CN115400342A - Plug-in transdermal drug delivery device and method of use - Google Patents
Plug-in transdermal drug delivery device and method of use Download PDFInfo
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- CN115400342A CN115400342A CN202211354336.9A CN202211354336A CN115400342A CN 115400342 A CN115400342 A CN 115400342A CN 202211354336 A CN202211354336 A CN 202211354336A CN 115400342 A CN115400342 A CN 115400342A
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- plug
- tray
- cover
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- assembly
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present application relates to the field of introducing drugs into the body transdermally, i.e., by skin penetration, and more particularly, to an insertion-type transdermal drug delivery device and method of use. In some embodiments of the application, the first electric plug is detachably connected with the second electric plug in a plugging mode, the tray body assembly is detachably connected with the tray cover assembly, and the tray body assembly in contact with the skin can be independently sterilized after treatment is finished, for example, high-temperature boiling sterilization is performed, so that the biological safety in the next use is ensured. In other embodiments of the present application, the support is provided with an air inlet and an air outlet, and the air inlet and the air outlet communicate a space formed by the support and the second socket with an inside of the cover body of the tray, so as to prevent air in the space formed by the support and the second socket from being compressed, which may cause the second electrical plug to be difficult to insert into the second electrical plug.
Description
Technical Field
The present application relates to the field of introducing drugs into the body transdermally, i.e., by skin penetration, and more particularly, to an insertion-type transdermal drug delivery device and method of use.
Background
Transdermal drug delivery is a method for introducing drugs into the body through skin penetration, and the drugs in the using process enter the pathological change part or acupuncture points of the human body through the skin to play a role, so that the damage of oral drugs to the gastrointestinal tract can be avoided, and the method is an effective method for treating diseases. However, the skin of the human body has a very meticulous structure, and the drug is subjected to considerable resistance through the skin, so that the drug is difficult to achieve the required treatment dosage. The transdermal speed of the medicine can be increased, and the transdermal penetration of the medicine can be increased by the following two means: firstly, the heating can raise the temperature of the skin at the medicine application part, accelerate the local blood circulation, increase the permeability of the skin and provide a physiological environment for the transdermal entry of the medicine on the one hand, and can promote the release of volatile components of the medicine on the other hand; the other is to close the local space (administration space) where the drug is located to create as high transdermal administration kinetics as possible.
After the existing transdermal drug delivery device is used, in order to avoid the damage of electronic components, alcohol cotton balls are generally used for wiping and disinfecting. With the increase of the disinfection mode, products with richer disinfection modes are needed.
Disclosure of Invention
In view of the above, the present application provides an insertion-type transdermal drug delivery device and a method for using the same, so as to solve one or more technical problems in the prior art, and the present application is implemented as follows:
in a first aspect, embodiments of the present application provide an insertion-type transdermal drug delivery device comprising:
a tray body assembly, the tray body assembly includes:
the disc body is provided with a central cavity, a central convex column positioned in the central cavity and an annular negative pressure annular cavity, the central cavity is connected with the negative pressure annular cavity through an annular groove with an upward opening, and the negative pressure annular cavity is provided with an air guide bent pipe interface;
the tray body cover is connected with the tray body and is arranged above the central cavity;
the electronic element comprises an electric heating element and a temperature sensing element, the electric heating element is positioned on the tray body and positioned above the central cavity to indirectly heat the central cavity, and the temperature sensing element is connected with the electric heating element to detect the temperature of the electric heating element;
a first sealing member connected with the tray body, the first sealing member sealing the electronic component against water;
a first electrical plug sealingly connected to the first seal member, a top portion of the first electrical plug extending beyond the first seal member, a bottom portion of the first electrical plug electrically connected to the electronic component;
the dish lid subassembly is arranged in on the disk body subassembly, the dish lid subassembly includes:
the disc cover body is used for covering the first sealing element and is connected with the first sealing element in a sealing way; the side surface of the disc cover body is provided with an air guide conduit joint and an air guide elbow joint, the air guide conduit joint is used for being connected with an external air extractor through an air guide conduit, the air guide conduit joint is used for forming ventilation connection with the air guide elbow joint, and the air guide elbow joint is used for forming ventilation connection with the air guide elbow joint;
a second electrical connector connected to and disposed inside the tray cover, the second electrical connector being electrically connected to an external power source; a support is formed in the disc cover body, the support is detachably connected with a second plug socket, and the second plug socket is used for connecting the second electric plug;
one end of the air guide bent pipe is connected to the negative pressure annular cavity, and the other end of the air guide bent pipe is connected with the disk cover body;
wherein the first electrical plug is frictionally connected when plugged with the second electrical plug, the tray assembly and the tray cover assembly engage with each other when the first electrical plug is plugged with the second electrical plug to prevent the tray cover assembly from falling off the tray assembly, and the tray assembly and the tray cover assembly separate from each other to sterilize the tray assembly when the first electrical plug is removed from the second electrical plug.
In some embodiments, the first electrical plug is a first electrical receptacle and the second electrical plug is a first electrical plug, such that viewing a pair of apertures from top to bottom inserts the first electrical plug into the first electrical receptacle; when the first electric plug is inserted into the first electric plug barrel, the tray body assembly and the tray cover assembly are combined with each other, and when the first electric plug is separated from the first electric plug barrel, the tray body assembly and the tray cover assembly are separated from each other; or
The first electric plug is a second electric plug, and the second electric plug is a second electric plug cylinder, so that residual liquid on the second electric plug can be cleaned after the tray body assembly is sterilized; when the second electric plug is inserted into the second electric plug barrel, the tray body assembly and the tray cover assembly are combined with each other, and when the second electric plug is separated from the second electric plug barrel, the tray body assembly and the tray cover assembly are separated from each other.
