CN107019843A - negative pressure transdermal delivery device - Google Patents
negative pressure transdermal delivery device Download PDFInfo
- Publication number
- CN107019843A CN107019843A CN201710418580.XA CN201710418580A CN107019843A CN 107019843 A CN107019843 A CN 107019843A CN 201710418580 A CN201710418580 A CN 201710418580A CN 107019843 A CN107019843 A CN 107019843A
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- negative pressure
- skin
- delivery device
- transdermal delivery
- drug
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- 230000037317 transdermal delivery Effects 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 claims abstract description 68
- 229940079593 drug Drugs 0.000 claims abstract description 41
- 239000002131 composite material Substances 0.000 claims abstract description 18
- 230000000694 effects Effects 0.000 claims abstract description 12
- 210000000481 breast Anatomy 0.000 claims abstract description 6
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 5
- 230000000717 retained effect Effects 0.000 claims abstract description 4
- 210000003491 skin Anatomy 0.000 claims description 66
- 210000001519 tissue Anatomy 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 210000002615 epidermis Anatomy 0.000 claims description 4
- 230000006378 damage Effects 0.000 claims description 3
- 210000004209 hair Anatomy 0.000 claims description 3
- 230000003204 osmotic effect Effects 0.000 claims description 3
- 239000013536 elastomeric material Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 230000002441 reversible effect Effects 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 8
- 230000035515 penetration Effects 0.000 description 7
- 230000009471 action Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 210000001736 capillary Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 241000719239 Oligoplites altus Species 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000749 chronicity Toxicity 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 230000036732 histological change Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 229920002529 medical grade silicone Polymers 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000019991 rice wine Nutrition 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of negative pressure transdermal delivery device, and problem to be solved is：Skin formation is destroyed during existing transdermal delivery device use, the transdermal administration curative effect of medicine is low, the invention is characterized in that：The composite drug-loaded dressing that this patent contains medicine is carried in negative pressure transdermal delivery device, device contact skin site has the reticulated elastomeric component for being fixed on inner wall edge, device bosom has gas-permeable semi-circular member, negative pressure transdermal delivery device is passed through after negative pressure, the skin surface of unit area is set to accumulate increase, amplify in skin histology gap, and then reduce the obstruction of drug transdermal, with the expansion of netted elastic component and semi-circular member limitation skin and tissue inside the aggrandizement apparatus of negative pressure, because acting in negative pressure for resistance forms deboost active force to skin, medicine is set easily to be carried in skin, medicine enters internal through the skin and tissue for expanding gap, human skin tissue recovery normal drug is retained in human body after negative pressure is released.
Description
Technical field
This technology belongs to a kind of doser in cutaneous penetration field
Background technology
The concept of " percutaneous technique " proposes first from the U.S. in 1974, so-called percutaneous technique（trandermal
Therapeutic systems, TTS）It is the new way of non-invasive administration, refers to be administered in skin surface, pass through medicine
Skin layers, into human body in and the circulatory system method that produces whole body or local therapeutic effects, be that Traditional skin medication is seen
The important breakthrough of thought, the research in this current new field is very active.
Cutaneous penetration technology has the advantages that its is unique compared to other medications, and its advantage is shown as：Cutaneous penetration first
" first pass effect " will not be caused to destroy liver function formation to human liver, do not disappeared by pH value, food and medicine in intestines and stomach
Change the influence destruction of the complicated factors such as liquid holdup time；Sustainable control injection speed；Agents area is in body surface, interruption of the administration side
Just, and longer action time can be provided, reduction drug toxicity and adverse reaction, moreover it is possible to remain stable and lasting blood medicine is dense
Degree, so as to improve curative effect, by the constantly improve of decades, transdermal drug delivery system has obtained swift and violent development.
Therefore overcome skin barrier to act on, promote medicine transdermal within a certain period of time in the case where not damaging human body skin
Infiltration reaches therapeutic dose, is the key issue of many drug transdermal doser researchs, and the conventional method of present cutaneous penetration has
Mixed using gel with medicine and be applied to percutaneous drug delivery mode；Using chemical reagent permeability by chemical diffusion permeate to
Medicine；Laser micropore technology irradiates human body with controllable laser, and body group is changed by laser energy in certain depth and scope
The molecule arranging structure knitted forms intensive duct in the tissue, brings it about histological change rather than anatomical change,
This technology be otherwise known as laser injection；Electroporation technology is to apply controllable high electric field pulse on affected skin tissue both sides,
Skin and tissue is set to occur limited " electricity, which is worn, to be hit ", in the presence of high-voltage pulse current, the fat of the membrane structure of skin and tissue
Matter particle rearrangement, is changed into orderly from unordered, and then produces potential reversible aqueous biological duct, and this technology is universal
For inhereditary material transmission and transfection between in vitro living cells；By ultrasonic conductance, this technology is widely used in facing for the country such as U.S.
