CN1994366B - Chinese medicinal formulation for treating gynecological disease and preparation process thereof - Google Patents
Chinese medicinal formulation for treating gynecological disease and preparation process thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal preparation for gynaecologic diseases and its preparing process, wherein the preparation is prepared from (by weight ratio): Siphonostegia chinensis Benth 1. 3-13 parts and motherwort 1-10 parts, or Siphonostegia chinensis Benth 3-5 parts, motherwort 2-5 parts, purslane 1-3 parts, bitter orange 1-3 parts, astragalus root 1-5 parts, dipsacus root 0.5-3 parts, hairy vein agrimony 0.5-3 parts, basket fern 0.5-3 parts and gamene 0.5-3 parts.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of gynaecopathia and preparation method thereof, belong to technical field of Chinese medicine.
Background technology: dysfunctional uterine hemorrhage, be called for short anovulatory dysfunctional uterine hemorrhage, be a kind of common gynaecopathia, be meant unusual metrorrhagia, after indagation, find no whole body and genitals's organic disease, but because due to the neuroendocrine system functional disorder.Show as menstrual cycle irregular, through measure too much, menostaxis or irregular bleeding, it has a strong impact on the physically and mentally healthy and normal work life of women.These sick means of treatment mainly contain hemostatic treatment, diagnostic curettage and hormonotherapy at present, but all have some problems.At first, though the dilatation and curettage treatment is one of hemorrhage best method of treatment, the requirements of operation height, and need be undertaken by the strict aseptic manipulation rules, postoperative needs to use antibiotics, and causes obstruction of fallopian tube easily patient's hygienic requirements strictness, causes woman infertility.The side effect of hormone therapy is then more obvious, as water-sodium retention, hyperlipidemia, hypoimmunity, osteoporosis etc.In addition, though the method for some dietetic therapies can adopt, as brown sugar Auricularia, clam liquid sponge with ginger juice and rice wine etc., effect is slow, and curative effect is very little, can only be as a kind of auxiliary treatment means.The treatment by Chinese herbs dysfunctional uterine hemorrhage, side effect is little, especially the proper compound preparation of compatibility, but the clinical compound Chinese medicinal preparation that is used for anovulatory dysfunctional uterine hemorrhage only is very limited, as Danzhi Xiaoyao San plus-minus, Bolus as a Kidney-Yin-Tonic plus-minus, not only effect is not clearly, and product selection face is little, is difficult to satisfy needs of patients.
Summary of the invention: technical problem to be solved by this invention provides a kind of Chinese medicine preparation for the treatment of gynaecopathia and preparation method thereof; The present invention is directed to prior art,, adopt siphonostegia chinensis, Herba Leonuri basis side, be equipped with Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae and make compound preparation according to the etiopathogenesis of dysfunctional uterine hemorrhage; Recipe quantity is little, and cost is reasonable, for the treatment dysfunctional uterine hemorrhage curative effect is preferably arranged.And the present invention is pure Chinese medicinal preparation, little, the taking convenience of its untoward reaction, and the patient takes like a shot.
Technical scheme of the present invention is to constitute like this: calculate by weight, the Chinese medicine preparation of treatment gynaecopathia is made for 1～10 part by 1.3～13 parts of siphonostegia chinensiss and Herba Leonuri.
Specifically, raw materials used calculating by weight, it is made for 1～5 part by 2.6～6.5 parts of siphonostegia chinensiss and Herba Leonuri.
The preparation method of the Chinese medicine preparation of above-mentioned treatment gynaecopathia is: get siphonostegia chinensis, Herba Leonuri respectively or merge and to decoct with water, collecting decoction filters, and filtrate concentrates, add ethanol, leave standstill, filter filtrate recycling ethanol, concentrate pure clear paste, the alcohol clear paste is re-refined, drying, pulverizes, and makes different preparations then respectively.