In some embodiments, the first electrical plug is an electrical wand and the second electrical plug is an electrical cartridge to facilitate cleaning of residual liquid on the electrical wand after retort sterilization of the tray assembly;
when the electric plunger is inserted into the electric insertion barrel, the disc body assembly and the disc cover assembly are combined with each other, and when the electric plunger is separated from the electric insertion barrel, the disc body assembly and the disc cover assembly are separated from each other.
In some embodiments, the first seal comprises a tray cover, a first socket, wherein,
the tray body cover is provided with an annular groove with an opening facing the center of the tray body cover, and the first plug socket is inserted into the annular groove and is connected with the annular groove in an adhesion manner so as to seal the tray body cover with the first plug socket; or
The first plug socket forms an annular groove with an opening facing the edge of the tray body cover, and the tray body cover is inserted into the annular groove and is connected with the annular groove in an adhesion mode so that the tray body cover and the first plug socket are sealed.
In some embodiments, the first seal comprises a tray cover, a first socket, wherein,
the tray body lid is formed with tray body lid annular groove that the opening is up, first plug socket is formed with the edgewise that extends downwards, the edgewise inserts in the tray body lid annular groove and through adhesive connection so that the tray body lid with first plug socket is sealed.
In some embodiments, the first seal comprises a tray cover, a first receptacle, wherein,
the tray body cover is provided with a tray body cover flange, the first plug socket is provided with a first plug socket flange, and a fastener is sleeved on the tray body cover flange and the first plug socket flange so as to seal the tray body cover and the first plug socket.
In some embodiments, the air guide conduit fitting forms a vent connection with the air guide elbow fitting, comprising:
an air pipe is connected between the air guide conduit joint and the air guide elbow joint to form ventilation connection; or
The tray cover body is used for covering the first sealing element and is in sealing connection with the first sealing element so as to enable the air guide conduit joint to form ventilation connection with the air guide elbow joint; when the air guide conduit joint and the air guide elbow joint form ventilation connection, a negative pressure space is formed inside the disc cover body, so that the sealing force between the disc cover body and the first sealing element is increased to prevent the disc cover body from falling off from the first sealing element.
In some embodiments, the first seal comprises a tray cover, a first socket, wherein,
a groove with an outward opening is formed in the outer surface of the first plug socket, a sealing ring is arranged in the groove, and the disc cover body is in sealing connection with the first plug socket through abutting against the sealing ring; or
The first plug socket is provided with a first plug socket annular groove with an upward opening, a U-shaped sealing ring with an upward opening is arranged in the first plug socket annular groove, and the disc cover body is inserted into the U-shaped sealing ring to be connected with the first plug socket in a sealing mode.
In some embodiments, the first electrical plug is a first electrical receptacle and the second electrical plug is a first electrical plug, such that viewing a pair of apertures from top to bottom inserts the first electrical plug into the first electrical receptacle; the bottom end of the first electric plug cylinder is closed to prevent liquid from contacting with the electronic element to cause short circuit, and the first electric plug rod is provided with an air exhaust channel to prevent the first electric plug rod from compressing air in the first electric plug cylinder to cause the first electric plug rod to be difficult to insert into the first electric plug cylinder; or
The first electric plug is a second electric plug, and the second electric plug is a second electric plug cylinder, so that residual liquid on the second electric plug can be cleaned after the tray body assembly is subjected to cooking sterilization; the top end of the second electric plug cylinder is provided with a through hole so as to prevent the second electric plug rod from compressing air in the second electric plug cylinder to cause the second electric plug rod to be difficult to insert into the second electric plug cylinder.
In a second aspect, embodiments of the present application provide a method of using an insertion-type transdermal drug delivery device, comprising:
the medicine pad is sleeved on the central convex column in the central cavity;
combine the disk lid subassembly with the disk body subassembly: connecting the first electrical plug with the second electrical plug;
air is extracted through an air guide pipe joint of the tray cover assembly, and negative pressure is formed in the tray cover body and a negative pressure annular cavity arranged on the tray body;
adsorbing the negative pressure ring cavity on the skin;
indirectly heating the central cavity by an electrical heating element, causing the temperature of the central cavity to increase to facilitate passage of drug molecules of the drug pad through the skin;
the temperature sensing element is connected with the electric heating element to detect the temperature of the electric heating element;
after treatment is finished, the tray cover assembly is separated from the tray body assembly, and the tray body assembly is subjected to cooking sterilization for next use.
The beneficial effects brought by some embodiments of the application are: through the plug-in combination of first electric plug with second electric plug with dismantle the separation, disk body subassembly and dish lid subassembly are detachable to be connected, can disinfect alone with the disk body subassembly of skin contact after the treatment, for example high temperature poaching disinfection, have guaranteed the biosafety when using next time.
In some embodiments of the application, the electronic element is sealed and waterproof by the first sealing element in the tray body assembly, so that the electronic element is always kept in an isolated state with water, alcohol and other disinfection liquid when being disinfected by high-temperature water boiling, and the electronic element is prevented from being wetted to be damaged by short circuit when being used next time.
In some embodiments of the present application, two sides of the first socket annular groove are provided with protrusions facing the disc cover body, and the top end of the U-shaped ring seal abuts against the protrusions, so that the U-shaped ring seal is prevented from being brought out of the first socket annular groove when the disc cover body is pulled out, and the damage rate of the plug-in type transdermal drug delivery device is reduced.
In some embodiments of the present application, the support is provided with an air inlet and an air outlet, and the air inlet and the air outlet communicate a space formed by the support and the second socket with an inside of the cover body of the tray, so as to prevent the second electrical plug from being difficult to insert into the second electrical plug barrel due to compression of air in the space formed by the support and the second socket.