Bed, this administration method is to be transmitted to drug percutaneous skin or mucous membrane are local with ultrasonic wave in body tissue, is referred to as by medical field
Third generation medication, also micropin side's row, iontophoresis promote the apparatus and method such as saturating method, and these have certain effect,
But some physical destructions can be formed to skin during these apparatus and method uses, wound also is caused to human body, while
Chronicity and stability administering effect in treatment be not also highly desirable, and this is also the transdermal administration weak curative effect of current external used medicine,
Where the problem of can not using and not widely apply steadily in the long term.
Skin is the maximum organ of human body, the 5%~15% of gross weight percentage of liveweight, the gross area is 1.5~2 square metres, thick
Degree is because of people or different because of position, is 0.5~4 millimeter.Skin covers whole body, and it makes various in vivo organize with organ from physics
Property, mechanicalness, invasion and attack chemically with pathogenic microorganism, skin has the barrier action of two aspects：On the one hand body is prevented
The loss of interior moisture, electrolyte and other materials；On the other hand the intrusion of extraneous harmful substance is prevented, human internal environment is remain
Stabilization on, physiologically playing important defencive function, while skin also assists in the metabolic process of human body, skin because ethnic group,
Age and position are different and different.Skin is made up of epidermis, corium and hypodermis, and containing accessory organ and capillary,
Lymphatic vessel, N＆M etc. are organized.
In percutaneous technique（TTS）The barrier that skin is solved the problems, such as in research is the key for determining Medicated Permeation speed.Skin
The seepage velocity of skin has the difference between individual difference and body different parts, and partes corporis humani's position seepage velocity is by following suitable
Sequence increases successively：After vola, preceding stern, instep, scalp, groin, scrotum, ear.Due to the barrier action of skin, make most of medicines
Even if the high medicine of the low curative effect of thing dosage, transdermal penetration speed is also difficult to the need for meeting treatment steady in a long-term.
The content of the invention
The present invention is to provide a kind of negative pressure transdermal delivery device.
This patent is carried in the composite drug-loaded dressing containing medicine in negative pressure transdermal delivery device, then the transdermal dress of negative pressure
Put and reload with human body, negative pressure transdermal delivery device accesses negative pressure by negative port.
Device contact skin site has the reticulated elastomeric component for being fixed on internal edge, is capped in composite drug-loaded dressing.
Negative pressure is partially formed skin and bodily tissue to swell, and the effect for passing through negative pressure in negative pressure transdermal delivery device is opened
Corium, epidermis, capillary and hair pore etc. open pore and skin, unit skin is opened 1-3 times by negative pressure, make skin
Surface area increase, the increase of skin histology gap, and then reduce the obstruction of drug transdermal, increase skin absorbs the drug and osmotic drug
Area.
Negative pressure transdermal delivery device bosom has semi-circular member, makes to be divided into two inside negative pressure transdermal delivery device
Point, the expansion of human body skin and tissue under negative pressure is limited by the semi-circular member of negative pressure transdermal delivery device bosom.
The resistance produced with the increase reticulated elastomeric component and semi-circular member of negative pressure is formed reversely to the skin swollen
Thrust power, the composite drug-loaded dressing patch containing medicine on the human body skin of distending tissue, between making medicine through expanding
The skin histology of gap smoothly enters internal, and human skin tissue recovers normal medicine locking and is retained in human body after negative pressure is released
It is interior.
Brief description of the drawings
Fig. 1 is the structure schematic diagram of the present invention
Fig. 2 is the profile of an embodiment of the negative pressure transdermal delivery device of the present invention.
Embodiment
Negative pressure transdermal delivery device
One feature of the transdermal delivery device of the present invention is that negative pressure is transdermal to give as described above, applying on its skin contact
Medicine device, the deboost active force for being directed to negative pressure of the resistance formation produced under negative pressure using internals, this sample
The negative pressure transdermal delivery device of invention is opened and increase skin gap on skin after stable attachment, easily makes medicine fast and stable
Ground discharges, so as to be advantageously used in that medicine is permanently effective and stably give in skin.