Preparation method is more specifically: get siphonostegia chinensis, 8～15 times of water gagings decoctions of Herba Leonuri adding 2～4 times, and each 0.5～3 hour, collecting decoction, filter, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, add ethanol, make that ethanol content is 40～60% in the solution, left standstill 24～72 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, add adjuvant then and make different preparations.
Calculate by weight, the present invention treats the Chinese medicine preparation of gynaecopathia and can also be made for 0.5～3 part by 3～5 parts of siphonostegia chinensiss, 2～5 parts of Herba Leonuris, 1～3 part of Herba Portulacae, 1～3 part of Fructus Aurantii, 1～5 part of the Radix Astragali, 0.5～3 part of Radix Dipsaci, 0.5～3 part of Herba Agrimoniae, 0.5～3 part of GUANZHONGTAN and Radix Rubiae.
Specifically, raw materials used calculating by weight, it is made for 1.8 parts by 4 parts of siphonostegia chinensiss, 3 parts of Herba Leonuris, 2.4 parts of Herba Portulacaes, 2.4 parts of Fructus Aurantiis, 3 parts of the Radixs Astragali, 1.8 parts of Radix Dipsacis, 1.8 parts of Herba Agrimoniaes, 1.8 parts of GUANZHONGTAN and Radix Rubiae.
Described Chinese medicine preparation is a receptible dosage form on granule, tablet, capsule or oral liquid and other pharmaceutics.
The preparation method of the Chinese medicine preparation of above-mentioned treatment gynaecopathia is: get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae, adding 8～15 times of water gagings decocts 2～4 times, each 0.5～3 hour, collecting decoction, filter, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, adds ethanol, make that ethanol content is 40～60% in the solution, left standstill 24～72 hours, and filtered filtrate recycling ethanol, be concentrated into relative density about 1.20, get pure clear paste, get pure clear paste and add adjuvant, be prepared into the preparation formulation that needs.
Granule in the described preparation prepares like this: get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae, decoct with water 3 times, each 10 times of water gagings, the each decoction 1.5 hours, collecting decoction filters, and it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, add ethanol, make concentration of alcohol reach 50%, left standstill 48 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, get 1 part of pure clear paste, add 3 parts of adjuvants, granulate drying, granulate, packing, promptly.
The added adjuvant of above-mentioned granule can be: one or more in 30 POVIDONE K 30 BP/USP 30, starch, dextrin, steviosin, protein sugar, sodium cyclamate, the essence mix use.
The present invention's prescription is made up of siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae nine herbal medicines.Siphonostegia chinensis is the dry herb of goatweed Herba Siphonostegiae Herba siphonostegiae in the side, and its bitter in the mouth is warm in nature, goes into the heart, spleen channel, and the function removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Tang Materia Medica carries it, and " main removing blood stasis expands down.", " Japan hanako materia medica " says that " control cardiac and abdominal pain, therapeutic method to keep the adverse QI flowing downwards watery distension, vim and vigour are led to married woman Jing Mai Disorder knot, end the cholera watery diarrhea for it.", " Kaibao Bencao " said it " treat incised wound, stopping blooding is key medicine; Puerperal surplus disease, hematochezia, pain relieving.", " it is former that book on Chinese herbal medicine is asked " controls motive pain, and chancre is hemorrhage.As seen siphonostegia chinensis function removing blood stasis stimulates the menstrual flow, and healing up sore and subduing swelling is established at the main pathogenesis of primary disease, is to be monarch drug.Join Herba Leonuri, the power of removing blood stasis dissipating blood stasis strengthens, and the hemostasis of can stimulating the menstrual flow.
