CN101284157B - Transdermal drug delivery device - Google Patents
Transdermal drug delivery device Download PDFInfo
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- CN101284157B CN101284157B CN2007100905507A CN200710090550A CN101284157B CN 101284157 B CN101284157 B CN 101284157B CN 2007100905507 A CN2007100905507 A CN 2007100905507A CN 200710090550 A CN200710090550 A CN 200710090550A CN 101284157 B CN101284157 B CN 101284157B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
- A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
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Abstract
The invention discloses a percutaneous drug-delivery device, comprising an application disk (1) stuck to skin, and a drug cushion (2) arranged under the lower part of the application disk (1). The upper part of the application disk (1) is a top surface (3); an outer-ring cavity (4) with a downward opening and a central cavity (5) are arranged under the top surface (3); an annular side wall (6) is arranged between the outer-ring cavity (4) and the central cavity (5); the outer-ring cavity (4) is communicated with a negative pressure source through a negative pressure passage port (7) of the top surface (3); the drug cushion (2) is arranged in the central cavity (5); the outer-ring cavity (4) is divided into an upper cavity and a lower cavity by a permeability clapboard (8), wherein, the upper cavity is communicated with the negative pressure source through the negative pressure passage port (7), and the lower cavity is open downwards. When being combined with drug therapy, the percutaneous drug-delivery device increases the percutaneous drug-delivery force, and also can form the well seal on the human skin surface.
Description
Technical field
The present invention relates to a kind of medical apparatus and instruments, particularly a kind of transdermal delivery device.
Background technology
Percutaneous has only function fixing, that cover medicine and promote drug osmotic to device.On March 20th, 1994, the Chinese invention patent CN2159790Y of bulletin disclosed a kind of " the medical medicinal cupping that puts a chimney on the stove and make the fire draw ".In the conventional cylinder cupping jar, set up a concentric cylinder tank body.During use between two cylinders annular chamber form negative pressure by common method, the skin at adsorbing therapy position makes the medicine that is built in the middle calamity chamber that inner cylinder encloses be able to the location, simultaneously, medicine under the attraction of annular chamber negative pressure, has increased the power of infiltration around.Annular chamber is raised skin under action of negative pressure, the time slightly length the blood capillary of skin is ruptured.That skin takes place is congested, break, even gets blister, and traditional cupping therapy is to reach therapeutical effect to the destruction of skin like this.So the treatment time of traditional cupping therapy generally was controlled in 8-10 minute, and two treatments takes between the time at interval more than 1 day at least, can not treat continuously every day.So the adsorption method of above-mentioned cupping jar-type can produce bigger negative pressure, and seal tightly, but cause infringement easily, be not suitable for the percutaneous dosing mode that on skin, use for a long time of needing skin.It applies ointment or plaster the Chinese invention patent CN1130237C institute public outer " transdermal medication apparatus " of December in 2003 bulletin on the 14th and coils by end face and inner ring, fixed the forming of outer ring twice annular sidewall.The annular chamber that multiplies each other between Internal and external cycle and the end face communicates with negative pressure source through the passway.During use, annular chamber adsorbs skin under action of negative pressure and raises, because the height of annular sidewall is low, skin is lifted to a certain degree and will contacts with end face, and when negative pressure continued to raise, skin can not continue to raise, and has stoped skin damage thus.But the skin of raising also can the passage mouth, make that the suffered negative pressure of skin is not high, that is the suffered negative pressure of skin is lower than the pressure of negative pressure source.Annular chamber is raised skin under action of negative pressure; The feasible medicine that is positioned at the central chamber of inner ring and end face formation is able to sealing; Central chamber temperature under the heating of heating raises, and pressure increases, and medicine is under the attraction of the promotion of central chamber normal pressure and annular chamber negative pressure on every side.Can quicken transdermal and get into performance therapeutical effect in the skin.When central chamber produces normal pressure.The end face of intracavity can receive outside thrust, and annular chamber receives the suction that is affixed to skin at its end face of action of negative pressure.The sealing of annular chamber imposes on the thrust of inner ring and outer ring twice annular sidewall and realizes that thrust is big more by end face, seals tight more.But because the thrust that makes progress that the central chamber normal pressure produces has been offset the part suction that is produced by annular chamber; Make the thrust that acts on the annular sidewall reduce to skin; And when annular chamber actual negative pressure is less; Will reduce the sealing of the dish of applying ointment or plaster, the dish that causes easily applying ointment or plaster comes off, and influences normally carrying out of operating process.