Below, the negative pressure transdermal delivery device of the present invention is illustrated by ideograph.
Fig. 2 is the profile of an embodiment of the negative pressure transdermal delivery device of the present invention.
As shown in Fig. 2 negative pressure transdermal device 1 from skin contact start by composite drug-loaded dressing 2, reticulated elastomeric component 3, half
Round member 4, device case 5 and negative pressure access port 6 are constituted, and composite drug-loaded dressing 4 is made up of separation layer 7 and drug storage layer 8.
This patent is carried in the composite drug-loaded dressing 6 containing medicine in negative pressure transdermal delivery device 1, and then negative pressure is transdermal
Device 1 is reloaded with human body, and negative pressure transdermal delivery device 1 accesses negative pressure, device contact skin site by negative port 6
There is the reticulated elastomeric component 3 for being fixed on internal edge, be capped in composite drug-loaded dressing 2, negative pressure makes skin and bodily tissue office
Portion is formed and swollen, and corium, epidermis, capillary and hair pore etc. are opened by the effect of negative pressure in negative pressure transdermal delivery device 1
Pore and skin are opened, unit skin is opened 1-3 times by negative pressure, makes the increase of skin surface product, the increase of skin histology gap,
And then reduce inside the obstruction of drug transdermal, the area that increase skin absorbs the drug with osmotic drug, negative pressure transdermal delivery device 1
There is semi-circular member 4 centre, and human body skin and group are limited by the semi-circular member 4 of the bosom of negative pressure transdermal delivery device 1
Expansion under negative pressure is knitted, the resistance produced with the increase reticulated elastomeric component 3 and semi-circular member 4 of negative pressure is to the skin that swells
Skin formation deboost active force, the composite drug-loaded dressing 2 containing medicine is attached on the human body skin of distending tissue, makes medicine
Smoothly enter internal through the skin histology for expanding gap, human skin tissue recovers normal after negative pressure is released, medicine locking and
It is retained in human body.
In addition, in fig. 2, semi-circular member 4 according to people age it is different with position can adjust semi-circular member depth,
The neck 9 that there is different depth the position fixed in the inwall of device case 5 can be positioned.
In fig. 2, the material of negative pressure transdermal delivery device 1 is the materials such as polyformaldehyde or aluminium alloy.
In fig. 2, the material of reticulated elastomeric component 3 is medical grade silicon rubber elastomeric material.
Embodiment, prepares dahuoluo pills one（Tongrentang of BeiJing, China（Group）Co., Ltd produces）, use yellow rice wine
Dissolving, is re-applied in combination drug dressing, negative pressure transdermal delivery device is loaded on leg skin, connects negative pressure, and negative pressure is saturating
Leather jacket puts interior vacuum and reaches 0.05mpa, and leg is clearly felt that medicine penetrates into after 5 minutes, feels that leg is obvious within 10 minutes
It is effective in cure, stop administration within 15 minutes, leg is felt good in 72 hours after negative pressure cutaneous penetration, walking is strong, curative effect shows
Write, no uncomfortable sensation, negative pressure cutaneous penetration effect exceedes oral result.
Claims (5)
1. this patent is carried in the composite drug-loaded dressing containing medicine in negative pressure transdermal delivery device, then negative pressure transdermal device
It is carried in human body, negative pressure transdermal delivery device accesses negative pressure by negative pressure access port, device contact skin site has fixation
Reticulated elastomeric component at enclosure interior edge, is capped in composite drug-loaded dressing, passes through negative pressure in negative pressure transdermal delivery device
Effect open corium, epidermis, capillary and hair pore etc. and open pore and skin, make the increase of skin surface product, skin
Tissue space increases, the area that increase skin absorbs the drug with osmotic drug, and then reduces the obstruction of Drug Percutaneous Absorption, negative pressure
Transdermal delivery device bosom has semi-circular member, passes through netted elastic component inside negative pressure transdermal delivery device and centre
Semi-circular member limits the expansion of human body skin and tissue under negative pressure, with the increase reticulated elastomeric component and semicircle of negative pressure
Component produces resistance to the skin swollen, and the composite drug-loaded dressing containing medicine is pressed in distending by the deboost active force of formation
On the human body skin of tissue, medicine is set smoothly to enter internal, human body skin after negative pressure is released through the skin histology for expanding gap
The locking of organized renewing normal drug and it is retained in human body.