It should be understood that the statements in this section do not necessarily identify key or critical features of the embodiments of the present application, nor do they limit the scope of the present application. Other features of the present application will become apparent from the following description. The above and other objects, advantages and features of the present application will become more apparent to those skilled in the art from the following detailed description of specific embodiments thereof, taken in conjunction with the accompanying drawings.
Drawings
Some specific embodiments of the present application will be described in detail hereinafter, by way of example and not by way of limitation, with reference to the accompanying drawings, which are included to provide a better understanding of the present application and are not to be construed as limiting the present application. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily to scale. In the drawings:
FIG. 1 is a schematic top view of an insertion-type transdermal drug delivery device according to some embodiments of the present application;
FIG. 2 isbase:Sub>A cross-sectional view A-A of FIG. 1 according to some embodiments of the present application;
FIG. 3 is a cross-sectional view B-B of FIG. 1 according to some embodiments of the present application;
FIG. 4 is a schematic view of a tray cover assembly according to some embodiments of the present application;
FIG. 5 is a schematic view of a tray assembly according to some embodiments of the present application;
FIG. 6 is an axial view of an electrical plug according to some embodiments of the present application;
FIG. 7 isbase:Sub>A cross-sectional view A-A of FIG. 1 in accordance with other embodiments of the present application;
FIG. 8 is a cross-sectional view B-B of FIG. 1 in accordance with other embodiments of the present application;
FIG. 9 is a schematic view of a cover assembly according to further embodiments of the present application;
FIG. 10 is a schematic view of a tray assembly according to further embodiments of the present application;
FIG. 11 is a schematic view of a seal ring according to some embodiments of the present application;
FIG. 12 isbase:Sub>A cross-sectional view A-A of FIG. 1 in accordance with still further embodiments of the present application;
FIG. 13 is a cross-sectional view B-B of FIG. 1 in accordance with still further embodiments of the present application;
FIG. 14 is a schematic view of a U-shaped seal ring according to some embodiments of the present application;
FIG. 15 is a schematic flow chart illustrating a method of using the plug-in transdermal drug delivery device according to some embodiments of the present application.
Description of the main element symbols:
10-a tray assembly;
11-a disk body, 111-a negative pressure ring cavity, 112-a central cavity, 113-a central convex column and 114-an air guide bent pipe interface;
12-disk cover, 121-disk cover inner edge, 122-disk cover ring groove, 123-disk cover flange, 124-disk cover sealing element, 124A-sealing ring, 124B-U-shaped sealing ring, 124C-fastening element;
13-an electric heating element;
14-temperature sensing element, 141-pin;
15-inner conductor;
16-first socket, 161-first socket outer rim, 162-first socket annular groove;
17-first electrical plug, 171-second electrical plug, 172-first electrical plug barrel;
20-a tray cover assembly;
21-tray cover, 211-air guide duct joint, 212-electric guide duct joint, 213-air guide elbow joint, 214-support;
22-conduit, 221-air guide conduit; 222-a conductive conduit;
23-a second socket;
24-a second electrical plug, 241-a second electrical plug barrel, 242-a first electrical plug, 242A-an exhaust channel;
30-gas guide bent pipe.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application, in which: numerous details of the embodiments of the present application are set forth to provide an understanding that the described embodiments are merely possible technical implementations of the present application and should be considered merely exemplary and not all possible implementations. Also, descriptions of well-known functions and constructions are omitted in the following description for clarity and conciseness.
The use of ordinal numbers such as "first," "second," etc., in the specification and claims to modify a corresponding element does not by itself connote any ordinal number of the element or any ordering of one element from another element or method of manufacture, and the use of the ordinal numbers is only used to distinguish one element having a certain name from another element having a same name. In the present application, "or/and", "and/or" means that the object is at least one of them, "or" means that the object is one of them.
The terms "upper", "lower", "vertical", "high" and "low" in this application are used in reference to fig. 2, and are used primarily for the purpose of better describing the application and its embodiments, and are not intended to limit the indicated devices, elements or components to a particular orientation or to be constructed and operated in a particular orientation. The term "plurality" shall mean two as well as more than two. The terms "inner", "outer", and the like, indicate an orientation or positional relationship based on that shown in the drawings, merely for convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present application.
According to a first aspect of the present application, there is provided an insertion-type transdermal drug delivery device comprising:
a tray assembly 10, said tray assembly 10 comprising:
the tray body 11 is provided with a central cavity 112 and an annular negative pressure annular cavity 111, and the negative pressure annular cavity 111 is provided with an air guide elbow joint 114;
a tray body cover 12 connected with the tray body 11 and disposed above the central cavity 112;
electronic components including electrical heating elements 13, the electrical heating elements 13 being located on the tray body 11 and above the central cavity 112 to indirectly heat the central cavity 112;
a first sealing member connected to the tray body 11, the first sealing member sealing the electronic component against water;
a first electrical connector 17 sealingly connected to the first seal member, a top portion of the first electrical connector 17 extending beyond the first seal member, and a bottom portion of the first electrical connector 17 electrically connected to the electronic component;
a tray cover assembly 20 disposed on the tray body assembly 10, the tray cover assembly 20 comprising:
a tray cover 21 for covering the first sealing member and sealing-connecting with the first sealing member; an air guide pipe joint 211 and an air guide elbow joint 213 are arranged on the side surface of the tray cover body 21, the air guide pipe joint 211 is used for being connected with an external air extracting device through an air guide pipe 221, the air guide pipe joint 211 is used for forming ventilation connection with the air guide elbow joint 213, and the air guide elbow joint 213 is used for forming ventilation connection with the air guide elbow joint 114;
and a second electrical connector 24 connected to the tray cover 21 and disposed inside the tray cover 21, wherein the second electrical connector 24 is electrically connected to an external power source. Specifically, the second electrical connector 24 is electrically connected to the conductive conduit 221 via internal wires, and the conductive conduit 221 is electrically connected to an external power source.
