CN201035002Y

CN201035002Y - Organization chip

Info

Publication number: CN201035002Y
Application number: CNU2007201076658U
Authority: CN
Inventors: 张可浩; 陈海啸
Original assignee: TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE
Current assignee: TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE
Priority date: 2007-04-02
Filing date: 2007-04-02
Publication date: 2008-03-12
Anticipated expiration: 2017-04-02

Abstract

The utility model relates to a tissue chip in fields of biology, zoology, medicine, etc. The technical scheme of the utility model is that: a plurality of array point micro tissue blocks are arranged on a glass support, the micro tissue blocks are formed into many small arrays, and the micro tissue blocks on the corners are larger than other micro tissue blocks. The distance H between neighbor small arrays is larger than the distance h between micro tissue blocks in the small array. The number of the small arrays is 2 to 15, and the rows of micro tissue blocks in the small array are 2 to 8, while the columns are 2 to 8 also. The micro tissue blocks in the small array are disposed as 3 rows and 5 columns, or 5 rows and 3 columns. Sub-zone process is implemented on the small arrays of the micro tissue blocks of tissue chip, and the tissue blocks in the small array are arranged according to a certain order. The diameter of the micro tissue blocks at one corner is larger than that of others, and the difference of the diameter can be significantly discriminated through naked eyes. The utility model facilitates to enhance the accuracy and working efficiency of workers producing the tissue chip, as well as facilitates to improve the efficiency of researchers to observe the study results of tissue chip.

Description

A kind of organization chip

Technical field:

The utility model relates to a kind of organization chip in fields such as biology, zoology and medical science.

Background technology:

At present domestic and international organization chip, its tens of points are so that hundreds of little piece of tissue forming array points are arranged on the microslide the horizontal longitudinal pitch uniformity of array point.There is certain defective in the organization chip of said structure in actual application, one, for the organization chip locality is carried out mark, generally the little piece of tissue on a certain angle of organization chip array is lacked as processing, influenced the integrality of organization chip integral body; They are two years old, whole little piece of tissue is integrated on the microslide with the pattern of horizontal longitudinal pitch uniformity, make when in making organization chip paraffin mass process, inserting sample paraffin organization core, cause staff's visual fatigue easily, will organize core wrong plug position easily; They are three years old, the experimental result of organization chip is mainly observed by manually carrying out microscopically at present, be difficult to during observation certain the chip piece tissue in the organization chip is quick and precisely located, causing section to have mobile slightly, debugging repeatedly and calculating that the observer just need cut into slices, so that redefine the position of certain chip piece tissue, increased researcher's non-productive work amount greatly; Observe an organization chip, the researcher is felt exhausted can't bear, not carefully slightly the mistake that result of study is fastened one person's story upon another person will occur; Its four, on the organization chip record in site and determine very inconvenient.

The utility model content:

The purpose of this utility model provides the accuracy that can improve staff and researcher and a kind of organization chip of work efficiency.

Scheme of the present utility model is: microslide is provided with a plurality of arrays and puts little piece of tissue, and above-mentioned little piece of tissue constitutes a plurality of little arrays, and the little piece of tissue on the angle is greater than other little piece of tissue.

The spacing H of adjacent little array is greater than the spacing h of little piece of tissue in the little array.The quantity of little array is 2-15.The line number of little piece of tissue is that 2-8 is capable in the little array, and columns is the 2-8 row; Little piece of tissue is set to 3 row, 5 row or 5 row, 3 row in the little array.

The utility model has the advantages that: to the little piece of tissue of organization chip carry out that little array subregion is handled and little array in discharge according to a graded, the diameter of the little piece of tissue on angle is bigger slightly than other sites, naked eyes can obviously be distinguished differentiation; Help improving accuracy and the work efficiency that organization chip is made the staff, more help improving researcher's tissues observed chip research result's efficient.

Description of drawings:

Fig. 1 is the synoptic diagram of the utility model embodiment.