2. negative pressure transdermal delivery device according to claim 1, it is characterised in that vacuum in device is according to specifically being controlled
Treat age, the physical condition of treated people, the concrete position difference of treated people and the pharmaceutical properties specific requirement of administration of people
Difference, vacuum degree control between 0.01-0.06mpa.
3. negative pressure transdermal delivery device according to claim 1, it is characterised in that device inner wall edge is fixed in housing
The reticulated elastomeric component at portion edge is capped in composite drug-loaded dressing, can play fixation through gas under negative pressure composite drug-loaded
Dressing and the effect of deboost, are used as the 1st layer under negative pressure reverse push masterpiece composite drug-loaded dressing being pushed on human body
Firmly, the bigger deboost active force played by reticulated elastomeric material apparatus of vacuum is bigger.
4. negative pressure transdermal delivery device according to claim 1, it is characterised in that device bosom semi-circular member can be with
Through gas, under vacuo during the 1st layer of deboost declines, the semi-circular member fixed by position can limit skin
It is overproof to swell and prevent skin from suffering damage, smoked and can not effectively be carried in by negative pressure while limiting composite drug-loaded dressing
On the skin swollen, it is used as the 2nd layer of mechanical deboost under negative pressure by semi-circular member, makes composite drug-loaded dressing fully
It is loaded on the human body skin bulged, semi-circular member has the neck of different depth in the position that device inwall is fixed, according to quilt
Treating the age of people different with concrete position can adjust semi-circular member depth.
5. negative pressure transdermal delivery device according to claim 1, it is characterised in that composite drug-loaded dressing is by 2 layers of group in device
Into lower floor is drug storage layer, and upper strata is separation layer, and lower floor sticks on skin after absorbing the drug, upper strata is impenetrable liquid breathable
Material, can so ensure that medicine is not extracted into outside by negative pressure, makes medicine easily be loaded into skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710418580.XA CN107019843B (en) | 2017-06-07 | 2017-06-07 | Negative pressure transdermal drug delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710418580.XA CN107019843B (en) | 2017-06-07 | 2017-06-07 | Negative pressure transdermal drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107019843A true CN107019843A (en) | 2017-08-08 |
| CN107019843B CN107019843B (en) | 2024-02-06 |
Family
ID=59531375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710418580.XA Active CN107019843B (en) | 2017-06-07 | 2017-06-07 | Negative pressure transdermal drug delivery device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107019843B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010027A (en) * | 2018-08-22 | 2018-12-18 | 胡春立 | One kind smells good moxibustion tool |
| CN110755740A (en) * | 2018-11-22 | 2020-02-07 | 柴雪青 | Negative-pressure transdermal drug delivery instrument and use method thereof |
| CN110841185A (en) * | 2019-11-13 | 2020-02-28 | 张子辰 | Pressure administration device and medicine storage core layer |
| CN111167004A (en) * | 2018-11-11 | 2020-05-19 | 张子辰 | Skin drug delivery device |
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| CN1303717A (en) * | 1999-12-14 | 2001-07-18 | 陈刚 | Transdermal medication apparatus |
| CN2418890Y (en) * | 2000-03-16 | 2001-02-14 | 董国臣 | Medicine supplier by negative pressure on skin |
| CN1438048A (en) * | 2003-02-18 | 2003-08-27 | 董国臣 | Optical power therapeutic combined device |
| US20070270745A1 (en) * | 2006-05-18 | 2007-11-22 | Camran Nezhat | Vacuum actuated tissue lifting device |
| KR20080003336U (en) * | 2008-07-16 | 2008-08-14 | 김중규 | Cupping glass for herb tea injection |
| CN202198964U (en) * | 2011-09-05 | 2012-04-25 | 马亮 | Local medicine delivery device for skin |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010027A (en) * | 2018-08-22 | 2018-12-18 | 胡春立 | One kind smells good moxibustion tool |
| CN111167004A (en) * | 2018-11-11 | 2020-05-19 | 张子辰 | Skin drug delivery device |
| CN110755740A (en) * | 2018-11-22 | 2020-02-07 | 柴雪青 | Negative-pressure transdermal drug delivery instrument and use method thereof |
| CN110841185A (en) * | 2019-11-13 | 2020-02-28 | 张子辰 | Pressure administration device and medicine storage core layer |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN107019843B (en) | 2024-02-06 |
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