Wherein the first electrical connector 17 is frictionally connected when plugged with the second electrical connector 24, the tray assembly 10 and the tray cover assembly 20 mutually engage to prevent the tray cover assembly 20 from falling off the tray assembly 10 when the first electrical connector 17 is plugged with the second electrical connector 24, and the tray assembly 10 and the tray cover assembly 20 are separated from each other to sterilize the tray assembly 10 when the first electrical connector 17 is detached from the second electrical connector 24.
In the application, through the plug-in combination and the dismantlement separation of first electric plug 17 with second electric plug 24, disk body subassembly 10 is detachable with the dish lid subassembly 20 and is connected, can disinfect alone with the disk body subassembly 10 of skin contact after the treatment, and the biosafety when having guaranteed next use for example high temperature poaching disinfection.
In this application, first sealing member in the disk body subassembly 10 will electronic component seals with waterproof, has guaranteed for example that electronic component is in the isolated state with disinfection liquid such as water, alcohol all the time when high temperature poaching is disinfected, and electronic component is stained with the condition that the short circuit takes place to damage when having prevented next use. In the embodiment shown in fig. 2, 3, 5, 7, 8, 10, 12 and 13, the first seal is a split structure comprising a tray cover 12 and a first receptacle 16; in other embodiments, the first seal may also be a unitary structure that fixedly couples the tray cover 12 and the first socket 16 together. The first socket 16 is tightly connected with the tray body cover 12, and a first electric plug 17 is fixedly connected thereon and is electrically connected with the electric heating element 13 and the temperature sensing element 14 through the inner lead 15.
A central convex column 113 protruding downwards is formed in the central cavity 112, and the medicine pad can be sleeved on the central convex column 113 for positioning. The central lumen 112 and the negative pressure annular lumen 111 are connected by an upwardly open annular groove to provide skin-compliant stretching and bending. In fig. 2, the electric heating element 13 is located between the tray 11 and the tray cover 12, and the temperature sensing element 14 connected to the electric heating element 13 is located in the central boss 113, so that the bottom surface of the central boss 113 can support and fix the temperature sensing element 14. The temperature sensing element 14 can detect the temperature of the electric heating element 13, thereby indirectly detecting the temperature in the central cavity 112, on one hand, the release speed of the drug molecules in the medicinal pad can be controlled, and on the other hand, the temperature of the skin can be controlled, thereby preventing the skin from being scalded or controlling the local blood circulation speed of the skin so as to control the permeability of the skin.
In some embodiments, the second socket 23 is detachably connected to a support 214 formed inside the tray cover 21, so that the second socket 23 is mounted on the tray cover 21. For example, in fig. 3, the first electrical plug 242 is inserted into the corresponding mounting hole of the second socket 23, the first electrical plug 242 is electrically connected to the conductive wire of the conductive conduit 222 by a conductive wire, and then the second socket 23 is mounted on the support 214.
In the embodiment shown in fig. 2 and 3, the first electrical plug 17 is a first electrical socket 172 and the second electrical plug 24 is a first electrical plug 242, such that the pair of holes can be seen from top to bottom to insert the first electrical plug 242 into the first electrical socket 172; the tray assembly 10 and the tray cover assembly 20 are engaged with each other when the first electrical plunger 242 is inserted into the first electrical cartridge 172, and the tray assembly 10 and the tray cover assembly 20 are disengaged from each other when the first electrical plunger 242 is disengaged from the first electrical cartridge 172.
In the embodiment of fig. 7 and 8, the first electrical plug 17 is a second electrical plug 171 and the second electrical plug 24 is a second electrical cartridge 241, so as to facilitate cleaning of the second electrical plug 171 from residual liquid after sterilization of the tray assembly 10; when the second electrical plunger 171 is inserted into the second electrical barrel 241, the tray assembly 10 and the tray cover assembly 20 are engaged with each other, and when the second electrical plunger 171 is disengaged from the second electrical barrel 241, the tray assembly 10 and the tray cover assembly 20 are disengaged from each other.
The present application provides three ways of sealing the tray body cover 12 with the first socket 16:
in the embodiment shown in fig. 2 and 3, the connection is sealed by means of plane adhesion: the tray body cover 12 is formed with an annular groove with an opening facing the center of the tray body cover 12, and the first socket 16 is inserted into the annular groove and is connected with the annular groove by bonding so as to seal the tray body cover 12 with the first socket 16. In other embodiments, it is also possible to: the first socket 16 forms an annular groove with an opening facing the edge of the tray body cover 12, and the tray body cover 12 is inserted into the annular groove and is connected with the annular groove by bonding so that the tray body cover 12 is sealed with the first socket 16. By arranging the annular groove, the tray body cover 12 forms a mechanical limit for the first socket 16, so that the first socket 16 can be effectively prevented from shaking and loosening relative to the tray body cover 12, and the long-term sealing effect of the tray body cover 12 and the first socket 16 is improved. In the embodiment shown in fig. 2 and 3, the inner edge 121 of the tray body is configured to cooperate with the outer edge 161 of the first socket.