Fig. 2 is the synoptic diagram of another embodiment of the utility model.

Embodiment:

With reference to Fig. 1, up to a hundred little piece of tissue 2 of the present utility model are arranged on the microslide 1, constitute 9 little arrays 3, and the spacing H of adjacent little array 3 is obviously greater than the spacing h of little piece of tissue 2 in the little array 3, and it is clear that each little array 3 is arranged, and distinguishes more convenient.Each little array 3 is made up of 15 little piece of tissue 2, is arranged in 3 row, 5 row.Little piece of tissue 2 is generally round dot, and little piece of tissue 2 ' diameter in the upper right corner just so just do not need to lack as handle and can identify, guarantees the integrality of organization chip integral body obviously greater than other little piece of tissue 2 diameters.

With reference to Fig. 2, hundreds of little piece of tissue 2 of this example constitute 8 little arrays 3, and little array 3 is made up of 15 little piece of tissue 2 of 5 row, 3 row.

2 in the little tissue of organization chip is structured the formation and can be arranged according to the needs of research, can constitute 2-15 little array 3, and the row of little piece of tissue 2 is to being provided with the 2-8 point in the little array 3, and row are to being provided with the 2-8 point.Little piece of tissue 2 ' of sign usefulness also can be arranged on the upper left corner, the lower left corner or the lower right corner, and the right side of array is provided with minute book 4.

Below be that example describes with Fig. 1, the record labeling method in site is on the organization chip: little array title is according to [row (A, B, C...)+row (1,2,3...)] numbering (as: A1, B3...) in turn, " OK " numbered in turn according to A, B, C in the little array, and " row " number in turn according to 1,2,3,4,5 in the little array.Be numbered " A3A5 " as little piece of tissue 2 ' among Fig. 1.Organize the numbering of core consistent in the numbering that the site is gone up in organization chip section and the paraffin mass.

As when making single sick tumor tissues chip of planting, but little piece of tissue 2 array random packet are arranged; When making the organization chip of many sick kinds, can with different sick organization arrangements of planting in different little arrays 3, perhaps be arranged in the corresponding row or column of different little arrays 3 respectively.When making the tumour progression organization chip, the tissue specimen (as cancerous tissue, cancer beside organism and normal structure sample) of the same internal organs different parts of same patient can be arranged to put in turn three sites of little array 3 same row respectively, a little array 3 can comprise 5 patients' tissue specimen; Also the tissue specimen (as cancerous tissue, carcinoma in situ tissue, dysplasia tissue, simple hyperplastic tissue and normal structure sample) of the same internal organs different parts of same patient can be arranged to put into five sites of little array 3 with delegation respectively in turn, a little array can comprise 3 patients' tissue specimen, or the like.

The little piece of tissue 2 of organization chip is carried out discharging according to a graded in little array 3 subregions processing and the little array 3, help improving accuracy and the work efficiency that organization chip is made the staff, more help improving researcher's tissues observed chip research result's efficient.

Claims

1. organization chip, microslide (1) is provided with a plurality of arrays and puts little piece of tissue (2), it is characterized in that above-mentioned little piece of tissue (2) constitutes a plurality of little arrays (3), and the little piece of tissue (2 ') on the angle is greater than other little piece of tissue (2).

2. a kind of organization chip according to claim 1 is characterized in that the spacing (h) of the spacing (H) of adjacent little array (3) greater than little piece of tissue (2) in the little array.

3. a kind of organization chip according to claim 1, the quantity that it is characterized in that little array (3) are 2-15.

4. according to claim 1 or 3 described a kind of organization chips, it is characterized in that the line number of little piece of tissue (2) in the little array (3) is that 2-8 is capable, columns is the 2-8 row.

5. a kind of organization chip according to claim 4 is characterized in that little piece of tissue (2) is set to 3 row, 5 row in the little array (3).

6. a kind of organization chip according to claim 4 is characterized in that little piece of tissue (2) is set to 5 row, 3 row in the little array (3).