JPH0541707Y2 - - Google Patents

Description

[Detailed description of the invention] The present invention is a local administration device for powdered drugs, specifically, a tube is inserted into a body cavity such as the digestive tract from outside the body.
The present invention relates to a device for administering a powdered drug directly to the inner wall of a body cavity through the tube.

Various chemotherapy methods are currently being used to treat mucosal and tissue lesions such as so-called peptic ulcers such as gastric ulcers and duodenal ulcers, as well as mucosal defects in body cavities, cancers, and polyps. In addition, in recent years, with the progress and development of diagnostic technology for the above-mentioned diseases and lesion states using fiberscopes (endoscopes), local administration of pharmaceuticals (transendoscopic injection) therapy using fiberscopes has been attracting attention. . For example, an aqueous sodium alginate solution, which has been newly researched and developed in recent years, can protect the gastrointestinal mucosa and stop bleeding in the gastrointestinal tract by oral administration and endoscopic injection, and can be used to stop bleeding and heal peptic ulcers. Confirmed (Patent application 1987-122565)
issue). However, in the above-mentioned transendoscopic injection, a tube is usually inserted through the forceps hole of an endoscope and the drug is injected through the tube, so the drugs used are limited to liquid drugs such as aqueous solutions. When applying the above injection operation to powdered drugs, there is a risk of blockage within the tube (in particular, the tip of the tube is in contact with the liquid flow in the digestive tract, so powdered drugs easily become wet and aggregate), and There is a drawback that it is difficult to adjust the injection amount, injection speed, etc. of the drug. Furthermore, in the case of not only powder medicines but also liquid medicines, when administering them endoscopically, before they adhere to the inner walls of the digestive organs, etc., they are fluidized or diffused by the internal fluids of these organs.
There is a drawback that the drug cannot be locally administered uniformly to the target lesion site at a high concentration or in a high concentration amount, and therefore it is difficult to exert the desired administration effect (therapeutic effect).

The present invention solves the above-mentioned drawbacks of the conventional technology, and enables stable local administration of the required amount of powdered medicine at all times through an endoscopic method, and thereby fully exerts the intended medical effect. It provides equipment.

That is, the present invention includes a tube that can be inserted into a body cavity from outside the body through an endoscope forceps port, a drug filling section provided in the middle of the tube, and a powder drug filled in the drug filling section being sprayed onto the inner wall of the body cavity from the tip of the tube. The present invention relates to a powder drug local administration device characterized in that it is equipped with a gas pressure injection means.

According to the present invention, at specified locations (lesioned areas) on the inner walls of various body cavities, including digestive organs such as the stomach and duodenum,
It is possible to always stably and directly spray and administer a constant amount of powdered medicine instantaneously and extremely easily. Furthermore, according to the present invention, the powdered drug is dispersed using gas pressure, which ensures that a predetermined amount of the powdered drug is uniformly and in large quantities applied to the target lesion site without being affected by the movement of fluid in the body cavity. can be attached to. Since the present invention allows for the local administration of a large amount of drug, it can be applied extremely effectively, especially when lesions such as ulcers extend deep into the body, and can be applied to conventional transendoscopic injection of liquid drugs Excellent therapeutic effects that cannot be achieved by oral or local administration of ordinary pharmaceuticals can be achieved.

The powdered medicine applied to the present invention is not particularly limited as long as it is in powder form, and may be any of various conventionally known pharmaceuticals. In particular, the present invention allows for the local administration of powdered drugs directly to the lesion site, making it extremely effective to administer drugs that have conventionally been ineffective through oral administration due to their metabolic and absorption properties. , and its usefulness is extremely high. An example of a typical powdered drug is sodium alginate. Other anti-ulcer agents such as alzaoxa, aceglutamide aluminum, suralfate, cimetidine, and cetraxate hydrochloride can also be used alone or in combination with sodium alginate, as well as 5-fluorouracine, which is applied to gastric cancer, etc. Anticancer agents such as ftorafur and mitomycin can also be used alone or in combination with the above-mentioned antiulcer agents such as sodium alginate.

The present invention will be explained below with reference to the accompanying drawings.

FIG. 1 is a diagram showing an embodiment of the present invention. In the figure, 1 is a syringe, 2 is a needle, 3 is a tube, and 4
5 indicates a powder medicine, 5 a stopper, and 6 a medicine filling part.