In the embodiment shown in fig. 7 and 8, the sealing connection is realized by groove bonding: the tray body cover 12 is formed with a tray body cover ring groove 122 with an upward opening, the first socket 16 is formed with a downward extending rim, and the rim is inserted into the tray body cover ring groove 122 and is connected by bonding to seal the tray body cover 12 with the first socket 16. For example, the bonding manner may be that a glue solution is injected into the disc body cover ring groove 122, the glue solution automatically levels in the disc body cover ring groove 122 due to the gravity, and the edge of the glue solution is tightly bonded with the disc body cover ring groove 122 into a whole after being inserted, so that the waterproof effect and the sealing effect are better.
In the embodiment shown in fig. 12 and 13, the connection is sealed in a flange-like manner: the tray body cover 12 is formed with a tray body cover flange 123, the first socket 16 is formed with a first socket flange, and the fastening member 124C is sleeved on the tray body cover flange 123 and the first socket flange to seal the tray body cover 12 with the first socket 16. In the embodiment shown in fig. 12 and 13, the fastener 124C is a nut. In some embodiments, a plurality of pairs of the tray cover flanges 123 and the first socket flange may be disposed on the periphery of the tray cover 12 and the first socket 16, and a corresponding number of fasteners 124C may be provided to enhance the sealing performance between the tray cover 12 and the first socket 16. The tray cover flange 123, the first socket flange, and the fastening member 124C cooperate with each other to increase the sealing reliability of the tray cover 12 and the first socket 16.
The present application provides two ways of forming a venting connection for the air guide conduit fitting 211 and the air guide elbow fitting 213:
the air guide duct joint 211 and the air guide elbow joint 213 form a ventilation connection, which may be: an air pipe is connected between the air guide duct joint 211 and the air guide elbow joint 213 to form an air-vent connection. In this way, the air pipe connects the air source, the air guide conduit joint 211, the air guide elbow joint 213, the air guide elbow joint 114 and the negative pressure annular cavity 111 together in sequence, so that an independent closed negative pressure system is formed in use, the influence of other parts, such as the sealing effect of the tray cover 12 and the first socket 16, is basically avoided, and the structure is simple and reliable.
The air guide duct joint 211 and the air guide elbow joint 213 form a ventilation connection, and may further include: in the embodiment shown in FIGS. 2, 3, 7, 8, 12 and 13, the cover tray body 21 is adapted to cover and sealingly engage the first sealing member to establish the air guide duct joint 211 in air-passing communication with the air guide elbow joint 213; when the air guide duct joint 211 and the air guide elbow joint 213 are connected to each other for ventilation, a negative pressure space is formed inside the tray cover body 21, so that the sealing force between the tray cover body 21 and the first sealing member is increased to prevent the tray cover body 21 from falling off the first sealing member. Specifically, in the embodiment shown in the drawings, the first sealing member is a split structure including the tray body cover 12 and the first socket 16, and the tray body 21 covers the first socket 16 and is sealingly connected with the first socket 16 to form the air guide duct joint 211 and the air guide elbow joint 213 in an air-tight connection.
The engagement of the tray cover 21 with the first receptacle 16 is achieved by friction between the electrical pins 242, 171 and the electrical sockets 241, 172. During actual operation, the friction should be sufficient to keep the tray cover assembly 20 and the tray body assembly 10 together. During the process of applying the tray assembly 10 to the skin, the operator holds the tray body 21 in the air and moves it with a friction force greater than the weight of the tray assembly 10 to prevent the tray assembly 10 from falling off the tray cover assembly 20 and falling to the ground. When the disc body assembly 10 is applied to the skin, the disc body assembly 10 is adsorbed to the skin by means of negative pressure formed by the annular negative pressure annular cavity 111, at this time, if the body position of the human body is lying on the back, the plug-in type transdermal drug delivery device is applied to the back of the human body, the disc cover assembly 20 and the conduit 22 mounted on the disc cover assembly 20 are pressed on the disc body assembly 10 by the gravity, and the combination of the disc cover assembly 20 and the disc body assembly 10 is stable. However, if the person is in a seated position, the weight of the cover assembly 20, including the conduit 22 mounted thereon, becomes a pulling separation force, increasing the risk of the cover assembly 20 falling off the cover assembly 10, and during treatment when the person shakes the conduit 22 mounted on the cover assembly 20 in the air, increasing this pulling separation force, and if the friction between the electrical plugs 242, 171 and the electrical sockets 241, 172 is low, the cover assembly 20 risks falling off. However, excessive friction results in great force for separating the cover assembly 20 from the tray body assembly 10 after the treatment is finished, and the difficulty of operation is increased.
In the embodiment where a negative pressure space is formed inside the tray cover 21, the negative pressure generated during the treatment process is used to reduce the friction between the electrical plugs 242, 171 and the electrical sockets 241, 172, so that only when the tray cover 21 is pinched in the air, the friction is greater than the gravity of the tray assembly 10, and the tray assembly 10 will not fall off. During the treatment process, a negative pressure space is formed inside the tray cover body 21, and the formed negative pressure enables the tray cover body 21 including the tray cover assembly 20 integrated with the tray cover body to be adsorbed on the first plug socket 16, so that the sealing force between the tray cover body 21 and the first plug socket 16 is increased, the gravity of the tray cover assembly 20 and the guide pipe 22 thereon and the pulling force formed when the guide pipe 22 swings are reduced or offset, and the risk that the tray cover assembly 20 falls off is avoided in the whole treatment process. Thus, the self-tightening effect of the plug-in type transdermal drug delivery device is achieved, the continuous electric connection is maintained, and the reliability of the plug-in type transdermal drug delivery device is improved.
