:

the disc body is provided with a central cavity, a central convex column positioned in the central cavity and an annular negative pressure annular cavity;

the first plug board is connected to the first support in a sealing manner;

the second inserting plate is arranged in the cover body and detachably connected to the second support;

2. The split transdermal drug delivery device according to claim 1,

the buckling piece is rotationally connected with a first pin shaft, the first pin shaft is connected to a vertical cover wall of the cover body, and a first pin hole matched with the first pin shaft is formed in the cover wall;

after the locking head and the buckling head are locked with each other, the top of the elastic strip is pressed to move downwards, so that two ends of the elastic strip extend towards the outer side direction of the cover body, the second pin shaft connected to the elastic strip and the top of the buckling piece move towards the outer side direction of the cover body, the buckling head located at the bottom of the buckling piece is driven to move towards the inner side direction of the cover body around the first pin shaft, and the buckling head and the locking head are separated from each other.

3. The split transdermal drug delivery device according to claim 2,

the first pin hole is circular.

4. The split transdermal drug delivery device according to claim 2,

the vertical size of the first pin hole is larger than the transverse size;

when the top of the elastic lath is loosened, the elastic lath provides restoring force to drive the top of the elastic lath, the second pin shaft and the top of the buckling piece to move upwards and drive the first pin shaft to slide upwards in the first pin hole; the elastic lath provides restoring force to drive the two ends of the elastic lath to retract towards the inner side direction of the cover body, the second pin shaft connected to the elastic lath and the top of the buckling piece are driven to move towards the inner side direction of the cover body, and then the buckling head positioned at the bottom of the buckling piece is driven to move towards the outer side direction of the cover body around the first pin shaft until the buckling head is upwards locked with the buckling head;

5. The split transdermal drug delivery device according to claim 1,

the elastic part is a cylindrical compression spring which is transversely arranged, and two ends of the cylindrical compression spring are respectively connected with the buckling part and the second support;

6. The split transdermal drug delivery device according to claim 1,

the elastic part is a conical compression spring comprising a cylindrical part and a conical part, the conical compression spring is transversely arranged, and two ends of the conical compression spring are respectively connected with the buckling part and the second support;

7. The split transdermal drug delivery device according to claim 5 or 6, further comprising:

at least one part of the elastic piece is sleeved on the guide rod to stretch out and draw back, so that the stretching stability of the elastic piece is improved.

8. The split transdermal drug delivery device according to claim 1,

a disc body air passage is arranged between the first support and the base wall, a disc cover air passage is arranged between the second support and the cover wall, and an annular sealing gasket is arranged between the disc body air passage and the disc cover air passage and seals the disc body air passage and the disc cover air passage;

the air guide elbow joint is used for communicating the negative pressure ring cavity through the air guide elbow, the air guide conduit is communicated with the air guide conduit arranged on the tray cover through the tray cover air passage, and the air guide conduit is communicated with an external air extractor.

9. The split transdermal drug delivery device according to claim 1,

the top of the first connector is flush with the top of the first plug board, so that residual liquid on the top of the first connector and the top of the first plug board can be cleaned conveniently after the tray body assembly is subjected to cooking sterilization.