Herba Leonuri bitter in the mouth, suffering are slightly cold.Return liver, pericardium channel.Gynecological uses key medicine always, and be good at especially managing property back lochiorrhea, the stasis of blood stomachache that stagnates has the effect of promoting tissue regeneration by removing blood stasis, thus have Herba Leonuri number." detailed outline " says it, and " root, stem, flower, leaf, reality, and all be used as medicine can be with using.If control brothers' cloudy blood system wind heat of fainting, the benefit that makes eye bright is smart, transfers married woman's passages through which vital energy circulates, and then single is good with Fructus Leonuri.If control the toxic swelling skin infection, the clear water promoting the circulation of blood, married woman's tire produces all diseases, then suitable also using to good.Gai Qigen, stem, flower, leaf are specially done row, and its son then has the event of benefit also in the row." " book on Chinese herbal medicine converge with speech " say its " promoting the circulation of blood is nourished blood, and promoting the circulation of blood and do not hinder fresh blood is nourished blood and the blood stasis that do not stagnate, really be blood man panacea also." book on Chinese herbal medicine is looked for the truth " calls it, and " the regulating menstruation detoxifcation is for wanting agent behind the tire front tyre for the water promoting the circulation of blood that disappears, eliminating blood stasis to promote regeneration of blood." Herba Leonuri nourishing blood and promoting blood circulation blood stasis dispelling, promoting the circulation of blood is nourished blood, promoting the circulation of blood and do not hinder fresh blood is nourished blood and the congestion that do not stagnate, the property benefaction is walked, can repercussive by stagnating, to strengthen the merit of monarch drug promoting blood circulation and hemostasis, be to be ministerial drug.
Herba Portulacae acid, cold.GUIXIN, large intestine channel.The function heat-clearing and toxic substances removing, removing heat from blood is controlled dysentery.Compendium of Material Medica is called its energy " it is treating stranguria to detoxify for the blood detumescence of loosing, sharp intestinal habitual abortion, the back sweating due to debility of managing property "; The GUANZHONGTAN hardship, liver, stomach warp are gone in cold.Function cooling blood for hemostasis, Compendium of Material Medica say its can " control the inferior in the metrorrhagia, leukorrhagia, puerperal the vim and vigour distending pain ", " the southern regions of the Yunnan Province book on Chinese herbal medicine " say its " poison of dispelling, the hemostasis, separate noxious water."; The Fructus Aurantii picric acid is slightly cold, and goes into spleen, stomach warp.The pain relieving of function regulating the flow of QI to dissipate blood stasis, the stagnant relieving distension of row." Kaibao Bencao " say its " the main air paralysis of itching, easing joint movement, the consumptive disease cough, back of the body arm is bored and listless, looses and stays knot, chest and diaphragm expectorant to stagnate, relieve oedema or abdominal distension through diuresis or purgation, full, the big hemorrhoidal hamorrhage of relieving distension, the peace stomach ends wind bitterly."; The Radix Astragali is warm in nature, and sweet in the mouth is returned the spleen lung meridian.The effect tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, inducing diuresis to remove edema." book on Chinese herbal medicine justice " claims that " so its hemostasis collapses stranguria with blood person, blood is from ending also, so say the blood prostration QI invigorating with gas-solid."; The Herba Agrimoniae bitter in the mouth is flat, and merit is arrogated to oneself hemostasis, can control the hemorrhage disease in each position, and no matter cold and heat and asthenia and sthenia all can be used.Herba Agrimoniae function hemostasis, action range can be used for each hemorrhage disease partly of health, and no matter cold, heat, empty, real person all can be used.The Radix Dipsaci toil, tepor is gone into liver, kidney channel.The function invigorating the liver and kidney, bone and muscle strengthening continues and traumatics fracture, and controls metrorrhagia." book on Chinese herbal medicine justice " says its " current hundred arteries and veins can continue exhausted the wound and QI and blood regulating ", and " book on Chinese herbal medicine is looked for the truth " says Radix Dipsaci, " real promoting