In order to realize that the interior of the tray cover body 21 forms a negative pressure space, the present application provides two types of tray cover bodies 21 and first sockets 16 in a plug-in sealing manner:
as shown in fig. 7, 8 and 10, a groove with an outward opening is formed on an outer surface of the first socket 16, a sealing ring 124A is disposed in the groove, and the tray cover 21 is in sealing connection with the first socket 16 by abutting against the sealing ring 124A. The sealing ring 124A used in this way is shown in FIG. 11, and has a simple structure and low production cost.
As shown in fig. 12 and 13, the first socket 16 is formed with a first socket annular groove 162 with an upward opening, a U-shaped sealing ring 124B with an upward opening is disposed in the first socket annular groove 162, and the tray cover 21 is inserted into the U-shaped sealing ring 124B to be sealingly connected with the first socket 16. The U-shaped sealing ring 124B used in this manner is shown in fig. 11, the U-shaped sealing ring 124B seals two sides of the tray cover 21, and the U-shaped sealing rings 124B at two sides and the bottom of the tray cover 21 can elastically deform, so as to achieve a better sealing effect between the tray cover 21 and the first socket 16. As shown in fig. 12 and 13, two sides of the first socket annular groove 162 are provided with protrusions facing the disc cover body 21, and the top end of the U-shaped ring seal abuts against the protrusions, so that the U-shaped ring seal is prevented from being taken out of the first socket annular groove 162 when the disc cover body 21 is drawn out, and the damage rate of the plug-in type transdermal drug delivery device is reduced.
The tray assembly 10 includes a first electrical connector 17 and the tray cover assembly 20 includes a second electrical connector 24. The first electrical plug 17 is a first electrical plug barrel 172, and the second electrical plug 24 is a first electrical plug 242, so that the first electrical plug 242 can be inserted into the first electrical plug barrel 172 when a hole is observed from top to bottom; the bottom end of the first electrical plug cylinder 172 is closed to prevent the liquid from contacting the electronic component and causing short circuit, and the first electrical plug 242 has an air exhaust channel 242A formed thereon to prevent the first electrical plug 242 from compressing the air in the first electrical plug cylinder 172, which makes it difficult for the first electrical plug 242 to be inserted into the first electrical plug cylinder 172. Figure 6 shows one form of the first electrical plunger 242 with the vent passage 242A formed therein in the form of a side groove. Fig. 4 shows the first electrical plunger 242, fig. 5 shows the first electrical plunger 172, in the embodiment shown in fig. 2 and 3, the first electrical plunger 172 and the first electrical plunger 242 are shown, and fig. 2 and 3 show the shape change of the first electrical plunger 242 with the air discharge passage 242A in different cross sections.
In the embodiment shown in fig. 7 and 8, the first electrical plug 17 is a second electrical plug 171, and the second electrical plug 24 is a second electrical socket 241, so as to clean the second electrical plug 171 of residual liquid after the tray assembly 10 is sterilized by cooking; a through hole is formed at the top end of the second electrical socket cylinder 241 to prevent the second electrical rod 171 from being difficult to insert into the second electrical socket cylinder 241 due to the second electrical rod 171 compressing the air in the second electrical socket cylinder 241. Fig. 9 shows a second electrical plug cylinder 241, fig. 10 shows a second electrical plug 171, fig. 9 shows that a gas inlet and outlet is arranged on the support 214, and the gas inlet and outlet communicates the space formed by the support 214 and the second plug seat 23 with the inside of the disk cover 21, so as to prevent the second electrical plug 171 from being difficult to insert into the second electrical plug cylinder 241 due to the compression of the air in the space formed by the support 214 and the second plug seat 23.
It should be noted that, in the present application, the technical features in the embodiments and the embodiments may be combined with each other without conflict, and some combined embodiments are schematically presented in the present application to illustrate possible combinations:
example 1:
fig. 1 is a schematic top view of an insertion-type transdermal drug delivery device according to some embodiments of the present application, which includes a tray assembly 10, a tray cover assembly 20, and a catheter 22, an airway tube 30. One end of the air guide bent pipe 30 is communicated with the negative pressure annular cavity 111 through an air guide bent pipe joint 114, and the other end is connected to an air guide bent pipe joint 213 on the disk cover body 21. The guide duct 22 includes an air guide duct 221 and an electrically conductive duct 222. An air guide duct joint 211 is arranged on the side surface of the tray cover body 21, the air guide duct joint 211 is connected with an air guide duct 221, an electric conduction duct joint 212 is arranged at the adjacent position, and the second electric plug 24 is connected with an electric conduction duct 222 through an inner lead 15; the side surface of the tray cover body 21 is further provided with an air guide elbow joint 213, the air guide elbow joint 213 is perpendicular to the side surface of the tray cover body 21, one end of the air guide elbow joint 213, which is positioned on the outer side of the tray cover body 21, is communicated with the air guide elbow 30, and one end of the air guide elbow joint 213, which is positioned on the inner side of the tray cover body 21, is communicated with the air guide conduit joint 211. Fig. 1 isbase:Sub>A schematic top view of an insertion-type transdermal drug delivery device according to some embodiments of the present application, fig. 2 isbase:Sub>A cross-sectional viewbase:Sub>A-base:Sub>A of fig. 1 according to some embodiments of the present application, fig. 3 isbase:Sub>A cross-sectional view B-B of fig. 1 according to some embodiments of the present application, fig. 4 isbase:Sub>A schematic diagram ofbase:Sub>A tray cover assembly 20 according to some embodiments of the present application, fig. 5 isbase:Sub>A schematic diagram ofbase:Sub>A tray assembly 10 according to some embodiments of the present application, and fig. 6 is an axial view of an electrical wand according to some embodiments of the present application. The embodiment of the combination is a combination of the structures shown in fig. 1-6, and has technical effects brought by corresponding structures.