The device of the present invention is used as follows. That is, first, a powdered drug is put into the syringe barrel of the syringe 1, the syringe needle 2 and the tip are connected to the closed tube 3 by an appropriate means, and the sucker (inner barrel) of the syringe is pushed to release the powder in the syringe barrel. The medicine is force-fed through the injection needle 2 to the medicine filling part 6 at the tip of the tube. Alternatively, a powdered medicine is placed in the tube 3 in advance using an appropriate device and then filled into the medicine filling part 6 using a vibrator or the like. In the above, the plug 5 is not particularly limited as long as it has air permeability and can prevent leakage of the powder medicine, but it can be moistened with body cavity fluid, forms a sealing plug, is harmless to the human body, and is excreted as is after use; Specifically, fibers, cotton, sponge, vegetable, animal or synthetic resins are preferred. Next, the tube 3 filled with the powdered drug 4 is inserted into the drug filling part 6 at the tip as described above, for example, through the endoscope forceps hole to the gastrointestinal tract or the like, near the lesion where the drug is desired to be sprayed.
Press the syringe sucker a little harder. With this operation, the inside of the tube becomes pressurized, and the plug 5 at the tip of the tube
As the needle is removed, the powdered medicine 4 is dispersed into the body cavity from the tip and adheres to the inner wall (lesioned area) of the body cavity.

In addition, the gas pressurization means in the device of the present invention is as follows:
Not limited to the syringe 1 using air shown in FIG.
Examples include aerosol cans, other gas cylinders, and double balls. The gas filled in the gas cylinder, aerosol can, etc. and used for spraying the powdered medicine is not particularly limited to air, and may be nitrogen gas, oxygen gas, carbon dioxide gas, etc., which are normally kept in medical institutions, and It may also be fluorocarbon or other liquefied gas that becomes gaseous by injection. These are simply used to spray powdered medicine onto the affected area through a tube, and the amount used is usually very small, so there is no danger of it posing any particular danger to the human body.

The tube 3, syringe 1, and other instruments used in the device of the present invention may be conventionally known medical instruments. The amount of powdered drug to be used per time may be determined appropriately depending on the type of drug, the patient to whom it is administered, the disease state, etc., but it is usually about 0.1 to 5 g, preferably about 0.3 to 5 g.
It is generally set at 3g. If it is desired to administer the drug in less than 0.1 g, it is preferably utilized in the present invention in the form of a suitable trituration.

Examples of how to use the device of the present invention will be given below.

Example 1 This case was an intractable ulcer, and endoscopic examination revealed a large ulcer at the angle of the stomach and bleeding from the bottom of the ulcer. This usage method was applied to the above gastric ulcer patient. That is, 1.5 g of sodium alginate was filled into a tube whose tip was lightly stuffed with a paper stopper of about 5 mm, while applying appropriate vibrations. Next, insert the tube through the forceps hole of the fiberscope,
After the tip reached the lesion, the syringe barrel was pressed firmly. It was observed that the terminal paper stopper was removed and the sodium alginate powder was spread over the ulcer site and coated the lesion.

When the above method was repeated 9 times in 3 weeks,
Seven days later, it was confirmed that the ulcer had become considerably smaller, and a black spot was seen at the bottom of the ulcer, but the occult blood was negative. Moreover, after 21 days, the ulcer had shrunk to around 5 mm in diameter. No side effects were observed due to implementation of this method. For the above patient, in order to avoid pain to the patient, the above-mentioned endoscopic administration and normal administration (1 dose of 50 to 100 ml of 5% sodium alginate aqueous solution)
The drug was administered twice a day (once during the day and once before bedtime).

Example 2 The same method as in Example 1 above was repeated once every 3 days on a patient with a duodenal ulcer in which a large, deep ulcer the size of a thumb was observed on the anterior wall of the duodenal bulb, accompanied by bleeding.

Five days after implementing this method, the ulcer became slightly shallower, and the fecal occult blood test became negative. After 12 days, the ulcer had shrunk and the bleeding became negative. After another 24 days, the ulcer turned into a linear white scar and was treated.

[Brief explanation of the drawing]

FIG. 1 is a diagram showing a specific example of the device of the present invention.

FIG. 2 is a diagram showing another specific example of the device of the present invention.

FIG. 3 is a diagram showing one embodiment of a drug filling part.

[Explanation of symbols]

1...Syringe 2……syringe needle 3...Tube 4...Powder drug 5...stopper 6...Drug filling section.

Claims (1)

[Scope of utility model registration request] Claims 1: A tube that can be inserted into a body cavity from outside the body through an endoscope forceps port, a drug filling section provided in the middle of the tube, and a powder drug filled in the drug filling section being sprayed onto the inner wall of the body cavity from the tip of the tube. A powder drug local administration device characterized in that it is equipped with a gas pressure injection means.