flow of QI and blood muscles and bones first medicine also ", " medicine justice " are said Radix Dipsaci " muscles and bones the wrecking of continuing is so a Radix Dipsaci for the hardship arteries and veins that nourishes blood, the hot fur of supporting; kind treating blood disorders arteries and veins trauma " again.Radix Dipsaci is mended the medicine of continuous blood vessels, mends the effect of the blood of being injurious to life again, tonify without causing stagnation, and row and not stagnating, blood vessels and QI and blood regulating work.Radix Rubiae hardship, cold.Go into Liver Channel.Radix Rubiae removing heat from blood and stopping blooding." not Lu " claims its " hemostasis, in collapse hematochezia "; " Japan hanako materia medica " says its " end serious epistaxis, leukorrhagia produces Hou blood fortune, breast knot, menstruation is more than, hemorrhoidal hamorrhage, the hemorrhoid flaccidity, furuncle is controlled in evacuation of pus, lets out essence, hematuria is pounced on and decreased blood stasis "; Compendium of Material Medica says that " qualcomm meridian is controlled joint wind pain, the promoting the circulation of blood of invigorating blood circulation for it." Radix Rubiae removing heat from blood promoting the circulation of blood hemostasis, dredge the meridian passage.Promoting the circulation of blood and not enriching blood helps the Radix Astragali with promoting the circulation of blood.Drawing blood returns through to reach the effect of hemostasis.More than seven flavors, or clearing away heat and cooling blood hemostasis, or regulating qi-flowing for activating stagnancy pain relieving, or blood circulation promoting and enriching nourishes blood, common assistant helps monarch-minister drug strengthening its promoting blood circulation and hemostasis, cooling blood and removing stasis, the merit of QI invigorating pain relieving is the shared adjuvant drug that is.
Take a broad view of full side, be total to the long memorial oxytocin bleeding, cooling blood and removing stasis, the effect of QI invigorating pain relieving is the effective good medicine that is used for dysfunctional uterine hemorrhage.
Compared with prior art, the present invention is a pure Chinese medicinal preparation, and it writes out a prescription novel, and reliable to the stable curative effect of dysfunctional uterine hemorrhage, side effect is little, has reduced dose, taking convenience, and cost is reasonable, and the patient takes like a shot.
The applicant has carried out a series of prescription experiments, can prove that medicine provided by the invention has effective effect:
Experimental example 1 full presciption medicine is imitated experimental result can obviously strengthen the phagocytic function of cyclophosphamide model mice mononuclear phagocyte and the generation of serum hemolysin.Xylol causes mice auricle swelling antagonism, can obviously shorten the bleeding time of mice.Can improve and put device rabbit endometrium pathomorphism, alleviate and put endometrial inflammatory cell of Cu-IUD rabbit and inflammatory exudation, endometrial damage is had repair.Zero difference between two groups can both reduce the partial prostacyclin of Cu-IUD family's rabbit uterus (PGI2) level of putting, rising thromboxane A2 (TXA2) level, the ratio of adjustment PCI2/TXA2; Reduce and put fine proenzyme activator (t-Pa) activity of the partial tectotype of Cu-IUD family's rabbit uterus; Can reduce the activity of putting partial NO of Cu-IUD family's rabbit uterus and NOS, thereby the main pathology link that causes bleeding behind the ring is put in influence, reaches the hemostatic purpose.And can reduce hematocrit value, whole blood contrast viscosity (basic, normal, high cutting) and plasma viscosity significantly, reach the purpose of improving hemorheological property.Viewpoint according to Chinese medicine plays hemostasis by removing blood stasis, makes the stasis of blood go new life, hemostasis and do not stay the effect of the stasis of blood.
The toxicity reaction of this prescription to mice and rat observed in experimental example 2 full side's toxicological experiment groupings.Mice does not have the acute poisoning symptom after the medication as a result; The blood parameters of long term toxicity test research rat all in normal range, there was no significant difference between high and low dose group and matched group (P＞0.05).Experimental result shows that this medicine is little, the safe compound preparation of a kind of toxicity.
Concrete embodiment:
The deal of the following stated raw medicinal material is weight portion.