Summary of the invention
The purpose of this invention is to provide a kind of transdermal delivery device; Make it when cooperating Drug therapy; When increasing transdermal administration power; Not only can form tight sealing at skin surface, and the infringement that can effectively avoid long negative-pressure adsorption that skin is caused, outer ring cavity is separated into two cavitys up and down by a ventilative dividing plate; Solved the long negative-pressure adsorption of existing transdermal delivery device to the hurtful technical deficiency of skin;
Also provide a kind of and on the end face above the central chamber, establish one from the transdermal delivery device of atmospheric environment through the air supply passage mouth of the inside QI invigorating of check valve; A kind of transdermal delivery device of establishing a malleation passway that communicates with positive pressure source also is provided; Solve existing central chamber and in therapeutic process, can not keep needed certain normal pressure, the technical deficiency of percutaneous dosing poor effect;
A kind of transdermal delivery device that between central chamber and end face, is provided with a secondary cavity that communicates with it also is provided; The medicinal liquid that has solved in the existing medicated cushion is adsorbed to the technical deficiency in passway and the pressure source.
For realizing that the technical scheme that the object of the invention is taked is:
A kind of transdermal delivery device, comprise post on skin applying ointment or plaster the dish and be located at apply ointment or plaster the dish bottom medicated cushion; Apply ointment or plaster the dish top be end face; Below end face, be provided with outer ring cavity and the central chamber that Open Side Down, outer ring cavity is between two annular sidewalls, and outer ring cavity communicates with negative pressure source through the negative pressure channel mouth in the end face; Medicated cushion places in the central chamber; It is characterized in that: described outer ring cavity is separated into two cavitys up and down by a ventilative dividing plate, and wherein upper plenum communicates with negative pressure source through described negative pressure channel mouth, and following cavity is under shed.
Described ventilative dividing plate is made up of gas permeable material, and ringwise, ventilative dividing plate sealing is located between the annular sidewall of outer ring cavity both sides.
The end of the annular sidewall of ring cavity both sides is provided with annular groove in annular sidewall outside described, on the medial extremity of two annular sidewalls, is provided with annular notches; Described ventilative separated pulling by gas permeable material constitutes, and ringwise, the longitudinal section is the bow font; Two side ends at ventilative dividing plate is respectively equipped with the spill endless belt, and the outboard end of two spill endless belt is embedded in the annular groove, being embedded in the annular notches bottom of ventilative dividing plate, and be lower than the outboard end of annular sidewall.
Described ventilative dividing plate is composited by sieve plate with some through holes and gas permeable material; Described sieve is pulled on the annular sidewall that is cemented in described outer ring cavity both sides, and described gas permeable material posts on the lower surface of sieve plate.
Described gas permeable material is at least a kind of in cloth, breathable rubber, the permeable-gas ceramics.
In described end face, be provided with heating, this heating joins through the connector and the power line on end face top.
On the end face above the described central chamber, be provided with an air supply passage mouth, the air supply passage mouth communicates with atmospheric environment through a check valve, and gas flow direction is for to flow to central chamber from atmospheric environment.
On the end face above the described central chamber, be provided with a malleation passway that communicates with positive pressure source.
Between described central chamber and end face, also be provided with a secondary cavity that communicates with central chamber, secondary cavity communicates with the variable pressure source through a variable pressure passway.
Saidly on the dividing plate between secondary cavity and the central chamber, be provided with several and be communicated with both through holes, it is inboard that through hole is evenly distributed in the center and the outer edge of dividing plate.