Example 2: fig. 1 isbase:Sub>A schematic top view of an insertion-type transdermal drug delivery device according to some embodiments of the present application, fig. 7 isbase:Sub>A cross-sectional viewbase:Sub>A-base:Sub>A of fig. 1 according to some embodiments of the present application, fig. 8 isbase:Sub>A cross-sectional view B-B of fig. 1 according to some embodiments of the present application, fig. 9 isbase:Sub>A schematic diagram ofbase:Sub>A tray cover assembly 20 according to some embodiments of the present application, fig. 10 isbase:Sub>A schematic diagram ofbase:Sub>A tray body assembly 10 according to some embodiments of the present application, and fig. 11 isbase:Sub>A schematic diagram ofbase:Sub>A sealing ring 124base:Sub>A according to some embodiments of the present application. The embodiment of the combination is a combination of the structures shown in fig. 1, 7-11, and has technical effects brought by corresponding structures.
Example 3: fig. 1 isbase:Sub>A schematic top view, fig. 12 isbase:Sub>A sectional viewbase:Sub>A-base:Sub>A in fig. 1, fig. 13 isbase:Sub>A sectional view B-B in fig. 1, and fig. 14 isbase:Sub>A schematic view ofbase:Sub>A U-shaped sealing ring 124B in accordance with some embodiments of the present application, in accordance with yet other embodiments of the present application. The embodiment of the combination is a combination of the structures shown in fig. 1, 12-14, and has technical effects brought by corresponding structures.
Based on the same concept, embodiments of the second aspect of the present application also provide a method of using an insertion-type transdermal drug delivery device, the method of using comprising:
s101, the medicine pad is sleeved on the central convex column 113 in the central cavity 112.
S102, combining the tray cover assembly 20 with the tray body assembly 10: the first electrical connector 17 is connected to the second electrical connector 24.
And S103, air is extracted through the air guide pipe joint 211 of the disk cover assembly 20, and negative pressure is formed in the disk cover body 21 and the negative pressure annular cavity arranged on the disk body 11.
And S104, adsorbing the negative pressure ring cavity 111 on the skin.
S105, the electric heating element 13 indirectly heats the central cavity 112, and the temperature of the central cavity 112 is increased to promote the drug molecules of the drug pad to pass through the skin.
S106, the temperature sensing element 14 is connected to the electric heating element 13 to detect the temperature of the electric heating element 13.
S107, after the treatment is finished, the tray cover assembly 20 is separated from the tray body assembly 10, and the tray body assembly 10 is steamed and disinfected for next use.
In the application, through the plug-in combination and the disassembly separation of the first electric plug 17 and the second electric plug 24, the tray body assembly 10 and the tray cover assembly 20 are detachably connected, and the tray body assembly 10 in contact with the skin can be independently sterilized after the treatment is finished, for example, high-temperature boiling sterilization is carried out, so that the biological safety in the next use is ensured.
So far, the embodiments of the present application have been described in detail with reference to the accompanying drawings. It is to be noted that, in the attached drawings or in the description, the implementation modes not shown or described are all the modes known by the ordinary skilled person in the field of technology, and are not described in detail.
The above embodiments are only examples of the present application and should not be construed as limiting the present application, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (10)
1. An insertion-type transdermal drug delivery device, comprising:
a tray body assembly, the tray body assembly includes:
the disc body is provided with a central cavity, a central convex column positioned in the central cavity and an annular negative pressure annular cavity, the central cavity is connected with the negative pressure annular cavity through an annular groove with an upward opening, and the negative pressure annular cavity is provided with an air guide bent pipe interface;
the tray body cover is connected with the tray body and is arranged above the central cavity;
the electronic element comprises an electric heating element and a temperature sensing element, the electric heating element is positioned on the tray body and positioned above the central cavity to indirectly heat the central cavity, and the temperature sensing element is connected with the electric heating element to detect the temperature of the electric heating element;
a first sealing member connected with the tray body, the first sealing member sealing the electronic component against water;
a first electrical plug sealingly connected to the first seal member, a top portion of the first electrical plug extending beyond the first seal member, a bottom portion of the first electrical plug electrically connected to the electronic component;
the dish lid subassembly is arranged in on the disk body subassembly, the dish lid subassembly includes:
the tray cover body is used for covering the first sealing element and is connected with the first sealing element in a sealing way; the side surface of the disc cover body is provided with an air guide conduit joint and an air guide elbow joint, the air guide conduit joint is used for being connected with an external air extractor through an air guide conduit, the air guide conduit joint is used for forming ventilation connection with the air guide elbow joint, and the air guide elbow joint is used for forming ventilation connection with the air guide elbow joint;
the second electric plug is connected with the disc cover body and arranged inside the disc cover body, and the second electric plug is electrically connected with an external power supply; a support is formed in the disc cover body, the support is detachably connected with a second plug socket, and the second plug socket is used for connecting the second electric plug;
one end of the air guide bent pipe is connected to the negative pressure annular cavity, and the other end of the air guide bent pipe is connected with the disk cover body;
wherein the first electrical connector is frictionally coupled to the second electrical connector when the first electrical connector is plugged into the second electrical connector, the tray assembly and the tray cover assembly engage with each other when the first electrical connector is plugged into the second electrical connector to prevent the tray cover assembly from falling off the tray assembly, and the tray assembly and the tray cover assembly separate from each other when the first electrical connector is disconnected from the second electrical connector to sterilize the tray assembly.