Embodiments of the invention 1: 4 parts of siphonostegia chinensiss, 3 parts of Herba Leonuris, 2.4 parts of Herba Portulacaes, 2.4 parts of Fructus Aurantiis, 3 parts of the Radixs Astragali, 1.8 parts of Radix Dipsacis, 1.8 parts of Herba Agrimoniaes, 1.8 parts of GUANZHONGTAN, 1.8 parts in Radix Rubiae
Get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae, decoct with water 3 times, each 10 times of water gagings, the each decoction 1.5 hours, collecting decoction filters, and it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, add ethanol, make concentration of alcohol reach 50%, left standstill 48 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, get 1 part of pure clear paste, add 30 3 parts of 30 POVIDONE K 30 BP/USPs, granulate drying, granulate, packing promptly gets granule.
Embodiments of the invention 2: 3 parts of siphonostegia chinensiss, 2 parts of Herba Leonuris, 1 part of Herba Portulacae, 1 part of Fructus Aurantii, 1 part of the Radix Astragali, 0.5 part of Radix Dipsaci, 0.5 part of Herba Agrimoniae, 0.5 part of GUANZHONGTAN, 0.5 part in Radix Rubiae
Get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae adds 8 times of water gagings and decocts each 3 hours 2 times, collecting decoction, filter, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, add ethanol, make that ethanol content is 40% in the solution, left standstill 24 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, get 1 part of pure clear paste, add adjuvant (30 POVIDONE K 30 BP/USP 30, starch, dextrin, steviosin, protein sugar, sodium cyclamate, in the essence one or more) 3 parts, granulate drying, granulate, packing promptly gets granule.
Embodiments of the invention 3: 5 parts of siphonostegia chinensiss, 5 parts of Herba Leonuris, 3 parts of Herba Portulacaes, 3 parts of Fructus Aurantiis, 5 parts of the Radixs Astragali, 3 parts of Radix Dipsacis, 3 parts of Herba Agrimoniaes, 3 parts of GUANZHONGTAN, 3 parts in Radix Rubiae
Get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae, add 15 times of water gagings and decoct 4 times, each 0.5 hour, collecting decoction, filter, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, adds ethanol, make that ethanol content is 60% in the solution, left standstill 72 hours, and filtered filtrate recycling ethanol, be concentrated into relative density about 1.20, get pure clear paste, get pure clear paste and add adjuvant, mixing, granulate, drying incapsulates, and promptly gets capsule.
Embodiments of the invention 4: 4 parts of siphonostegia chinensiss, 4 parts of Herba Leonuris, 2 parts of Herba Portulacaes, 2 parts of Fructus Aurantiis, 4 parts of the Radixs Astragali, 2 parts of Radix Dipsacis, 2 parts of Herba Agrimoniaes, 2 parts of GUANZHONGTAN, 2 parts in Radix Rubiae
Get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae, add 8～12 times of water gagings and decoct each 2 hours 3 times, collecting decoction, filter, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, add ethanol, make that ethanol content is 50% in the solution, left standstill 60 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, drying, pulverize, add adjuvant, mixing, in blocks with alcohol granulation, drying, compacting, the bag film-coat promptly gets tablet.
Embodiments of the invention 5: 4.5 parts of siphonostegia chinensiss, 3 parts of Herba Leonuris
Get siphonostegia chinensis, 10 times of water gagings decoctions of Herba Leonuri adding 3 times, each 1.5 hours, collecting decoction filtered, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, adds ethanol, make that ethanol content is 50% in the solution, left standstill 48 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, add adjuvant, mixing is granulated, drying incapsulates, and promptly gets capsule.
Embodiments of the invention 6: 1.3 parts of siphonostegia chinensiss, 1 part of Herba Leonuri
Get siphonostegia chinensis, 8 times of water gagings decoctions of Herba Leonuri adding 2 times, each 3 hours, collecting decoction filtered, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, adds ethanol, makes that ethanol content is 40% in the solution, left standstill 24 hours, and filtered filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, drying, pulverize, add adjuvant, mixing, in blocks with alcohol granulation, drying, compacting, the bag film-coat promptly gets tablet.