The invention has the beneficial effects as follows: when cooperating Drug therapy, increase transdermal administration power, also can form tight sealing on the human body skin surface; Carrying out percutaneous dosing when treatment, the negative pressure channel mouth of outer ring cavity is with after negative pressure source is communicated with, pressure decline; Pairing skin can progressively stretch and raise; Because the outer shroud intracavity has increased a ventilative dividing plate, contact skin can not continue to raise behind ventilative dividing plate lower surface; Thereby protection skin does not receive excessively to stretch to cause damage, and guarantees that percutaneous dosing can normally carry out for a long time; And this moment, outer ring cavity cavity pressure also can continue to descend, up to equating with negative pressure source pressure; Because outer ring cavity negative pressure is big, under same outer shroud cavity area, the absorption affinity that acts on the dish of applying ointment or plaster is big, on skin absorption firm, can effectively offset the outside thrust that the central chamber normal pressure produces, the dish that prevents to apply ointment or plaster comes off and the treatment interruption that causes; Simultaneously, increase, can improve sealing from the thrust that acts on annular sidewall; Make the leakage of central chamber reduce, guarantee that more effectively central chamber keeps higher normal pressure, add the negative pressure increase of outer ring cavity; Can make the power of percutaneous dosing increase, improve the percutaneous dosing effect; Medicinal liquid in the central chamber medicated cushion can not be adsorbed in passway and the pressure source.
Description of drawings
Fig. 1 is the cross-sectional schematic under user mode of the embodiment of the invention;
Fig. 2 is the upward view of the embodiment of the invention;
Fig. 3 is the partial sectional view of the embodiment of the invention 1;
Fig. 4 is the partial sectional view of the embodiment of the invention 2;
Fig. 5 is the partial sectional view of the embodiment of the invention 3;
Fig. 6 is the cutaway view of the embodiment of the invention 4;
Fig. 7 is the cutaway view of the embodiment of the invention 5;
Fig. 8 is the cutaway view of the embodiment of the invention 6;
Fig. 9 is the upward view of the embodiment of the invention 6.
1, apply ointment or plaster dish 2, medicated cushion 3, end face 4, outer ring cavity 5, central chamber 6, annular sidewall 7, negative pressure channel mouth 8, ventilative dividing plate 9, annular groove 10, annular notches 11, spill endless belt 12; Connector 13, sieve plate 14, gas permeable material 15, heating 16, malleation passway 17, secondary cavity 18, variable pressure passway 19 through holes
The specific embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is done further detailed explanation.
Like Fig. 1, shown in Figure 2, Fig. 1 is the structure chart under user mode of the embodiment of the invention.The present invention includes the medicated cushion 20 applying ointment or plaster dish 1 and being located at dish 1 bottom of applying ointment or plaster that posts on skin dish 1 the top of applying ointment or plaster is end face 3, below end face 3, is provided with the outer ring cavity 4 and central chamber 5 that Open Side Down, and outer ring cavity 4 is between two annular sidewalls 6.Described outer ring cavity 4 is separated into two cavitys up and down by a ventilative dividing plate 8, and wherein upper plenum communicates with negative pressure source through described negative pressure channel mouth 7, and following cavity is under shed.Following cavity can hold the skin that is lifted by negative-pressure adsorption in use.Outer ring cavity 4 communicates with negative pressure source through the negative pressure channel mouth 7 in the end face 3, and medicated cushion 2 places in the central chamber 5.
In embodiment as shown in Figure 31, described ventilative dividing plate 8 is made up of gas permeable material 14, and ringwise, ventilative dividing plate 8 sealings are located between the annular sidewall 6 of outer ring cavity 4 both sides, and are parallel with end face 3.
In embodiment as shown in Figure 42, the end of the annular sidewall 6 of ring cavity 4 both sides is provided with annular groove 9 in annular sidewall 6 outside described.And on the medial extremity of two annular sidewalls 6, be provided with annular notches 10.Described ventilative separated pulling by gas permeable material constitutes, and ringwise, the longitudinal section is the bow font.Two side ends at ventilative dividing plate 8 is respectively equipped with spill endless belt 11, and the outboard end of spill endless belt 11 is embedded in the annular groove 9, and promptly both adopt plug to connect mode.Being embedded in bottom in the annular notches 10 of ventilative dividing plate 8, and be lower than the outboard end of annular sidewall 6.Back spill endless belt 11 skin under the central chamber 5 when treatment is used is installed under suction function, is raised, contact with ventilative dividing plate 8, spill endless belt 11 is close to skin, and sealing function can be played in its adjacent annular sidewall 6 ends.