2. The plug-in transdermal drug delivery device according to claim 1,
the first electric plug is a first electric plug barrel, the second electric plug is a first electric plug rod, and therefore the first electric plug rod can be inserted into the first electric plug barrel by observing a hole from top to bottom; when the first electric plug is inserted into the first electric plug barrel, the tray body assembly and the tray cover assembly are combined with each other, and when the first electric plug is separated from the first electric plug barrel, the tray body assembly and the tray cover assembly are separated from each other; or
The first electric plug is a second electric plug, and the second electric plug is a second electric plug cylinder, so that residual liquid on the second electric plug can be cleaned after the tray body assembly is sterilized; when the second electric plug is inserted into the second electric plug barrel, the tray body assembly and the tray cover assembly are combined with each other, and when the second electric plug is separated from the second electric plug barrel, the tray body assembly and the tray cover assembly are separated from each other.
3. The plug-in transdermal drug delivery device according to claim 1,
the first electric plug is an electric plug, and the second electric plug is an electric plug cylinder, so that residual liquid on the electric plug can be cleaned after the tray body assembly is steamed and disinfected;
when the electric plunger is inserted into the electric insertion barrel, the disc body assembly and the disc cover assembly are combined with each other, and when the electric plunger is separated from the electric insertion barrel, the disc body assembly and the disc cover assembly are separated from each other.
4. The plug-in transdermal drug delivery device according to claim 1, wherein the first seal comprises a disk cover, a first socket, wherein,
the tray body cover is provided with an annular groove with an opening facing the center of the tray body cover, and the first plug socket is inserted into the annular groove and is connected with the annular groove in an adhesion manner so as to seal the tray body cover with the first plug socket; or
The first plug socket forms an annular groove with an opening facing the edge of the tray body cover, and the tray body cover is inserted into the annular groove and is connected with the annular groove in an adhesion mode so that the tray body cover and the first plug socket are sealed.
5. The plug-in transdermal drug delivery device of claim 1, wherein the first seal comprises a tray cover, a first hub, wherein,
the tray body lid is formed with tray body lid annular groove that the opening is up, first plug socket is formed with the edgewise that extends downwards, the edgewise inserts in the tray body lid annular groove and through adhesive connection so that the tray body lid with first plug socket is sealed.
6. The plug-in transdermal drug delivery device of claim 1, wherein the first seal comprises a tray cover, a first hub, wherein,
the tray body cover is provided with a tray body cover flange, the first plug socket is provided with a first plug socket flange, and a fastener is sleeved on the tray body cover flange and the first plug socket flange so as to seal the tray body cover and the first plug socket.
7. The plug-in transdermal drug delivery device according to claim 1, wherein the air guide conduit fitting forms an air-vent connection with the air guide elbow fitting, comprising:
an air pipe is connected between the air guide conduit joint and the air guide elbow joint to form ventilation connection; or
The tray cover body is used for covering the first sealing element and is in sealing connection with the first sealing element so as to enable the air guide conduit joint to form ventilation connection with the air guide elbow joint; when the air guide conduit joint and the air guide elbow joint form ventilation connection, a negative pressure space is formed inside the tray cover body, so that the sealing force between the tray cover body and the first sealing element is increased to prevent the tray cover body from falling off from the first sealing element.
8. The plug-in transdermal drug delivery device according to claim 1, wherein the first seal comprises a disk cover, a first socket, wherein,
a groove with an outward opening is formed in the outer surface of the first plug socket, a sealing ring is arranged in the groove, and the disc cover body is in sealing connection with the first plug socket through abutting against the sealing ring; or
The first plug socket is provided with a first plug socket annular groove with an upward opening, a U-shaped sealing ring with an upward opening is arranged in the first plug socket annular groove, and the disc cover body is inserted into the U-shaped sealing ring to be connected with the first plug socket in a sealing mode.
9. The plug-in transdermal drug delivery device according to claim 1,
the first electric plug is a first electric plug barrel, the second electric plug is a first electric plug rod, and therefore the first electric plug rod can be inserted into the first electric plug barrel by observing a hole from top to bottom; the bottom end of the first electric plug cylinder is closed to prevent liquid from contacting with the electronic element to cause short circuit, and the first electric plug rod is provided with an air exhaust channel to prevent the first electric plug rod from compressing air in the first electric plug cylinder to cause the first electric plug rod to be difficult to insert into the first electric plug cylinder; or
The first electric plug is a second electric plug, and the second electric plug is a second electric plug cylinder, so that residual liquid on the second electric plug can be cleaned after the tray body assembly is subjected to cooking sterilization; the top end of the second electric plug cylinder is provided with a through hole so as to prevent the second electric plug rod from compressing air in the second electric plug cylinder to cause the second electric plug rod to be difficult to insert into the second electric plug cylinder.
10. A method of using a plug-in transdermal drug delivery device, comprising:
the medicine pad is sleeved on the central convex column in the central cavity;
combining the tray cover assembly with the tray body assembly: connecting the first electrical plug with the second electrical plug;
air is extracted through an air guide pipe joint of the tray cover assembly, and negative pressure is formed in the tray cover body and a negative pressure annular cavity arranged on the tray body;
adsorbing the negative pressure ring cavity on the skin;
indirectly heating the central cavity by an electrical heating element, causing the temperature of the central cavity to increase to facilitate passage of drug molecules of the drug pad through the skin;
the temperature sensing element is connected with the electric heating element to detect the temperature of the electric heating element;
after treatment is finished, the tray cover assembly is separated from the tray body assembly, and the tray body assembly is subjected to cooking sterilization for next use.
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| CN202211354336.9A CN115400342B (en) | 2022-11-01 | 2022-11-01 | Plug-in transdermal drug delivery device and method of use |
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| CN202211354336.9A CN115400342B (en) | 2022-11-01 | 2022-11-01 | Plug-in transdermal drug delivery device and method of use |
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| CN115400342B (en) | 2023-02-10 |
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