Embodiments of the invention 7: 13 parts of siphonostegia chinensiss, 10 parts of Herba Leonuris
Get siphonostegia chinensis, 15 times of water gagings decoctions of Herba Leonuri adding 4 times, each 0.5 hour, collecting decoction filtered, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, gets above-mentioned clear paste, adds ethanol, make that ethanol content is 60% in the solution, left standstill 72 hours, filter, filtrate recycling ethanol, it is about 1.20 to be concentrated into relative density, pure clear paste, add adjuvant, granulate drying, granulate, packing promptly gets granule.
Claims (6)
1. Chinese medicine preparation for the treatment of gynaecopathia is characterized in that: raw materials usedly calculate by weight: it is made for 0.5～3 part by 3～5 parts of siphonostegia chinensiss, 2～5 parts of Herba Leonuris, 1～3 part of Herba Portulacae, 1～3 part of Fructus Aurantii, 1～5 part of the Radix Astragali, 0.5～3 part of Radix Dipsaci, 0.5～3 part of Herba Agrimoniae, 0.5～3 part of GUANZHONGTAN and Radix Rubiae.
2. according to the Chinese medicine preparation of the described treatment gynaecopathia of claim 1, it is characterized in that: raw materials used calculating by weight, it is made for 1.8 parts by 4 parts of siphonostegia chinensiss, 3 parts of Herba Leonuris, 2.4 parts of Herba Portulacaes, 2.4 parts of Fructus Aurantiis, 3 parts of the Radixs Astragali, 1.8 parts of Radix Dipsacis, 1.8 parts of Herba Agrimoniaes, 1.8 parts of GUANZHONGTAN and Radix Rubiae.
3. according to the Chinese medicine preparation of the described treatment gynaecopathia of claim 2, it is characterized in that: described preparation is granule, tablet, capsule or oral liquid.
4. the preparation method of the Chinese medicine preparation of treatment gynaecopathia as claimed in claim 1 or 2, it is characterized in that: get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae, adding 8～15 times of water gagings decocts 2～4 times, each 0.5～3 hour, collecting decoction filters, and it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, get above-mentioned clear paste, add ethanol, make that ethanol content is 40～60% in the solution, left standstill 24～72 hours, filter, filtrate recycling ethanol is concentrated into relative density 1.20, gets pure clear paste, get pure clear paste and add adjuvant, preparations shaping.
5. according to the preparation method of the Chinese medicine preparation of the described treatment gynaecopathia of claim 4, it is characterized in that: the granule in the described preparation prepares like this: get siphonostegia chinensis, Herba Leonuri, Herba Portulacae, Fructus Aurantii, the Radix Astragali, Radix Dipsaci, Herba Agrimoniae, GUANZHONGTAN, Radix Rubiae decocts with water 3 times, each 10 times of water gagings decocted collecting decoction 1.5 hours at every turn, filter, it is 1.05～1.10 clear paste that filtrate is concentrated into relative density, adds ethanol, makes concentration of alcohol reach 50%, left standstill 48 hours, filter, filtrate recycling ethanol is concentrated into relative density 1.20, get pure clear paste, get 1 part of pure clear paste, add 3 parts of adjuvants, granulate, dry, granulate, packing, promptly.
6. according to the preparation method of the Chinese medicine preparation of the described treatment gynaecopathia of claim 5, it is characterized in that: the added adjuvant of granule is: one or more in 30 POVIDONE K 30 BP/USP 30, starch, dextrin, steviosin, protein sugar, sodium cyclamate, the essence mix and use.
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| CN1211436A (en) * | 1997-09-18 | 1999-03-24 | 天津市计划生育研究所 | Medicine for preventing and curing bleeding side reaction after abortion by drug |
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| CN1994366A (en) | 2007-07-11 |
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