In embodiment as shown in Figure 53, described ventilative dividing plate 8 is composited by sieve plate with some through holes 13 and gas permeable material 14.Described sieve is pulled 13 and is cemented on the annular sidewall 6 of described outer ring cavity 4 both sides, and described gas permeable material 14 posts on the lower surface of sieve plate 13, when promptly treating towards skin surface.Sieve is pulled 13 material, also material different.If sieve is pulled 13 and adopted pottery, outer ring cavity 4 can adopt the imitative method molding of dewax pattern to fire; If sieve plate 13 adopts elastomeric material, can adopt Di-cure method, first procedure is divided the sieve plate semi-finished product of mold forming and the back, disc main body location of applying ointment or plaster get into the second operation work sulfuration, obtain end product.Aperture on the sieve plate 13 can directly be made in patternmaking process.Also can process the back through bore mode processing at finished product.
Among the embodiment 1-3, provided the fixed form of ventilative dividing plate 8 and annular sidewall 6, described gas permeable material 14 is at least a kind of in cloth, breathable rubber, the permeable-gas ceramics.Embodiment 1, for inflexible permeable-gas ceramics, can adopt friction tight consolidation style.The dish 1 of will applying ointment or plaster when using like this posts on human body skin, and the negative pressure channel mouth 7 that is positioned on outer ring cavity 4 end faces 3 communicates with negative pressure source, the pressure reduction that outer ring cavity 4 is interior, pairing skin is lifted gradually, up to be full of whole outside during ring cavity 4.Like this,, do not have the slit, stopped that skin is snapped into the slit and the danger that damages in conjunction with closely.Softish cloth or breathable rubber are adopted agglutinating consolidation style.
In embodiment as shown in Figure 64, in described end face 3, be provided with heating 15, this heating 15 joins with power line through the connector 12 on end face 3 tops.In therapeutic process, along with 15 pairs of central chambers 5 of heating are heated, the intracavity gas temperature of central chamber 5 raises, the volatile ingredient of medicine progressively discharges, and cavity pressure raises.Simultaneously, treatment place skin temperature also can raise, and can accelerate the movement velocity of subcutaneous blood capillary inner blood, increases the permeability of skin, promotes the infiltration of medicine.Applying ointment or plaster the end face 3 of dish 1 central chamber 5 can be the same with the end face 3 of outer ring cavity 4, is in the same plane, and with shown in Figure 1 similar, medicated cushion is through convection current and radiating mode and end face generation heat exchange, the absorption heat.Also can be as shown in Figure 5; Central chamber 5 end faces 3 are provided with lowlyer; The height of the height of central chamber 5 and medicated cushion 2 is suitable, and the mode that the heat of end face 3 can directly conduct with contact adds Hot medicine pad, and is little in heater element power; Under the not high situation of table top surface surface temperature, such heat transfer type more directly effectively.
In embodiment as shown in Figure 75, on the end face above the described central chamber 5, be provided with an air supply passage mouth, the air supply passage mouth communicates with atmospheric environment through a check valve, and gas flow direction is for to flow to central chamber 5 from atmospheric environment.Can stop outer ring cavity 4 like this when bleeding with the negative pressure source connection; Under the poorly sealed situation of annular sidewall 6 and skin and make the gas in the central chamber 5 leak in the adjacent outer ring cavity 4; Cause the initial pressure of central chamber 5 low; Even be negative pressure, and making central chamber 5 under the situation that the heating nature heats up, final elevated pressure is low.After adopting this check valve, relatively promote the power of percutaneous dosing, can promote the osmotic effect of medicine.On the end face above the said central chamber 5, be provided with a malleation passway 16 that communicates with positive pressure source.Can make central chamber 5 keep needed normal pressure so always, improve the effect of percutaneous dosing.
In embodiment as shown in Figure 86, on the basis of embodiment 5, between said central chamber 5 and end face 3, also be provided with a secondary cavity that communicates with it 17, secondary cavity 17 communicates with the variable pressure source through a variable pressure passway 18.During the treatment beginning, connect negative pressure source earlier, secondary cavity 17 all is a negative pressure with central chamber 5, and the skin under the central chamber 5 receives vacuum suction and increases permeability.Connect positive pressure source again, secondary cavity 17 has all become malleation with central chamber 5, can make in medicine penetrates to the skin better.Secondary cavity 17 is set; When in the negative pressure in cut-in pressure source during the stage; Because 2 of the medicated cushion of variable pressure passway 18 and central chamber 5 are across secondary cavity 17; Can avoid placing the medicinal liquid in the medicated cushion 2 in the central chamber 5 to be adsorbed in variable pressure passway 18 and the pressure source, and cause, also avoid the loss of medicinal liquid simultaneously the pollution of variable pressure passway 18 and the fault of pressure source.On the dividing plate between secondary cavity 17 and the central chamber 5, be provided with several through holes that is communicated with both 19, through hole 19 is evenly distributed in the dividing plate center and outer edge is inboard.When secondary cavity 17 was connected negative pressure source, medicinal liquid was drawn onto in the secondary cavity 17 from central chamber 5; When secondary cavity 17 was connected positive pressure source, medicinal liquid via through holes 19 was again got back to central chamber 5.
In sum, embodiment 1～3rd, to the explanation of several kinds of different structures of the ventilative dividing plate 8 of the present invention.And embodiment 4～6th, the structure optimization of on the basis of embodiment 1～3, carrying out can be selected a kind of or combinative structure wherein for use.And can make up with three kinds that are showed ventilative dividing plates 8.In addition, ventilative dividing plate 8 structures also are not limited to above three kinds of structures.For the cross section of said invention is racetrack as shown in Figure 2, or circle shown in Figure 9, or special-shaped formula.
Claims (10)
1. transdermal delivery device; Comprise the dish (1) and be located at the medicated cushion (2) of dish (1) bottom of applying ointment or plaster of applying ointment or plaster that posts on skin, the top of the dish (1) of applying ointment or plaster is end face (3); Be provided with outer ring cavity (4) and the central chamber (5) that Open Side Down in end face (3) below; Outer ring cavity (4) is positioned between two annular sidewalls (6), and outer ring cavity (4) communicates with negative pressure source through the negative pressure channel mouth (7) in the end face (3), and medicated cushion (2) places in the central chamber (5); It is characterized in that: described outer ring cavity (4) is separated into two cavitys up and down by a ventilative dividing plate (8), and said ventilative dividing plate (8) is made up of gas permeable material (14); Wherein upper plenum communicates with negative pressure source through described negative pressure channel mouth (7), and following cavity is under shed.
2. a kind of transdermal delivery device according to claim 1 is characterized by: described ventilative dividing plate (8) ringwise, ventilative dividing plate (8) sealing is located between the annular sidewall (6) of outer ring cavity (4) both sides.
3. a kind of transdermal delivery device according to claim 1; It is characterized by: the end of the annular sidewall (6) of ring cavity outside described (4) both sides is provided with annular groove (9) in annular sidewall (6), on the medial extremity of two annular sidewalls (6), be provided with annular notches (10); Described breathing freely is made up of gas permeable material at a distance from pulling (8), and ringwise, the longitudinal section is the bow font; Two side ends at ventilative dividing plate (8) is respectively equipped with spill endless belt (11), and the outboard end of two spill endless belt is embedded in the annular groove (9), being embedded in bottom in the annular notches (10) of ventilative dividing plate (8), and be lower than the outboard end of annular sidewall (6).
4. a kind of transdermal delivery device according to claim 1 is characterized by: described ventilative dividing plate (8) is composited by sieve plate with some through holes (13) and gas permeable material (14); Described sieve is pulled on the annular sidewall (6) that is cemented in described outer ring cavity (4) both sides, and described gas permeable material (14) posts on the lower surface of sieve plate (13).
5. according to claim 1 or 2 or 3 or 4 described a kind of transdermal delivery devices, it is characterized by: described gas permeable material (14) is at least a kind of in cloth, breathable rubber, the permeable-gas ceramics.
6. a kind of transdermal delivery device according to claim 1 is characterized by: in described end face (3), be provided with heating (15), this heating joins with power line through the connector (12) on end face (3) top.
7. a kind of transdermal delivery device according to claim 1; It is characterized by: on the end face of described central chamber (5) top, be provided with an air supply passage mouth; The air supply passage mouth communicates with atmospheric environment through a check valve, and gas flow direction is for to flow to central chamber (5) from atmospheric environment.
8. a kind of transdermal delivery device according to claim 7 is characterized by: on the end face of described central chamber (5) top, be provided with a malleation passway (16) that communicates with positive pressure source.
9. according to claim 1 or 6 described a kind of transdermal delivery devices; It is characterized by: between described central chamber (5) and end face (3), also be provided with a secondary cavity (17) that communicates with central chamber (5), secondary cavity (17) communicates with the variable pressure source through a variable pressure passway (18).
10. a kind of transdermal delivery device according to claim 9 is characterized by: on the dividing plate between secondary cavity (17) and the central chamber (5), be provided with several through holes that is communicated with both (19), it is inboard that through hole (19) is evenly distributed in the center and the outer edge of dividing plate.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100905507A CN101284157B (en) | 2007-04-11 | 2007-04-11 | Transdermal drug delivery device |
| PCT/CN2007/003218 WO2008124979A1 (en) | 2007-04-11 | 2007-11-14 | Transdermal medication apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100905507A CN101284157B (en) | 2007-04-11 | 2007-04-11 | Transdermal drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101284157A CN101284157A (en) | 2008-10-15 |
| CN101284157B true CN101284157B (en) | 2012-05-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100905507A Active CN101284157B (en) | 2007-04-11 | 2007-04-11 | Transdermal drug delivery device |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101284157B (en) |
| WO (1) | WO2008124979A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056345B (en) * | 2013-03-22 | 2017-04-19 | 北京神州汉方医药科技有限公司 | Transdermal drug delivery device |
| CN106163463A (en) * | 2014-01-22 | 2016-11-23 | 马尔西奥·马克·阿布雷乌 | It is configured to the device processed in ABREU brain fever passage offer |
| CN111388859A (en) * | 2020-03-25 | 2020-07-10 | 多能干细胞再生医学科技（广州）有限公司 | Stem cell transdermal drug delivery treatment equipment |
| CN111905249A (en) * | 2020-08-21 | 2020-11-10 | 王慧玲 | Positive and negative air pressure target medicine feeding therapeutic device |
| CN111905250A (en) * | 2020-08-21 | 2020-11-10 | 王慧玲 | Acupoint drug delivery treatment device and application method thereof |
| CN115671527A (en) * | 2022-07-27 | 2023-02-03 | 北京神州汉方医药科技有限公司 | Skin drug administration control device based on temperature and pressure coupling control and drug administration device |
| CN115738057A (en) * | 2022-07-28 | 2023-03-07 | 北京神州汉方医药科技有限公司 | Drug administration control device for external treatment of internal diseases |
| CN115400342B (en) * | 2022-11-01 | 2023-02-10 | 北京神州汉方医药科技有限公司 | Plug-in transdermal drug delivery device and method of use |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5358467A (en) * | 1991-05-05 | 1994-10-25 | Anatole Milstein | Method for vacuum mechanothermal stimulation of the body surface |
| CN1303717A (en) * | 1999-12-14 | 2001-07-18 | 陈刚 | Transdermal medication apparatus |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2336542A (en) * | 1998-04-21 | 1999-10-27 | Marble Arch Medical Centre Lim | Immunity enhancing device |
| CN2414777Y (en) * | 1999-12-14 | 2001-01-17 | 陈刚 | Transcutaneous medicine osmosis instrument |
| US20030125646A1 (en) * | 2001-12-29 | 2003-07-03 | Whitlock Russell Ward | Device and method for relieving pain |
-
2007
- 2007-04-11 CN CN2007100905507A patent/CN101284157B/en active Active
- 2007-11-14 WO PCT/CN2007/003218 patent/WO2008124979A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5358467A (en) * | 1991-05-05 | 1994-10-25 | Anatole Milstein | Method for vacuum mechanothermal stimulation of the body surface |
| CN1303717A (en) * | 1999-12-14 | 2001-07-18 | 陈刚 | Transdermal medication apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008124979A1 (en) | 2008-10-23 |
| CN101284157A (en) | 2008-10-15 |
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